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Petrova N.N.

Saint Petersburg State University

Comorbidity of depression and dementia: epidemiological, biological and therapeutic aspects

Authors:

Petrova N.N.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(11): 113‑121

DOI: 10.17116/jnevro2024124111113

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Table of contents

To cite this article:

Petrova NN. Comorbidity of depression and dementia: epidemiological, biological and therapeutic aspects. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(11):113‑121. (In Russ.)
https://doi.org/10.17116/jnevro2024124111113

 
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The literature review is devoted to the problem of the relationship between dementia and depression, the role of depression as a risk factor for dementia and the place of depression in the structure of neurocognitive disorders in dementia. Epidemiological data are presented and the mechanisms of interrelation of disorders are considered. The search for sources included only qualitative research, meta-analyses, full-text articles and was conducted in the PubMed, Google system using the keywords «dementia, depression». The presented epidemiological and biological data indicate that depression increases the risk of dementia, confirming the hypothesis of a causal factor. The main directions of research on the relationship between depression and dementia in the context of Alzheimer’s disease prevention are given.

Keywords:

dementia
depression
Alzheimer’s disease
interrelation
mechanisms

Authors:

Petrova N.N.

Saint Petersburg State University

Received:

09.10.2024

Accepted:

16.10.2024

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