The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Radivilko A.S.

Research Institute for Complex Issues of Cardiovascular Diseases 6, Sosnovy Blvd, 650002, Kemerovo, Russia

Grigor'ev E.V.

kafedra anesteziologii i reanimatologii Kemerovskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Shukevich D.L.

Kemerovskaia oblastnaia klinicheskaia bol'nitsa

Plotnikov G.P.

Research Institute for Complex Issues of Cardiovascular Diseases 6, Sosnovy Blvd, 650002, Kemerovo, Russia

Multiple organ failure: early diagnosis and prognosis

Authors:

Radivilko A.S., Grigor'ev E.V., Shukevich D.L., Plotnikov G.P.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2018;(6): 15‑21

DOI: 10.17116/anaesthesiology201806115

Views: 25420

Downloaded: 556

Download PDF (RU)
Contact the author
Table of contents

MULTIPLE ORGAN FAILURE: EARLY DIAGNOSIS AND PROGNOSIS
MULTIPLE ORGAN FAILURE: EARLY DIAGNOSIS AND PROGNOSIS

To cite this article:

Radivilko AS, Grigor'ev EV, Shukevich DL, Plotnikov GP. Multiple organ failure: early diagnosis and prognosis. Russian Journal of Anesthesiology and Reanimatology. 2018;(6):15‑21. (In Russ.)
https://doi.org/10.17116/anaesthesiology201806115

Подписка 2025-2 (АиР)
МСФ на ЯМ
Close metadata
Recommended articles:
Airway mana­gement in obese patients: a review. Russian Journal of Anesthesiology and Reanimatology. 2024;(3):67-73
Hypoalbuminemia as an inde­pendent predictor of complications, critical illness and premature death. Russian Journal of Anesthesiology and Reanimatology. 2024;(4):83-89
Influence of sevo­flurane on neutrophils in patients with sepsis. Russian Journal of Anesthesiology and Reanimatology. 2024;(5):50-57
Characteristics of gastric neuroendocrine tumors and the PDX-1 transcription factor expression. Russian Journal of Archive of Pathology. 2024;(3):12-20
Electroencephalography: features of the obtained data and its applicability in psychiatry. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(5):31-39
Oppo­rtunities of patient-oriented systems for digi­tal prevention of chro­nic non-communicable diseases. Russian Journal of Preventive Medi­cine. 2024;(6):7-13
New viral infe­ctions — new challenges. Russian Journal of Preventive Medi­cine. 2024;(7):114-119
Treatment of atopic dermatitis considering asse­ssment of neurotransmitters in blood. Russian Journal of Clinical Dermatology and Vene­reology. 2024;(4):368-376
Prediction of papi­llary thyroid cancer recu­rrence acco­rding to preoperative data. Piro­gov Russian Journal of Surgery. 2024;(9):76-85
Modern aspe­cts of etiopathogenesis, diagnosis and treatment of lipe­dema. Plastic Surgery and Aesthetic Medi­cine. 2024;(3):86-92

Multiple organ dysfunction syndrome is a universal critical state syndrome is caused by an overwhelming, uncontrolled systemic inflammatory response that is activated by a number of hostile stimuli including sepsis, hypovolemic shock and cardiopulmonary bypass. Despite the introduction of assessing the scoring systems for MOD, which include the instrumental and biochemical monitoring, diagnostic and prognostic significance of such scales is far from perfect. The use of biochemical markers MOD is the most promising with regard to the expansion of diagnostic possibilities and assess the severity of MODS prediction. The review provides an analysis of the proposed markers in terms of the reality of implementation as a bedside diagnostics.

Keywords:

multiple organ dysfunction
biomarkers
prognosis
sepsis
SIRS
review

Authors:

Radivilko A.S.

Research Institute for Complex Issues of Cardiovascular Diseases 6, Sosnovy Blvd, 650002, Kemerovo, Russia

Grigor'ev E.V.

kafedra anesteziologii i reanimatologii Kemerovskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Shukevich D.L.

Kemerovskaia oblastnaia klinicheskaia bol'nitsa

Plotnikov G.P.

Research Institute for Complex Issues of Cardiovascular Diseases 6, Sosnovy Blvd, 650002, Kemerovo, Russia

List of references:

  1. Dewar D, Moore FA, Moore EE, Balogh Z. Postinjury multiple organ failure. Injury. 2009;40(9):912-918. https://doi.org/10.1016/j.injury.2009.05.024
  2. Cryer HG, Leong K, McArthur DL, Demetriades D, Bongard FS, Fleming AW, Hiatt JR, Kraus JF. Multiple organ failure: by the time you predict it, it’s already there. The Journal of Trauma. 1999;46(4):597-604.
  3. Sauaia A, Moore EE, Johnson JL, Chin TL, Banerjee A, Sperry JL, Maier RV, Burlew CC. Temporal trends of postinjury multiple-organ failure: Still resource intensive, morbid, and lethal. The Journal of Trauma and Acute Care Surgery. 2014;76(3):582-593. https://doi.org/10.1097/TA.0000000000000147
  4. Baue AE, Durham R, Faist E. Systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), multiple organ failure (MOF): are we winning the battle? Shock. 1998;10(2):79-89.
  5. Zilber AP. Etyudy kriticheskoy meditsiny. Moscow: MEDpress-inform; 2006. (In Russ.)
  6. Minei JP, Cuschieri J, Sperry J, Moore EE, West MA, Harbrecht BG, O’Keefe GE, Cohen MJ, Moldawer LL, Tompkins RG, Maier RV; Inflammation and the Host Response to Injury Collaborative Research Program. The changing pattern and implications of multiple organ failure (MOF) after blunt injury with hemorrhagic shock. Critical Care Meditsine. 2012;40(4):1129-1135. https://doi.org/10.1097/CCM.0b013e3182376e9f
  7. Kamenskaya OV, Klinkova AS, Lomivorotov VV, Ponomarev DN, Cherniavsky AM, Karaskov AM. Risks of complications in coronary artery bypass grafting when using effective pulmonary ventilation. Patologiya krovoobrashcheniya i kardiohirurgiya. 2015;19(3):68-73. (In Russ.) https://doi.org/10.21688/1681-3472-2015-3-68-73
  8. Vanzant EL, Hilton RE, Lopez CM, Zhang J, Ungaro RF, Gentile LF, Szpila BE, Maier RV, Cuschieri J, Bihorac A, Leeuwenburgh C, Moore FA, Baker HV, Moldawer LL, Brakenridge SC, Efron PA; Inflammation and Host Response to Injury Investigators. Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock. Critical Care. 2015;19:77. https://doi.org/10.1186/s13054-015-0788-x
  9. Li X, Zhao Y, Xue Q. Predictors for development of multiple organ dysfunction syndrome in elderly patients with acute myocardial infarction. Journal of Geriatric Cardiology. 2008;5(4):199-202.
  10. Michelena J, Altamirano J, Abraldes JG, Affò S, Morales-Ibanez O, Sancho-Bru P, Dominguez M, García-Pagán JC, Fernández J, Arroyo V, Ginès P, Louvet A, Mathurin P, Mehal WZ, Caballería J, Bataller R. Systemic inflammatory response and serum lipopolysaccharide levels predict multiple organ failure and death in alcoholic hepatitis. Hepatology. 2015;62(3):762-72. https://doi.org/10.1002/hep.27779
  11. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). Journal of the American Medical Association. 2016;315(8):801-810. https://doi.org/10.1001/jama.2016.0287
  12. Meertens JH, Nienhuis HL, Lefrandt JD, Schalkwijk CG, Nyyssönen K, Ligtenberg JJ, Smit AJ, Zijlstra JG, Mulder DJ. The course of skin and serum biomarkers of advanced glycation endproducts and its association with oxidative stress, inflammation, disease severity, and mortality during icu admission in critically ill patients: results from a prospective pilot study. PLoS One. 2016;16:11(8):e0160893. https://doi.org/10.1371/journal.pone.0160893
  13. Tsukamoto T, Chanthaphavong RS, Pape HC. Current theories on the pathophysiology of multiple organ failure after trauma. Injury. 2010;41(1):21-26. https://doi.org/10.1016/j.injury.2009.07.010
  14. Gelfand BR, Yaroshetskiy AI, Protsenko DN, Romanovsky YuYa. Integral risk stratification of patients at polytrauma. Vestnik intensivnoy terapii. 2004;1:58-65. (In Russ.)
  15. Vogel JA, Newgard CD, Holmes JF, Diercks DB, Arens AM, Boatright DH, Bueso A, Gaona SD, Gee KZ, Nelson A, Voros JJ, Moore EE, Colwell CB, Haukoos JS; Western Emergency Services Translational Research Network. Validation of the Denver Emergency Department Trauma Organ Failure Score to Predict Post-Injury Multiple Organ Failure. Journal of the American College of Surgeons. 2016;222(1):73-82. https://doi.org/10.1016/j.jamcollsurg.2015.10.010
  16. Mihajlovic D, Lendak D, Mitic G, Cebovic T, Draskovic B, Novakov A, Brkic S. Prognostic value of hemostasis-related parameters for prediction of organ dysfunction and mortality in sepsis. Turkish Journal of Medical Sciences. 2015;45(1):93-98.
  17. Itani R, Minami Y, Haruki S, Watanabe E, Hagiwara N. Prognostic impact of disseminated intravascular coagulation score in acute heart failure patients referred to a cardiac intensive care unit: a retrospective cohort study. Heart and Vessels. 2017;32(7):872-879. https://doi.org/10.1007/s00380-017-0946-y
  18. Van Dreden P, Woodhams B, Rousseau A, Dreyfus JF, Vasse M. Contribution of procoagulant phospholipids, thrombomodulin activity and thrombin generation assays as prognostic factors in intensive care patients with septic and non-septic organ failure. Clinical Chemistry and Laboratory Meditsine. 2013;51(2):387-396. https://doi.org/10.1515/cclm-2012-0262
  19. Sung J, Bochicchio GV, Joshi M, Bochicchio K, Tracy K, Scalea TM. Admission Hyperglycemia Is Predictive of Outcome in Critically Ill Trauma Patients. The Journal of Trauma. 2005;59(1):80-83. https://doi.org/10.1097/01.TA.000 0171452.96585.84
  20. Cirstea M, Walley KR, Russell JA, Brunham LR, Genga KR, Boyd JH. Decreased high-density lipoprotein cholesterol level is an early prognostic marker for organ dysfunction and death in patients with suspected sepsis. Journal of Critical Care. 2017;38:289-294. https://doi.org/10.1016/j.jcrc.2016.11.041
  21. Samraj RS, Zingarelli B, Wong HR. Role of biomarkers in sepsis care. Shock. 2013;40(5):358-365. https://doi.org/10.1097/SHK.0b013e3182a66bd6
  22. Lausevic Z, Lausevic M, Trbojevic-Stankovic J, Krstic S, Stojimirovic B. Predicting multiple organ failure in patients with severe trauma. Canadian Journal of Surgery. 2008;51(2):97-102.
  23. Takala A, Jousela I, Jansson SE, Olkkola KT, Takkunen O, Orpana A, Karonen SL, Repo H. Markers of systemic inflammation predicting organ failure in community-acquired septic shock. Clinical Science. 1999;97(5):529-538. https://doi.org/10.1042/cs0970529
  24. Margraf S, Lögters T, Reipen J, Altrichter J, Scholz M, Windolf J. Neutrophil-derived circulating free DNA (cf-DNA/NETs): a potential prognostic marker for posttraumatic development of inflammatory second hit and sepsis. Shock. 2008;30(4):352-358. https://doi.org/10.1097/SHK.0b013e31816a6bb1
  25. Christ-Crain M, Muller B. Procalcitonin on the dusty way to Holy Grail: a progress report. Yearbook of Intensive Care and Emergency Medicine. 2005: 461-476.
  26. Hensler T, Sauerland S, Lefering R, Nagelschmidt M, Bouillon B, Andermahr J, Neugebauer EA. The clinical value of procalcitonin and neopterin in predicting sepsis and organ failure after major trauma. Shock. 2003;20(5):420-426.
  27. Ivatury RR, Simon RJ, Havriliak D, Garcia C, Greenbarg J, Stahl WM. Gastric mucosal pH and oxygen delivery and oxygen consumption indices in the assessment of adequacy of resuscitation after trauma: a prospective, randomized study. The Journal of Trauma. 1995;39(1):128-134.
  28. Chan T, Gu F. Early Diagnosis of Sepsis Using Serum Biomarkers. Expert Review of Molecular Diagnostics. 2011;11(5):487-496. https://doi.org/10.1586/ERM.11.26
  29. Matveeva VG, Golovkin AS, Grigoriev EV. Monocyte subsets is a predictor of severe complications of systemic inflammatory response after coronary bypass surgery. Kompleksnye problemy serdechno-sosudistyh zabolevanij. 2014;4:5-12. (In Russ.) https://doi.org/10.17802/2306-1278-2014-4-5-12
  30. McDaniel DO, Hamilton J, Brock M, May W, Calcote L, Tee LY, Vick L, Newman DB, Vick K, Harrison S, Timberlake G, Toevs C. Molecular analysis of inflammatory markers in trauma patients at risk of postinjury complications. The Journal of Trauma. 2007;63(1):147-158. https://doi.org/10.1097/TA.0b013e31806bf0ab
  31. Sandquist M, Wong HR. Biomarkers of sepsis and their potential value in diagnosis, prognosis and treatment. Expert Review of Clinical Immunology. 2014;10(10):1349-1356. https://doi.org/10.1586/1744666X.2014.949675
  32. Easton R, Balogh ZJ. Peri-operative changes in serum immune markers after trauma: a systematic review. Injury. 2014;45(6):934-941. https://doi.org/10.1016/j.injury.2013.12.002
  33. Kraft R, Herndon DN, Finnerty CC, Cox RA, Song J, Jeschke MG. Predictive value of IL-8 for sepsis and severe infections after burn injury: a clinical study. Shock. 2015;43(3):222-227. https://doi.org/10.1097/SHK.0000000000000294
  34. Visser T, Pillay J, Koenderman L, Leenen LP. Postinjury immune monitoring: can multiple organ failure be predicted? Current Opinion in Critical Care. 2008;14(6):666-672. https://doi.org/10.1097/MCC.0b013e3283196522
  35. Rello J, Díaz E, Rodríguez A, eds. Management of Sepsis: The PIRO Approach. Berlin—Heidelberg: Springer-Verlag, 2009. https://doi.org/10.1007/978-3-642-00479-7_9
  36. Pinheiro da Silva F, Nizet V. Cell death during sepsis: integration of disintegration in the inflammatory response to overwhelming infection. Apoptosis. 2009;14(4):509-521. https://doi.org/10.1007/s10495-009-0320-3
  37. Kitamura M, Endo S, Sato N, Yaegashi Y, Suxzuki Y, Kojika N, Wakabayashi G. Soluble Fas and soluble FasL in multiple organ dysfunction syndrome complicating diffuse peritonitis. Research Communications in Molecular Pathology and Pharmacology. 2004;115-116:235-242.
  38. Paunel-Görgülü A, Lögters T, Flohé S, Cinatl J, Altrichter J, Windolf J, Scholz M. Stimulation of Fas signaling down-regulates activity of neutrophils from major trauma patients with SIRS. Immunobiology. 2011;216(3):334-342. https://doi.org/10.1016/j.imbio.2010.07.005
  39. Papathanassoglou ED, Moynihan JA, Ackerman MH. Does programmed cell death (apoptosis) play a role in the development of multiple organ dysfunction in critically ill patients? a review and a theoretical framework. Critical Care Meditsine. 2000;28(2):537-549.
  40. Hosoya M, Kawasaki Y, Katayose M, Sakuma H, Watanabe M, Igarashi E, Aoyama M, Nunoi H, Suzuki H. Prognostic predictive values of serum cytochrome c, cytokines, and other laboratory measurements in acute encephalopathy with multiple organ failure. Archives of Disease in Childhood. 2006;91:469-472. https://doi.org/10.1136/adc.2005.078436
  41. Nguyen HB, Loomba M, Yang JJ, Jacobsen G, Shah K, Otero RM, Suarez A, Parekh H, Jaehne A, Rivers EP. Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock. Journal of Inflammation. 2010;7:6. https://doi.org/10.1186/1476-9255-7-6
  42. Chen Q, Ye L, Jin Y, Zhang N, Lou T, Qiu Z, Jin Y, Cheng B, Fang X. Circulating nucleosomes as a predictor of sepsis and organ dysfunction in critically ill patients. International Journal of Infectious Diseases. 2012;16(7):e558-564. https://doi.org/10.1016/j.ijid.2012.03.007
  43. Hu Q, Ren J, Wu J, Li G, Wu X, Liu S, Wang G, Gu G, Li J. Elevated levels of plasma mitochondrial DNA are associated with clinical outcome in intra-abdominal infections caused by severe trauma. Surgical Infections. 2017;18(5):610-618. https://doi.org/10.1089/sur.2016.276
  44. Pachl J, Duska F, Waldauf P, Fric M, Fanta J, Zdárský E. Apoptosis as an Early Event in the Development of Multiple Organ Failure? Physiological Research. 2005;54(6):697-699.
  45. Orwoll BE, Spicer AC, Zinter MS, Alkhouli MF, Khemani RG, Flori HR, Neuhaus JM, Calfee CS, Matthay MA, Sapru A. Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study. Critical Care. 2015;19:435. https://doi.org/10.1186/s13054-015-1145-9
  46. Buendgens L, Yagmur E, Bruensing J, Herbers U, Baeck C, Trautwein C, Koch A, Tacke F. C-terminal proendothelin-1 (CT-proET-1) is associated with organ failure and predicts mortality in critically ill patients. Journal of Intensive Care. 2017;20(5):25. https://doi.org/10.1186/s40560-017-0219-y
  47. Xing K, Murthy S, Liles WC, Singh JM. Clinical utility of biomarkers of endothelial activation in sepsis — a systematic review. Critical Care. 2012; 16(1):R7. https://doi.org/10.1186/cc11145
  48. Mikacenic C, Hahn WO, Price BL, Harju-Baker S, Katz R, Kain KC, Himmelfarb J, Liles WC, Wurfel MM. Biomarkers of endothelial activation are associated with poor outcome in critical illness. PLoS One. 2015;10(10): e0141251. https://doi.org/10.1371/journal.pone.0141251
  49. Duan ZX, Gu W, Zhang LY, Du DY, Hu P, Huang J, Liu Q, Wang ZG, Hao J, Jiang JX. Clinical relevance of the TLR4 11367 polymorphism in patients with major trauma. Archives of Surgery. 2009;144(12):1144-1148. https://doi.org/10.1001/archsurg.2009.211
  50. Abrams ST, Zhang N, Manson J, Liu T, Dart C, Baluwa F, Wang SS, Brohi K, Kipar A, Yu W, Wang G, Toh CH. Circulating Histones Are Mediators of Trauma-associated Lung Injury. American Journal of Respiratory and Critical Care Medicine. 2013;187(2):160-169. https://doi.org/10.1164/rccm.201206-1037OC
  51. Donadello K, Scolletta S, Taccone FS, Covajes C, Santonocito C, Cortes DO, Grazulyte D, Gottin L, Vincent JL. Soluble urokinase-type plasminogen activator receptor as a prognostic biomarker in critically ill patients. Journal of Critical Care. 2014;29(1):144-149. https://doi.org/10.1016/j.jcrc.2013.08.005
  52. Voth M, Holzberger S, Auner B, Henrich D, Marzi I, Relja B. I-FABP and L-FABP are early markers for abdominal injury with limited prognostic value for secondary organ failures in the post-traumatic course. Clinical Chemistry and Laboratory Medicine. 2017;53(5):771-780. https://doi.org/10.1515/cclm-2014-0354
  53. Shapiro NI, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson KJ, Milzman D, Gaieski DF, Goyal M, Cairns CB, Ngo L, Rivers EP. A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis. Critical Care Meditsine. 2009;37(1):96-104. https://doi.org/10.1097/CCM.0b013e318192fd9d
  54. Gibot S, Béné MC, Noel R, Massin F, Guy J, Cravoisy A, Barraud D, De Carvalho Bittencourt M, Quenot JP, Bollaert PE, Faure G, Charles PE. Combination biomarkers to diagnose sepsis in the critically ill patient. American Journal of Respiratory and Critical Care Medicine. 2012;186(1):65-71. https://doi.org/10.1164/rccm.201201-0037OC
  55. Helliksson F, Wernerman J, Wiklund L, Rosell J, Karlsson M. The combined use of three widely available biochemical markers as predictor of organ failure in critically ill patients. Scandinavian Journal of Clinical and Laboratory Investigation. 2016;76(6):479-485. https://doi.org/10.1080/00365513.2016.1201850
  56. Mayeux R. Biomarkers: potential uses and limitations. NeuroRx. 2004;1(2):182-188. https://doi.org/10.1602/neurorx.1.2.182

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.