Genes of the circadian rhythm and sleep disorders in an open population of men aged 25—64 years (an epidemiological study under the WHO MONICA-PSYCHOSOCIAL program)

Gafarov V.V.

Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences;
Collaborative Laboratory of Epidemiology of Cardiovascular Diseases

ORCID: 0000-0001-5701-7856

Gromova E.A.

ORCID: 0000-0001-8313-3893

Tripelgorn A.N.

Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences

ORCID: 0000-0002-3898-3247

Gagulin I.V.

ORCID: 0000-0001-5255-5647

Maksimov V.N.

Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences

ORCID: 0000-0002-7165-4496

Gafarova A.V.

ORCID: 0000-0001-5380-9434

Genes of the circadian rhythm and sleep disorders in an open population of men aged 25—64 years (an epidemiological study under the WHO MONICA-PSYCHOSOCIAL program)

Authors:

Gafarov V.V., Gromova E.A., Tripelgorn A.N., Gagulin I.V., Maksimov V.N., Gafarova A.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(6): 88‑93

DOI: 10.17116/jnevro202312306188

Downloaded: 17

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To cite this article:

Gafarov VV, Gromova EA, Tripelgorn AN, Gagulin IV, Maksimov VN, Gafarova AV. Genes of the circadian rhythm and sleep disorders in an open population of men aged 25—64 years (an epidemiological study under the WHO MONICA-PSYCHOSOCIAL program). S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(6):88‑93. (In Russ.)
https://doi.org/10.17116/jnevro202312306188

Подписка 2025 (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

To study an effect of polymorphisms of genes encoding circadian rhythm proteins (CLOCK, BMAL1, PER2, NPAS2) on sleep disorders in men aged 25-64 years.

MATERIAL AND METHODS

The general examination was carried out according to standard methods included in the WHO MONICA-psychosocial (MOPSY) program. The standard Jenkins questionnaire was used to study sleep disorders. Genotyping of the polymorphisms of CLOCK, BMAL1, PER2, NPAS2 was carried out.

RESULTS

Carriers of the C/T genotype of CLOCK rs2412646 were more likely to think that their sleep was «satisfactory» or «bad». Carriers of the C/T genotype of BMAL1 rs2278749 were more likely to experience disturbing dreams, they woke up tired and exhausted. Carriers of the A/A genotype of PER2 rs934945 were more likely (25%) to wake up two or more times a night, in general, from 4 to 7 times a week. In the population, the C/T and T/T genotypes of NPAS2 rs4851377 were significantly more common in individuals with 7-hour sleep (50% and 53.3%, respectively).

CONCLUSION

An association of certain polymorphisms of tCLOCK, BMAL1, PER2, NPAS2 with sleep disorders was found.

Keywords:

population

men

sleep disorders

CLOCK gene

BMAL1 gene

PER2 gene

NPAS2 gene

Authors:

Gafarov V.V.

ORCID: 0000-0001-5701-7856

Gromova E.A.

ORCID: 0000-0001-8313-3893

Tripelgorn A.N.

Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences

ORCID: 0000-0002-3898-3247

Gagulin I.V.

ORCID: 0000-0001-5255-5647

Maksimov V.N.

Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences

ORCID: 0000-0002-7165-4496

Gafarova A.V.

ORCID: 0000-0001-5380-9434

Received:

10.02.2023

Accepted:

06.03.2023

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