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Gumennik E.V.

Neurology and Epileptology Clinic «EpiJay»

Bobylova M.Yu.

St. Luka’s Institute of Child Neurology and Epilepsy

Sergeeva T.V.

Saint Petersburg State Pediatric Medical University;
Saint Petersburg State University

Butko D.Yu.

Saint Petersburg State Pediatric Medical University

Yatsenko A.V.

Neurology and Epileptology Clinic «EpiJay»

Fomina M.Yu.

Saint Petersburg State Pediatric Medical University

Yakovleva Yu.A.

V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology

Kalinina Yu.Yu.

Academician I.P. Pavlov Ryazan State Medical University

Kovelenova M.V.

Neurology and Epileptology Clinic «EpiJay»

Korostovtsev D.D.

Neurology and Epileptology Clinic «EpiJay»

Danylenko L.A.

Saint Petersburg State Pediatric Medical University

Belyakova L.A.

Academician I.P. Pavlov First Saint Petersburg State Medical University

Cognitive effects of perampanel assessed by the EpiTrack Junior Test in school-aged children with epilepsy

Authors:

Gumennik E.V., Bobylova M.Yu., Sergeeva T.V., Butko D.Yu., Yatsenko A.V., Fomina M.Yu., Yakovleva Yu.A., Kalinina Yu.Yu., Kovelenova M.V., Korostovtsev D.D., Danylenko L.A., Belyakova L.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(12): 178‑187

DOI: 10.17116/jnevro2025125121178

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Table of contents

COGNITIVE EFFECTS OF PERAMPANEL ASSESSED BY THE EPITRACK JUNIOR TEST IN SCHOOL-AGED CHILDREN WITH EPILEPSY
COGNITIVE EFFECTS OF PERAMPANEL ASSESSED BY THE EPITRACK JUNIOR TEST IN SCHOOL-AGED CHILDREN WITH EPILEPSY

To cite this article:

Gumennik EV, Bobylova MYu, Sergeeva TV, et al. Cognitive effects of perampanel assessed by the EpiTrack Junior Test in school-aged children with epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(12):178‑187. (In Russ.)
https://doi.org/10.17116/jnevro2025125121178

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To evaluate the impact of add-on perampanel on cognitive functions in school-aged children with epilepsy using the EpiTrack Junior test.

MATERIAL AND METHODS

Seventy-five patients aged 6—18 years were assessed before and 2 months after reaching a stable perampanel dose. They are divided into 2 groups according to the inclusion period (before 2023 and after 2023) due to the emergence of new literature data on the drug’s specific effectiveness in early adjuvant therapy after 2023. The 1st retrospective group consisted of 49 patients, most of whom were prescribed perampanel as a 4th—6th drug (54%). The 2nd prospective group consisted of 26 patients, most of whom (65%) were prescribed perampanel as a 2nd—3rd drug. Changes in total and subtest scores were analyzed versus diagnosis, sex, seizure-onset age, pharmacoresistance and EEG.

RESULTS

66 patients completed the study. A significant increase in total EpiTrack score was observed (p<0.05) with positive correlation to seizure-onset age. Seizure reduction ≥50 % occurred in 68% and EEG improved in 40.9%. Reversible adverse events were reported in 25.8%. No statistically significant differences were found between the groups for any of these factors

CONCLUSION

Adjunctive perampanel improves executive functions and is well tolerated in school-aged children with epilepsy.

Keywords:

perampanel
epilepsy
childhood
cognitive impairment
EpiTrack Junior

Authors:

Gumennik E.V.

Neurology and Epileptology Clinic «EpiJay»

Bobylova M.Yu.

St. Luka’s Institute of Child Neurology and Epilepsy

Sergeeva T.V.

Saint Petersburg State Pediatric Medical University;
Saint Petersburg State University

Butko D.Yu.

Saint Petersburg State Pediatric Medical University

Yatsenko A.V.

Neurology and Epileptology Clinic «EpiJay»

Fomina M.Yu.

Saint Petersburg State Pediatric Medical University

Yakovleva Yu.A.

V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology

Kalinina Yu.Yu.

Academician I.P. Pavlov Ryazan State Medical University

Kovelenova M.V.

Neurology and Epileptology Clinic «EpiJay»

Korostovtsev D.D.

Neurology and Epileptology Clinic «EpiJay»

Danylenko L.A.

Saint Petersburg State Pediatric Medical University

Belyakova L.A.

Academician I.P. Pavlov First Saint Petersburg State Medical University

Received:

16.09.2025

Accepted:

20.11.2025

Close metadata

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