The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Pestryakova I.Yu.

Dental polyclinic

Bolmasova A.V.

National Medical Research Center of Endocrinology

Avraamova O.G.

Central Research Institute of Dentistry and Maxillofacial Surgery

Khamadeeva A.M.

Samara State Medical University

Unsolved dental problems in children with congenital hyperinsulin

Authors:

Pestryakova I.Yu., Bolmasova A.V., Avraamova O.G., Khamadeeva A.M.

More about the authors

Journal: Stomatology. 2025;104(6): 67‑73

DOI: 10.17116/stomat202510406167

Read: 649 times

Contact the author
Table of contents

UNSOLVED DENTAL PROBLEMS IN CHILDREN WITH CONGENITAL HYPERINSULIN
UNSOLVED DENTAL PROBLEMS IN CHILDREN WITH CONGENITAL HYPERINSULIN

To cite this article:

Pestryakova IYu, Bolmasova AV, Avraamova OG, Khamadeeva AM. Unsolved dental problems in children with congenital hyperinsulin. Stomatology. 2025;104(6):67‑73. (In Russ.)
https://doi.org/10.17116/stomat202510406167

Подписка 2026 Стоматология (Stomatology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Circular tracheal rese­ction in a 9-year-old child with posttracheotomy cica­tricial stenosis with tracheomalacia: the first expe­rience in the Sibe­rian Fede­ral District. Piro­gov Russian Journal of Surgery. 2025;(7):81-86
Bacterial vagi­nosis: modern views. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(3):261-268
Method of photodynamic action in surgical treatment of local limi­ted peri­tonitis in the expe­riment. Russian Journal of Operative Surgery and Clinical Anatomy. 2025;(2-2):77-86
Appe­ndicular dive­rticulum in acute appe­ndix. Russian Journal of Operative Surgery and Clinical Anatomy. 2025;(2-2):117-120
Rela­tionship of the professional characteristics and the orga­nization of the mid-level medi­cal personnel reha­bilitation depa­rtments acti­vity to the health psychophysical indi­cators of children with disa­bilities. Russian Journal of Preventive Medi­cine. 2025;(7):28-35
Effect of preoperative fluid mana­gement on water body sectors in children. Russian Journal of Anesthesiology and Reanimatology. 2025;(4):47-53
Features of the clinical course of multiple scle­rosis as a factor in persistent disa­bility. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7-2):39-44
Traumatic inju­ries of the rectum and anus in childhood. Piro­gov Russian Journal of Surgery. 2025;(8):62-66
Electrical Injury in Pediatric Practice. Piro­gov Russian Journal of Surgery. 2025;(8):67-74
Course and outcomes of pregnancy in patients with multiple pregnancies with rhesus isoimmunization. Russian Bulletin of Obstetrician-Gynecologist. 2025;(4):59-65
Abstract:

The review of modern literature on congenital hyperinsulinism in children is presented, highlighting the features of the clinical course, nutrition treatment and dynamic monitoring of children. Only a few publications have hypothesized about possible dental problems in children with congenital hyperinsulinism, without specifying and describing them. The risk factors for caries, the specifics of dental care, and ways to improve the quality of life have not been sanctified. The general condition of the child can be so severe that dental problems are not taken into account by specialists of other profiles. The study of risk factors for dental diseases (dental caries, diseases of the oral mucosa, chronic oral sepsis) in children with congenital hyperinsulinism, their prevention, and treatment features is relevant for planning dental support, and it is important to route children in connection with the expected behavioral risk factors for treatment, both underlying and concomitant diseases.

Keywords:

congenital hyperinsulin
hypoglycemia
children
caries
treatment

Authors:

Pestryakova I.Yu.

Dental polyclinic

Bolmasova A.V.

National Medical Research Center of Endocrinology

Avraamova O.G.

Central Research Institute of Dentistry and Maxillofacial Surgery

Khamadeeva A.M.

Samara State Medical University

Received:

11.02.2025

Accepted:

16.04.2025

Close metadata

References:

  1. Derzhavina K.A., Ilyin N.P., Seredinskaya M.V., Nerush M.O., Zakharchenko K.V., Sorokin D.V., Demin K.A., Kalueff A.V. Zebrafish as a model organism for rare diseases of nervous system. Rossijskij zhurnal personalizirovannoj mediciny. 2022;2(2):17-32. (In Russ.). https://doi.org/10.18705/2782-3806-2022-2-2-17-32
  2. Quarta A, Iannucci D, Guarino M, Blasetti A, Chiarelli F. Hypoglycemia in Children: Major Endocrine-Metabolic Causes and Novel Therapeutic Perspectives. Nutrients. 2023;15(16):3544. https://doi.org/10.3390/nu15163544
  3. Balabolkin M.I., Klebanova E.M., Kreminskaya V.M. Differencial’naya diagnostika i lechenie ehndokrinnykh zabolevanij (rukovodstvo dlya vrachej). M.: Medicina; 2002. (In Russ.). https://doi.org/10.18705/2782-3806-2022-2-2-17-32
  4. Perantie DC, Lim A, Wu J, Weaver P, Warren SL, Sadler M, White NH, Hershey T. Effects of prior hypoglycemia and hyperglycemia on cognition in children with type 1 diabetes mellitus. Pediatr Diabetes. 2008;9(2):87-95.  https://doi.org/10.1111/j.1399-5448.2007.00274.x
  5. Mc Quarrie I. Idiopathic spontaneously occurring hypoglycemia in infants; clinical significance of problem and treatment. AMA Am J Dis Child. 1954; 87(4):399-428.  https://doi.org/10.1001/archpedi.1954.02050090387001
  6. Gubaeva D.N., Melikyan M.A., Ryzhkova D.V., Pojda M.D., Bairov V.G., Suhockaya A.A., Sokolov Yu.Yu., Efremenkov A.M., Mitrofanova L.B., Christesen H., Nikitina I.L. Klinicheskie, geneticheskie i radionuklidnye harakteristiki pacientov s fokal’noj formoj vrozhdennogo giperinsulinizma. Problemy endokrinologii. 2019;65():319-329. (In Russ.). https://doi.org/10.14341/probl103
  7. Melikian M.A., Kareva M.A., Petriaĭkina E.E., Volkov I.É., Aver’ianova I.V., Kolomina G., Gurevich L.E., Peterkova V.A., Brusgaard K., Christesen H., Dedov I.I. Congenital hyperinsulinism. Results of molecular-genetic investigations in a Russian population. Problemy ehndokrinologii. 2012;58(2):3-9. (In Russ.). https://doi.org/10.14341/probl20125823-9
  8. Arnoux JB, Verkarre V, Saint-Martin C, Montravers F, Brassier A, Valayannopoulos V, Brunelle F, Fournet JC, Jean- Jacques R, Aigrain Y, Bellanné-Chantelot C, de Lonlay P. Congenital hyperinsulinism: current trends in diagnosis and therapy. Orphanet J Rare Dis. 2011;6:63.  https://doi.org/10.1186/1750-1172-6-63
  9. Mathew PM, Young JM, Abu-Osba YK, Mulhern BD, Hammoudi S, Hamdan JA JA, Sa’di ARPersistent Neonatal Hyperinsulinism. Clin Pediatr. 1988;27(3):148-151.  https://doi.org/10.1177/000992288802700307
  10. Sukhotskaya A.A., Bairov V.G., Nikitina I.L., Mitrofanova L.B., Perminova A.A., Ryzhkova D.V. Congenital hyperinsulinism in newborns and young children: the state of the problem and the results of surgical treatment. Meditsinskiy sovet. 2021;11:226-239. (In Russ.). https://doi.org/10.21518/2079-701X-2021-11-226-239
  11. Yorifuji T, Horikawa R, Hasegawa T, Adachi M, Soneda S, Minagawa M, Ida S, Yonekura T, Kinoshita Y, Kanamori Y, Kitagava H, Shinkai M, Sasaki H, Nio M. Clinical practice guidelines for congenital hyperinsulinism. Clin Pediatr Endocrinol. 2017;26(3):127-152. 
  12. Pasquini TLS, Mesfin M, Schmitt J, Raskin J. Global Registries in Congenital Hyperinsulinism. Front Endocrinol. 2022;13.  https://doi.org/10.3389/fendo.2022.876903
  13. Diagnostika i lechenie vrozhdennogo giperinsulinizma u detei: klinicheskie rekomendatsii. M.: Ministerstvo zdravookhraneniya rossiiskoi federatsii. 2021. (In Russ.).
  14. Hoe FM, Thornton PS, Wanner LA, Steinkrauss L, Simmons RA, Stanley CA. Clinical features and insulin regulation in infants with a syndrome of prolonged neonatal hyperinsulinism. J Pediatr. 2006;148(2):207-212.  https://doi.org/10.1016/j.jpeds.2005.10.002
  15. Vajravelu ME, De León DD. Genetic characteristics of patients with congenital hyperinsulinism. Curr Opin Pediatr. 2018;30(4):568-575.  https://doi.org/10.1097/mop.0000000000000645
  16. Berezhansky S.B., Afonin A.A., Papsheva E.A., Vostrykh N.N., Galkina G.A. A clinical case of congenital hyperinsulinism in an early child. Medicinskij vestnik Yuga Rossii. 2020;11(3):54-59. (In Russ.). https://doi.org/10.21886/2219-8075-2020-11-3-54-59.
  17. Melikian M. Federalnye klinicheskie rekomendatsii po diagnostike lecheniyu i vedeniyu detei i podrostkov s vrozhdennym giperinsulinizmom. Problemy ehndokrinologii. 2014;60(2):34-41. (In Russ.). https://doi.org/10.14341/probl201460231-41
  18. De Leon DD, Arnoux JB, Banerjee I, Bergada I, Bhatti T, Conwell L, Fu J, Flana gan S, Gillis D, Meissner T, Klaus Mohnike, Pasquini T, Shah P, Stanley CA, Vella A, Yorifuji T, Thornton PS. International Guidelines for the Diagnosis and Management of Hyperinsulinism. Hormone research in pediatrics. 2024;97(3):279-298.  https://doi.org/10.1159/000531766
  19. Melikyan M.A., Petryaykina E.E., Fomina I.G., Rybkina V.L., Garyaeva I.V., Pronina E.A., Mikhailova T.D., Volkov I.E., Averyanova Yu.V., Kolomina I.G., Peterkova V.A. Congenital hyperinsulinism: diagnosis and treatment. Pediatrics. Journal named after Speransky. 2011;90(1):59-65. 
  20. Thompson-Branch A, Havranek T. Neonatal Hypoglycemia. Pediatr Rev. 2017;38(4):147-157.  https://doi.org/10.1542/pir.2016-0063
  21. De Leon DD, Thornton P, Stanley CA, Sperling MA. Hypoglycemia in the Newborn and Infant. Sperling Pediatr Endocrinol. 2021;175-201.  https://doi.org/10.1016/b978-0-323-62520-3.00007-5
  22. Skorbich O.O. Vrozhdennyi giperinsulinizm. Forcipe. 2020;3(S1):697-698. (In Russ.).
  23. Solntseva A.V., Zagrebaeva O.Y. Questions of diagnosis and treatment of congenital hyperinsulinism at children. Reproduktivnoe zdorov’e. Vostochnaya Evropa. 2011;17(5):26-34. (In Russ.).
  24. Dedov I.I., Shestakova M.V., Maiorov A.Y., eds. Algoritmy spetsializirovannoi meditsinskoi pomoshchi bolnym sakharnym diabetom. M.; 2019 (In Russ.). https://doi.org/10.14341/DM13042
  25. de Lonlay P, Fournet JC, Rahier J, Gross-Morand MS, Poggi-Travert F, Foussier V, J P Bonnefont J.P, Brusset M.C, BrunelleF, Robert JJ, Nihoul-Fékété C, Saudubray JM, Junien C. Somatic deletion of the imprinted 11p15 region in sporadic persistent hyperinsulinemic hypoglycemia of infancy is specific of focal adenomatous hyperplasia and endorses partial pancreatectomy. J Clin Investigat. 1997;100(4):802-807.  https://doi.org/10.1172/jci119594
  26. Perminova A.A. Congenital hyperinsulinism: etiopathogenesis and treatment. Medline.ru. Rossijskij biomedicinskij zhurnal. 2019;20(2):385-403. (In Russ.).
  27. Nikitina I.L., Bairov V.G., Sukhotskaya A.A., Smorodin A.P., Ryzhkova D.V., Mitrofanova L.B., Eftich E.A., Melikyan M.A., Kelmanson I.A. Neurodevelopmental outcomes and neurophysiological parameters in children with congenital hyperinsulinism. Meditsinskiy Sovet. 2022;16(12):86-94. (In Russ.). https://doi.org/10.21518/2079-701X-2022-16-12-86-94
  28. Chen X, Feng L, Yao H, Yang L, Qin Y. Efficacy and safety of diazoxide for treating hyperinsulinemic hypoglycemia: A systematic review and meta-analysis. PLoS One. 2021;16(2):0246463. https://doi.org/10.1371/journal.pone.0246463
  29. Solntseva A.V., Volkova N.V. Treatment of Congenital Hyperinsulinism in Children: Reality and Prospects. Recipe. 2020;23(2-3):395-405. (In Russ.). https://doi.org/10.34883/PI.2020.2.2.046
  30. Adzick NS, De Leon DD, States LJ, Lord K, Bhatti TR, Becker SA, Staniey CA. Surgical treatment of congenital hyperinsulinism: Results from 500 pancreatectomies in neonates and children. J Pediatr Surg. 2019;54(1):27-32.  https://doi.org/10.1016/j.jpedsurg.2018.10.030
  31. Melikian M.A. Vrozhdennyi giperinsulinizm (Rekomendatsii dlya roditelei detei s VGI). M., 2015. (In Russ.).
  32. Kapoor RR, James C, Hussain K. Advances in the diagnosis and management of hyperinsulinemic hypoglycemia. Nature Rev Endocrinol. 2009;5(3): 180-180.  https://doi.org/doi:10.1038/ncpendmet1046
  33. Smolin A.I. Miasteniya dlya vrachei; uchebnoe posobie dlya vrachei. Irkutsk: IGMU; 2014 (In Russ.).
  34. Rihani FB, Altayeh MM, Al-Kilani RZ, Alrejjal RA. Solitary median maxillary central incisor in Kabuki syndrome 2 with novel missense mutation of KDM6 and ABCC8 genes. J Clin Pediatr Dent. 2023;47(2):108-116.  https://doi.org/10.22514/jocpd.2023.005
  35. Leus P.A. Microbial biofilm on teeth. Physiological role and pathogenic significance. Stomatologicheskii zhurnal. 2007;2:100-111. (In Russ.).
  36. Friedlander L, Vincent M, Berdal A, Cormier-Daire V, Lyonnet S, Garcelon N. Consideration of oral health in rare disease experertise centres: a retrospective study on 39 rare diseases using text mining extraction method. Orphanet J Rare Dis. 2022;17:317. https://doi.org/10/1186/s13023-022-02467-7
  37. Atezhanov D.O. Clinical-experimental rationale for application of remineralizing drug for children of preschool age with somatic pathology. Part II. Stomatologiya detskogo vozrasta i profilaktika. 2018;18(4):12-16. (In Russ.). https://doi.org/10.25636/PMP.3.2018.4.2
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.