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Gareev I.F.

Bashkir State Medical University of the Ministry of Health of the Russia, Ufa, Russia

Safin Sh.M.

Respublikanskiĭ neĭrokhirurgicheskiĭ tsentr, Ufa

The role of endogenous miRNAs in the development of cerebral aneurysms

Authors:

Gareev I.F., Safin Sh.M.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2019;83(1): 112‑118

DOI: 10.17116/neiro201983011112

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THE ROLE OF ENDOGENOUS MIRNAS IN THE DEVELOPMENT OF CEREBRAL ANEURYSMS
THE ROLE OF ENDOGENOUS MIRNAS IN THE DEVELOPMENT OF CEREBRAL ANEURYSMS

To cite this article:

Gareev IF, Safin ShM. The role of endogenous miRNAs in the development of cerebral aneurysms. Burdenko's Journal of Neurosurgery. 2019;83(1):112‑118. (In Russ., In Engl.)
https://doi.org/10.17116/neiro201983011112

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
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Abstract:

Cerebral aneurysms are characterized by pathological expansion and thinning of the wall of vessels on the brain base, which may lead to rupture and subarachnoid hemorrhage (SAH) that is a life-threatening condition. This dictates the need for identification of new biological markers that predict the presence of aneurysms and the risk of their rupture. In the last decade, the role of microRNAs (miRNAs), which are considered to be key regulators of biological processes, has been investigated. miRNAs have been shown to play a role in the development of aneurysms, but today there is little similar data. In this literature review, we analyze the existing data on the role of miRNAs in development, progression, and rupture of cerebral aneurysms. We describe the relationship between miRNA expression profiles and specific molecular and cellular processes leading to the development of aneurysms. Also, we discuss the potential clinical significance of miRNAs for predicting the risk of aneurysm rupture.

Keywords:

microRNA
cerebral aneurysm
subarachnoid hemorrhage
pathogenesis

Authors:

Gareev I.F.

Bashkir State Medical University of the Ministry of Health of the Russia, Ufa, Russia

Safin Sh.M.

Respublikanskiĭ neĭrokhirurgicheskiĭ tsentr, Ufa

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References:

  1. Schnell S, Ansari SA, Vakil P, Wasielewski M, Carr ML, Hurley MC, Bendok BR, Batjer H, Carroll TJ, Carr J, Markl M. Three-dimensional hemodynamics in intracranial aneurysms: influence of size and morphology. Journal of magnetic resonance imaging. JMRI. 2014;39:120-131. https://doi.org/10.1002/jmri.24110
  2. Frosen J, Piippo A, Paetau A, Kangasniemi M, Niemela M, Hernesniemi J, Jaaskelainen J. Remodeling of saccular cerebral artery aneurysm wall is associated with rupture: Histological analysis of 24 unruptured and 42 ruptured cases. Stroke. 2004;35:2287-2293. https://doi.org/10.1161/01.str.0000140636.30204.da
  3. Krings T, Mandell DM, Kiehl TR, Geibprasert S, Tymianski M, Alvarez H, terBrugge KG, Hans FJ. Intracranial aneurysms: From vessel wall pathology to therapeutic approach. Nat Rev Neurol. 2011;7:547-549. https://doi.org/10.1038/nrneurol.2011.136
  4. Di LG, Garofalo M, Croce CM. MicroRNAs in cancer. Ann Rev Pathol. 2014;9:287-314. https://doi.org/10.1146/annurev-pathol-012513-104715
  5. Liu D, Han L, Wu X, Yang X, Zhang Q1, Jiang F. Genome-wide microRNA changes in human intracranial aneurysms. BMC Neurol. 2014;14:188. https://doi.org/10.1186/s12883-014-0188-x
  6. Starke RM, Chalouhi N, Ali MS, Jabbour PM, Tjoumakaris SI, Gonzalez LF, Rosenwasser RH, Koch WJ, Dumont AS. The role of oxidative stress in cerebral aneurysm formation and rupture. Curr Neurovasc Res. 2013;10:247-255.
  7. Penn DL, Witte SR, Komotar RJ, Sander Connolly E, Jr. The role of vascular remodeling and inflammation in the pathogenesis of intracranial aneurysms. Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia. 2014;21:28-32.
  8. Turjman AS, Turjman F, Edelman ER. Role of fluid dynamics and inflammation in intracranial aneurysm formation. Circulation. 2014;129:373-382. https://doi.org/10.1161/CIRCULATIONAHA.113.001444
  9. Kolega J, Gao L, Mandelbaum M, Mocco J, Siddiqui AH, Natarajan SK, Meng H. Cellular and molecular responses of the basilar terminus to hemodynamics during intracranial aneurysm initiation in a rabbit model. Journal of vascular research. 2011;48:429-442. https://doi.org/10.1159/000324840
  10. Aoki T, Kataoka H, Ishibashi R, Nozaki K, Morishita R, Hashimoto N. Reduced collagen biosynthesis is the hallmark of cerebral aneurysm: contribution of interleukin-1beta and nuclear factor-κB. Arteriosclerosis, thrombosis, and vascular biology. 2009;29:1080-1086. https://doi.org/10.2176/nmc.ra.2014-0337
  11. Frösen J, Tulamo R, Paetau A, Laaksamo E, Korja M, Laakso A, Niemelä M, Hernesniemi J. Saccular intracranial aneurysm: pathology and mechanisms. Acta Neuropathol. 2012;123:773-786. https://doi.org/10.1007/s00401-011-0939-3
  12. Meng H, Metaxa E, Gao L, Liaw N, Natarajan SK, Swartz DD, Siddiqui AH, Kolega J, Mocco J. Progressive aneurysm development following hemodynamic insult. J Neurosurg. 2011;114:1095-1103. https://doi.org/10.3171/2010.9.JNS10368
  13. Jiang Y, Zhang M, He H, Chen J, Zeng H, Li J, Duan R. MicroRNA/mR NA profiling and regulatory network of intracranial aneurysm. BMC Med Genomics. 2013;6:36. https://doi.org/10.1186/1755-8794-6-36
  14. Long X, Miano JM. Transforming growth factor-beta1 (TGF-beta1) utilizes distinct pathways for the transcriptional activation of microRNA 143/145 in human coronary artery smooth muscle cells. J Biol Chem. 2011;286:30119-30129. https://doi.org/10.1074/jbc.M111.258814
  15. Rangrez AY, Massy ZA, Metzinger-Le Meuth V, Metzinger L. MiR-143 and miR-145: molecular keys to switch the phenotype of vascular smooth muscle cells. Circ Cardiovasc Genet. 2011;4:197-205. https://doi.org/10.1161/CIRCGENETICS.110.958702
  16. Xie C, Huang H, Sun X, Guo Y, Hamblin M, Ritchie RP, Garcia-Barrio MT, Zhang J, Chen YE. MicroRNA-1 regulates smooth muscle cell differentiation by repressing Kruppel-like factor 4. Stem Cells Dev. 2011;20:205-210. https://doi.org/10.1089/scd.2010.0283
  17. Liu N, Bezprozvannaya S, Williams AH, Qi X, Richardson JA, Bassel-Duby R, Olson EN. microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev. 2008;22:3242-3254. https://doi.org/10.1101/gad.1738708
  18. Li P, Zhang Q, Wu X, Yang X, Zhang Y, Li Y, Jiang F. Circulating microRNAs serve as novel biological markers for intracranial aneurysms. Journal of the American Heart Association. 2014;3:E000972. https://doi.org/10.1161/JAHA.114.000972
  19. Maegdefessel L, Azuma J, Tsao PS. MicroRNA-29b regulation of abdominal aortic aneurysm development. Trends Cardiovasc Med. 2014;24:1-6. https://doi.org/10.1016/j.tcm.2013.05.002
  20. Kriegel AJ, Liu Y, Fang Y, Ding X, Liang M. The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury. Physiol Genomics. 2012;44:237-244. https://doi.org/10.1152/physiolgenomics.00141.2011
  21. Corsten MF, Dennert R, Jochems S, Kuznetsova T, Devaux Y, Hofstra L, Wagner DR, Staessen JA, Heymans S, Schroen B. Circulating microRNA-208b and microRNA-499 reflect myocardial damage in cardiovascular disease. Circulation Cardiovascular genetics. 2010;3:499-506. https://doi.org/10.1161/CIRCGENETICS.110.957415
  22. Lee HJ, Yi JS, Lee HJ, Lee IW, Park KC, Yang JH. Dysregulated Expression Profiles of MicroRNAs of Experimentally Induced Cerebral Aneurysms in Rats. Journal of Korean Neurosurgical Society. 2013;53:72-76. https://doi.org/10.3340/jkns.2013.53.2.72
  23. Chan MC, Hilyard AC, Wu C, Davis BN, Hill NS, Lal A, Lieberman J, Lagna G, Hata A. Molecular basis for antagonism between PDGF and the TGF beta family of signaling pathways by control of miR-24 expression. EMBO J. 2010;29:559-573. https://doi.org/10.1038/emboj.2009.370
  24. Badi I, Burba I, Ruggeri C, Zeni F, Bertolotti M, Scopece A, Pompilio G, Raucci A. MicroRNA- 34a Induces Vascular Smooth Muscle Cells Senescence by SIRT1 Downregulation and Promotes the Expression of Age-Associated Proinflammatory Secretory Factors. J Gerontol A Biol Sci Med Sci. 2015;70:1304-1311. https://doi.org/10.1093/gerona/glu180
  25. Boon RA, Iekushi K, Lechner S, Seeger T, Fischer A, Heydt S, Kaluza D, Tréguer K, Carmona G, Bonauer A, Horrevoets AJ, Didier N, Girmatsion Z, Biliczki P, Ehrlich JR, Katus HA, Müller OJ, Potente M, Zeiher AM, Hermeking H, Dimmeler S. MicroRNA-34a regulates cardiac ageing and function. Nature. 2013;495:107-110. https://doi.org/10.1038/nature11919
  26. Aoki T, Kataoka H, Moriwaki T, Nozaki K, Hashimoto N. Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms. Stroke. 2007;38:2337-2345. https://doi.org/10.1161/STROKEAHA.107.481838
  27. Horstmann S, Su Y, Koziol J, Meyding-Lamadé U, Nagel S, Wagner S. MMP-2 and MMP-9 levels in peripheral blood after subarachnoid hemorrhage. J Neurol Sci. 2006;251:82-86. https://doi.org/10.1186/s40064-016-2837-6
  28. Hossain M, Sathe T, Fazio V, Mazzone P, Weksler B, Janigro D, Rapp E, Cucullo L. Tobacco smoke: a critical etiological factor for vascular impairment at the blood-brain barrier. Brain Res. 2009;1287:192-205. https://doi.org/10.1016/j.brainres.2009.06.033
  29. Aoki T, Kataoka H, Morimoto M, Nozaki K, Hashimoto N. Macrophagederived matrix metalloproteinase-2 and -9 promote the progression of cerebral aneurysms in rats. Stroke. 2007;38:162-169.
  30. Merk DR, Chin JT, Dake BA, Maegdefessel L, Miller MO, Kimura N, Tsao PS, Iosef C, Berry GJ, Mohr FW, Spin JM, Alvira CM, Robbins RC, Fischbein MP. MiR-29b participates in early aneurysm development in Marfan syndrome. Circ Res. 2012;110:312-324.
  31. Oviedo-Orta E, Bermudez-Fajardo A, Karanam S, Benbow U, Newby AC. Comparison of MMP-2 and MMP-9 secretion from T helper 0, 1 and 2 lymphocytes alone and in coculture with macrophages. Immunology. 2008;124:42-50. https://doi.org/10.1111/j.1365-2567.2007.02728.x
  32. Chen KC, Wang YS, Hu CY, Chang WC, Liao YC, Dai CY, Juo SH. OxLDL up-regulates microRNA-29b, leading to epigenetic modifications of MMP-2/MMP-9 genes: a novel mechanism for cardiovascular diseases. FASEB J. 2011;25:1718-1728. https://doi.org/10.1096/fj.10-174904
  33. Fang JH, Zhou HC, Zeng C, Yang J, Liu Y, Huang X, Zhang JP, Guan XY, Zhuang SM. MicroRNA-29b suppresses tumor angiogenesis, invasion, and metastasis by regulating matrix metalloproteinase 2 expression. Hepatology. 2011;54:1729-1740.
  34. Mishra PK, Metreveli N, Tyagi SC. MMP-9 gene ablation and TIMP-4 mitigate PAR-1-mediated cardiomyocyte dysfunction: a plausible role of dicer and miRNA. Cell Biochem Biophys. 2010;57:67-76. https://doi.org/10.1007/s12013-010-9084-1
  35. Marin T, Gongol B, Chen Z, Woo B, Subramaniam S, Chien S, Shyy JY. Mechanosensitive microRNAs-role in endothelial responses to shear stress and redox state. Free Radic Biol Med. 2013;64:61-68. https://doi.org/10.1016/j.freeradbiomed.2013.05.034
  36. Chiu JJ, Lee PL, Chen CN, Lee CI, Chang SF, Chen LJ, Lien SC, Ko YC, Usami S, Chien S. Shear stress increases ICAM-1 and decreases VCAM-1 and E-selectin expressions induced by tumor necrosis factor-α in endothelial cells. Arteriosclerosis, thrombosis, and vascular biology. 2004;24:73-79. https://doi.org/10.1161/01.ATV.0000106321.63667.24
  37. Kong W, Yang H, He L, Zhao JJ, Coppola D, Dalton WS, Cheng JQ. MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol Cell Biol. 2008;28:6773-6784. https://doi.org/10.1128/MCB.00941-08
  38. Muramatsu F, Kidoya H, Naito H, Sakimoto S, Takakura N. MicroRNA-125b inhibits tube formation of blood vessels through translational suppression of VE-cadherin. Oncogene. 2013;32:414-421. https://doi.org/10.1038/onc.2012.68
  39. Hoh BL, Hosaka K, Downes DP, Nowicki KW, Wilmer EN, Velat GJ, Scott EW. Stromal cell-derived factor-1 promoted angiogenesis and inflammatory cell infiltration in aneurysm walls. J Neurosurg. 2014;120:73-86. https://doi.org/10.3171/2013.9.JNS122074
  40. Kanematsu Y, Kanematsu M, Kurihara C, Tada Y, Tsou TL, van Rooijen N, Lawton MT, Young WL, Liang EI, Nuki Y, Hashimoto T. Critical roles of macrophages in the formation of intracranial aneurysm. Stroke. 2011;42:173-178. https://doi.org/10.1161/STROKEAHA.110.590976
  41. Natarelli L, Schober A. MicroRNAs and the response to injury in atherosclerosis. Hamostaseologie. 2015;35:142-150.
  42. Zhang J, Ren J, Chen H, Geng Q. Inflammation induced-endothelial cells release angiogenesis associated-microRNAs into circulation by microparticles. Chinese medical journal. 2014;127:2212-2217.
  43. Sun X, He S, Wara AK, Icli B, Shvartz E, Tesmenitsky Y, Belkin N, Li D, Blackwell TS, Sukhova GK, Croce K, Feinberg MW. Systemic delivery of microRNA-181b inhibits nuclear factor-ΠB activation, vascular inflammation, and atherosclerosis in apolipoprotein E-deficient mice. Circ Res. 2014;114:32-40. https://doi.org/10.1161/CIRCRESAHA.113.302089
  44. Li T, Yang GM, Zhu Y, Wu Y, Chen XY, Lan D, Tian KL, Liu LM. Diabetes and hyperlipidemia induce dysfunction of VSMCs: contribution of the metabolic inflammation/miRNA pathway. Am J Physiol Endocrinol Metab. 2015;308:E257-E269. https://doi.org/10.1152/ajpendo.00348.2014
  45. Maegdefessel L, Spin JM, Raaz U, Eken SM, Toh R, Azuma J, Adam M, Nakagami F, Heymann HM, Chernogubova E, Jin H, Roy J, Hultgren R, Caidahl K, Schrepfer S, Hamsten A, Eriksson P, McConnell MV, Dalman RL, Tsao PS. MiR-24 limits aortic vascular inflammation and murine abdominal aneurysm development. Nature communications. 2014;5:5214. https://doi.org/10.1038/ncomms6214
  46. de Lucia C, Komici K, Borghetti G, Femminella GD, Bencivenga L, Cannavo A, Corbi G, Ferrara N, Houser SR, Koch WJ, Rengo G. MicroRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases. Front Med (Lausanne). 2017;4:74. https://doi.org/10.3389/fmed.2017.00074
  47. Alessandra S, Anna T, Giulio C, Maria C. Circulating microRNAs as emerging non-invasive biomarkers for gliomas. Ann Transl Med. 2017;5(13):277. https://doi.org/10.21037/atm.2017.06.15
  48. Seyed EK, William W, Yaghoob F, Hadi FM, Maryam F. Emerging Roles of microRNAs in Ischemic Stroke: As Possible Therapeutic Agents. J Stroke. 2017;19(2):166-187. https://doi.org/10.5853/jos.2016.01368
  49. Shafat A, Shazia N, Ponnusamy K, Ekta R, Swarkar S and Bamezai N. Understanding Genetic Heterogeneity in Type 2 Diabetes by Delineating Physiological Phenotypes: SIRT1 and its Gene Network in Impaired Insulin Secretion. Rev Diabet Stud. 2016;13(1):17-34. https://doi.org/10.1900/RDS.2016.13.17
  50. Meeuwsen JAL, van ´t Hof FNG, van Rheenen W, Rinkel GJE, Veldink JH, Ynte M. Circulating microRNAs in patients with intracranial aneurysms. Ruigrok. 2017. https://doi.org/10.1371/journal.pone.0176558
  51. Jin H, Li C, Ge H, Jiang Y1, Li Y. Circulating microRNA: a novel potential biomarker for early diagnosis of intracranial aneurysm rupture: a case control study. J Transl Med. 2013;11:296. https://doi.org/10.1186/1479-5876-11-296
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