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Adamyan L.V.
Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine;
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Pivazyan L.G.
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Kurbatova K.S.
Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine
Mailova K.S.
Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine
Stepanian A.A.
Academy of Women’s Health and Endoscopic Surgery
Oxidative stress, ferroptosis, somatic mutations, antioxidant therapy, and endometriosis: a new perspective on the issue
Journal: Russian Journal of Human Reproduction. 2024;30(6): 32‑44
Views: 700
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To cite this article:
Adamyan LV, Pivazyan LG, Kurbatova KS, Mailova KS, Stepanian AA. Oxidative stress, ferroptosis, somatic mutations, antioxidant therapy, and endometriosis: a new perspective on the issue. Russian Journal of Human Reproduction.
2024;30(6):32‑44. (In Russ.)
https://doi.org/10.17116/repro20243006132
The article focuses on the role of oxidative stress, ferroptosis, and antioxidant therapy in the pathogenesis and treatment of endometriosis — a gynecological condition affecting up to 10% of women of reproductive age. Oxidative stress and ferroptosis, which cause cellular damage and inflammation, play a significant role in the progression of endometriosis and may contribute to the accumulation of somatic mutations and DNA damage, exacerbating the pathological processes. Mutations in driver genes such as TP53, PTEN, and KRAS lead to dysregulation of cellular processes, enhancing the proliferation and invasion of endometrial cells. Antioxidant therapy is considered a promising approach in the treatment of endometriosis, in combination with surgical and pharmacological interventions. Antioxidants such as resveratrol, melatonin, curcumin, and N-acetylcysteine possess anti-inflammatory and antioxidant properties, helping to reduce oxidative stress, slow disease progression, and improve patient outcomes. The article emphasizes the need for further research to develop new treatment strategies aimed at reducing oxidative stress, preventing granulosa cell ferroptosis, and minimizing genetic damage, which may improve reproductive outcomes and the quality of life for women with endometriosis.
Keywords:
Authors:
Adamyan L.V.
Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine;
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Pivazyan L.G.
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Kurbatova K.S.
Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine
Mailova K.S.
Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine
Stepanian A.A.
Academy of Women’s Health and Endoscopic Surgery
Received:
17.09.2024
Accepted:
31.10.2024
List of references:
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