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Korotkova D.G.

South Ural State Medical University

Karpova M.I.

South-Ural State Medical University

Dolgushina V.F.

South Ural State Medical University

Sinitsky A.I.

South Urals State Medical University of the Ministry of Healthcare of the Russian Federation

Nikushkina K.V.

Research Institute of Immunology of the South Ural State Medical University

Sigalov D.O.

South Ural State Medical University

Factors predisposing to unfavorable course of migraine in II—III trimesters of pregnancy

Authors:

Korotkova D.G., Karpova M.I., Dolgushina V.F., Sinitsky A.I., Nikushkina K.V., Sigalov D.O.

More about the authors

Journal: Russian Journal of Pain. 2023;21(1): 39‑46

DOI: 10.17116/pain20232101139

Read: 3125 times

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Table of contents

FACTORS PREDISPOSING TO UNFAVORABLE COURSE OF MIGRAINE IN II—III TRIMESTERS OF PREGNANCY
FACTORS PREDISPOSING TO UNFAVORABLE COURSE OF MIGRAINE IN II—III TRIMESTERS OF PREGNANCY

To cite this article:

Korotkova DG, Karpova MI, Dolgushina VF, Sinitsky AI, Nikushkina KV, Sigalov DO. Factors predisposing to unfavorable course of migraine in II—III trimesters of pregnancy. Russian Journal of Pain. 2023;21(1):39‑46. (In Russ.)
https://doi.org/10.17116/pain20232101139

Подписка 2025 Российский журнал боли (Russian Journal of Pain)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To study clinical features of migraine in pregnant women, as well as the factors predisposing to unfavorable course of migraine in II—III trimesters of pregnancy.

MATERIAL AND METHODS

This study enrolled 106 pregnant women including 88 ones with migraine. We analyzed the incidence of headache at 3 visits: 9—16, 36—38 weeks of pregnancy and 3—5 weeks after delivery. At the first visit, we assessed the Beck Anxiety Inventory score, Beck Depression Inventory score and Psychological Stress Measure (PSM-25) score, as well as serum serotonin, progesterone, estradiol and free estriol.

RESULTS

In most cases, II—III trimesters of pregnancy were characterized by favorable course of migraine with decrease in the incidence of attacks or their remission. However, incidence of headache attacks did not change in 19% of women and increased in 7% of patients. Overweight and depression (Beck Depression Inventory) significantly correlated with unfavorable course of migraine during this period. There was a significant increase of serum serotonin in patients with unfavorable course of migraine. No significant differences in serum progesterone, estradiol and free estriol were found in patients with unfavorable and favorable course of migraine.

CONCLUSION

Incidence of migraine attacks in II—III trimesters of pregnancy did not decrease in significant number of women. Overweight and depression can affect unfavorable prognosis of migraine during this period. Dysfunction of serotonergic system is essential for migraine phenotype in pregnancy.

Keywords:

migraine
pregnancy
incidence of pain attacks
serotonin
sex hormones

Authors:

Korotkova D.G.

South Ural State Medical University

Karpova M.I.

South-Ural State Medical University

Dolgushina V.F.

South Ural State Medical University

Sinitsky A.I.

South Urals State Medical University of the Ministry of Healthcare of the Russian Federation

Nikushkina K.V.

Research Institute of Immunology of the South Ural State Medical University

Sigalov D.O.

South Ural State Medical University

Received:

31.10.2022

Accepted:

18.11.2022

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