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Zorkina Y.A.
Serbsky National Medical Research Center of Psychiatry and Narcology;
Alexeev Mental-Health Clinic No. 1 of Moscow Healthcare Department
Morozova I.O.
Alexeev Mental-Health Clinic No. 1 of Moscow Healthcare Department
Abramova O.V.
Serbsky National Medical Research Center of Psychiatry and Narcology;
Alexeev Mental-Health Clinic No. 1 of Moscow Healthcare Department
Ochneva A.G.
Serbsky National Medical Research Center of Psychiatry and Narcology;
Alexeev Mental-Health Clinic No. 1 of Moscow Healthcare Department
Gankina O.A.
Alexeev Mental-Health Clinic No. 1 of Moscow Healthcare Department;
Russian Medical Academy of Continuous Professional Education
Andryushenko A.V.
Alexeev Mental-Health Clinic No. 1 of Moscow Healthcare Department;
Lomonosov Moscow State University
Kurmyshev M.V.
Alexeev Mental-Health Clinic No. 1 of Moscow Healthcare Department
Kostyuk G.P.
Alexeev Mental-Health Clinic No. 1 of Moscow Healthcare Department
Morozova A.Yu.
Serbsky National Medical Research Center of Psychiatry and Narcology;
Alexeev Mental-Health Clinic No. 1 of Moscow Healthcare Department
Use of modern classification systems for complex diagnostics of Alzheimer’s disease
Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(1): 121‑127
Read: 1809 times
To cite this article:
Zorkina YA, Morozova IO, Abramova OV, et al. . Use of modern classification systems for complex diagnostics of Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry.
2024;124(1):121‑127. (In Russ.)
https://doi.org/10.17116/jnevro2024124011121
To compare the content of β-amyloid (Aβ) peptides Aβ40, Aβ42, total and threonine phosphorylated 181 tau-protein in cerebrospinal fluid (CSF) of patients with the clinical diagnosis of Alzheimer’s disease (AD).
The study was performed on 64 patients with a diagnosis of dementia and MMSE scores of 24 or lower. All patients underwent lumbar puncture. Aβ40, Aβ42, Aβ42/40 ratio, total tau, phosphorylated tau at threonine 181 were determined in the CSF using a multiplex assay according to the manufacturer’s protocol, the concentration was determined in pkg/ml.
The preliminary diagnosis of AD was made in 3 patients (5%). As a result of the study of protein content in the CSF, signs of AD were detected in 48 (75%) people. The findings suggest that the diagnosis of AD is made 10—14 times less frequently than it should be according to the World Health Organization data. The discrepancy between clinical diagnosis and laboratory findings is confirmed by our study.
Differences in the therapy of dementias and the development of new drugs targeting specific links in the pathogenesis of different types of dementias require accurate and complete diagnosis of dementias, especially AD, as the most common type of dementia.
Keywords:
Authors:
Zorkina Y.A.
Serbsky National Medical Research Center of Psychiatry and Narcology;
Alexeev Mental-Health Clinic No. 1 of Moscow Healthcare Department
Morozova I.O.
Alexeev Mental-Health Clinic No. 1 of Moscow Healthcare Department
Abramova O.V.
Serbsky National Medical Research Center of Psychiatry and Narcology;
Alexeev Mental-Health Clinic No. 1 of Moscow Healthcare Department
Ochneva A.G.
Serbsky National Medical Research Center of Psychiatry and Narcology;
Alexeev Mental-Health Clinic No. 1 of Moscow Healthcare Department
Gankina O.A.
Alexeev Mental-Health Clinic No. 1 of Moscow Healthcare Department;
Russian Medical Academy of Continuous Professional Education
Andryushenko A.V.
Alexeev Mental-Health Clinic No. 1 of Moscow Healthcare Department;
Lomonosov Moscow State University
Kurmyshev M.V.
Alexeev Mental-Health Clinic No. 1 of Moscow Healthcare Department
Kostyuk G.P.
Alexeev Mental-Health Clinic No. 1 of Moscow Healthcare Department
Morozova A.Yu.
Serbsky National Medical Research Center of Psychiatry and Narcology;
Alexeev Mental-Health Clinic No. 1 of Moscow Healthcare Department
Received:
14.09.2023
Accepted:
16.09.2023
List of references:
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