The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Kakurina G.V.

Cancer Research Institute a subdivision of the Tomsk National Research Medical Center, Tomsk, Russia;
Siberian State Medical University, Tomsk, Russia

Yunusova N.V.

Cancer Research Institute a subdivision of the Tomsk National Research Medical Center, Tomsk, Russia;
Siberian State Medical University, Tomsk, Russia

Voronina V.D.

Siberian State Medical University, Tomsk, Russia

Popova N.O.

Cancer Research Institute a subdivision of the Tomsk National Research Medical Center, Tomsk, Russia

Role of actin/actin-binding proteins in extracellular vesicles in mechanisms of tumor progression and development of drug-induced polyneuropathy

Authors:

Kakurina G.V., Yunusova N.V., Voronina V.D., Popova N.O.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2026;126(3): 7‑12

DOI: 10.17116/jnevro20261260317

Read: 350 times

Buy for 300₽
Contact the author
Table of contents

ROLE OF ACTIN/ACTIN-BINDING PROTEINS IN EXTRACELLULAR VESICLES IN MECHANISMS OF TUMOR PROGRESSION AND DEVELOPMENT OF DRUG-INDUCED POLYNEUROPATHY
ROLE OF ACTIN/ACTIN-BINDING PROTEINS IN EXTRACELLULAR VESICLES IN MECHANISMS OF TUMOR PROGRESSION AND DEVELOPMENT OF DRUG-INDUCED POLYNEUROPATHY

To cite this article:

Kakurina GV, Yunusova NV, Voronina VD, Popova NO. Role of actin/actin-binding proteins in extracellular vesicles in mechanisms of tumor progression and development of drug-induced polyneuropathy. S.S. Korsakov Journal of Neurology and Psychiatry. 2026;126(3):7‑12. (In Russ.)
https://doi.org/10.17116/jnevro20261260317

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Multiple foci of cere­bral ischemia in cancer patients with seco­ndary anti­phospholipid syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2026;(3-2):84-89
Meta­static meni­ngiomas: a case series and lite­rature review. Burdenko's Journal of Neurosurgery. 2025;(3):83-91
The stru­cture of causes of death of the adult popu­lation of the Moscow region in 2019 and 2023. Russian Journal of Archive of Pathology. 2025;(3):40-48
Surgical treatment of giant meta­static myxoid lipo­sarcoma of the peri­cardium. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;(3):363-365
Ethmoid laby­rinth cancer with exte­nsion into the orbi­tal cavity. Russian Bulletin of Otorhinolaryngology. 2025;(4):119-122
Extracellular vesi­cles and their role in endo­metrial rece­ptivity in patients with recu­rrent implantation failure. Russian Journal of Human Reproduction. 2025;(4):46-52
Systemic toxi­city of local anesthetics. Clinical guidelines of the All-Russian public orga­nization «Federation of anesthesiologists and reanimatologists». Russian Journal of Anesthesiology and Reanimatology. 2025;(5):8-21
New analgesics in onco­logy. Tafa­lgin employed as an alte­rnative to opioid analgesics. P.A. Herzen Journal of Onco­logy. 2025;(5):73-77
Intraoperative visualization of central zone lymph nodes after hemi­thyroidectomy in patients with papi­llary thyroid carcinoma. Piro­gov Russian Journal of Surgery. 2025;(10):47-55
Tumor progression: a clinical case in the practice of a gene­ral practitioner. Russian Journal of Preventive Medi­cine. 2026;(3):98-101
Abstract:

A major challenge in treating tumors is the development of polyneuropathy caused by the neurotoxicity of chemotherapy agents. Currently, there are no specific markers to monitor chemotherapy-induced complications. This review examines the potential of extracellular vesicles as predictive tools for chemotherapy-induced polyneuropathy. Extracellular vesicles facilitate intercellular communication in both normal and pathological conditions, including tumor progression. However, the mechanisms underlying chemotherapy-induced polyneuropathy and the involvement of extracellular vesicles remain unclear. The roles of the actin cytoskeleton and actin-binding proteins in extracellular vesicle dynamics are still under investigation. Advancing our understanding of cytoskeletal proteins in extracellular vesicle metabolism, alongside the neurotoxic effects of antitumor agents, may offer new insights into the pathogenesis of chemotherapy complications. This research could enable the use of extracellular vesicles as both diagnostic markers and therapeutic targets in cancer treatment.

Keywords:

actin-binding protein
extracellular vesicles
cancer
metastasis
neurotoxicity
taxanes
platinum-based agents

Authors:

Kakurina G.V.

Cancer Research Institute a subdivision of the Tomsk National Research Medical Center, Tomsk, Russia;
Siberian State Medical University, Tomsk, Russia

Yunusova N.V.

Cancer Research Institute a subdivision of the Tomsk National Research Medical Center, Tomsk, Russia;
Siberian State Medical University, Tomsk, Russia

Voronina V.D.

Siberian State Medical University, Tomsk, Russia

Popova N.O.

Cancer Research Institute a subdivision of the Tomsk National Research Medical Center, Tomsk, Russia

Received:

03.03.2025

Accepted:

12.12.2025

Close metadata

References:

  1. Palkina NV, Zenaishvili RD, Ruksha TG. The role of exosomes in the diagnostics and treatment of immune mediated skin disoders, wounds and alopecia. Vestnik dermatologii i venerologi. 2024;100(2):8-17. (In Russ.). https://doi.org/10.25208/vdv11876
  2. Yadav A, Nandy A, Sharma A, et al. Exosome Mediated Cell-Cell Crosstalk in Tissue Injury and Repair. Results and Problems in Cell Differentiation. 2024;73:249-297.  https://doi.org/10.1007/978-3-031-62036-2_12
  3. Palakurthi SS, Shah B, Kapre S, et al. A comprehensive review of challenges and advances in exosome-based drug delivery systems. Nanoscale Advances. 2024;6:5803-5826. https://doi.org/10.1039/d4na00501e
  4. Shao M, Gao Y, Xu X, et al. Exosomes: Key Factors in Ovarian Cancer Peritoneal Metastasis and Drug Resistance. Biomolecules. 2024;14(9):1099. https://doi.org/10.3390/biom14091099
  5. Simons M, Raposo G. Exosomes-vesicular carriers for intercellular communication. Current Opinion in Cell Biology. 2009;21(4):575-581.  https://doi.org/10.1016/j.ceb.2009.03.007
  6. Yunusova NV, Popova NO, Udintseva IN, et al. The Role of Intravesicular Proteins and the Protein Corona of Extracellular Vesicles in the Development of Drug-Induced Polyneuropathy. Current Issues in Molecular Biology. 2023;45(4):3302-3314. https://doi.org/10.3390/cimb45040216
  7. Tamkovich SN, Yunusova NV, Somov AK, et al. Comparative sub-population analysis of exosomes from blood plasma of cancer patients. Biomeditsinskaya Khimiya. 2018;64(1):110-114. (In Russ.). https://doi.org/10.18097/PBMC20186401110
  8. Kornilova ES. Receptor-mediated endocytosis and cytoskeleton. Biokhimiya. 2014;79(9):1079-1094. (In Russ.). https://doi.org/10.1134/S0006297914090041
  9. Kharchenko MV, Zlobina MV, Kamentseva RS., et al. Microtubulees and actin filaments facilitate fusions and separations of vesicules on the endocytic pathway of EGF-receptor complexes. Tsitologiya. 2020;62(5):356-366. (In Russ.). https://doi.org/10.31857/S004137712005003X
  10. Yunusova NV, Swarovsky DA, Konovalov AI, et al. Association of exosome proteins with the effectiveness of thermoradiochemotherapy in overweight and rectal cancer patients: a pilot prospective cohort study. Al’manakh klinicheskoi meditsiny. 2024;52(2):66-76. (In Russ.). https://doi.org/10.18786/2072-0505-2024-52-013
  11. Morad G, Carman CV, Hagedorn EJ, et al. Tumor-Derived Extracellular Vesicles Breach the Intact Blood-Brain Barrier via Transcytosis. ACS Nano. 2019;13:13853-13865. https://doi.org/10.1021/acsnano.9b04397
  12. Hurwitz SN, Rider MA, Bundy JL, et al. Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. Oncotarget. 2016;27:7(52):86999-87015. https://doi.org/10.18632/oncotarget.13569
  13. Granger E, Mc Nee G, Allan V, et al. The role of the cytoskeleton and molecular motors in endosomal dynamics. Seminars in Cell and Developmental Biology. 2014;31(100):20-29.  https://doi.org/10.1016/j.semcdb.2014.04.011
  14. Holliday LS, Faria LP, Rody WJ Jr. Actin and Actin-Associated Proteins in Extracellular Vesicles Shed by Osteoclasts. The International Journal of Molecular Sciences. 2019;21(1):158.  https://doi.org/10.3390/ijms21010158
  15. Lima LG, Leal AC, Vargas G, et al. Intercellular transfer of tissue factor via the uptake of tumor-derived microvesicles. Thrombosis Research. 2013;132(4):450-456.  https://doi.org/10.1016/j.thromres.2013.07.026
  16. Li B, Antonyak MA, Zhang J, Cerione RA. RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells. Oncogene. 2012;8:31(45):4740-4749. https://doi.org/10.1038/onc.2011.636
  17. Kakurina GV, Kolegova ES, Shashova EE, et al. Relationship between the mRNA Expression Levels of Calpains 1/2 and Proteins Involved in Cytoskeleton Remodeling. Acta Naturae. 2020;12(1):110-113.  https://doi.org/10.32607/actanaturae.10947
  18. Harshman SW, Canella A, Ciarlariello PD, et al. Characterization of multiple myeloma vesicles by label-free relative quantitation. Proteomics. 2013;13(20):3013-3029. https://doi.org/10.1002/pmic.201300142
  19. Syn N, Wang L, Sethi G, et al. Exosome-mediated metastasis: from epithelial-mesenchymal transition to escape from immunosurveillance. Trends in pharmacological sciences. 2016;37(7):606-617.  https://doi.org/10.1016/j.tips.2016.04.006
  20. Niu T, Zhu J, Dong L, et al. Inorganic pyrophosphatase 1 activates the phosphatidylinositol 3-kinase/Akt signaling to promote tumorigenicity and stemness properties in colorectal cancer. Cell Signal. 2023;108:110693. https://doi.org/10.1016/j.cellsig.2023.110693
  21. Wubbolts R, Leckie RS, Veenhuizen PT, et al. Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation. The Journal of Biological Chemistry. 2003;278(13):10963-10972. https://doi.org/10.1074/jbc.M207550200
  22. Was H, Borkowska A, Bagues A, et al. Mechanisms of Chemotherapy-Induced Neurotoxicity. Frontiers in Pharmacology. 2022;28:13:750507. https://doi.org/10.3389/fphar.2022.750507
  23. Tian H, Ma D, Tan X, et al. Platinum and Taxane Based Adjuvant and Neoadjuvant Chemotherapy in Early Triple-Negative Breast Cancer: A Narrative Review. Frontiers in Pharmacology. 2021;12:770663. https://doi.org/10.3389/fphar.2021.770663
  24. Kuzmin EA, Shamitko ZV, Piavchenko GA, et al. Biomarkers of neuroinflammation in the diagnosis of traumatic brain injury and neurodegenerative diseases: a literature review. Sechenovskii vestnik. 2024;15(1):20-35. (In Russ.). https://doi.org/10.47093/2218-7332.2024.15.1.20-35
  25. Apollonova VS, Sidina EI, Tkachenko EV, et al. MicroRNA-dependent mechanisms of taxane resistance in breast cancer. Opukholi zhenskoi reproduktivnoi sistemy. 2022;18(3):52-63. (In Russ.). https://doi.org/10.17650/1994-4098-2022-18-3-52-63
  26. Lyubimova NV, Timofeev YS, Mitrofanov AA, et al. Gliofibrillary acid protein in the diagnosis and prognosis of malignant glial tumors. Byulleten` e`ksperimental`noj biologii i mediciny`. 2020;168(10):491-495. (In Russ.).
  27. Helson L. Radiation-induced Demyelination and Remyelination in the Central Nervous System: A Literature Review. Anticancer Research. 2018;38(9):4999-5002. https://doi.org/10.21873/anticanres.12818
  28. Thebault S, Fereshtehnejad SM, Bergman HP, et al. The combination of CSF neurofilament light chain and glial fibrillary acidic protein improves the prediction of long-term confirmed disability worsening in multiple sclerosis. Scientific Reports. 2024;14(1):29135. https://doi.org/10.1038/s41598-024-75290-8
  29. Martin DD, Heit RJ, Yap MC, et al. Identification of a post-translationally myristoylated autophagy-inducing domain released by caspase cleavage of huntingtin. Human Molecular Genetics. 2014;23(12):3166-3179. https://doi.org/10.1093/hmg/ddu027
  30. Kolegova ES, Kakurina GV, Kostromitskiy DN, et al. Increases in mRNA and protein levels of the genes for the actin-binding proteins profilin, fascin, and ezrin promote metastasis in non-small cell lung cancer. Molekulyarnaya biologiya. 2020;54(2):285-292. (In Russ.). https://doi.org/10.1134/S0026893320020065
  31. Li CH, Chan MH, Liang SM, et al. Fascin-1: Updated biological functions and therapeutic implications in cancer biology. Biochimica et Biophysica Acta. 2022;17(2):100052. https://doi.org/10.1016/j.bbadva.2022.100052
  32. Zrelski MM, Kustermann M, Winter L. Muscle-Related Plectinopathies. Cells. 2021;19:10(9):2480. https://doi.org/10.3390/cells10092480
  33. Lo Surdo P, Iannuccelli M, Contino S, et al. SIGNOR 3.0, the SIGnaling network open resource 3.0: 2022 update. Nucleic Acids Research. 2023;51(D1):D631-D637. https://doi.org/10.1093/nar/gkac883
  34. Romagnolo A, Dematteis G, Scheper M, et al. Astroglial calcium signaling and homeostasis in tuberous sclerosis complex. Acta Neuropathologica. 2024;147(1):48.  https://doi.org/10.1007/s00401-024-02711-3
  35. Ecker V, Stumpf M, Brandmeier L, et al. Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia. Nature Communications. 2021;12(1):3526. https://doi.org/10.1038/s41467-021-23752-2
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.