OBJECTIVE
To analyze myofascial pain mechanisms in practical aspect and evaluate the effect of changes in muscle fibers architectonics on formation of clinical symptom complex.
MATERIAL AND METHODS
The research was based on the own analysis of long-term outcomes in patients with myofascial pain. The diagnosis was based on kinesthetic study of myofascial trigger zone according major and minor criteria. Clinical electromyography combined with ultrastructural analysis of muscle fibers and ultrasound examination of the muscles were selected as a methodological technique for this study.
RESULTS
It was concluded that formation of myofascial trigger zones is based on neuromuscular dysfunction of the end plates of extrafusal muscle fibers with local intramuscular hypoperfusion and subsequent hypoxia. Local injection therapy with tolperisone hydrochloride ensured restoration of blood flow within the myofascial trigger zone. Structural abnormalities in the taut band of trapezius muscle including altered myofibrils, divergence of myofilaments and Z-lines with uneven distribution of mitochondria and appearance of autophagosomes in the muscle compression zone were observed in patients with myofascial pain. These disorders may be a result of inadequate depleting physical load on the muscle in spasmodic condition with local hypoxia or ische-mia.
CONCLUSION
Analysis of myofascial pain mechanisms is important due to inextricable relationship between treatment and pathogenesis. Long-term static load contributes to muscle overload and overstrain and subsequent activation of pain receptors. These data are valuable to develop therapeutic measures aimed at restoration of muscle function and nociceptive pain relief.