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Adamyan L.V.

Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine;
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Pivazyan L.G.

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Kurbatova K.S.

Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine

Mailova K.S.

Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine

Stepanian A.A.

Academy of Women’s Health and Endoscopic Surgery

Oxidative stress, ferroptosis, somatic mutations, antioxidant therapy, and endometriosis: a new perspective on the issue

Authors:

Adamyan L.V., Pivazyan L.G., Kurbatova K.S., Mailova K.S., Stepanian A.A.

More about the authors

Journal: Russian Journal of Human Reproduction. 2024;30(6): 32‑44

DOI: 10.17116/repro20243006132

Read: 3042 times

Contact the author
Table of contents

OXIDATIVE STRESS, FERROPTOSIS, SOMATIC MUTATIONS, ANTIOXIDANT THERAPY, AND ENDOMETRIOSIS: A NEW PERSPECTIVE ON THE ISSUE
OXIDATIVE STRESS, FERROPTOSIS, SOMATIC MUTATIONS, ANTIOXIDANT THERAPY, AND ENDOMETRIOSIS: A NEW PERSPECTIVE ON THE ISSUE

To cite this article:

Adamyan LV, Pivazyan LG, Kurbatova KS, Mailova KS, Stepanian AA. Oxidative stress, ferroptosis, somatic mutations, antioxidant therapy, and endometriosis: a new perspective on the issue. Russian Journal of Human Reproduction. 2024;30(6):32‑44. (In Russ.)
https://doi.org/10.17116/repro20243006132

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The article focuses on the role of oxidative stress, ferroptosis, and antioxidant therapy in the pathogenesis and treatment of endometriosis — a gynecological condition affecting up to 10% of women of reproductive age. Oxidative stress and ferroptosis, which cause cellular damage and inflammation, play a significant role in the progression of endometriosis and may contribute to the accumulation of somatic mutations and DNA damage, exacerbating the pathological processes. Mutations in driver genes such as TP53, PTEN, and KRAS lead to dysregulation of cellular processes, enhancing the proliferation and invasion of endometrial cells. Antioxidant therapy is considered a promising approach in the treatment of endometriosis, in combination with surgical and pharmacological interventions. Antioxidants such as resveratrol, melatonin, curcumin, and N-acetylcysteine possess anti-inflammatory and antioxidant properties, helping to reduce oxidative stress, slow disease progression, and improve patient outcomes. The article emphasizes the need for further research to develop new treatment strategies aimed at reducing oxidative stress, preventing granulosa cell ferroptosis, and minimizing genetic damage, which may improve reproductive outcomes and the quality of life for women with endometriosis.

Keywords:

antioxidants
iron
endometriosis
reproduction

Authors:

Adamyan L.V.

Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine;
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Pivazyan L.G.

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Kurbatova K.S.

Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine

Mailova K.S.

Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine

Stepanian A.A.

Academy of Women’s Health and Endoscopic Surgery

Received:

17.09.2024

Accepted:

31.10.2024

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