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Matveeva N.Yu.

Pacific State Medical University

Pavlush D.G.

Pacific State Medical University

Kalinichenko S.G.

Pacific State Medical University

Morphogenesis and molecular regulation of polyposis rhinosinusitis

Authors:

Matveeva N.Yu., Pavlush D.G., Kalinichenko S.G.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2025;87(1): 68‑76

DOI: 10.17116/patol20258701168

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Table of contents

MORPHOGENESIS AND MOLECULAR REGULATION OF POLYPOSIS RHINOSINUSITIS
MORPHOGENESIS AND MOLECULAR REGULATION OF POLYPOSIS RHINOSINUSITIS

To cite this article:

Matveeva NYu, Pavlush DG, Kalinichenko SG. Morphogenesis and molecular regulation of polyposis rhinosinusitis. Russian Journal of Archive of Pathology. 2025;87(1):68‑76. (In Russ.)
https://doi.org/10.17116/patol20258701168

Подписка 2025-2 (Russian Journal of Archive of Pathology)
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Polyposis rhinosinusitis (CRSwNP) is a heterogeneous proliferative disease characterized by inflammatory hyperplasia of the nasal mucosa with dysregulation of apoptosis and cell differentiation. The review summarizes data on the molecular cellular mechanisms of CRSwNP and presents the concept of intercellular signaling during polyposis growth. Various factors that form a specific endotype are involved in the development of a polyp. Features of morphogenesis make it possible to distinguish edematous, eosinophilic and fibrous NP. In all cases, markers of neurogenic inflammation, impaired expression of proinflammatory cytokines, NO synthase, BMP-2 and other morphogenetic molecules arerecorded. The growing polyp and the inflammatory reaction damage the epithelium of the mucous membrane and bone wall of the nasal cavity. Interleukin-1β and BMP-2 are an integrative link in the pathogenesis of these events.

Keywords:

polyposis growth
small apoptotic molecules
apoptosis
neuropeptides
neurogenic inflammation

Authors:

Matveeva N.Yu.

Pacific State Medical University

Pavlush D.G.

Pacific State Medical University

Kalinichenko S.G.

Pacific State Medical University

Received:

07.05.2024

Accepted:

30.10.2024

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