Genetic factors in degenerative disc disease

Chekhonatsky VA, Mirzaev KB, Pavlova GV, et al. . Genetic factors in degenerative disc disease. Burdenko's Journal of Neurosurgery. 2024;88(2):112‑118. (In Russ., In Engl.)
https://doi.org/10.17116/neiro202488021112

Подписка 2025-2 (Burdenko's Journal of Neurosurgery)

Использование инфографики авторами научных работ

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OBJECTIVE

To analyze available literature data on the role of genetic factors in degenerative disc disease.

METHODOLOGY

We reviewed the PubMed, MEDLINE, Cohrane Library, e-Library databases using the following keywords: degenerative spine lesions, intervertebral disc herniation, pathogenesis, genetic regulation.

RESULTS

Searching depth was 2002—2022. We reviewed 84 references. Exclusion criteria: duplicate publications, reviews without detailed description of results, opinions. Finally, we included 43 the most significant studies.

CONCLUSION

There are literature data on proinflammatory cytokines, growth factors and osteodestructive processes in pathogenesis of degenerative disc disease. However, there is only fragmentary information about the role of genetic regulation of these processes. Some factors, such as microRNA, TGF-b, VEGF, MMP are still poorly understood.

Keywords:

degenerative disc disease

pathogenesis

genetic factors

Authors:

Chekhonatsky V.A.

Russian Medical Academy of Continuous Postgraduate Education

ORCID: 0000-0003-0046-6612

Mirzaev K.B.

Russian Medical Academy of Continuous Postgraduate Education

ORCID: 0000-0002-9307-4994

Pavlova G.V.

Burdenko National Medical Research Center of Neurosurgery

SPIN RSCI: 4633-8339
Scopus AuthorID: 7005650683
ORCID: 0000-0002-6885-6601

Usachev D.Yu.

Russian Medical Academy of Continuous Postgraduate Education;
Burdenko Neurosurgical Center

ORCID: 0000-0002-9811-9442

Zakharova N.B.

Razumovsky Saratov State Medical University

ORCID: 0000-0001-9410-2240

Chekhonatsky A.A.

Razumovsky Saratov State Medical University

ORCID: 0000-0003-3327-1483

Kuznetsov A.V.

Russian Medical Academy of Continuous Postgraduate Education

ORCID: 0000-0003-0046-6612

Gorozhanin A.V.

Russian Medical Academy of Continuous Postgraduate Education;
Botkin Moscow City Clinical Hospital

ORCID: 0000-0002-1209-8960

Dreval O.N.

Russian Medical Academy of Continuous Postgraduate Education

ORCID: 0000-0002-8944-9837

Received:

14.11.2023

Accepted:

12.01.2024

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