Неинвазивные биомаркеры ранней диагностики болезни Альцгеймера в биологических жидкостях

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Одной из актуальных проблем современного здравоохранения являются болезнь Альцгеймера (БА) и ее ранняя диагностика. Это обусловлено быстрым глобальным распространением БА, отсутствием патогенетической терапии и возможностью стабилизировать прогрессирование когнитивных нарушений на ранних стадиях заболевания. В современных условиях только аутопсия способна подтвердить диагноз БА с достоверностью в 100%, а классические лабораторно-инструментальные методы верификации диагноза сложно внедрить в рутинную клиническую практику, так как они имеют ряд ограничений. Именно поэтому исследование новых и доступных биомаркеров, выделенных из биологических жидкостей организма человека, представляет привлекательную перспективу для ранней диагностики БА. Обзор посвящен проблеме верификации БА с помощью маркеров в биологических жидкостях организма человека, которые возможно получить неинвазивным способом. Рассмотрены потенциальные биомаркеры БА в слюне, слезной жидкости, моче и назальном секрете, оценены их прогностические возможности в качестве индикаторов БА на ранней стадии.

Ключевые слова:

деменция

когнитивные нарушения

болезнь Альцгеймера

неинвазивные биомаркеры

слюна

слеза

моча

назальный секрет

Авторы:

Коваленко Е.А.

ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России (Пироговский университет);
ФГБУ «Федеральный центр мозга и нейротехнологий» Федерального медико-биологического агентства России

ORCID: 0000-0003-0828-9868

Махнович Е.В.

ORCID: 0000-0002-8606-5715

Первунина А.В.

ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России (Пироговский университет)

ORCID: 0000-0002-3233-1213

Гилёва Е.А.

ORCID: 0000-0002-6824-8868

Боголепова А.Н.

SPIN РИНЦ: 6775-0279
Scopus AuthorID: 6602240836
ORCID: 0000-0002-6327-3546

Дата поступления:

23.07.2024

Дата принятия в печать:

25.07.2024

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