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Vasilenko A.V.

Chelyabinsk Regional Bureau of Forensic Medical Examination

Melentyev A.B.

Chelyabinsk Regional Bureau of Forensic Medical Examination

Dvorskaya O.N.

South Ural State Medical University

Development of a method for moxonidine quantification in blood and urine by high-performance liquid chromatography with tandem mass-selective detection

Authors:

Vasilenko A.V., Melentyev A.B., Dvorskaya O.N.

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Journal: Forensic Medical Expertise. 2024;67(6): 42‑47

DOI: 10.17116/sudmed20246706142

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Table of contents

DEVELOPMENT OF A METHOD FOR MOXONIDINE QUANTIFICATION IN BLOOD AND URINE BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY WITH TANDEM MASS-SELECTIVE DETECTION
DEVELOPMENT OF A METHOD FOR MOXONIDINE QUANTIFICATION IN BLOOD AND URINE BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY WITH TANDEM MASS-SELECTIVE DETECTION

To cite this article:

Vasilenko AV, Melentyev AB, Dvorskaya ON. Development of a method for moxonidine quantification in blood and urine by high-performance liquid chromatography with tandem mass-selective detection. Forensic Medical Expertise. 2024;67(6):42‑47. (In Russ.)
https://doi.org/10.17116/sudmed20246706142

Подписка 2025-2 (Forensic Medical Expertise)
 
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OBJECTIVE

Development and validation of a sensitive and rapid method for moxonidine detection and quantification in blood and/or urine in clinical toxicology and forensic chemistry.

MATERIAL AND METHODS

The method included the following stages: acetonitrile extraction, centrifugation, identification, and quantitative analysis of moxonidine in cadaveric blood and/or urine by high-performance liquid chromatography with a triple quadrupole mass spectrometer.

RESULTS

The method was validated by the following parameters: limit of detection, limit of quantification, linearity, trueness, and precision. Over the entire range of determined concentrations, the relative standard deviation did not exceed 6%.

CONCLUSION

The obtained results allow future use of this method to detect cases of moxonidine poisoning.

Keywords:

moxonidine
blood
urine
validation
high-performance liquid chromatography with tandem mass-selective detection

Authors:

Vasilenko A.V.

Chelyabinsk Regional Bureau of Forensic Medical Examination

Melentyev A.B.

Chelyabinsk Regional Bureau of Forensic Medical Examination

Dvorskaya O.N.

South Ural State Medical University

Received:

07.02.2024

Accepted:

27.02.2024

List of references:

  1. Barsegjan SS, Salomatin EM, Pleteneva TV, Maksimova TV, Dolinkin AO. Metodicheskie rekomendacii po validacii analiticheskih metodik, ispol’zuemyh v sudebno-himicheskom i himiko-toksikologicheskom analize biologicheskogo materiala. Moskva; 2014. (In Russ.).

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