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Kicherova O.A.

Tyumen State Medical University

Kiprin I.A.

Tyumen State Medical University

Reichert L.I.

Tyumen State Medical University

Kicherova K.P.

Tyumen Cardiology Research Center

Verbakh T.E.

Tyumen State Medical University;
Tyumen Hospital of the West Siberian Medical Center of the Federal Bio-Medical Agency

Doyan Y.I.

Tyumen State Medical University;
Regional Clinical Hospital No. 2

Gorbachevsky A.V.

Tyumen Cardiology Research Center

Saltanova V.A.

Tyumen State Medical University;
Regional Clinical Hospital No. 2

Mazurov N.A.

Tyumen State Medical University

The role of the glymphatic system in the development of chronopathological disorders in patients after surgery with prolonged anesthesia

Authors:

Kicherova O.A., Kiprin I.A., Reichert L.I., Kicherova K.P., Verbakh T.E., Doyan Y.I., Gorbachevsky A.V., Saltanova V.A., Mazurov N.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2026;126(2): 7‑12

DOI: 10.17116/jnevro20261260217

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Table of contents

THE ROLE OF THE GLYMPHATIC SYSTEM IN THE DEVELOPMENT OF CHRONOPATHOLOGICAL DISORDERS IN PATIENTS AFTER SURGERY WITH PROLONGED ANESTHESIA
THE ROLE OF THE GLYMPHATIC SYSTEM IN THE DEVELOPMENT OF CHRONOPATHOLOGICAL DISORDERS IN PATIENTS AFTER SURGERY WITH PROLONGED ANESTHESIA

To cite this article:

Kicherova OA, Kiprin IA, Reichert LI, et al. The role of the glymphatic system in the development of chronopathological disorders in patients after surgery with prolonged anesthesia. S.S. Korsakov Journal of Neurology and Psychiatry. 2026;126(2):7‑12. (In Russ.)
https://doi.org/10.17116/jnevro20261260217

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The glymphatic system, which provides clearance for CNS metabolites, plays a key role in maintaining brain homeostasis, especially during sleep. Its dysfunction induced by prolonged general anesthesia can cause persistent postoperative sleep disorders. The paper describes in detail the pathophysiological mechanisms of this process, including the inhibition of aquaporin-4 activity, the development of oxidative stress and neuroinflammation, as well as the alteration of neurovascular and circadian regulation. Particular attention is paid to the effect of anesthetics on the suprachiasmatic nucleus and melatonin secretion, which leads to the disorganization of the normal sleep pattern. The role of genetic factors, particularly the APOE4 allele, in increasing vulnerability to anesthetic effects is demonstrated. Chronotherapy, using melatonin, antioxidants, and glymphatic function modulators to restore physiological sleep patterns, is considered a promising therapeutic approach. The data obtained emphasize the need to develop personalized anesthesia protocols, considering the effect on the glymphatic system and circadian rhythms to prevent postoperative chronopathological disorders.

Keywords:

glymphatic system
prolonged anesthesia
postoperative sleep disorders
aquaporin-4
β-amyloid
tau protein
circadian rhythms
melatonin
neuroinflammation

Authors:

Kicherova O.A.

Tyumen State Medical University

Kiprin I.A.

Tyumen State Medical University

Reichert L.I.

Tyumen State Medical University

Kicherova K.P.

Tyumen Cardiology Research Center

Verbakh T.E.

Tyumen State Medical University;
Tyumen Hospital of the West Siberian Medical Center of the Federal Bio-Medical Agency

Doyan Y.I.

Tyumen State Medical University;
Regional Clinical Hospital No. 2

Gorbachevsky A.V.

Tyumen Cardiology Research Center

Saltanova V.A.

Tyumen State Medical University;
Regional Clinical Hospital No. 2

Mazurov N.A.

Tyumen State Medical University

Received:

04.08.2025

Accepted:

15.08.2025

Close metadata

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