Clinical and laboratory characteristics of migraine associated with antiphospholipid syndrome and genetic thrombophilia

Dashdamirova L.R.; Voskresenskaya O.N.; Khizroeva D.Kh.; Spektor E.D.

doi:https://doi.org/10.17116/pain20252303152

Dashdamirova L.R.

Sechenov First Moscow State Medical University (Sechenov University)

Voskresenskaya O.N.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0002-7330-633X

Khizroeva D.Kh.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0002-0725-9686

Spektor E.D.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0003-0714-9476

Clinical and laboratory characteristics of migraine associated with antiphospholipid syndrome and genetic thrombophilia

Authors:

Dashdamirova L.R., Voskresenskaya O.N., Khizroeva D.Kh., Spektor E.D.

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Journal: Russian Journal of Pain. 2025;23(3): 52‑57

DOI: 10.17116/pain20252303152

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To cite this article:

Dashdamirova LR, Voskresenskaya ON, Khizroeva DKh, Spektor ED. Clinical and laboratory characteristics of migraine associated with antiphospholipid syndrome and genetic thrombophilia. Russian Journal of Pain. 2025;23(3):52‑57. (In Russ.)
https://doi.org/10.17116/pain20252303152

Подписка 2025 Российский журнал боли (Russian Journal of Pain)

Использование инфографики авторами научных работ

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OBJECTIVE

To identify clinical and laboratory markers of migraine associated with APS and GT.

MATERIAL AND METHODS

The study included 105 women with at least one of the following diagnoses: 1) migraine with or without aura, 2) APS or GT. Patients were divided into three groups depending on combination of diagnoses: group 1 (n=41) — patients with a verified diagnosis of APS/GT and no headache; group 2 (n=31) — patients with migraine and no APS/GT; group 3 (n=33) — patients with APS/GT and migraine. Each patient underwent clinical and biochemical blood tests, clotting test. Anamnesis and obstetric-gynecological data were analyzed.

RESULTS

Repeated miscarriage, spontaneous abortions in early stages of gestation and delayed fetal development are markers of migraine associated with AFS/GT. AFS/GT is characterized by a tendency to lower erythrocytes (p=0.001), hematocrit (p<0.001), platelets (p=0.012) and increased leukocyte count (p=0.044) due to neutrophils (p=0.001) while maintaining these indicators within reference values. Possible laboratory predictors of AFS/GT in migraine are hematocrit (odds ratio (OR)=0.34, p=0.012), erythrocyte count (OR=0.42, p=0.021) and neutrophils (OR=2.2, p=0.049).

CONCLUSION

APS/GT is characterized by a tendency towards suppression of erythrocyte and platelet hematopoiesis, as well as increased leukocyte count due to neutrophils without abnormal values. These data together with obstetric-gynecological history allows for suspicion of possible migraine associated with APS/GT after routine clinical examination and justify further investigation.

Keywords:

migraine

antiphospholipid syndrome

antiphospholipid antibodies

hypercoagulation

headache

laboratory diagnostics

Authors:

Dashdamirova L.R.

Sechenov First Moscow State Medical University (Sechenov University)

Voskresenskaya O.N.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0002-7330-633X

Khizroeva D.Kh.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0002-0725-9686

Spektor E.D.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0003-0714-9476

Received:

16.01.2025

Accepted:

11.04.2025

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References:

Yakhno NN, Abuzarova GR, Alekseev VV. Pain. Practical guide. Moscow: MEDpress-inform; 2022. (In Russ.).
Tabeeva GR. Migraine and cerebrovascular pathology. Reference book for outpatient physicians. 2014:45. (In Russ.).
Linstra KM, Ibrahimi K, Terwindt GM, Wermer MJ, MaassenVanDenBrink A. Migraine and cardiovascular disease in women. Maturitas. 2017 Mar;97:28-31. Epub 2016 Dec 22. PMID: 28159058. https://doi.org/10.1016/j.maturitas.2016.12.008
Schürks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T. Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ. 2009 Oct 27;339:b3914. PMID: 19861375; PMCID: PMC2768778. https://doi.org/10.1136/bmj.b3914
Adelborg K, Szépligeti SK, Holland-Bill L, Ehrenstein V, Horváth-Puhó E, Henderson VW, Sørensen HT. Migraine and risk of cardiovascular diseases: Danish population based matched cohort study. BMJ. 2018 Jan 31;360:k96. PMID: 29386181; PMCID: PMC5791041. https://doi.org/10.1136/bmj.k96
Kurth T, Schürks M, Logroscino G, Buring JE. Migraine frequency and risk of cardiovascular disease in women. Neurology. 2009;73:581-588.
Kim C, Schreiner PJ, Yin Z, Whitney R, Sidney S, Ebong I, Levine DA. Migraines, vasomotor symptoms, and cardiovascular disease in the Coronary Artery Risk Development in Young Adults study. Menopause. 2024 Mar 01;31(3):202-208. Epub 2024 Feb 13. PMID: 38350045; PMCID: PMC10940187. https://doi.org/10.1097/GME.0000000000002311
Tabeeva GR. Cerebrovascular disorders associated with migraine. Medical Council. 2017;10:32-35. (In Russ.).
Hassan M, Belavadi R, Gudigopuram SVR, Raguthu CC, Gajjela H, Kela I, Kakarala CL, Modi S, Sange I. Migraine and Stroke: In Search of Shared Pathways, Mechanisms, and Risk Factors. Cureus. 2021 Dec 06; 13(12):e20202. PMID: 34900505; PMCID: PMC8647778. https://doi.org/10.7759/cureus.20202
Tabeeva GR, Vasiliev SA, Azimova YuE. Migraine associated with polymorphism of blood coagulation system genes. Neurological Journal. 2007; 12:25-29. (In Russ.).
Cherebillo KK, Nazarov VD, Kiryanov YuM, et al. Genetic characteristics and clinical features of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Russian Neurological Journal. 2022;27(1):32-42. (In Russ.).
Voskresenskaya ON, Bitsadze VO, Khizroeva DKh, et al. Features of nervous system involvement in antiphospholipid syndrome. Obstetrics, Gynecology and Reproduction. 2021;15:404-414. (In Russ.).
Kalashnikova LA. Neurology of antiphospholipid syndrome. Moscow: Medicine; 2003. (In Russ.).
Maitrot-Mantelet L, Horellou MH, Massiou H, Conard J, Gompel A, Plu-Bureau G. Should women suffering from migraine with aura be screened for biological thrombophilia?: results from a cross-sectional French study. Thromb Res. 2014 May;133(5):714-718. Epub 2014 Jan 29. PMID: 24530211. https://doi.org/10.1016/j.thromres.2014.01.025
Herak DC, Antolic MR, Krleza JL, Pavic M, Dodig S, Duranovic V, Brkic AB, Zadro R. Inherited prothrombotic risk factors in children with stroke, transient ischemic attack, or migraine. Pediatrics. 2009 Apr;123(4):e653-e660. PMID: 19336355. https://doi.org/10.1542/peds.2007-3737
Corral J, Iniesta JA, González-Conejero R, Lozano ML, Rivera J, Vicente V. Migraine and prothrombotic genetic risk factors. Cephalalgia. 1998 June;18(5):257-260. PMID: 9673804.
Iniesta JA, Corral J, González-Conejero R, Rivera J, Vicente V. Prothrombotic genetic risk factors in patients with coexisting migraine and ischemic cerebrovascular disease. Headache. 1999 July-Aug;39(7):486-489. PMID: 11279932. https://doi.org/10.1046/j.1526-4610.1999.3907486.x
Islam MA, Alam F, Wong KK. Comorbid association of antiphospholipid antibodies and migraine: A systematic review and meta-analysis. Autoimmun Rev. 2017;16:512-522.
Arumugam M, Parthasarathy V. Reduction of CD4+CD25+ regulatory T-cells in migraine: Is migraine an autoimmune disorder? J Neuroimmunol. 2016;290:54-59.
Yücel M, Kotan D, Gurol Çiftçi G, Çiftçi IH, Cikriklar HI. Serum levels of endocan, claudin-5 and cytokines in migraine. Eur Rev Med Pharmacol Sci. 2016 Mar;20(5):930-936. PMID: 27010153.
Gainetdinova DD, Tukhfatullina SI. Clinical and Doppler ultrasound examination of women with cephalgia and antiphospholipid syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119:48-53. (In Russ.). https://doi.org/10.17116/jnevro201911907148