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Adamyan L.V.

Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine;
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Pivazyan L.G.

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Kurbatova K.S.

Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine

Mailova K.S.

Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine

Stepanian A.A.

Academy of Women’s Health and Endoscopic Surgery

Oxidative stress, ferroptosis, somatic mutations, antioxidant therapy, and endometriosis: a new perspective on the issue

Authors:

Adamyan L.V., Pivazyan L.G., Kurbatova K.S., Mailova K.S., Stepanian A.A.

More about the authors

Journal: Russian Journal of Human Reproduction. 2024;30(6): 32‑44

DOI: 10.17116/repro20243006132

Views: 700

Downloaded: 62

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Table of contents

OXIDATIVE STRESS, FERROPTOSIS, SOMATIC MUTATIONS, ANTIOXIDANT THERAPY, AND ENDOMETRIOSIS: A NEW PERSPECTIVE ON THE ISSUE
OXIDATIVE STRESS, FERROPTOSIS, SOMATIC MUTATIONS, ANTIOXIDANT THERAPY, AND ENDOMETRIOSIS: A NEW PERSPECTIVE ON THE ISSUE

To cite this article:

Adamyan LV, Pivazyan LG, Kurbatova KS, Mailova KS, Stepanian AA. Oxidative stress, ferroptosis, somatic mutations, antioxidant therapy, and endometriosis: a new perspective on the issue. Russian Journal of Human Reproduction. 2024;30(6):32‑44. (In Russ.)
https://doi.org/10.17116/repro20243006132

 
Подписка 2025-2 (Russian Journal of Human Reproduction)
 
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The article focuses on the role of oxidative stress, ferroptosis, and antioxidant therapy in the pathogenesis and treatment of endometriosis — a gynecological condition affecting up to 10% of women of reproductive age. Oxidative stress and ferroptosis, which cause cellular damage and inflammation, play a significant role in the progression of endometriosis and may contribute to the accumulation of somatic mutations and DNA damage, exacerbating the pathological processes. Mutations in driver genes such as TP53, PTEN, and KRAS lead to dysregulation of cellular processes, enhancing the proliferation and invasion of endometrial cells. Antioxidant therapy is considered a promising approach in the treatment of endometriosis, in combination with surgical and pharmacological interventions. Antioxidants such as resveratrol, melatonin, curcumin, and N-acetylcysteine possess anti-inflammatory and antioxidant properties, helping to reduce oxidative stress, slow disease progression, and improve patient outcomes. The article emphasizes the need for further research to develop new treatment strategies aimed at reducing oxidative stress, preventing granulosa cell ferroptosis, and minimizing genetic damage, which may improve reproductive outcomes and the quality of life for women with endometriosis.

Keywords:

antioxidants
iron
endometriosis
reproduction

Authors:

Adamyan L.V.

Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine;
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Pivazyan L.G.

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Kurbatova K.S.

Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine

Mailova K.S.

Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine

Stepanian A.A.

Academy of Women’s Health and Endoscopic Surgery

Received:

17.09.2024

Accepted:

31.10.2024

List of references:

  1. Becker CM, Bokor A, Heikinheimo O, Horne A, Jansen F, Kiesel L, King K, Kvaskoff M, Nap A, Petersen K, Saridogan E, Tomassetti C, van Hanegem N, Vulliemoz N, Vermeulen N; ESHRE Endometriosis Guideline Group. ESHRE guideline: endometriosis. Human Reproduction Open. 2022;2022(2):hoac009. https://doi.org/10.1093/hropen/hoac009
  2. Koninckx PR, Ussia A, Adamyan L, Tahlak M, Keckstein J, Wattiez A, Martin DC. The epidemiology of endometriosis is poorly known as the pathophysiology and diagnosis are unclear. Best Practice and Research. Clinical Obstetrics and Gynaecology. 2021;71:14-26.  https://doi.org/10.1016/j.bpobgyn.2020.08.005
  3. Yovich JL, Rowlands PK, Lingham S, Sillender M, Srinivasan S. Pathogenesis of endometriosis: Look no further than John Sampson. Reproductive BioMedicine Online. 2020;40(1):7-11.  https://doi.org/10.1016/j.rbmo.2019.10.007
  4. Lamceva J, Uljanovs R, Strumfa I. The Main Theories on the Pathogenesis of Endometriosis. International Journal of Molecular Sciences. 2023;24(5):4254. https://doi.org/10.3390/ijms24054254
  5. Koninckx PR, Ussia A, Adamyan L, Wattiez A, Gomel V, Martin DC. Pathogenesis of endometriosis: the genetic/epigenetic theory. Fertility and Sterility. 2019;111(2):327-340.  https://doi.org/10.1016/j.fertnstert.2018.10.013
  6. Adamyan L V, Burkova E N, Mikoyan V D, Vanin AF, Ionova RM, Cheprasova GP, Gasparyan SA. Violation of the electron transport chain as a manifestation of oxidative stress in endometriosis. Russian Journal of Human Reproduction. 2007;13(5):103-107. (In Russ.).
  7. Sopasi F, Spyropoulou I, Kourti M, Vasileiadis S, Tripsianis G, Galazios G, Koutlaki N. Oxidative stress and female Infertilty: the role of follicular fluid soluble receptor of advanced glycation end-products (sRAGE) in women with endometriosis. Human Fertility. 2023;26(6):1400-1407. https://doi.org/10.1080/14647273.2023.2230360
  8. Adamyan L V, Sonova M, Arslanyan KN, Loginova ON, Kharchenko E I. Oxidative stress and endometriosis: a literature review. Lechashchij vrach. 2020;12:20-25. (In Russ.). https://doi.org/10.26295/OS.2019.72.92.003
  9. Sahoo BM, Banik BK, Borah P, Jain A. Reactive Oxygen Species (ROS): Key Components in Cancer Therapies. Anti-Cancer Agents in Medicinal Chemistry. 2022;22(2):215-222.  https://doi.org/10.2174/1871520621666210608095512
  10. Mittler R, Zandalinas SI, Fichman Y, Van Breusegem F. Reactive oxygen species signalling in plant stress responses. Nature Reviews Molecular Cell Biology. 2022;23(10):663-679.  https://doi.org/10.1038/s41580-022-00499-2
  11. Aitken RJ. Impact of oxidative stress on male and female germ cells: implications for fertility. Reproduction (Cambridge, England). 2020; 159(4):R189-R201. https://doi.org/10.1530/REP-19-0452
  12. Sun Y, Lu Y, Saredy J, Wang X, Drummer Iv C, Shao Y, Saaoud F, Xu K, Liu M, Yang WY, Jiang X, Wang H, Yang X. ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes. Redox Biology. 2020;37: 101696. https://doi.org/10.1016/j.redox.2020.101696
  13. Zaha I, Muresan M, Tulcan C, Huniadi A, Naghi P, Sandor M, Tripon R, Gaspar C, Klaudia-Melinda M, Sachelarie L, Stefan L. The Role of Oxidative Stress in Infertilty. Journal of Personalized Medicine. 2023;13(8):1264. https://doi.org/10.3390/jpm13081264
  14. Li Y, Zhao T, Li J, Xia M, Li Y, Wang X, Liu C, Zheng T, Chen R, Kan D, Xie Y, Song J, Feng Y, Yu T, Sun P. Oxidative Stress and 4-hydroxy-2-nonenal (4-HNE): Implications in the Pathogenesis and Treatment of Aging-related Diseases. Journal of Immunology Research. 2022;2022:1-12.  https://doi.org/10.1155/2022/2233906
  15. Akagawa M. Protein carbonylation: molecular mechanisms, biological implications, and analytical approaches. Free Radical Research. 2021;55(4):307-320.  https://doi.org/10.1080/10715762.2020.1851027
  16. Pisoschi AM, Pop A, Iordache F, Stanca L, Predoi G, Serban AI. Oxidative stress mitigation by antioxidants — An overview on their chemistry and influences on health status. European Journal of Medicinal Chemistry. 2021;209:112891. https://doi.org/10.1016/j.ejmech.2020.112891
  17. Adamyan LV, Pivazyan LG, Mailova KS. The role of ferroptosis in the pathogenesis and progression of endometriosis. History of the question and current evidence. Russian Journal of Human Reproduction. 2023;29(5):92. (In Russ.). https://doi.org/10.17116/repro20232905192
  18. Ansariniya H, Yavari A, Javaheri A, Zare F. Oxidative stress-related effects on various aspects of endometriosis. American Journal of Reproductive Immunology. 2022;88(3):e13593. https://doi.org/10.1111/aji.13593
  19. Adamyan L, Pivazyan L, Krylova E, Tarlakyan V, Murvatova K. Iron metabolism markers in peritoneal fluid of patients with endometriosis: systematic review and meta-analysis. Journal of Endometriosis and Uterine Disorders. 2024;5:100061. https://doi.org/10.1016/j.jeud.2024.100061
  20. Yang L, Chen Y, Liu Y, Xing Y, Miao C, Zhao Y, Chang X, Zhang Q. The Role of Oxidative Stress and Natural Antioxidants in Ovarian Aging. Frontiers in Pharmacology. 2021;11:617843. https://doi.org/10.3389/fphar.2020.617843
  21. Burgova EN, Tkachev NA, Adamyan LV, Mikoyan VD, Paklina OV, Stepanyan AA, Vanin AF. Dinitrosyl iron complexes with glutathione suppress experimental endometriosis in rats European Journal of Pharmacology. 2014;727:140-147.  https://doi.org/10.1016/j.ejphar.2014.01.002
  22. Zheng SH, Chen XX, Chen Y, Wu ZC, Chen XQ, Li XL. Antioxidant vitamins supplementation reduce endometriosis related pelvic pain in humans: a systematic review and meta-analysis. Reproductive Biology and Endocrinology. 2023;21(1):79.  https://doi.org/10.1186/s12958-023-01126-1
  23. Julio T, Fenerich BA, Halpern G, Carrera-Bastos P, Schor E, Kopelman A. The effects of oral nutritional supplements on endometriosis-related pain: A narrative review of clinical studies. Journal of Gynecology Obstetrics and Human Reproduction. 2024;53(10):102830. https://doi.org/10.1016/j.jogoh.2024.102830
  24. Adamyan LV, Burgova EN, Serezhenkov VA, Sonova MM, Osipova AA, Arslanyan KN, Poddubnaya O.M. Role of blood iron-binding proteins in antioxidant protection and their association with genital endometriosis. Akusherstvo i ginekologiya. 2009;(5):37-41. (In Russ.).
  25. Adamyan L V, Burkova E N, Sonova M, Osipova A A, Aslanyan KN, Poddubnaya ON. Oxidative stress and genital endometriosis (literature review). Russian Journal of Human Reproduction. 2008;14(4):6-8. (In Russ.).
  26. Aznaurova YaB, Petrov IA, Suntsova MV, Garazha AV, Buzdin AA, Adamyan LV. Interconnection between gene expression and signaling pathways activation profiles in eutopic and ectopic endometrium of patients with external genital endometriosis. Russian Journal of Human Reproduction. 2018;24(4):13. (In Russ.). https://doi.org/10.17116/repro20182404113
  27. Amreen S, Kumar P, Gupta P, Rao P. Evaluation of Oxidative Stress and Severity of Endometriosis. Journal of Human Reproductive Sciences. 2019;12(1):40-46.  https://doi.org/10.4103/jhrs.JHRS_27_17
  28. Cacciottola L, Donnez J, Dolmans MM. Can Endometriosis-Related Oxidative Stress Pave the Way for New Treatment Targets? International Journal of Molecular Sciences. 2021;22(13):7138. https://doi.org/10.3390/ijms22137138
  29. Didziokaite G, Biliute G, Gudaite J, Kvedariene V. Oxidative Stress as a Potential Underlying Cause of Minimal and mild Endometriosis-Related Infertilty. International Journal of Molecular Sciences. 2023;24(4):3809. https://doi.org/10.3390/ijms24043809
  30. Krechetova LV, Inviyaeva EV, Korotkova TD, Vanko LV, Adamyan LV. Features of the relationship between the subpopulation composition and the content of cytokines in the peripheral blood and peritoneal fluid of women with endometriosis. Russian Journal of Human Reproduction. 2023;29(1):19. (In Russ.). https://doi.org/10.17116/repro20232901119
  31. Nanda A, K T, Banerjee P, Dutta M, Wangdi T, Sharma P, Chaudhury K, Jana SK. Cytokines, Angiogenesis, and Extracellular Matrix Degradation are Augmented by Oxidative Stress in Endometriosis. Annals of Laboratory Medicine. 2020;40(5):390-397.  https://doi.org/10.3343/alm.2020.40.5.390
  32. Dai Y, Lin X, Liu N, Shi L, Zhuo F, Huang Q, Gu W, Zhao F, Zhang Y, Zhang Y, Pan Y, Zhang S. Integrative analysis of transcriptomic and metabolomic profiles reveals abnormal phosphatidylinositol metabolism in follicles from endometriosis-associated infertility patients. Journal of Pathology. 2023;260(3):248-260.  https://doi.org/10.1002/path.6079
  33. Vallée A, Lecarpentier Y. Curcumin and Endometriosis. International Journal of Molecular Sciences. 2020;21(7):2440. https://doi.org/10.3390/ijms21072440
  34. Giordano A, Tommonaro G. Curcumin and Cancer. Nutrients. 2019;11(10):2376. https://doi.org/10.3390/nu11102376
  35. Wang X, Zhou L, Dong Z, Wang G. Identification of iron metabolism-related predictive markers of endometriosis and endometriosis-relevant ovarian cancer. Medicine (Baltimore). 2023;102(15): e33478. https://doi.org/10.1097/MD.0000000000033478
  36. Wyatt J, Fernando SM, Powell SG, Hill CJ, Arshad I, Probert C, Ahmed S, Hapangama DK. The role of iron in the pathogenesis of endometriosis: a systematic review. Human Reproduction Open. 2023;2023(3):hoad033. https://doi.org/10.1093/hropen/hoad033
  37. Liu YY, Liu YK, Hu WT, Tang LL, Sheng YR, Wei CY, Li MQ, Zhu XY. Elevated heme impairs macrophage phagocytosis in endometriosis. Reproduction. 2019;158(3):257-266.  https://doi.org/10.1530/REP-19-0028
  38. Ferreira EM, Giorgi VSI, Rodrigues JK, de Andrade AZ, Junior AAJ, Navarro PA. Systemic oxidative stress as a possible mechanism underlying the pathogenesis of mild endometriosis-related Infertilty. Reproductive BioMedicine Online. 2019;39(5):785-794.  https://doi.org/10.1016/j.rbmo.2019.06.011
  39. Woo JH, Choi YS, Choi JH. Iron-Storage Protein Ferritin Is Upregulated in Endometriosis and Iron Overload Contributes to a Migratory Phenotype. Biomedicines. 2020;8(11):454.  https://doi.org/10.3390/biomedicines8110454
  40. Wu Y, Yang R, Lan J, Wu Y, Huang J, Fan Q, You Y, Lin H, Jiao X, Chen H, Cao C, Zhang Q. Iron overload modulates follicular microenvironment via ROS/HIF-1α/FSHR signaling. Free Radical Biology and Medicine. 2023;196:37-52.  https://doi.org/10.1016/j.freeradbiomed.2022.12.105
  41. Zhou Y, Zhao X, Zhang L, Xia Q, Peng Y, Zhang H, Yan D, Yang Z, Li J. Iron overload inhibits cell proliferation and promotes autophagy via PARP1/SIRT1 signaling in endometriosis and adenomyosis. Toxicology. 2022;465:153050. https://doi.org/10.1016/j.tox.2021.153050
  42. Li Y, Zeng X, Lu D, Yin M, Shan M, Gao Y. Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis. Human Reproduction. 2021;36(4):951-964.  https://doi.org/10.1093/humrep/deaa363
  43. Matsuzaki S, Pankhurst MW. Hyperactivation of dormant primordial follicles in ovarian endometrioma patients Reproduction. 2020; 160(6):R145-R153. https://doi.org/10.1530/REP-20-0265
  44. Guo SW. Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis. Reproductive Medicine and Biology. 2018;17(4):369-397.  https://doi.org/10.1002/rmb2.12221
  45. Zhang Q, Duan J, Olson M, Fazleabas A, Guo SW. Cellular Changes Consistent with Epithelial-Mesenchymal Transition and Fibroblast-to-Myofibroblast Transdifferentiation in the Progression of Experimental Endometriosis in Baboons. Reproductive Sciences. 2016;23(10):1409-1421. https://doi.org/10.1177/1933719116641763
  46. Baker DJ, Alimirah F, van Deursen JM, Campisi J, Nildesheim J. Oncogenic senescence: a multi-functional perspective. Oncotarget. 2017;8(16):27661-27672. https://doi.org/10.18632/oncotarget.15742
  47. Barnard ND, Holtz DN, Schmidt N, Kolipaka S, Hata E, Sutton M, Znayenko-Miller T, Hazen ND, Cobb C, Kahleova H. Nutrition in the prevention and treatment of endometriosis: A review. Frontiers in Nutrition. 2023;10:1089891. https://doi.org/10.3389/fnut.2023.1089891
  48. Galiniak S, Aebisher D, Bartusik-Aebisher D. Health benefits of resveratrol administration. Acta Biochimica Polonica. 2019;66(1):13-21.  https://doi.org/10.18388/abp.2018_2749
  49. Kang JE, Yoo N, Jeon BJ, Kim BS, Chung EH. Resveratrol Oligomers, Plant-Produced Natural Products with Anti-virulence and Plant Immune-Priming Roles. Frontiers in Plant Science. 2022; 13:885625. https://doi.org/10.3389/fpls.2022.885625
  50. Gołąbek-Grenda A, Kaczmarek M, Juzwa W, Olejnik A. Natural resveratrol analogs differentially target endometriotic cells into apoptosis pathways. Scientific Reports. 2023;13(1):11468. https://doi.org/10.1038/s41598-023-38692-8
  51. Arablou T, Aryaeian N, Khodaverdi S, Kolahdouz-Mohammadi R, Moradi Z, Rashidi N, Delbandi AA. The effects of resveratrol on the expression of VEGF, TGF-β, and MMP-9 in endometrial stromal cells of women with endometriosis. Scientific Reports. 2021; 11(1):6054. https://doi.org/10.1038/s41598-021-85512-y
  52. Kolahdouz-Mohammadi R, Shidfar F, Khodaverdi S, Arablou T, Heidari S, Rashidi N, Delbandi AA. Resveratrol treatment reduces expression of MCP-1, IL-6, IL-8 and RANTES in endometriotic stromal cells. J Journal of Cellular and Molecular Medicine. 2021; 25(2):1116-1127. https://doi.org/10.1111/jcmm.16178
  53. Anastasiu CV, Moga MA, Elena Neculau A, Bălan A, Scârneciu I, Dragomir RM, Dull AM, Chicea LM. Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives. International Journal of Molecular Sciences. 2020; 21(5):1750. https://doi.org/10.3390/ijms21051750
  54. Chen Z, Wang C, Lin C, Zhang L, Zheng H, Zhou Y, Li X, Li C, Zhang X, Yang X, Guan M, Xi Y. Lipidomic Alterations and PPARα Activation Induced by Resveratrol Lead to Reduction in Lesion Size in Endometriosis Models. Oxidative Medicine and Cellular Longevity. 2021;2021(1):9979953. https://doi.org/10.1155/2021/9979953
  55. Zou W, Wang X, Xia X, Zhang T, Nie M, Xiong J, Fang X. Resveratrol protected against the development of endometriosis by promoting ferroptosis through miR-21-3p/p53/SLC7A11 signaling pathway. Biochemical and Biophysical Research Communications. 2024;692:149338. https://doi.org/10.1016/j.bbrc.2023.149338
  56. Lai ZZ, Yang HL, Ha SY, Chang KK, Mei J, Zhou WJ, Qiu XM, Wang XQ, Zhu R, Li DJ, Li MQ. Cyclooxygenase-2 in Endometriosis. International Journal of Biological Sciences. 2019;15(13): 2783-2797. https://doi.org/10.7150/ijbs.35128
  57. Khodarahmian M, Amidi F, Moini A, Kashani L, Salahi E, Danaii-Mehrabad S, Nashtaei MS, Mojtahedi MF, Esfandyari S, Sobhani A. A randomized exploratory trial to assess the effects of resveratrol on VEGF and TNF-α 2 expression in endometriosis women. Journal of Reproductive Immunology. 2021;143:103248. https://doi.org/10.1016/j.jri.2020.103248
  58. Li Y, Hung SW, Zhang R, Man GC, Zhang T, Chung JP, Fang L, Wang CC. Melatonin in Endometriosis: Mechanistic Understanding and Clinical Insight. Nutrients. 2022;14(19):4087. https://doi.org/10.3390/nu14194087
  59. Dymanowska-Dyjak I, Frankowska K, Abramiuk M, Polak G. Oxidative Imbalance in Endometriosis-Related Infertilty — The Therapeutic Role of Antioxidants. International Journal of Molecular Sciences. 2024;25(12):6298. https://doi.org/10.3390/ijms25126298
  60. Lin X, Dai Y, Tong X, Xu W, Huang Q, Jin X, Li C, Zhou F, Zhou H, Lin X, Huang D, Zhang S. Excessive oxidative stress in cumulus granulosa cells induced cell senescence contributes to endometriosis-associated Infertilty. Redox Biology. 2020;30:101431. https://doi.org/10.1016/j.redox.2020.101431
  61. Park S, Ham J, Yang C, Park W, Park H, An G, Song J, Hong T, Park SJ, Kim HS, Song G, Lim W. Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs. Journal of Pineal Research. 2023;74(1):e12842. https://doi.org/10.1111/jpi.12842
  62. Zarezadeh M, Khorshidi M, Emami M, Janmohammadi P, Kord-Varkaneh H, Mousavi SM, Mohammed SH, Saedisomeolia A, Alizadeh S. Melatonin supplementation and pro-inflammatory mediators: a systematic review and meta-analysis of clinical trials. European Journal of Nutrition. 2020;59(5):1803-1813. https://doi.org/10.1007/s00394-019-02123-0
  63. González-González A, Mediavilla MD, Sánchez-Barceló EJ. Melatonin: A Molecule for Reducing Breast Cancer Risk. Molecules. 2018;23(2):336.  https://doi.org/10.3390/molecules23020336
  64. Mohd Kamal DA, Salamt N, Muhammad Yusuf A, Mohd Kashim MIA, Mokhtar MH. Potential Health Benefits of Curcumin on Female Reproductive Disorders: A Review. Nutrients. 2021; 13:3126. https://doi.org/10.3390/nu13093126
  65. Ding J, Mei S, Wang K, Cheng W, Sun S, Ni Z, Wang X, Yu C. Curcumin modulates oxidative stress to inhibit pyroptosis and improve the inflammatory microenvironment to treat endometriosis. Genes and Diseases. 2024;11(3):101053. https://doi.org/10.1016/j.gendis.2023.06.022
  66. Chowdhury I, Banerjee S, Driss A, Xu W, Mehrabi S, Nezhat C, Sidell N, Taylor RN, Thompson WE. Curcumin attenuates proangiogenic and proinflammatory factors in human eutopic endometrial stromal cells through the NF‐κB signaling pathway. Journal of Cellular Physiology. 2019;234(5):6298-6312. https://doi.org/10.1002/jcp.27360
  67. Ding J, Mei S, Cheng W, Ni Z, Yu C. Curcumin treats endometriosis in mice by the HIF signaling pathway. American Journal of Translational Research. 2022;14(4):2184-2198.
  68. Aldini G, Altomare A, Baron G, Vistoli G, Carini M, Borsani L, Sergio F. N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Free Radical Research. 2018;52(7):751-762.  https://doi.org/10.1080/10715762.2018.1468564
  69. Karuppagounder SS, Alin L, Chen Y, Brand D, Bourassa MW, Dietrich K, Wilkinson CM, Nadeau CA, Kumar A, Perry S, Pinto JT, Darley-Usmar V, Sanchez S, Milne GL, Pratico D, Holman TR, Carmichael ST, Coppola G, Colbourne F, Ratan RR. N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice. Annals of Neurology. 2018; 84(6):854-872.  https://doi.org/10.1002/ana.25356
  70. Anastasi E, Scaramuzzino S, Viscardi MF, Viggiani V, Piccioni MG, Cacciamani L, Merlino L, Angeloni A, Muzii L, Porpora MG. Efficacy of N-Acetylcysteine on Endometriosis-Related Pain, Size Reduction of Ovarian Endometriomas, and Fertility Outcomes. International Journal of Environmental Research and Public Health. 2023; 20(6):4686. https://doi.org/10.3390/ijerph20064686
  71. Lv SY, He S, Ling XL, Wang YQ, Huang C, Long JR, Wang JQ, Qin Y, Wei H, Yu CY. Review of lipoic acid: From a clinical therapeutic agent to various emerging biomaterials. International Journal of Pharmacology. 2022;627:122201. https://doi.org/10.1016/j.ijpharm.2022.122201
  72. Di Nicuolo F, Castellani R, De Cicco Nardone A, Barbaro G, Paciullo C, Pontecorvi A, Scambia G, Di Simone N. Alpha-Lipoic Acid Plays a Role in Endometriosis: New Evidence on Inflammasome-Mediated Interleukin Production, Cellular Adhesion and Invasion. Molecules. 2021;26(2):288.  https://doi.org/10.3390/molecules26020288
  73. Agostinis C, Zorzet S, De Leo R, Zauli G, De Seta F, Bulla R. The Combination of N‐Acetyl Cysteine, Alpha‐Lipoic Acid, and Bromelain Shows High Anti‐Inflammatory Properties in Novel In Vivo and In Vitro Models of Endometriosis. Mediators of Inflammation. 2015;2015(1):918089. https://doi.org/10.1155/2015/918089
  74. De Leo V, Cagnacci A, Cappelli V, Biasioli A, Leonardi D, Seracchioli R. Role of a natural integrator based on lipoic acid, palmitoiletanolamide and myrrh in the treatment of chronic pelvic pain and endometriosis. Minerva Ginecologica. 2019;71(3):191-195.  https://doi.org/10.23736/S0026-4784.19.04384-3
  75. Amini L, Chekini R, Nateghi MR, Haghani H, Jamialahmadi T, Sathyapalan T, Sahebkar A. The Effect of Combined Vitamin C and Vitamin E Supplementation on Oxidative Stress Markers in Women with Endometriosis: A Randomized, Triple-Blind Placebo-Controlled Clinical Trial. Pain Research and Management. 2021;2021:1-6.  https://doi.org/10.1155/2021/5529741
  76. Hoorsan H, Simbar M, Tehrani FR, Fathi F, Mosaffa N, Riazi H, Akradi L, Nasseri S, Bazrafkan S. The effectiveness of antioxidant therapy (vitamin C) in an experimentally induced mouse model of ovarian endometriosis. Womens Health. 2022;18:174550572210962. https://doi.org/10.1177/17455057221096218
  77. Talebi H, Farahpour MR, Hamishehkar H. The effectiveness of Rutin for prevention of surgical induced endometriosis development in a rat model. Scientific Reports. 2021;11(1):7180. https://doi.org/10.1038/s41598-021-86586-4
  78. Cheng K, Huang Y, Wang C. 1,25(OH)2D3 Inhibited Ferroptosis in Zebrafish Liver Cells (ZFL) by Regulating Keap1-Nrf2-GPx4 and NF-κB-hepcidin Axis. International Journal of Molecular Sciences. 2021;22(21):11334. https://doi.org/10.3390/ijms222111334
  79. Mehdizadehkashi A, Rokhgireh S, Tahermanesh K, Eslahi N, Minaeian S, Samimi M. The effect of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosis. Gynecological Endocrinology. 2021;37(7):640-645.  https://doi.org/10.1080/09513590.2021.1878138
  80. Nodler JL, DiVasta AD, Vitonis AF, Karevicius S, Malsch M, Sarda V, Fadayomi A, Harris HR, Missmer SA. Supplementation with vitamin D or ω-3 fatty acids in adolescent girls and young women with endometriosis (SAGE): a double-blind, randomized, placebo-controlled trial. American Journal of Clinical Nutrition. 2020;112(1): 229-236.  https://doi.org/10.1093/ajcn/nqaa096
  81. Burjiah AR, Sa’adi A, Widjiati W. Vitamin D inhibited endometriosis development in mice model through interleukin-17 modulation. Open Veterinary Journal. 2022;12(6):956-964.  https://doi.org/10.5455/OVJ.2022.v12.i6.23
  82. Kalaitzopoulos DR, Samartzis N, Daniilidis A, Leeners B, Makieva S, Nirgianakis K, Dedes I, Metzler JM, Imesch P, Lempesis IG. Effects of vitamin D supplementation in endometriosis: a systematic review. Reproductive Biology and Endocrinology. 2022;20(1):176.  https://doi.org/10.1186/s12958-022-01051-9
  83. Yarmolinskaya M, Denisova A, Tkachenko N, Ivashenko T, Bespalova O, Tolibova G, Tral T. Vitamin D significance in pathogenesis of endometriosis. Gynecological Endocrinology. 2021;37(Suppl 1):40-43.  https://doi.org/10.1080/09513590.2021.2006516
  84. Bayu P, Wibisono JJ. Vitamin C and E antioxidant supplementation may significantly reduce pain symptoms in endometriosis: A systematic review and meta-analysis of randomized controlled trials. PloS One. 2024;19(5):e0301867. https://doi.org/10.1371/journal.pone.0301867
  85. García-Izquierdo L, Marín-Sánchez P, García-Peñarrubia P, Martínez-Esparza M. New Potential Pharmacological Options for Endometriosis Associated Pain. International Journal of Molecular Sciences. 2024;25(13):7068. https://doi.org/10.3390/ijms25137068
  86. Yi ZH, Li SQ, Ke JY, Wang Y, Zhao MZ, Li J, Li MQ, Zhu ZL. Baicalein Relieves Ferroptosis-Mediated Phagocytosis Inhibition of Macrophages in Ovarian Endometriosis. Current Issues in Molecular Biology. 2022;44(12):6189-6204. https://doi.org/10.3390/cimb44120422
  87. Ke JY, Yang J, Li J, Xu Z, Li MQ, Zhu ZL. Baicalein inhibits FURIN-MT1-MMP-mediated invasion of ectopic endometrial stromal cells in endometriosis possibly by reducing the secretion of TGFB1. American Journal of Reproductive Immunology. 2021;85(3):e13344. https://doi.org/10.1111/aji.13344
  88. Park W, Jang H, Kim HS, Park SJ, Lim W, Song G, Park S. Therapeutic efficacy and anti-inflammatory mechanism of baicalein on endometriosis progression in patient-derived cell line and mouse model. Phytomedicine. 2024;130:155469. https://doi.org/10.1016/j.phymed.2024.155469
  89. Jin Z, Huang J, Zhu Z. Baicalein reduces endometriosis by suppressing the viability of human endometrial stromal cells through the nuclear factor-κB pathway in vitro. Experimental and Therapeutic Medicine. 2017;14(4):2992-2998. https://doi.org/10.3892/etm.2017.4860
  90. Fadin M, Nicoletti MC, Pellizzato M, Accardi M, Baietti MG, Fratter A. Effectiveness of the integration of quercetin, turmeric, and N-acetylcysteine in reducing inflammation and pain associated with endometriosis. In-vitro and in-vivo studies. Minerva Ginecologica. 2020;72(5). https://doi.org/10.23736/S0026-4784.20.04615-8
  91. Delenko J, Xue X, Chatterjee PK, Hyman N, Shih AJ, Adelson RP, Safaric Tepes P, Gregersen PK, Metz CN. Quercetin enhances decidualization through AKT-ERK-p53 signaling and supports a role for senescence in endometriosis. Reproductive Biology and Endocrinology. 2024;22(1):100.  https://doi.org/10.1186/s12958-024-01265-z
  92. Zhang L, Mohankumar K, Martin G, Mariyam F, Park Y, Han SJ, Safe S. Flavonoids Quercetin and Kaempferol Are NR4A1 Antagonists and Suppress Endometriosis in Female Mice. Endocrinology. 2023;164(10):bqad133. https://doi.org/10.1210/endocr/bqad133
  93. Jamali N, Zal F, Mostafavi-Pour Z, Samare-Najaf M, Poordast T, Dehghanian A. Ameliorative Effects of Quercetin and Metformin and Their Combination Against Experimental Endometriosis in Rats. Reproductive Sciences. 2021;28(3):683-692.  https://doi.org/10.1007/s43032-020-00377-2
  94. Aaseth J, Alexander J, Alehagen U. Coenzyme Q10 supplementation — In ageing and disease. Mechanisms of Ageing and Development. 2021;197:111521. https://doi.org/10.1016/j.mad.2021.111521
  95. Wang Y, Hekimi S. Understanding Ubiquinone. Trends in Cell Biology. 2016;26(5):367-378.  https://doi.org/10.1016/j.tcb.2015.12.007
  96. Marcheggiani F, Kordes S, Cirilli I, Orlando P, Silvestri S, Vogelsang A, Möller N, Blatt T, Weise JM, Damiani E, Tiano L. Anti-ageing effects of ubiquinone and ubiquinol in a senescence model of human dermal fibroblasts. Free Radical Biology and Medicine. 2021;165:282-288.  https://doi.org/10.1016/j.freeradbiomed.2021.01.032
  97. Akarca-Dizakar SÖ, Demirel MA, Coşkun Akçay N, Sipahi M, Karakoç Sökmensüer L, Boyunaga H, Köylü A, Ömeroğlu S. The therapeutic effects of coenzyme Q10 on surgically induced endometriosis in Sprague Dawley rats. Journal of Obstetrics and Gynaecology. 2022;42(7):3290-3298. https://doi.org/10.1080/01443615.2022.2114322
  98. Lai GL, Yeh CC, Yeh CY, Chen RY, Fu CL, Chen CH, Tzeng CR. Decreased zinc and increased lead blood levels are associated with endometriosis in Asian Women. Reproductive Toxicology. 2017;74:77-84.  https://doi.org/10.1016/j.reprotox.2017.09.001
  99. Onuma T, Mizutani T, Fujita Y, Ohgami N, Ohnuma S, Kato M, Yoshida Y. Zinc deficiency is associated with the development of ovarian endometrial cysts. American Journal of Cancer Research. 2023;13(3):1049-1066.
  100. Shi YQ, Zhu XT, Zhang SN, Ma YF, Han YH, Jiang Y, Zhang YH. Premature ovarian insufficiency: a review on the role of oxidative stress and the application of antioxidants. Frontiers in Endocrinology. 2023;14:1172481. https://doi.org/10.3389/fendo.2023.1172481
  101. Banerjee S, Xu W, Doctor A, Driss A, Nezhat C, Sidell N, Taylor RN, Thompson WE, Chowdhury I. TNFα-Induced Altered miRNA Expression Links to NF-κB Signaling Pathway in Endometriosis. Inflammation. 2023;46(6):2055-2070. https://doi.org/10.1007/s10753-023-01862-x
  102. Kapur A, Ayuso JM, Rehman S, Kumari S, Felder M, Stenerson Z, Skala MC, Beebe D, Barroilhet L, Patankar MS. Oxidative phosphorylation inhibitors inhibit proliferation of endometriosis cells. Reproduction. 2023;165(6):617-628.  https://doi.org/10.1530/REP-22-0265
  103. Chen TC, Chuang JY, Ko CY, Kao TJ, Yang PY, Yu CH, Liu MS, Hu SL, Tsai YT, Chan H, Chang WC, Hsu TI. AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis. Redox Biology. 2020;30:101413. https://doi.org/10.1016/j.redox.2019.101413
  104. Yang C, Han M, Li R, Zhou L, Zhang Y, Duan L, Su S, Li M, Wang Q, Chen T, Mo Y. Curcumin Nanoparticles Inhibiting Ferroptosis for the Enhanced Treatment of Intracerebral Hemorrhage. International Journal of Nanomedicine. 2021;16:8049-8065. https://doi.org/10.2147/IJN.S334965
  105. Huang J, Hodis HN, Weinstein SJ, Mack WJ, Sampson JN, Mondul AM, Albanes D. Serum Metabolomic Response to Low- and High-Dose Vitamin E Supplementation in Two Randomized Controlled Trials. Cancer. 2020;29(7):1329-1334. https://doi.org/10.1158/1055-9965.EPI-20-0187
  106. Clower L, Fleshman T, Geldenhuys WJ, Santanam N. Targeting Oxidative Stress Involved in Endometriosis and Its Pain. Biomolecules. 2022;12(8):1055. https://doi.org/10.3390/biom12081055
  107. Kimball SM, Holick MF. Official recommendations for vitamin D through the life stages in developed countries. European Journal of Clinical Nutrition. 2020;74(11):1514-1518. https://doi.org/10.1038/s41430-020-00706-3
  108. Wimalawansa SJ. Vitamin D Deficiency: Effects on Oxidative Stress, Epigenetics, Gene Regulation, and Aging. Biology. 2019;8(2):30.  https://doi.org/10.3390/biology8020030
  109. Hu Z, Zhang H, Yi B, Yang S, Liu J, Hu J, Wang J, Cao K, Zhang W. VDR activation attenuate cisplatin induced AKI by inhibiting ferroptosis. Cell Death and Disease. 2020;11(1):73.  https://doi.org/10.1038/s41419-020-2256-z
  110. Hoppe C, Freuding M, Büntzel J, Münstedt K, Hübner J. Clinical efficacy and safety of oral and intravenous vitamin C use in patients with malignant diseases. Journal of Cancer Research and Clinical Oncology. 2021;147(10):3025-3042. https://doi.org/10.1007/s00432-021-03759-4
  111. Liu H, Ye F, Sun Q, Liang H, Li C, Li S, Lu R, Huang B, Tan W, Lai L. Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro. Journal of Enzyme Inhibition and Medicinal Chemistry. 2021;36(1):497-503.  https://doi.org/10.1080/14756366.2021.1873977
  112. Kenny EM, Fidan E, Yang Q, Anthonymuthu TS, New LA, Meyer EA, Wang H, Kochanek PM, Dixon CE, Kagan VE, Bayir H. Ferroptosis Contributes to Neuronal Death and Functional Outcome after Traumatic Brain Injury. Critcal Care Medicine. 2019;47(3): 410-418.  https://doi.org/10.1097/CCM.0000000000003555
  113. López-Lluch G, Del Pozo-Cruz J, Sánchez-Cuesta A, Cortés-Rodríguez AB, Navas P. Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization. Nutrition. 2019;57:133-140.  https://doi.org/10.1016/j.nut.2018.05.20

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