Systemic thrombolysis in postoperative neurosurgical patients with massive pulmonary embolism (case series and review)

Baranich AI, Sychev AA, Yakovlev SB, et al. Systemic thrombolysis in postoperative neurosurgical patients with massive pulmonary embolism (case series and review). Russian Journal of Anesthesiology and Reanimatology. 2026;(1):84‑91. (In Russ., In Engl.)
https://doi.org/10.17116/anaesthesiology202601184

Использование инфографики авторами научных работ

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Abstract:

Neurosurgical patients represent a high-risk group for pulmonary embolism (PE). Patients with PE and high risk of death require immediate reperfusion therapy—mechanical reperfusion or systemic thrombolysis. Thrombolytic therapy (TLT) provides rapid reduction of obstruction and decreases pulmonary artery pressure, but it is associated with high risk of hemorrhagic complications. An absolute contraindication for TLT is central nervous system disease. When choosing a treatment strategy, one should consider PE-related risk of death with likelihood and consequences of intracranial hemorrhage. This article describes TLT in neurosurgical patients with massive PE and high risk of death over a 4.5-year follow-up period.

Keywords:

pulmonary embolism

systemic thrombolysis

thrombolytic therapy

hemodynamics

neurosurgery

Authors:

Baranich A.I.

Burdenko Neurosurgery Center;
Plekhanov Russian University of Economics

RSCI AuthorID: 1006875
Scopus AuthorID: 57202735861
ORCID: 0000-0002-1167-0742

Sychev A.A.

Burdenko Neurosurgery Center

SPIN RSCI: 1171-7690
Scopus AuthorID: 36997601100
ORCID: 0000-0002-0038-1005

Yakovlev S.B.

Burdenko Neurosurgery Center

ORCID: 0000-0002-0798-2604

Savin I.A.

Burdenko Neurosurgery Center

SPIN RSCI: 1342-7065
Scopus AuthorID: 35974373500
ORCID: 0000-0003-3874-4147

Veliev Z.Sh.

Burdenko Neurosurgery Center

ORCID: 0009-0004-4545-8215

Abramov T.A.

Burdenko Neurosurgery Center

ORCID: 0000-0002-9542-3801

Kurdyumova N.V.

Burdenko Neurosurgery Center

ORCID: 0000-0002-9741-0692

Korotkov D.S.

Burdenko Neurosurgery Center

ORCID: 0000-0002-2204-4480

Kudrina V.G.

Plekhanov Russian University of Economics;
Russian Medical Academy of Continuous Professional Education

ORCID: 0000-0002-4329-1165

Received:

09.06.2025

Accepted:

28.07.2025

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References:

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