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Kutlubaev M.A.

Bashkir State Medical University

Promising approaches to the pathogenetic therapy of amyotrophic lateral sclerosis

Authors:

Kutlubaev M.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(4): 13‑21

DOI: 10.17116/jnevro202412404113

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To cite this article:

Kutlubaev MA. Promising approaches to the pathogenetic therapy of amyotrophic lateral sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(4):13‑21. (In Russ.)
https://doi.org/10.17116/jnevro202412404113

Подписка 2025 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Amyotrophic lateral sclerosis is a severe incurable disease of the nervous system. Currently only methods of palliative care for the patients with this disease are available. Few medications for the pathogenetic therapy are registered in some countries, i.e. riluzole, edaravon, sodium phenylbutyrate/taurursodiol as well as tofersen (conditionally). Their efficacy is relatively low. The main directions in the development of pathogenetic therapy of ALS include gene therapy, use of stem cells, immunomodulators, agents affecting gut microbiota. A search is also underway for low-molecular compounds with neuroprotective and antioxidant properties. Perspective direction is prevention of ALS. This will be possible when biomarkers for identification of patients in pre-manifest/prodromal stage are detected.

Keywords:

amyotrophic lateral sclerosis
motor neuron disease
treatment
prevention

Authors:

Kutlubaev M.A.

Bashkir State Medical University

Received:

28.09.2023

Accepted:

14.10.2023

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