Liver cancer: etiology, pathogenesis, results of long-term clinical and epidemiological observation (in Russian only)

I.A. Chekmazov

Central Clinical Hospital with Out-patient Clinic of the Department of Presidential Affairs, Moscow, Russia

I.O. Ivanikov

Meditsinskiĭ tsentr Upravleniia delami prezidenta RF, Moskva

G.V. Sapronov

Central Clinical Hospital with Out-patient Clinic of the Department of Presidential Affairs, Moscow, Russia

N.Ch. Kirillova

Central Clinical Hospital with Out-patient Clinic of the Department of Presidential Affairs, Moscow, Russia

N.N. Vinogradova

FGBU "Tsentral'naia klinicheskaia bol'nitsa s poliklinikoĭ" Upravleniia delami Prezidenta RF, Moskva

Journal: Russian Journal of Evidence-Based Gastroenterology. 2019;8(1): 5–15

Liver cancer: etiology, pathogenesis, results of long-term clinical and epidemiological observation (in Russian only)

Authors:

I.A. Chekmazov, I.O. Ivanikov, G.V. Sapronov, N.Ch. Kirillova, N.N. Vinogradova

More about the authors

DOI: 10.17116/dokgastro201980115

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Open to cite this article

Chekmazov IA, Ivanikov IO, Sapronov GV, Kirillova NCh, Vinogradova NN. Liver cancer: etiology, pathogenesis, results of long-term clinical and epidemiological observation (in Russian only). Russian Journal of Evidence-Based Gastroenterology. 2019;8(1):5‑15. (In Russ., In Engl.).
https://doi.org/10.17116/dokgastro201980115

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Aim — to analyse some variables in liver cancer including morbidity, mortality, quality of specialized care and in-hospital survival in the clinics of Department of Presidential Affairs of the Russian Federation. Material and methods. Current views regarding etiological factors, pathogenesis, diagnosis and treatment of liver cancer, incidence and prevalence of liver cancer in the world and in Russia are reviewed in the article. So, 227 cases of primary liver malignancies have been diagnosed for the 35-year period, lifetime morphological verification of liver cancer was 75%. Results. Disease-related annual mortality is 61.5% after diagnosis. This value is 51.6% for the last 5-year period. In general, we revealed positive changes in the quality of medical and diagnostic care. Five-year periods reflecting development of medical and diagnostic base were studied. case report from the clinical practice is presented.

Keywords:

liver cancer

epidemiology and risk factors

hepatocellular carcinoma

cholangiocellular carcinoma

Authors:

I.A. Chekmazov

Central Clinical Hospital with Out-patient Clinic of the Department of Presidential Affairs, Moscow, Russia

I.O. Ivanikov

Meditsinskiĭ tsentr Upravleniia delami prezidenta RF, Moskva

G.V. Sapronov

Central Clinical Hospital with Out-patient Clinic of the Department of Presidential Affairs, Moscow, Russia

N.Ch. Kirillova

Central Clinical Hospital with Out-patient Clinic of the Department of Presidential Affairs, Moscow, Russia

N.N. Vinogradova

FGBU "Tsentral'naia klinicheskaia bol'nitsa s poliklinikoĭ" Upravleniia delami Prezidenta RF, Moskva

List of references:

Forman D, Bray F, Brewster DH, Gombe Mbalawa, Kohlef B, Piñeros M, Steliarova-Foucher E, Swaminathan R, Ferlay J. Cancer incidence in five continents//IARC Sci Publ. No 164. Vol. IX. Lyon, 2012.1365 p.
Merabishvili VM, Merabishvili EN, Chepik OF. Epidemiology of liver cancer. Morbidity, mortality, histological structure dynamics. Siberian journal of Oncology. 2015;2:5-15. (In Russ.)
Shain AA. Primary liver cancer in the Tyumen region: Dis... Dr. honey. sciences’. M. 1973. (In Russ.)
Malignant neoplasms in Russia in 2017 (morbidity and mortality). Eds. Kaprin AD, Starinsky VV, Petrova GV. M. 2018;247. (In Russ.)
State of cancer care in Russia in 2017. Eds. Kaprina AD, Stalinskogo VV, Petrova GV. M. 2018;234. (In Russ.)
Zaridze DG. Cancer prevention. Guide for doctors. M. 2009. (In Russ.)
Merabishvili VM. Dynamics of performance indicators of the cancer service of St. Petersburg in the districts of the city in 2010—2012. Express information of The population cancer register. SPB. 2013. (In Russ.)
Merabishvili VM. Oncology service of St. Petersburg (operational reporting for 2011-2012, in-depth development of the register database according to international standards). OL (IACR No221). SPb. 2013;18:364. (In Russ.)
Rehermann B. Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells. Nat Med. 2013;19(7):859-868.
Mohd Hanafiah K, Groeger J, Flaxman AD, Wiersma ST. Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV Hepatology. 2013;57(4):1333-1342. http://www.ncbi.nlm.nih.gov/pubmed/23172780
Alter MJ. Epidemiology of hepatitis C virus infection. World J Gastroenterol. 2007;13:2436-2441.
Samokhvalov EI, Nikolaeva LI, Alkhovsky SV, and others frequency of occurrence of separate subtypes of the hepatitis C virus in the Moscow region. Vopr. virusol. 2013;1:36-40. (In Russ.)
Thomas DL, Seeff LB. The natural history of hepatitis C. Clin Liver Dis. 2005;9:383-398.
Kew MC. The role of cirrhosis in the etiology of hepatocellular carcinoma. J Gastrointest Cancer. 2013;8:ahead of print.
Caldwell S, Park SH. The epidemiology of hepatocellular cancer: from the perspectives of public health problem to tumor biology. J Gastroenterol. 2009;44(Suppl. 19):96-101.
Arutyunov AT, Ivanikov IO, Syutkin VE. Diagnosis and treatment of chronic liver diseases (guide). M. 2005;303. (In Russ.)
Ivanikov IO, Syutkin VE. General Hepatology. Textbook, 3-ed. M. 2003;160. (In Russ.)
Patholoical anatomy. National leadership. Editor Paltsev MA, Kaktourski LV, Zairatyants OV. Liver Tumors. Chapter 1, p. 610-620. M. 2011. (In Russ.)
Afanasyev SG, Tuzikov SA. Non-Resectable liver tumors (literature review). Siberian journal of Oncology. 2006;1:49-54. (In Russ.)
Sherlock Sh, Dooley J. Diseases of the liver and biliary tract. M. 1999. (In Russ.)
Branda M, Wands JR. Signal transduction cascades and hepatitis B and C related hepatocellular carcinoma. Hepatology. 2006;43:891-902.
Llovet JM, Bruix J. Molecular targeted therapies in hepatocellular carcinoma. Hepatology. 2008;48:1312-1327.
Tsai WL, Chung RT. Viral hepatocarcinogenesis. Oncogene. 2010;29:2309-2324.
Zekri Ael-R, Nassar AA, El-Din El-Rouby MN, Shousha HI, Barakat AB, El-Desouky ED, et al. Disease progression from chronic hepatitis C to cirrhosis and hepatocellular carcinoma is associated with increasing DNA promoter methylation. Asian Pac J Cancer Prev. 2013;14:6721-6726.
Practical recommendations for drug treatment of malignant tumors. Practical recommendations for maintenance therapy in Oncology. RUSSCO. International quarterly scientific and practical journal of Oncology ed. Moiseenko VM. 2015;4:454. (In Russ.)