Molecular markers of neuro-oncogenesis in patients with glioblastoma

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The problem of current treatment approaches to brain gliomas is short-term life expectancy in these patients. Apparently, it is required to change treatment approach via analysis of glioma stem cells rather cells with overexpression of marker genes. This review is devoted to similarities and differences between neurogenesis and neuro-oncogenesis characterized with molecular markers (CD133 as an example). The role of tumor stem cells and their relationship with neural stem cells are considered regarding development of glioma. The authors analyzed CD133 as a marker of glioma stem cells. In the future, stem cells will be important target for eradication during target therapy. A single molecular marker cannot characterize tumor stem cells as supported by CD133 studies. A set of molecular markers specific for certain cell type is required, and their combination will provide more accurate establishment of tumor stem cells.

Keywords:

glioblastoma

CD133

tumor stem cells

cell differentiation

apoptosis

gliomagenesis

Authors:

Kopylov A.M.

Lomonosov Moscow State University

SPIN RSCI: 6718-5281
Scopus AuthorID: 7102153297
ORCID: 0000-0003-0962-8905

Antipova O.A.

Lomonosov Moscow State University

ORCID: 0000-0002-1242-3612

Pavlova G.V.

Sechenov First Moscow State Medical University;
Institute of Higher Nervous Activity and Neurophysiology;
Burdenko Neurosurgical Center

SPIN RSCI: 4633-8339
Scopus AuthorID: 7005650683
ORCID: 0000-0002-6885-6601

Received:

19.08.2022

Accepted:

11.10.2022

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