The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Shamalov N.A.

Federal Center for Brain and Neurotechnology;
Pirogov Russian National Research Medical University

Martynov M.Yu.

Federal Center for Brain and Neurotechnology;
Pirogov Russian National Research Medical University

Gusev E.I.

Federal Center for Brain and Neurotechnology;
Pirogov Russian National Research Medical University

Khasanova D.R.

Kazan State Medical University

Nesterova V.N.

N.A. Semashko Nizhny Novgorod Regional Clinical Hospital

Marskaya N.A.

Center of the Brain and Neurotechnologies

Yarovaya E.B.

Lomonosov Moscow State University

Chefranova Zh.Yu.

Belgorod State National Research University

Voznuk I.A.

Academian I.P. Pavlov First Saint Petersburg State Medical University

Kharitonova T.V.

I.I. Dzhanelidze Research Institute of Emergency Care

Alasheev A.M.

Sverdlovsk Regional Clinical Hospital No. 1

Sutormin M.V.

M.F. Vladimirsky Moscow Regional Research Clinical Institute

Khalo N.V.

I.S. Berzon Krasnoyarsk Interdistrict Clinical Hospital No. 20

Bogatyreva M.D.

Stavropol Regional Clinical Hospital

Khan D.S.

Primorsky Regional Clinical Hospital No. 1

Korsunskaya L.L.

Simferopol City Clinical Hospital No. 7

Timchenko L.V.

S.V. Ochapovsky Research Institute — Regional Clinical Hospital No. 1

Kulesh A.A.

E.A. Wagner Perm State Medical University;
City Clinical Hospital No. 4

Zhukovskaya N.V.

Leningrad Regional Clinical Hospital

Furman O.E.

M.F. Vladimirsky Moscow Regional Research Clinical Institute

Bulanov A.A.

N.N. Burdenko Penza Regional Clinical Hospital

Shamalova D.N.

Federal Center for Brain and Neurotechnology

Ermachenko N.E.

Regional Emergency Clinical Hospital

Kutsenko V.A.

National Medical Research Center for Therapy and Preventive Medicine

Ivlev O.E.

Lomonosov Moscow State University;
National Medical Research Center for Therapy and Preventive Medicine

Soplenkova A.G.

Lomonosov Moscow State University;
National Medical Research Center for Therapy and Preventive Medicine

Semenov A.M.

SuperGene LLC

Semenov M.P.

SuperGene LLC

Ivanov S.V.

SuperGene LLC;
Institute of Biomedical Chemistry

Romashova Y.A.

Institute of Biomedical Chemistry

Beregovykh V.V.

Institute of Biomedical Chemistry

Markin S.S.

SuperGene LLC;
Institute of Biomedical Chemistry

Fortelizin in bridging therapy of acute ischemic stroke: data from the observational study FORPI registry

Authors:

Shamalov N.A., Martynov M.Yu., Gusev E.I., Khasanova D.R., Nesterova V.N., Marskaya N.A., Yarovaya E.B., Chefranova Zh.Yu., Voznuk I.A., Kharitonova T.V., Alasheev A.M., Sutormin M.V., Khalo N.V., Bogatyreva M.D., Khan D.S., Korsunskaya L.L., Timchenko L.V., Kulesh A.A., Zhukovskaya N.V., Furman O.E., Bulanov A.A., Shamalova D.N., Ermachenko N.E., Kutsenko V.A., Ivlev O.E., Soplenkova A.G., Semenov A.M., Semenov M.P., Ivanov S.V., Romashova Y.A., Beregovykh V.V., Markin S.S.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2026;126(2): 59‑67

DOI: 10.17116/jnevro202612602159

Read: 454 times

Buy for 300₽
Contact the author
Table of contents

FORTELIZIN IN BRIDGING THERAPY OF ACUTE ISCHEMIC STROKE: DATA FROM THE OBSERVATIONAL STUDY FORPI REGISTRY
FORTELIZIN IN BRIDGING THERAPY OF ACUTE ISCHEMIC STROKE: DATA FROM THE OBSERVATIONAL STUDY FORPI REGISTRY

To cite this article:

Shamalov NA, Martynov MYu, Gusev EI, et al. Fortelizin in bridging therapy of acute ischemic stroke: data from the observational study FORPI registry. S.S. Korsakov Journal of Neurology and Psychiatry. 2026;126(2):59‑67. (In Russ.)
https://doi.org/10.17116/jnevro202612602159

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Cere­brolysin with repe­rfusion therapy in ischemic stroke: a prospective analysis of multimodal brain imaging data from the CERE­HETIS trial. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):84-98
Prediction of mortality in severe ischemic stroke during COVID-19 in patients with multiorgan dysfunction. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):120-127
A clinical case of treating a patient with severe ischemic stroke and cancer. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8):114-117
Early anti­thrombotic protection of the brain in patients with ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8-2):5-10
Resu­lts of the implementation of repe­rfusion technologies in ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8-2):32-39
Resu­lts of the inte­rnational multicenter randomized, double-blind, placebo-controlled clinical trial for the evaluation of the effi­cacy and safety of the sequential therapy with ethy­lmethylhydroxypyridine succinate in patients in the acute and early reco­very periods of ischemic stroke (MIR). S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8-2):40-53
Role of magnetic reso­nance imaging in dete­cting the signs of inte­rnal caro­tid artery stenosis in the acute period of athe­rothrombotic ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8-2):67-73
Mathematical mode­ling of outcomes in patients with clinical combination of ischemic stroke and COVID-19 complicated by multiple organ failure. Russian Journal of Anesthesiology and Reanimatology. 2025;(3):42-49
Socio-economic damage caused by elevated low-density lipo­protein cholesterol levels. Medi­cal Technologies. Asse­ssment and Choice. 2025;(2):88-98
Thro­mboembolic complications in the postpartum period. Russian Bulletin of Obstetrician-Gynecologist. 2025;(4):102-107
Abstract:

OBJECTIVE

To evaluate the safety and efficacy of Fortelyzin during bridging therapy (thrombolysis followed by thrombectomy) in real-world clinical practice using data from the FORPI registry.

MATERIAL AND METHODS

The FORPI registry is an open-label, prospective, non-interventional observational study of Fortelyzin in patients with acute ischemic stroke. In this article we analyzed the safety and efficacy of Fortelyzin in patients undergoing thrombolysis followed by thrombectomy. The safety outcomes were the rate of symptomatic intracranial hemorrhage (sICH) according to ECASS III and SITS-MOST definitions, as well as all-cause mortality on day 90. The efficacy outcome was a good functional recovery, defined by mRS score of 0—2 on day 90.

RESULTS

The analysis included 1116 patients undergoing thrombolysis followed by thrombectomy who were enrolled in a registry at 120 medical cites in 55 regions of the Russian Federation. The median patient age was 69 (61—77) years. The median NIHSS score at admission was 15 (12—19) points. The sICH rate according to ECASS III was 13% (144/1116), and according to SITS-MOST was 9% (98/1116). In hospital mortality rate was 27% (301/1116 patients). All-cause mortality on day 90 was 29% (322/1116 patients). Good functional outcome (mRS 0—2) on day 90 was achieved in 38% (422/1116) of patients.

CONCLUSION

This study demonstrates the safety and efficacy of Fortelizin in bridging therapy of acute ischemic stroke in real-world clinical practice.

Keywords:

Fortelyzin
ischemic stroke
thrombolytic therapy
thrombectomy
bridging therapy

Authors:

Shamalov N.A.

Federal Center for Brain and Neurotechnology;
Pirogov Russian National Research Medical University

Martynov M.Yu.

Federal Center for Brain and Neurotechnology;
Pirogov Russian National Research Medical University

Gusev E.I.

Federal Center for Brain and Neurotechnology;
Pirogov Russian National Research Medical University

Khasanova D.R.

Kazan State Medical University

Nesterova V.N.

N.A. Semashko Nizhny Novgorod Regional Clinical Hospital

Marskaya N.A.

Center of the Brain and Neurotechnologies

Yarovaya E.B.

Lomonosov Moscow State University

Chefranova Zh.Yu.

Belgorod State National Research University

Voznuk I.A.

Academian I.P. Pavlov First Saint Petersburg State Medical University

Kharitonova T.V.

I.I. Dzhanelidze Research Institute of Emergency Care

Alasheev A.M.

Sverdlovsk Regional Clinical Hospital No. 1

Sutormin M.V.

M.F. Vladimirsky Moscow Regional Research Clinical Institute

Khalo N.V.

I.S. Berzon Krasnoyarsk Interdistrict Clinical Hospital No. 20

Bogatyreva M.D.

Stavropol Regional Clinical Hospital

Khan D.S.

Primorsky Regional Clinical Hospital No. 1

Korsunskaya L.L.

Simferopol City Clinical Hospital No. 7

Timchenko L.V.

S.V. Ochapovsky Research Institute — Regional Clinical Hospital No. 1

Kulesh A.A.

E.A. Wagner Perm State Medical University;
City Clinical Hospital No. 4

Zhukovskaya N.V.

Leningrad Regional Clinical Hospital

Furman O.E.

M.F. Vladimirsky Moscow Regional Research Clinical Institute

Bulanov A.A.

N.N. Burdenko Penza Regional Clinical Hospital

Shamalova D.N.

Federal Center for Brain and Neurotechnology

Ermachenko N.E.

Regional Emergency Clinical Hospital

Kutsenko V.A.

National Medical Research Center for Therapy and Preventive Medicine

Ivlev O.E.

Lomonosov Moscow State University;
National Medical Research Center for Therapy and Preventive Medicine

Soplenkova A.G.

Lomonosov Moscow State University;
National Medical Research Center for Therapy and Preventive Medicine

Semenov A.M.

SuperGene LLC

Semenov M.P.

SuperGene LLC

Ivanov S.V.

SuperGene LLC;
Institute of Biomedical Chemistry

Romashova Y.A.

Institute of Biomedical Chemistry

Beregovykh V.V.

Institute of Biomedical Chemistry

Markin S.S.

SuperGene LLC;
Institute of Biomedical Chemistry

Received:

19.12.2025

Accepted:

19.01.2026

Close metadata

References:

  1. Ministry of Health of the Russian Federation. Ischemic stroke and transient ischemic attack in adults. Clinical guidelines. M. 2024. (In Russ.). https://cr.minzdrav.gov.ru/view-cr/814_1
  2. Gusev EI, Martynov MYu, Nikonov AA, et al. Non-immunogenic recombinant staphylokinase versus alteplase for patients with acute ischaemic stroke 4.5 h after symptom onset In Russia (FRIDA): a randomised, open label, multicentre, parallel-group, non-inferiority trial. Lancet Neurol. 2021;20:721-728.  https://doi.org/10.1016/S1474-4422(21)00210-6
  3. Gusev EI, Martynov MYu, Shamalov NA, et al. Non-immunogenic staphylokinase in the treatment of acute ischemic stroke (FRIDA trial results). S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(7):56-65. (In Russ.). https://doi.org/10.17116/jnevro202212207156
  4. Yao X, Ma K, Zhao B, et al. Safety Outcomes Following Intravenous Thrombolysis in Acute Ischemic Stroke: A Systematic Review and Network Meta-analysis. CNS Drugs. 2026;40:215-232.  https://doi.org/10.1007/s40263-025-01228-x
  5. Markin SS, Ivanov SV, Beletsky IP, et al. Assessment of the allergenic and immunotoxic properties of the recombinant non-immunogenic staphylokinase in preclinical and clinical trials. Pharmacy & Pharmacology. 2025;13(1):31-44. (In Russ.). https://doi.org/10.19163/2307-9266-2025-13-1-31-44
  6. Ivanov SV, Beletsky IP, Zakharova MV, et al. Study of the pharmacokinetics of non-immunogenic staphylokinase in patients with acute myocardial infarction and acute ischemic stroke. Pharmacy & Pharmacology. 2025;13(5):415-428. (In Russ.). https://doi.org/10.19163/2307-9266-2025-13-5-415-428
  7. Shamalov NA, Martynov MYu, Yarovaya EB, et al. Thrombolysis with the non-immunogenic staphylokinase for acute ischaemic stroke in FORPI registry: an observational study. Stroke. 2026;57(2):394-403.  https://doi.org/10.1161/STROKEAHA.125.051115
  8. Shamalov NA, Martynov MYu, Gusev EI, et al. Fortelyzin for acute ischaemic stroke treatment: an open, prospective, non-interventional, observational study FORPI registry. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(12):1-17. (In Russ.). https://doi.org/10.17116/jnevro202512512143
  9. Volodyukhin MYu, Khasanova DR, Timchenko LV, et al. Multicenter experience of using Fortelyzin during staged reperfusion therapy of acute ischemic stroke in anterior circulation. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(6):72-77. (In Russ.). https://doi.org/10.17116/jnevro202312306172
  10. Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. New Eng J Med. 2008;359:1317-1729. https://doi.org/10.1056/NEJMoa0804656
  11. Wahlgren N, Ahmed N, Dávalos A, et al. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study. Lancet. 2007;369(9558):275-282.  https://doi.org/10.1016/S0140-6736(07)60149-4
  12. Skrypnik DV, Anisimov KV, Botsina AY, et al. Endovascular treatment results in patients with large cerebral artery occlusions in a metropolis. Moscow Stroke Registry data over 2019. Nevrologiya, Neiropsikhiatriya, Psikhosomatika. 2020;12(5):9-17. (In Russ.). https://doi.org/10.14412/2074-2711-2020-5-9-17
  13. Bourcier R, Goyal M, Liebeskind DS, et al. Association of Time From Stroke Onset to Groin Puncture With Quality of Reperfusion After Mechanical Thrombectomy: A Meta-analysis of Individual Patient Data From 7 Randomized Clinical Trials. JAMA Neurol. 2019;76(4):405-411.  https://doi.org/10.1001/jamaneurol.2018.4510
  14. Sedghi A, Kaiser DPO, Cuberi A, et al. Intravenous Thrombolysis Before Thrombectomy Improves Functional Outcome After Stroke Independent of Reperfusion Grade. J Am Heart Ass. 2024;13(6):e031854. https://doi.org/10.1161/JAHA.123.031854
  15. Ghaith HS, Elfil M, Gabra MD, et al. Intravenous thrombolysis before mechanical thrombectomy for acute ischemic stroke due to large vessel occlusion; should we cross that bridge? A systematic review and meta-analysis of 36,123 patients. Neurol Sci. 2022;43(11):6243-6269. https://doi.org/10.1007/s10072-022-06283-6
  16. Zheng M, Li L, Chen L, et al. Mechanical thrombectomy combined with intravenous thrombolysis for acute ischemic stroke: a systematic review and meta-analyses. Sci Rep. 2023;13(1):8597. https://doi.org/10.1038/s41598-023-35532-7
  17. Anisimov KV, Galkin SS, Gorst NH, et al. Endovascular Thrombectomy Combined with Intravenous Thrombolysis: Technical Aspects and Clinical Outcomes from the Moscow Stroke Registry. S.S. Korsakov Journal of Neurology and Psychiatry. 2026;126(1):69-77. (In Russ.). https://doi.org/10.17116/jnevro202612601169
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.