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Eliseeva N.M.

Burdenko Neurosurgical Center

Serova N.K.

N.N. Burdenko National Medical Research Center of Neurosurgery

Pitskhelauri D.I.

Skolkovo Institute of Science and Technology

Kuchina O.B.

Burdenko Neurosurgical Center

Kudieva E.S.

Burdenko Neurosurgical Center

Retrograde degeneration of visual pathway

Authors:

Eliseeva N.M., Serova N.K., Pitskhelauri D.I., Kuchina O.B., Kudieva E.S.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2021;85(6): 92‑96

DOI: 10.17116/neiro20218506192

Read: 2665 times

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Table of contents

RETROGRADE DEGENERATION OF VISUAL PATHWAY
RETROGRADE DEGENERATION OF VISUAL PATHWAY

To cite this article:

Eliseeva NM, Serova NK, Pitskhelauri DI, Kuchina OB, Kudieva ES. Retrograde degeneration of visual pathway. Burdenko's Journal of Neurosurgery. 2021;85(6):92‑96. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20218506192

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

BACKGROUND

Optical coherence tomography (OCT) gives the opportunity to examine retrograde degeneration of visual pathway damaged at various levels.

OBJECTIVE

To estimate OCT data on retrograde degeneration of visual pathway damaged at various levels.

MATERIAL AND METHODS

Ganglion cell layer (GCL) thickness was measured by OCT in 79 patients with visual pathway damaged at various levels and known duration of visual disturbances. Twenty-One patients were diagnosed with traumatic lesions of the optic nerves and/or chiasma. Fifty-eight patients had retro-genicular visual pathway damage. Thirty-three patients were examined for postoperative homonymous hemianopia after surgery for drug-resistant temporal lobe epilepsy. Twenty-five patients were diagnosed with occipital lobe damage following stroke (12 patients), surgery for arteriovenous malformation (11 patients) and traumatic brain injury (2 patients). All patients underwent assessment of visual acuity, automatic static perimetry, MRI/CT of the brain. Retinal ganglion cell complex was analyzed during OCT.

RESULTS

GCL thinning following anterior visual pathway damage was detected in 20 out of 21 patients after ≥22 days. In case of post-genicular visual pathway damage, GCL thinning was found in 25 out of 58 patients (9 out of 33 ones after surgery for temporal lobe epilepsy and 16 out of 25 patients with occipital lobe lesion). After surgery for temporal lobe epilepsy, minimum period until GCL thinning detection after previous visual pathway damage was 3 months, in case of occipital lobe lesion — 5 months.

CONCLUSION

Retrograde visual pathway degeneration is followed by GCL thinning and depends on the level of visual pathway lesion.

Keywords:

retrograde degeneration of visual pathway
optical coherent tomography

Authors:

Eliseeva N.M.

Burdenko Neurosurgical Center

Serova N.K.

N.N. Burdenko National Medical Research Center of Neurosurgery

Pitskhelauri D.I.

Skolkovo Institute of Science and Technology

Kuchina O.B.

Burdenko Neurosurgical Center

Kudieva E.S.

Burdenko Neurosurgical Center

Received:

18.11.2020

Accepted:

08.10.2021

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