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Lapin K.S.

Volosevich Arkhangelsk City Hospital

Fot E.V.

Volosevich Arkhangelsk City Hospital;
Northern State Medical University

Kuzkov V.V.

Volosevich Arkhangelsk City Hospital;
Northern State Medical University

Kirov M.Yu.

Volosevich Arkhangelsk City Hospital;
Northern State Medical University

Prevention of ventilator-associated pneumonia: review and prophylaxis checklist

Authors:

Lapin K.S., Fot E.V., Kuzkov V.V., Kirov M.Yu.

More about the authors

Read: 1992 times


To cite this article:

Lapin KS, Fot EV, Kuzkov VV, Kirov MYu. Prevention of ventilator-associated pneumonia: review and prophylaxis checklist. Russian Journal of Anesthesiology and Reanimatology. 2025;(6):87‑98. (In Russ.)
https://doi.org/10.17116/anaesthesiology202506187

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References:

  1. Bonell A, Azarrafiy R, Huong VTL, Viet TL, Phu VD, Dat VQ, Wertheim H, van Doorn HR, Lewycka S, Nadjm B. A Systematic Review and Meta-analysis of Ventilator-associated Pneumonia in Adults in Asia: An Analysis of National Income Level on Incidence and Etiology. Clinical Infectious Diseases. 2019;68:511-518.  https://doi/10.1093/cid/ciy543
  2. Pickens CO, Gao CA, Cuttica MJ, Smith SB, Pesce LL, Grant RA, Kang M, Morales-Nebreda L, Bavishi AA, Arnold JM, Pawlowski A, Qi C, Budinger GRS, Singer BD, Wunderink RG; NU COVID Investigators. Bacterial Superinfection Pneumonia in Patients Mechanically Ventilated for COVID-19 Pneumonia. American Journal of Respiratory Critical Care Medicine. 2021;204(8):921-932.  https://doi/10.1164/rccm.202106-1354OC
  3. Shi Y, Huang Y, Zhang TT, Cao B, Wang H, Zhuo C, Ye F, Su X, Fan H, Xu JF, Zhang J, Lai GX, She DY, Zhang XY, He B, He LX, Liu YN, Qu JM. Chinese guidelines for the diagnosis and treatment of hospital-acquired pneumonia and ventilator-associated pneumonia in adults (2018 Edition). Journal of Thoracic Disease. 2019;11(6):2581-2616. https://doi/10.21037/jtd.2019.06.09
  4. Wu D, Wu C, Zhang S, Zhong Y. Risk Factors of Ventilator-Associated Pneumonia in Critically III Patients. Frontiers in Pharmacology. 2019;10:482.  https://doi/10.3389/fphar.2019.00482
  5. Fumagalli J, Panigada M, Klompas M, Berra L. Ventilator-associated pneumonia among SARS-CoV-2 acute respiratory distress syndrome patients. Current Opinion in Critical Care. 2022;28(1):74-82.  https://doi/10.1097/MCC.0000000000000908
  6. Ershov VI, Gritsan AI, Belkin AA, Zabolotskikh IB, Gorbachev VI, Lebedinskii KM, Leyderman IN, Petrikov SS, Protsenko DN, Solodov AA, Shchegolev AV, Tikhomirova AA, Khodchenko VV, Borzdyko AA, Meshcheryakov AO. Russian multiple-center observational clinical study “Register of respiratory therapy for patients with stroke (RETAS)”: aspects of mechanical ventilation. Russian Journal of Anesthesiology and Reanimatology. 2021;(6):25-34. (In Russ.). https://doi/10.17116/anaesthesiology202106125
  7. Nanao T, Nishizawa H, Fujimoto J, Ogawa T. Additional medical costs associated with ventilator-associated pneumonia in an intensive care unit in Japan. American Journal of Infection Control. 2021;49(3):340-344.  https://doi/10.1016/j.ajic.2020.07.027
  8. Nozokomial’naya pnevmoniya u vzroslykh: Rossijskie natsional’nye rekomendatsii. Gelfand BR, ed. 2-e izd., pererab. i dop. M.: MIA; 2016. (In Russ.).
  9. Klompas M, Branson R, Cawcutt K, Crist M, Eichenwald EC, Greene LR, Lee G, Maragakis LL, Powell K, Priebe GP, Speck K, Yokoe DS, Berenholtz SM. Strategies to prevent ventilator-associated pneumonia, ventilator-associated events, and non-ventilator hospital-acquired pneumonia in acute-care hospitals: 2022 Update. Infection Control and Hospital Epidemiology. 2022;43(6):687-713.  https://doi/10.1017/ice.2022.88
  10. McCaughey EJ, Jonkman AH, Boswell-Ruys CL, McBain RA, Bye EA, Hudson AL, Collins DW, Heunks LMA, McLachlan AJ, Gandevia SC, Butler JE. Abdominal functional electrical stimulation to assist ventilator weaning in critical illness: a double-blinded, randomised, sham-controlled pilot study. Critical Care. 2019;23(1):261.  https://doi/10.1186/s13054-019-2544-0
  11. Shi ZH, Jonkman A, de Vries H, Jansen D, Ottenheijm C, Girbes A, Spoelstra-de Man A, Zhou JX, Brochard L, Heunks L. Expiratory muscle dysfunction in critically ill patients: towards improved understanding. Intensive Care Medicine. 2019;45(8):1061-1071. https://doi/10.1007/s00134-019-05664-4
  12. Torres A, Niederman MS, Chastre J, Ewig S, Fernandez-Vandellos P, Hanberger H, Kollef M, Li Bassi G, Luna CM, Martin-Loeches I, Paiva JA, Read RC, Rigau D, Timsit JF, Welte T, Wunderink R. International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia: Guidelines for the management of hospital-acquired pneumonia (HAP)/ventilator-associated pneumonia (VAP) of the European Respiratory Society (ERS), European Society of Intensive Care Medicine (ESICM), European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and Asociación Latinoamericana del Tórax (ALAT). European Respiratory Journal. 2017;50(3):1700582. https://doi/10.1183/13993003.00582-2017
  13. Kalil AC, Metersky ML, Klompas M, Muscedere J, Sweeney DA, Palmer LB, Napolitano LM, O’Grady NP, Bartlett JG, Carratalà J, El Solh AA, Ewig S, Fey PD, File TM Jr, Restrepo MI, Roberts JA, Waterer GW, Cruse P, Knight SL, Brozek JL. Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clinical Infectious Diseases. 2016;63(5):e61-e111. https://doi/10.1093/cid/cix759
  14. Wang B, Briegel J, Krueger WA, Draenert R, Jung J, Weber A, Bogner J, Schubert S, Liebchen U, Frank S, Zoller M, Irlbeck M, Ney L, Weig T, Hinske L, Niedermayer S, Kilger E, Möhnle P, Grabein B. Ecological effects of selective oral decontamination on multidrug-resistance bacteria acquired in the intensive care unit: a case-control study over 5 years. Intensive Care Medicine. 2022;48(9):1165-1175. https://doi/10.1007/s00134-022-06826-7
  15. Hurley JC. Is selective decontamination (SDD/SOD) safe in the ICU context? Journal of Antimicrobial Chemotherapy. 2019;74(5):1167-1172. https://doi/10.1093/jac/dky573
  16. Klompas M. What is new in the prevention of nosocomial pneumonia in the ICU? Current Opinion in Critical Care. 2017;23(5):378-384.  https://doi/10.1097/MCC.0000000000000443
  17. Álvarez-Lerma F, Palomar-Martínez M, Sánchez-García M, Martínez-Alonso M, Álvarez-Rodríguez J, Lorente L, Arias-Rivera S, García R, Gordo F, Añón JM, Jam-Gatell R, Vázquez-Calatayud M, Agra Y. Prevention of Ventilator-Associated Pneumonia: The Multimodal Approach of the Spanish ICU «Pneumonia Zero» Program. Critical Care Medicine. 2018;46(2):181-188.  https://doi/10.1097/CCM.0000000000002736
  18. Bouadma L, Klompas M. Oral care with chlorhexidine: beware! Intensive Care Medicine. 2018;44(7):1153-1155. https://doi/10.1007/s00134-018-5221-x
  19. La Combe B, Bleibtreu A, Messika J, Fernandes R, Clermont O, Branger C, Billard-Pomares T, Barnaud G, Magdoud F, Eveillard M, Kouatchet A, Lasocki S, Asfar P, Corvec S, Lakhal K, Armand-Lefevre L, Wolff M, Timsit JF, Bourdon S, Reignier J, Martin S, Fihman V, de Prost N, Bador J, Charles PE, Goret J, Boyer A, Wallet F, Jaillette E, Nseir S, Landraud L, Ruimy R, Danin PE, Dellamonica J, Cremniter J, Frat JP, Jauréguy F, Clec’h C, Decré D, Maury E, Dreyfuss D, Denamur E, Ricard JD. Decreased susceptibility to chlorhexidine affects a quarter of Escherichia coli isolates responsible for pneumonia in ICU patients. Intensive Care Medicine. 2018;44(4):531-533.  https://doi/10.1007/s00134-018-5061-8
  20. Klompas M. Oropharyngeal Decontamination with Antiseptics to Prevent Ventilator-Associated Pneumonia: Rethinking the Benefits of Chlorhexidine. Seminars in Respiratory and Critical Care Medicine. 2017;38(3):381-390.  https://doi/10.1055/s-0037-1602584
  21. Postanovlenie Glavnogo gosudarstvennogo sanitarnogo vracha Rossijskoj Federatsii ot 28.01.2021 №4 (red. ot 25.05.2022) «Ob utverzhdenii sanitarnykh pravil i norm SanPiN 3.3686-21 «Sanitarno-epidemiologicheskie trebovaniya po profilaktike infektsionnykh boleznej» (zaregistrirovano v Minyuste Rossii 15.02.2021 za №62500). (In Russ.). Accessed October 11, 2025. https://www.rospotrebnadzor.ru/sanitary_rules/polnye-teksty-dokumentov.php
  22. Lapin KS, Kuzkov VV, Chernova TV, Galkina TV, Kirov MYu. Impact of closed suction system on the incidence of ventilator-associated pneumonia, patient colonization and contamination of inanimate surfaces. Russian Journal of Anesthesiology and Reanimatology. 2020;(4):32-41. (In Russ.). https://doi/10.17116/anaesthesiology202004132
  23. Lapin KS, Fot EV, Kuzkov VV, Kirov MYu. Impact of multizonal decontamination of upper respiratory tract on incidence of ventilator-associated pneumonia: multicenter randomized pilot study. Vestnik intensivnoj terapii imeni A.I. Saltanova. 2023;3:66-81. (In Russ.). https://doi.org/10.21320/1818-474X-2023-3-66-81
  24. Mezhdunarodnaya statisticheskaya klassifikatsiya boleznej i problem, svyazannykh so zdorov’em, desyatyj peresmotr. (In Russ.). Accessed October 11, 2025. https://mkb-10.com
  25. Krone M, Seeber C, Nydahl P. Preventing ventilator-associated pneumonia non-pharmacologically. Intensive Care Medicine. 2024;50(12):2185-2187. https://doi/10.1007/s00134-024-07696-x
  26. Coppadoro A, Bellani G, Foti G. Non-Pharmacological Interventions to Prevent Ventilator-Associated Pneumonia: A Literature Review. Respiratory Care. 2019;64(12):1586-1595. https://doi/10.4187/respcare.07127
  27. Güner CK, Kutlutürkan S. Role of head-of-bed elevation in preventing ventilator-associated pneumonia bed elevation and pneumonia. Nursing Critical Care. 2022;27(5):635-645.  https://doi/10.1111/nicc.12633
  28. Lian C, Zhang J, Wang P, Mao W. Impact of head-of-bed elevation angle on the development of pressure ulcers and pneumonia in patients on mechanical ventilation: a systematic review and meta-analysis. BMC Pulmonary Medicine. 2024;24(1):462.  https://doi/10.1186/s12890-024-03270-9
  29. Li Bassi G, Panigada M, Ranzani OT, Zanella A, Berra L, Cressoni M, Parrini V, Kandil H, Salati G, Selvaggi P, Amatu A, Sanz-Moncosi M, Biagioni E, Tagliaferri F, Furia M, Mercurio G, Costa A, Manca T, Lindau S, Babel J, Cavana M, Chiurazzi C, Marti JD, Consonni D, Gattinoni L, Pesenti A, Wiener-Kronish J, Bruschi C, Ballotta A, Salsi P, Livigni S, Iotti G, Fernandez J, Girardis M, Barbagallo M, Moise G, Antonelli M, Caspani ML, Vezzani A, Meybohm P, Gasparovic V, Geat E, Amato M, Niederman M, Kolobow T, Torres A; Gravity-VAP Network. Randomized, multicenter trial of lateral Trendelenburg versus semirecumbent body position for the prevention of ventilator-associated pneumonia. Intensive Care Medicine. 2017;43(11):1572-1584. https://doi/10.1007/s00134-017-4858-1
  30. Zhou Y, He H, Cui N, Wang X, Long Y, Liu D. Elevation of the head of bed reduces splanchnic blood flow in patients with intra-abdominal hypertension. BMC Anesthesiology. 2023;23(1):133.  https://doi/10.1186/s12871-023-02046-8
  31. Kallet RH, Zhuo H, Yip V, Gomez A, Lipnick MS. Spontaneous Breathing Trials and Conservative Sedation Practices Reduce Mechanical Ventilation Duration in Subjects With ARDS. Respiratory Care. 2018;63(1):1-10.  https://doi/10.4187/respcare.05270
  32. Potievskaya VI, Zabolotskikh IB, Gridchik IE, Gritsan AI, Eremenko AA, Kozlov IA, Lebedinskii KM, Levit AL, Mazurok VA, Molchanov IV, Nikolaenko EM. Sedation of patients in intensive care units. Russian Journal of Anaesthesiology and Reanimatology. 2020;5:7-22. (In Russ.). https://doi/10.17116/anaesthesiology20200517
  33. Farmer MJS, Callahan CD, Hughes AM, Riska KL, Hill NS. Applying Noninvasive Ventilation in Treatment of Acute Exacerbation of COPD Using Evidence-Based Interprofessional Clinical Practice. Chest. 2024;165(6): 1469-1480. https://doi/10.1016/j.chest.2024.02.040
  34. Kuzkov VV, Lapin KS, Fot EV, Kirov MYu. Ventilator-associated lung injury in the intensive care unit and operating room — what’s new? Vestnik anesteziologii i reanimatologii. 2020;17(5):47-61. (In Russ.). https://doi/10.21292/2078-5658-2020-17-5-47-61
  35. Fernandes A, Rodrigues J, Lages P, Lança S, Mendes P, Antunes L, Santos CS, Castro C, Costa RS, Lopes CS, da Costa PM, Santos LL. Root causes and outcomes of postoperative pulmonary complications after abdominal surgery: a retrospective observational cohort study. Patient Safety in Surgery. 2019;13:40.  https://doi/10.1186/s13037-019-0221-5
  36. Poroyko V, Meng F, Meliton A, Afonyushkin T, Ulanov A, Semenyuk E, Latif O, Tesic V, Birukova AA, Birukov KG. Alterations of lung microbiota in a mouse model of LPS-induced lung injury. American Journal of Physiology. Lung Cellular and Molecular Physiology. 2015;309(1):L76-83.  https://doi/10.1152/ajplung.00061.2014
  37. Six S, Jaffal K, Ledoux G, Jaillette E, Wallet F, Nseir S. Hyperoxemia as a risk factor for ventilator-associated pneumonia. Critical Care. 2016;20(1):195.  https://doi/10.1186/s13054-016-1368-4
  38. Andriolo BN, Andriolo RB, Saconato H, Atallah ÁN, Valente O. Early versus late tracheostomy for critically ill patients. The Cochrane Database of Systematic Reviews. 2015;1(1):CD007271. https://doi/10.1002/14651858.CD007271.pub3
  39. Chorath K, Hoang A, Rajasekaran K, Moreira A. Association of Early vs Late Tracheostomy Placement With Pneumonia and Ventilator Days in Critically Ill Patients: A Meta-analysis. JAMA Otolaryngology — Head and Neck Surgery. 2021;147(5):450-459.  https://doi/10.1001/jamaoto.2021.0025
  40. Marra A, Vargas M, Buonanno P, Iacovazzo C, Coviello A, Servillo G. Early vs. Late Tracheostomy in Patients with Traumatic Brain Injury: Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 2021;10(15):3319. https://doi/10.3390/jcm10153319
  41. Pozuelo-Carrascosa DP, Herráiz-Adillo Á, Alvarez-Bueno C, Añón JM, Martínez-Vizcaíno V, Cavero-Redondo I. Subglottic secretion drainage for preventing ventilator-associated pneumonia: an overview of systematic reviews and an updated meta-analysis. European Respiratory Review. 2020;29(155):190107. https://doi/10.1183/16000617.0107-2019
  42. Wen Z, Zhang H, Ding J, Wang Z, Shen M. Continuous Versus Intermittent Subglottic Secretion Drainage to Prevent Ventilator-Associated Pneumonia: A Systematic Review. Critical Care Nurse. 2017;37(5):e10-e17.  https://doi/10.4037/ccn2017940
  43. Bajracharya A, Rajbanshi LK. Comparative Study of Continuous Versus Intermittent Subglottic Suction Drainage to Prevent Ventilator Associated Pneumonia in Intubated Patients. Birat Journal of Health Sciences. 2021;6(3):1621-1625. https://doi/10.3126/bjhs.v6i3.43205
  44. Li J, Zong Y, Zhou Q, Dai H, Wang C. Evaluation of the Safety and Effectiveness of the Rapid Flow Expulsion Maneuver to Clear Subglottic Secretions in Vitro and in Vivo. Respiratory Care. 2017;62(8):1007-1013. https://doi/10.4187/respcare.05348
  45. Zanella A, Florio G, Rezoagli E, Pastore M, Cadringer P, Biancolilli O, Carlesso E, Scaravilli V, Ristagno G, Pesenti AM. An Artificial Cough Maneuver to Remove Secretions from Below the Endotracheal Tube Cuff. Respiratory Care. 2019;64(4):372-383.  https://doi/10.4187/respcare.06076
  46. Aeppli N, Lindauer B, Steurer MP, Weiss M, Dullenkopf A. Endotracheal tube cuff pressure changes during manual cuff pressure control manoeuvres: An in-vitro assessment. Acta Anaesthesiologica Scandinavica. 2019;63(1):55-60.  https://doi/10.1111/aas.13249
  47. Maertens B, Lin F, Chen Y, Rello J, Lathyris D, Blot S. Effectiveness of Continuous Cuff Pressure Control in Preventing Ventilator-Associated Pneumonia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Critical Care Medicine. 2022;50(10):1430-1439. https://doi/10.1097/CCM.0000000000005630
  48. Maertens B, Blot K, Blot S. Prevention of Ventilator-Associated and Early Postoperative Pneumonia through Tapered Endotracheal Tube Cuffs: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Critical Care Medicine. 2018;46(2):316-323.  https://doi/10.1097/CCM.0000000000002889
  49. Philippart F, Gaudry S, Quinquis L, Lau N, Ouanes I, Touati S, Nguyen JC, Branger C, Faibis F, Mastouri M, Forceville X, Abroug F, Ricard JD, Grabar S, Misset B; TOP-Cuff Study Group. Randomized intubation with polyurethane or conical cuffs to prevent pneumonia in ventilated patients. American Journal of Respiratory Critical Care Medicine. 2015;191(6):637-45.  https://doi/10.1164/rccm.201408-1398OC
  50. Wu Y, Zhao C, Sun M, Bu J, Hu Z, Yin Y. Efficacy of Endotracheal Tube Cuff Modification in Preventing Ventilator-associated Pneumonia. Journal of the College of Physicians and Surgeons — Pakistan: JCPSP. 2023;33(9):1050-1057. https://doi/10.29271/jcpsp.2023.09.1050
  51. Spapen H, Suys E, De Regt J, Troubleyn J, Jonckheer J, De Waele E. An endotracheal tube providing “pressurized sealing” prevents fluid leakage in mechanically ventilated critically ill patients: a pilot study. Journal of Anesthesiology. 2020;34(1):144-148.  https://doi/10.1007/s00540-019-02707-4
  52. Ehrenzeller S, Klompas M. Association between Daily Toothbrushing and Hospital-Acquired Pneumonia: A Systematic Review and Meta-Analysis. JAMA Internal Medicine. 2024;184(2):131-142.  https://doi/10.1001/jamainternmed.2023.6638
  53. David D, Samuel P, David T, Keshava SN, Irodi A, Peter JV. An open-labelled randomized controlled trial comparing costs and clinical outcomes of open endotracheal suctioning with closed endotracheal suctioning in mechanically ventilated medical intensive care patients. Journal of Critical Care. 2011;26(5):482-488.  https://doi/10.1016/j.jcrc.2010.10.002
  54. Berra L, Coppadoro A, Bittner EA, Kolobow T, Laquerriere P, Pohlmann JR, Bramati S, Moss J, Pesenti A. A clinical assessment of the Mucus Shaver: a device to keep the endotracheal tube free from secretions. Critical Care Medicine. 2012;40(1):119-124.  https://doi/10.1097/CCM.0b013e31822e9fe3
  55. Pinciroli R, Mietto C, Piriyapatsom A, Chenelle CT, Thomas JG, Pirrone M, Bry L, Wojtkiewicz GR, Nahrendorf MP, Kacmarek RM, Berra L. Endotracheal Tubes Cleaned With a Novel Mechanism for Secretion Removal: A Randomized Controlled Clinical Study. Respiratory Care. 2016;61(11):1431-1439. https://doi/10.4187/respcare.04363
  56. Hashemi MM, Rovig J, Bateman J, Holden BS, Modelzelewski T, Gueorguieva I, von Dyck M, Bracken R, Genberg C, Deng S, Savage PB. Preclinical testing of a broad-spectrum antimicrobial endotracheal tube coated with an innate immune synthetic mimic. Journal of Antimicrobial Chemotherapy. 2018;73(1):143-150.  https://doi/10.1093/jac/dkx347
  57. Tokmaji G, Vermeulen H, Müller MC, Kwakman PH, Schultz MJ, Zaat SA. Silver-coated endotracheal tubes for prevention of ventilator-associated pneumonia in critically ill patients. The Cochrane Database of Systematic Reviews. 2015;2015(8):CD009201. https://doi/10.1002/14651858.CD009201.pub2
  58. Seitz AP, Schumacher F, Baker J, Soddemann M, Wilker B, Caldwell CC, Gobble RM, Kamler M, Becker KA, Beck S, Kleuser B, Edwards MJ, Gulbins E. Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia. Journal of Molecular Medicine. 2019;97(8):1195-1211. https://doi/10.1007/s00109-019-01800-1
  59. Vlasenko AV, Koryakin AG, Evdokimov EA, Eremin DA. Protection of upper respiratory tract of patient in conditions of respiratory support: the current state of the issue. Meditsinskij alfavit. 2019; 16(391):30-36. (In Russ.). https://doi/10.33667/2078-5631-2019-1-16(391)-30-36
  60. Lorente L, Lecuona M, Jiménez A, Mora ML, Sierra A. Ventilator-associated pneumonia using a heated humidifier or a heat and moisture exchanger: a randomized controlled trial [ISRCTN88724583]. Critical Care. 2006;10(4):R116. https://doi/10.1186/cc5009
  61. Kola A, Eckmanns T, Gastmeier P. Efficacy of heat and moisture exchangers in preventing ventilator-associated pneumonia: meta-analysis of randomized controlled trials. Intensive Care Medicine. 2005;31(1):5-11.  https://doi/10.1007/s00134-004-2431-1
  62. Gillies D, Todd DA, Foster JP, Batuwitage BT. Heat and moisture exchangers versus heated humidifiers for mechanically ventilated adults and children. The Cochrane Database of Systematic Reviews. 2017;9(9):CD004711. https://doi/10.1002/14651858.CD004711.pub3
  63. Shi Z, Xie H, Wang P, Zhang Q, Wu Y, Chen E, Ng L, Worthington HV, Needleman I, Furness S. Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia. The Cochrane Database of Systematic Reviews. 2016;10:CD008367. https://doi/10.1002/14651858.CD008367.pub3
  64. Lescat M, Magnan M, Kenmoe S, Nordmann P, Poirel L. Co-Lateral Effect of Octenidine, Chlorhexidine and Colistin Selective Pressures on Four Enterobacterial Species: A Comparative Genomic Analysis. Antibiotics (Basel). 2021;11(1):50.  https://doi/10.3390/antibiotics11010050
  65. Vlassov VV, Tikunova NV, Morozova VV. Bacteriophages as Therapeutic Preparations: What Restricts Their Application in Medicine. Biokhimiya. 2020;85(11):1350-1361. (In Russ.). https://doi/10.1134/S0006297920110061
  66. Virk HS, Wiersinga WJ. Current place of probiotics for VAP. Critical Care. 2019;23(1):46.  https://doi/10.1186/s13054-019-2325-9
  67. Ratsional’noe primenenie bakteriofagov v lechebnoj i protivoepidemicheskoj praktike. Metodicheskie rekomendatsii. M.: NP «NASKI»; 2022. (In Russ.). Accessed October 11, 2025. https://nasci.confreg.org/libs/files/3._mr_racionaljnoe_primenenie_bakteriofagov_v_lechebnoy_i_protivoepidemicheskoy_praktike__2022.pdf
  68. Grechko AV, Gurkova MM, Zhdanova MA, Zurabov AYu, Zurabov FM, Kuzovlev AN, Petrova MV, Polyakov PA, Cheboksarov DV, Chernevskaya EA, Yuryev MYu, Yakovlev AA. Prevention of nosocomial pneumonia recurrence using a bacteriophage cocktail in intensive care unit. Russian Journal of Anesthesiology and Reanimatology. 2024;(2):39-48. (In Russ.). https://doi/10.17116/anaesthesiology202402139
  69. Batra P, Soni KD, Mathur P. Efficacy of probiotics in the prevention of VAP in critically ill ICU patients: an updated systematic review and meta-analysis of randomized control trials. Journal of the Intensive Care. 2020; 8: 81.  https://doi/10.1186/s40560-020-00487-8
  70. Fan QL, Yu XM, Liu QX, Yang W, Chang Q, Zhang YP. Synbiotics for prevention of ventilator-associated pneumonia: a probiotics strain-specific network meta-analysis. The Journal of International Medical Research. 2019;47(11):5349-5374. https://doi/10.1177/0300060519876753
  71. Klarin B, Adolfsson A, Torstensson A, Larsson A. Can probiotics be an alternative to chlorhexidine for oral care in the mechanically ventilated patient? A multicentre, prospective, randomised controlled open trial. Critical Care. 2018;22(1):272.  https://doi/10.1186/s13054-018-2209-4
  72. Croce MA, Brasel KJ, Coimbra R, Adams CA Jr, Miller PR, Pasquale MD, McDonald CS, Vuthipadadon S, Fabian TC, Tolley EA. National Trauma Institute prospective evaluation of the ventilator bundle in trauma patients: does it really work? Journal of Trauma and Acute Care Surgery. 2013; 74(2):354-60; discussion 360-2.  https://doi/10.1097/TA.0b013e31827a0c65
  73. Wang M, Wang W, Jia X, He Q, Zhu S, Kang Y, Zhang R, Ren Y, Li L, Zou K, Zong Z, Sun X. Associations Between Antithrombosis and Ventilator-Associated Events, ICU Stays, and Mortality Among Mechanically Ventilated Patients: A Registry-Based Cohort Study. Frontiers in Pharmacology. 2022;13:891178. https://doi/10.3389/fphar.2022.891178
  74. Huang HB, Jiang W, Wang CY, Qin HY, Du B. Stress ulcer prophylaxis in intensive care unit patients receiving enteral nutrition: a systematic review and meta-analysis. Critical Care. 2018;22(1):20.  https://doi/10.1186/s13054-017-1937-1
  75. MacLaren R, Reynolds PM, Allen RR. Histamine-2 receptor antagonists vs proton pump inhibitors on gastrointestinal tract hemorrhage and infectious complications in the intensive care unit. JAMA Internal Medicine. 2014;174(4):564-574.  https://doi/10.1001/jamainternmed.2013.14673
  76. Xun X, Yin Q, Fu Y, He X, Dong Z. Proton Pump Inhibitors and the Risk of Community-Acquired Pneumonia: An Updated Meta-analysis. Annals of Pharmacotherapy. 2022;56(5):524-532.  https://doi/10.1177/10600280211039240
  77. Li F, Liu H, Zhang L, Huang X, Liu Y, Li B, Xu C, Lyu J, Yin H. Effects of Gastric Acid Secretion Inhibitors for Ventilator-Associated Pneumonia. Frontiers in Pharmacology. 2022;13:898422. https://doi/10.3389/fphar.2022.898422
  78. Cook D, Deane A, Lauzier F, Zytaruk N, Guyatt G, Saunders L, Hardie M, Heels-Ansdell D, Alhazzani W, Marshall J, Muscedere J, Myburgh J, English S, Arabi YM, Ostermann M, Knowles S, Hammond N, Byrne KM, Chapman M, Venkatesh B, Young P, Rajbhandari D, Poole A, Al-Fares A, Reis G, Johnson D, Iqbal M, Hall R, Meade M, Hand L, Duan E, Clarke F, Dionne JC, Tsang JLY, Rochwerg B, Karachi T, Lamontagne F, D’Aragon F, St Arnaud C, Reeve B, Geagea A, Niven D, Vazquez-Grande G, Zarychanski R, Ovakim D, Wood G, Burns KEA, Goffi A, Wilcox ME, Henderson W, Forrest D, Fowler R, Adhikari NKJ, Ball I, Mele T, Binnie A, Trop S, Mehta S, Morgan I, Loubani O, Vanstone M, Fiest K, Charbonney E, Cavayas YA, Archambault P, Rewa OG, Lau V, Kristof AS, Khwaja K, Williamson D, Kanji S, Sy E, Dennis B, Reynolds S, Marquis F, Lellouche F, Rahman A, Hosek P, Barletta JF, Cirrone R, Tutschka M, Xie F, Billot L, Thabane L, Finfer S; REVISE Investigators. Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation. New England Journal of Medicine. 2024;391(1):9-20. Epub 2024 June 14. PMID: 38875111. https://doi/10.1056/NEJMoa2404245
  79. Ehrmann S, Barbier F, Demiselle J, Quenot JP, Herbrecht JE, Roux D, Lacherade JC, Landais M, Seguin P, Schnell D, Veinstein A, Gouin P, Lasocki S, Lu Q, Beduneau G, Ferrandiere M, Plantefève G, Dahyot-Fizelier C, Chebib N, Mercier E, Heuzé-Vourc’h N, Respaud R, Gregoire N, Garot D, Nay MA, Meziani F, Andreu P, Clere-Jehl R, Zucman N, Azaïs MA, Saint-Martin M, Gandonnière CS, Benzekri D, Merdji H, Tavernier E; Reva and CRICS-TRIGGERSEP F-CRIN Research Networks. Inhaled Amikacin to Prevent Ventilator-Associated Pneumonia. New England Journal of Medicine. 2023;389(22):2052-2062. https://doi/10.1056/NEJMoa2310307
  80. Dahyot-Fizelier C, Lasocki S, Kerforne T, Perrigault PF, Geeraerts T, Asehnoune K, Cinotti R, Launey Y, Cottenceau V, Laffon M, Gaillard T, Boisson M, Aleyrat C, Frasca D, Mimoz O; PROPHY-VAP Study Group and the ATLANREA Study Group. Ceftriaxone to prevent early ventilator-associated pneumonia in patients with acute brain injury: a multicentre, randomised, double-blind, placebo-controlled, assessor-masked superiority trial. Lancet Respiratory Medicine. 2024;12(5):375-385.  https://doi/10.1016/S2213-2600(23)00471-X

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