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Atkova E.L.

Krasnov Research Institute of Eye Diseases

Yartsev V.D.

Krasnov Research Institute of Eye Diseases

Kulish K.K.

Krasnov Research Institute of Eye Diseases

Zhukov O.V.

Krasnov Research Institute of Eye Diseases

Pak A.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Diagnostic capabilities of optical coherence tomography in obstruction of the upper lacrimal pathway

Authors:

Atkova E.L., Yartsev V.D., Kulish K.K., Zhukov O.V., Pak A.V.

More about the authors

Journal: Russian Annals of Ophthalmology. 2025;141(3): 37‑47

DOI: 10.17116/oftalma202514103137

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Table of contents

DIAGNOSTIC CAPABILITIES OF OPTICAL COHERENCE TOMOGRAPHY IN OBSTRUCTION OF THE UPPER LACRIMAL PATHWAY
DIAGNOSTIC CAPABILITIES OF OPTICAL COHERENCE TOMOGRAPHY IN OBSTRUCTION OF THE UPPER LACRIMAL PATHWAY

To cite this article:

Atkova EL, Yartsev VD, Kulish KK, Zhukov OV, Pak AV. Diagnostic capabilities of optical coherence tomography in obstruction of the upper lacrimal pathway. Russian Annals of Ophthalmology. 2025;141(3):37‑47. (In Russ.)
https://doi.org/10.17116/oftalma202514103137

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

An objective assessment of the lacrimal punctum (LP) and peripunctal area, essential for appropriate treatment planning, is only possible through optical coherence tomography (OCT). To date, global experience with this method remains limited, underscoring the need for further investigation of its diagnostic value.

PURPOSE

This study evaluated the diagnostic capabilities of OCT in cases of obstruction of the upper lacrimal pathway.

MATERIAL AND METHODS

The study included 26 patients (39 LP and canaliculi) with epiphora, in whom stenosis or obliteration of the LP by a membranous structure was identified. All patients underwent OCT of the LP and lacrimal canaliculus (LC) using the SD-OCT Optovue RTVue-100 system. The following morphological parameters were assessed: external LP diameter, LP depth, depth of the tear well, thickness of the epithelial, connective tissue, and muscle layers in the peripunctal area, epithelial thickness and lumen width of lacrimal canaliculus, as well as the thickness of the LP membrane. Histological structure, location, membrane thickness, and degree of canalicular lumen obstruction were also evaluated. Comparative and correlation analyses were performed.

RESULTS

The following types of membranes have been identified: thick, complete, superficial epithelial-connective tissue membrane (33%); thin, complete, deep epithelial membrane (23%); and thick, complete, superficial epithelial membrane (15%). The most pronounced differences were found when comparing epithelial and epithelial-connective tissue membranes. Some OCT signs were found to be potential markers of ocular surface inflammation and inflammation of the upper lacrimal pathway, indicating a need for conservative etiopathogenetic therapy before surgical intervention.

CONCLUSION

OCT is a valuable diagnostic tool, and its findings may serve as the foundation for developing rational approaches to both conservative and surgical treatment in patients with idiopathic inflammation of the LP and LC, as well as with stenosis or obliteration of the upper lacrimal pathway.

Keywords:

optical coherence tomography
upper lacrimal pathway
membrane
stenosis
lacrimal drainage obstruction
lacrimal punctum
lacrimal canaliculus

Authors:

Atkova E.L.

Krasnov Research Institute of Eye Diseases

Yartsev V.D.

Krasnov Research Institute of Eye Diseases

Kulish K.K.

Krasnov Research Institute of Eye Diseases

Zhukov O.V.

Krasnov Research Institute of Eye Diseases

Pak A.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Received:

24.01.2025

Accepted:

13.03.2025

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References:

  1. Fiorino MG, Quaranta-Leoni C, Quaranta-Leoni FM. Proximal lacrimal obstructions: a review. Acta Ophthalmol. 2021;99(7):701-711.  https://doi.org/10.1111/aos.14762
  2. Wladis EJ, Aakalu VK, Tao JP, Sobel RK, Freitag SK, Foster JA, Mawn LA. Monocanalicular Stents in Eyelid Lacerations: A Report by the American Academy of Ophthalmology. Ophthalmology. 2019;126(9):1324-1329. https://doi.org/10.1016/j.ophtha.2019.03.045
  3. Cherkunov BF. Bolezni sleznykh organov. Samara: G.P. «Perspektiva»; 2001 (In Russ.).
  4. Khoubian JF, Kikkawa DO, Gonnering RS. Trephination and silicone stent intubation for the treatment of canalicular obstruction: effect of the level of obstruction. Ophthalmic Plast Reconstr Surg. 2006;22(4):248-252.  https://doi.org/10.1097/01.iop.0000226863.21961.35
  5. Bubnova IA, Surnina ZV, Averich VV, Sarkisova KG. The effects of corneal collagen cross-linking on the corneal structure in keratoconus. Russian Annals of Ophthalmology=Vestnik oftal’mologii. 2020;136(5):268-276 (In Russ.). https://doi.org/10.17116/oftalma2020136052268
  6. Budnikova EA, Trufanov SV, Novikov IA, Voronin GV. Optical properties of the cornea after different modifications of penetrating keratoplasty. Russian Annals of Ophthalmology=Vestnik oftal’mologii. 2022;138(5-2):162-168 (In Russ.). https://doi.org/10.17116/oftalma2022138052162
  7. Kiseleva TN, Saakyan SV, Makukhina VV, Lugovkina KV, Milash SV, Musova NF, Zharov AA. Use of optical coherence tomography angiography in assessment in conjunctival vascular architecture in health and pathology. Russian Annals of Ophthalmology=Vestnik oftal’mologii. 2022;138(6):32-42 (In Russ.). https://doi.org/10.17116/oftalma202213806132
  8. Alkharki L, Yusef YuN, Budzinskaya MV, Avetisov KS, Shitikova AV. Current capabilities of anterior segment optical coherence tomography. Russian Annals of Ophthalmology=Vestnik oftal’mologii. 2024;140(2-2):190-195 (In Russ.). https://doi.org/10.17116/oftalma2024140022190
  9. Ali MJ, Singh S. Optical coherence tomography and the proximal lacrimal drainage system: a major review. Graefes Arch Clin Exp Ophthalmol. 2021; 259(11):3197-3208. https://doi.org/10.1007/s00417-021-05175-3
  10. Atkova EL, Surnina ZV, Maydanova AA, Krakhovetskiy NN. Optical coherence tomography in the diagnosis of pathologies of the horizontal portion of the lacrimal drainage system. Russian Annals of Ophthalmology=Vestnik oftal’mologii. 2022;138(5-2):279-284 (In Russ.). https://doi.org/10.17116/oftalma2022138052279
  11. Atkova EL, Maydanova AA, Krakhovetskiy NN, Reznikova LV. Punctal stenosis: etiology, diagnosis, treatment. Russian Annals of Ophthalmology=Vestnik oftal’mologii. 2022;138(2):100-107 (In Russ.). https://doi.org/10.17116/oftalma2022138021100
  12. Kashkouli MB, Nilforushan N, Nojomi M, Rezaee R. External lacrimal punctum grading: reliability and interobserver variation. Eur J Ophthalmol. 2018;18(4):507-511.  https://doi.org/10.1177/112067210801800401
  13. Munk PL, Lin DT, Morris DC. Epiphora: treatment by means of dacryocystoplasty with balloon dilation of the nasolacrimal drainage apparatus. Radiology. 1990;177(3):687-690.  https://doi.org/10.1148/radiology.177.3.2243969
  14. Schulz CB, Malhotra R. The ‘tears’ score: A tool for grading and monitoring epiphora. Eur J Ophthalmol. 2022;32(4):2108-2115. https://doi.org/10.1177/11206721221104550
  15. Schiffman RM. Reliability and Validity of the Ocular Surface Disease Index. Arch Ophthalmol. 2000;118(5):615-621.  https://doi.org/10.1001/archopht.118.5.615
  16. Wolffsohn JS, Arita R, Chalmers R, Djalilian A, Dogru M, Dumbleton K, Gupta PK, Karpecki P, Lazreg S, Pult H, Sullivan BD, Tomlinson A, Tong L, Villani E, Yoon KC, Jones L, Craig JP. TFOS DEWS II Diagnostic Methodology report. Ocul Surf. 2017;15(3):539-574.  https://doi.org/10.1016/j.jtos.2017.05.001
  17. Sung Y, Park JS, Lew H. Measurement of lacrimal punctum using spectralis domain anterior optical coherence tomography. Acta Ophthalmol. 2017; 95(7):e619-e624. https://doi.org/10.1111/aos.13322
  18. Yartsev VD, Atkova EL. Nasolacrimal Duct Obstruction in the Patients Receiving Treatment for Cancer. Int Ophthalmol Clin. 2023;63(3):137-145.  https://doi.org/10.1097/IIO.0000000000000458
  19. Dantas RR. Lacrimal drainage system obstruction. Semin Ophthalmol. 2010; 25(3):98-103.  https://doi.org/10.3109/08820538.2010.488577
  20. Tao H, Xu LP, Han C, Wang P, Bai F. Diagnosis of lacrimal canalicular diseases using ultrasound biomicroscopy: a preliminary study. Int J Ophthalmol. 2014;7(4):659-662.  https://doi.org/10.3980/j.issn.2222-3959.2014.04.15.13
  21. Shkol’nik SF, Shkol’nik GS. Transcanalicular endoscopy of the lacrimal pathways. Russian Annals of Ophthalmology=Vestnik oftal’mologii. 2019;135(4): 78-82 (In Russ.). https://doi.org/10.17116/oftalma201913504178
  22. Hu J, Xiang N, Li GG, Luo B, Zhang Y, Zhu Y, Liu R. Imaging and anatomical parameters of the lacrimal punctum and vertical canaliculus using optical coherence tomography. Int J Med Sci. 2021;18(12):2493-2499. https://doi.org/10.7150/ijms.58291
  23. Yan X., Xiang N., Hu W., Liu R., Luo B. Characteristics of lacrimal passage diseases by 80-MHz ultrasound biomicroscopy: an observational study. Graefes Arch Clin Exp Ophthalmol. 2020;258(2):403-410.  https://doi.org/10.1007/s00417-019-04515
  24. Al-Faky YH. Anatomical utility of ultrasound biomicroscopy in the lacrimal drainage system. Br J Ophthalmol. 2011;95(10):1446-1450. https://doi.org/10.1136/bjo.2010.195479
  25. Ali MJ, Mohapatra S, Mulay K, Naik MN, Honavar SG. Incomplete punctal canalisation: the external and internal punctal membranes. Outcomes of membranotomy and adjunctive procedures. Br J Ophthalmol. 2013;97(1):92-95.  https://doi.org/10.1136/bjophthalmol-2012-302277
  26. Saini P, Bothra N, Ali MJ. Update on the Long-Term Outcomes Following the Management of Incomplete Punctal Canalization. Ophthalmic Plast Reconstr Surg. 2022;38(2):151-153.  https://doi.org/10.1097/IOP.0000000000002011
  27. Ali MJ. Idiopathic Canalicular Inflammatory Disease: New Disease Description of Clinical Patterns, Investigations, Management, and Outcomes. Ophthalmic Plast Reconstr Surg. 2018;34(6):528-532.  https://doi.org/10.1097/IOP.0000000000001064
  28. Ali MJ, Bothra N. Update on Idiopathic Canalicular Inflammatory Disease (ICID): Outcomes With Addition of Topical Cyclosporine and the Modified Treatment Protocol. Ophthalmic Plast Reconstr Surg. 2021;37(1):38-41.  https://doi.org/10.1097/IOP.0000000000001672
  29. Nassief M, Lotfy NM. Topical cyclosporin A 0.05% eye drops for management of symptomatic acquired punctal stenosis: a prospective, controlled clinical study. Orbit. 2024;43(2):190-195.  https://doi.org/10.1080/01676830.2023.2232028
  30. Hu J., Xiang N., Li G.G., Luo B., Zhang Y., Zhu Y., Liu R. Imaging and anatomical parameters of the lacrimal punctum and vertical canaliculus using optical coherence tomography. Int J Med Sci. 2021;18(12):2493-2499. https://doi.org/10.7150/ijms.58291
  31. Yoon S., Lee H., Baek S. Anterior Segment Optical Coherence Tomography for Canaliculitis. J Craniofac Surg. 2023;34(1):e59-e61.  https://doi.org/10.1097/SCS.0000000000008983
  32. Imagawa Y., Vaidya A., Takahashi Y. Bilateral acquired canaliculops: Report of two cases. Orbit. 2023;42(5):558-560.  https://doi.org/10.1080/01676830.2022.2050407
  33. Fujimoto M, Uji A, Ogino K, Akagi T, Yoshimura N. Lacrimal Canaliculus Imaging Using Optical Coherence Tomography Dacryography. Sci Rep. 2018;8(1):9808. https://doi.org/10.1038/s41598-018-27802-6
  34. Bothra N, Saini P, Ali MJ. Age-Related Changes in the Lacrimal Punctum Morphology in a Normal Population: Punctum Update (PUP) Study—Paper 1. Ophthalmic Plast Reconstr Surg. 2023;39(1):34-39.  https://doi.org/10.1097/IOP.0000000000002225
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