Therapeutic anesthesia: past, present and future

Tsentsiper L.M.; Pshenisnov K.V.; Aleksandrovich Yu.S.; Nezabudkin S.N.; Nechaeva E.A.; Kondratiev A.N.

doi:https://doi.org/10.17116/anaesthesiology2022061107

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Abstract:

The article focuses on historical aspects and perspectives of therapeutic anesthesia in critically ill patients. The authors analyze the main milestones in development of this therapeutic concept, anti-stress effects and mechanisms of sanogenesis following therapeutic anesthesia. Positive therapeutic effects of α₂-adrenoagonists and sevoflurane and their combination for prevention of abnormal patterns of CNS functioning are described in detail. Finally, the authors conclude that therapeutic anesthesia is a pharmacological protection when sedation, analgesia, relief of seizures, reduction of intracranial hypertension and sympathetic activity are provided simultaneously through the action of anesthetics.

Keywords:

therapeutic anesthesia

neuroprotection

inhalation sedation

sevoflurane

dexmedetomidine

children

cardiac protection

Authors:

Tsentsiper L.M.

Neurosurgery Research Institute (RNSRI) named after Prof. A.L. Polenov — Branch of the Almazov National Medical Research Center

Pshenisnov K.V.

Children’s Scientific Clinical Center for Infectious Diseases

ORCID: 0000-0003-1113-5296

Aleksandrovich Yu.S.

Children’s Scientific Clinical Center for Infectious Diseases

ORCID: 0000-0002-2131-4813

Nezabudkin S.N.

Saint-Petersburg State Pediatric Medical University

Nechaeva E.A.

Almazov National Medical Research Center

Kondratiev A.N.

Polenov Neurosurgical Institute

SPIN RSCI: 8235-9765
ORCID: 0000-0002-7648-2208

Received:

01.05.2022

Accepted:

16.08.2022

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References:

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