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Voronkova K.V.

Pirogov Russian National Research Medical University;
Petrovsky Russian Scientific Center for Surgery

Alieva A.M.

Pirogov Russian National Research Medical University

Nikitin I.G.

Pirogov Russian National Research Medical University

Musina G.M.

Medical Center NORIS

Surskaya E.V.

Petrovsky Russian Scientific Center for Surgery

Zaitseva O.S.

Petrovsky Russian Scientific Center for Surgery

Mashkevich N.G.

Petrovsky Russian Scientific Center for Surgery

Gomonova L.V.

Petrovsky Russian Scientific Center for Surgery

Petrukhin A.S.

Pirogov Russian National Research Medical University

The role of the phenosanic acid in the combined treatment of patients with epilepsy

Authors:

Voronkova K.V., Alieva A.M., Nikitin I.G., Musina G.M., Surskaya E.V., Zaitseva O.S., Mashkevich N.G., Gomonova L.V., Petrukhin A.S.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(2): 151‑157

DOI: 10.17116/jnevro2023123021151

Read: 3190 times

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Table of contents

THE ROLE OF THE PHENOSANIC ACID IN THE COMBINED TREATMENT OF PATIENTS WITH EPILEPSY
THE ROLE OF THE PHENOSANIC ACID IN THE COMBINED TREATMENT OF PATIENTS WITH EPILEPSY

To cite this article:

Voronkova KV, Alieva AM, Nikitin IG, et al. . The role of the phenosanic acid in the combined treatment of patients with epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(2):151‑157. (In Russ.)
https://doi.org/10.17116/jnevro2023123021151

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

Epilepsy is one of the most studied chronic neurological disorders in the world. Despite significant progress in epilepsy research, some patients continue to experience recurrent seizures. It has been proven that oxidative stress plays an important role in epilepsy. Targeting oxidative stress may provide a novel therapeutic intervention to attenuate epileptogenesis as well as cognitive and psychiatric impairment in patients with epilepsy. One of the promising directions in the search for new strategies for the treatment of epilepsy is the combined use of antiepileptic drugs with antioxidants that affect the pathogenetic links of this disease. The new Russian antiepileptic drug fenosanoic acid (Dibufelon) has an anticonvulsant effect due to the inhibition of lipid peroxidation of brain cells and the reconstruction of cell membranes. This mechanism of action also paves the way for an increase in the effectiveness of co-administered drugs with phenosanoic acid. The effect of the drug on the cognitive and mental functions of patients, the regression of asthenia phenomena is also observed. The clinical efficacy and safety of the combination of this drug with other antiepileptic drugs in epilepsy has been demonstrated in experimental and clinical studies.

Keywords:

epilepsy
oxidative stress
reactive oxygen species
antioxidants
phenosanoic acid

Authors:

Voronkova K.V.

Pirogov Russian National Research Medical University;
Petrovsky Russian Scientific Center for Surgery

Alieva A.M.

Pirogov Russian National Research Medical University

Nikitin I.G.

Pirogov Russian National Research Medical University

Musina G.M.

Medical Center NORIS

Surskaya E.V.

Petrovsky Russian Scientific Center for Surgery

Zaitseva O.S.

Petrovsky Russian Scientific Center for Surgery

Mashkevich N.G.

Petrovsky Russian Scientific Center for Surgery

Gomonova L.V.

Petrovsky Russian Scientific Center for Surgery

Petrukhin A.S.

Pirogov Russian National Research Medical University

Received:

19.01.2023

Accepted:

15.02.2023

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References:

  1. Beghi E. The Epidemiology of Epilepsy. Neuroepidemiology. 2020;54(2):185-191.  https://doi.org/10.1159/000503831
  2. Levite M, Goldberg H. Autoimmune Epilepsy — Novel Multidisciplinary Analysis, Discoveries and Insights. Front Immunol. 2022;12:762743. https://doi.org/10.3389/fimmu.2021.762743
  3. Baker J, Savage S, Milton F, et al. The syndrome of transient epileptic amnesia: a combined series of 115 cases and literature review. Brain Commun. 2021;3(2):fcab038. https://doi.org/10.1093/braincomms/fcab038
  4. Novak A, Vizjak K, Rakusa M. Cognitive Impairment in People with Epilepsy. J Clin Med. 2022;11(1):267.  https://doi.org/10.3390/jcm11010267
  5. Nakken EI, Grinde F, Vaaler A, et al. Epilepsy and other seizure disorders in acute psychiatric inpatients. BMC Psychiatry. 2021;21(1):626.  https://doi.org/10.1186/s12888-021-03619-y
  6. Lai ST, Tan WY, Wo MC, et al. Burden in caregivers of adults with epilepsy in Asian families. Seizure. 2019;71:132-139.  https://doi.org/10.1016/j.seizure.2019.07.008
  7. Perucca P, Scheffer IE, Kiley M. The management of epilepsy in children and adults. Med J Aust. 2018;208(5):226-233.  https://doi.org/10.5694/mja17.00951
  8. Mula M, Kanner AM, Jetté N, Sander JW. Psychiatric Comorbidities in People with Epilepsy. Neurol Clin Pract. 2021;11(2):112-120.  https://doi.org/10.1212/CPJ.0000000000000874
  9. Helmstaedter C, Witt JA. Epilepsy and cognition — A bidirectional relationship? Seizure. 2017;49:83-89.  https://doi.org/10.1016/j.seizure.2017.02.017
  10. Fedin AI, Starykh EV, Torshin DV. Oxidative stress in epilepsy. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakov. 2019;119(1):97-101. (In Russ.). https://doi.org/10.17116/jnevro201911901197
  11. Fabisiak T, Patel M. Crosstalk between neuroinflammation and oxidative stress in epilepsy. Front Cell Dev Biol. 2022;10:976953. https://doi.org/10.3389/fcell.2022.976953
  12. Sun H, Li X, Guo Q, Liu S. Research progress on oxidative stress regulating different types of neuronal death caused by epileptic seizures. Neurol Sci. 2022;43(11):6279-6298. https://doi.org/10.1007/s10072-022-06302-6
  13. Pearson-Smith JN, Patel M. Metabolic Dysfunction and Oxidative Stress in Epilepsy. Int J Mol Sci. 2017;18(11):2365. https://doi.org/10.3390/ijms18112365
  14. Halliwell B. Reactive oxygen species and the central nervous system. J Neurochem. 1992;59:1609-1623. https://doi.org/10.1111/j.1471-4159.1992.tb10990.x
  15. Stadtman ER. Protein oxidation in aging and age-related diseases. Ann NY Acad Sci. 2001;928:22-38.  https://doi.org/10.1111/j.1749-6632.2001.tb05632.x
  16. Wong-ekkabut J, Xu Z, Triampo W, et al. Effect of lipid peroxidation on the properties of lipid bilayers: A molecular dynamics study. Biophys J 2007;93:4225-4236. https://doi.org/10.1529/biophysj.107.112565
  17. Sies H, Berndt C, Jones DP. Oxidative Stress. Annu Rev Biochem. 2017;86:715-748.  https://doi.org/10.1146/annurev-biochem-061516-045037
  18. Hybertson BM, Gao B, Bose SK, McCord JM. Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Mol Aspects Med. 2011;32(4-6):234-246.  https://doi.org/10.1016/j.mam.2011.10.006
  19. Pizzino G, Irrera N, Cucinotta M, et al. Oxidative Stress: Harms and Benefits for Human Health. Oxid Med Cell Longev. 2017;2017:8416763. https://doi.org/10.1155/2017/8416763
  20. Jakubczyk K, Dec K, Kałduńska J, et al. Reactive oxygen species — sources, functions, oxidative damage. Pol Merkur Lekarski. 2020;48(284):124-127. 
  21. Salim S. Oxidative Stress and the Central Nervous System. J Pharmacol Exp Ther. 2017;360(1):201-205.  https://doi.org/10.1124/jpet.116.237503
  22. Rodrigo R, Fernández-Gajardo R, Gutiérrez R, et al. Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities. CNS Neurol Disord Drug Targets. 2013;12(5):698-714.  https://doi.org/10.2174/1871527311312050015
  23. Parsons ALM, Bucknor EMV, Castroflorio E, et al. The Interconnected Mechanisms of Oxidative Stress and Neuroinflammation in Epilepsy. Antioxidants (Basel). 2022;11(1):157.  https://doi.org/10.3390/antiox11010157
  24. Alyu F, Dikmen M. Inflammatory aspects of epileptogenesis: Contribution of molecular inflammatory mechanisms. Acta Neuropsychiatr. 2017;29:1-16.  https://doi.org/10.1017/neu.2016.47
  25. Vezzani A, French J, Bartfai T, Baram T. The role of inflammation in epilepsy. Nat Rev Neurol. 2011;7:31-40.  https://doi.org/10.1038/nrneurol.2010.178
  26. Lipatova LV, Alekseeva DV. The use of antioxidants in the complex therapy of patients with pharmacoresistant epilepsy. Collection of methodical recommendations. SPb. 2018;80-95. (In Russ.).
  27. Srivastava NK, Mukherjee S, Sharma R, et al. Altered lipid metabolism in post-traumatic epileptic rat model: one proposed pathway. Mol Biol Rep. 2019;46(2):1757-1773. https://doi.org/10.1007/s11033-019-04626-9
  28. Rahman S. Mitochondrial diseases and status epilepticus. Epilepsia. 2018;59(suppl 2):70-77.  https://doi.org/10.1111/epi.14485
  29. Strzelczyk A, Schubert-Bast S. Psychobehavioural and Cognitive Adverse Events of Anti-Seizure Medications for the Treatment of Developmental and Epileptic Encephalopathies. CNS Drugs. 2022;36(10):1079-1111. https://doi.org/10.1007/s40263-022-00955-9
  30. Witt J, Helmstaedter C. How can we overcome neuropsychological adverse effects of antiepileptic drugs? Expert Opin Pharmacother. 2017;18(6):551-554.  https://doi.org/10.1080/14656566.2017.1309025
  31. Elkommos S, Mula M. Current and future pharmacotherapy options for drug-resistant epilepsy. Expert Opin Pharmacother. 2022;23(18):2023-2034. https://doi.org/10.1080/14656566.2022.2128670
  32. Forouzanfar F, Majeed M, Jamialahmadi T, et al. Curcumin: A Review of Its Effects on Epilepsy. Adv Exp Med Biol. 2021;1291:363-373.  https://doi.org/10.1007/978-3-030-56153-6_21
  33. Dhir A. Natural polyphenols in preclinical models of epilepsy. Phytother Res. 2020;34(6):1268-1281. https://doi.org/10.1002/ptr.6617
  34. Akyuz E, Paudel YN, Polat AK, et al. Enlightening the neuroprotective effect of quercetin in epilepsy: From mechanism to therapeutic opportunities. Epilepsy Behav. 2021;115:107701. https://doi.org/10.1016/j.yebeh.2020.107701
  35. Nosal LA, Simonova NV, Dorovskikh VA, et al. Results of the study of the parameters of the pro- and antioxidant system in children with epilepsy. Bulletin of physiology and pathology of respiration. 2019;(74):104-110. (In Russ.). https://doi.org/10.36604/1998-5029-2019-74-104-110
  36. Javaid MS, Antonic-Baker A, Pitsillou E, et al. Alpha-lipoic acid analogues in the regulation of redox balance in epilepsy: A molecular docking and simulation study. J Mol Graph Model. 2022;112:108116. https://doi.org/10.1016/j.jmgm.2021.108116
  37. Vezzani A, Balosso S, Ravizza T. Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy. Nat Rev Neurol. 2019;15(8):459-472.  https://doi.org/10.1038/s41582-019-0217-x
  38. Xu C, Gong Y, Wang Y, Chen Z. New advances in pharmacoresistant epilepsy towards precise management-from prognosis to treatments. Pharmacol Ther. 2022;233:108026. https://doi.org/10.1016/j.pharmthera.2021.108026
  39. Vasquez A, Buraniqi E, Wirrell EC. New and emerging pharmacologic treatments for developmental and epileptic encephalopathies. Curr Opin Neurol. 2022;35(2):145-154.  https://doi.org/10.1097/WCO.0000000000001029
  40. Lou S, Cui S. Drug Treatment of Epilepsy: From Serendipitous Discovery to Evolutionary Mechanisms. Curr Med Chem. 2022;29(19):3366-3391. https://doi.org/10.2174/0929867328666210910124727
  41. Dini G, Tulli E, Dell’Isola GB, et al. Improving Therapy of Pharmacoresistant Epilepsies: The Role of Fenfluramine. Front Pharmacol. 2022;13:832929. https://doi.org/10.3389/fphar.2022.832929
  42. Shakhmardanova SA, Gulevskaya ON, Seletskaya VV, et al. Antioxidants: classification, pharmacotherapeutic properties, use in practical medicine. Journal of Fundamental Medicine and Biology. 2016;3:4-15. (In Russ.).
  43. Martusevich AK, Karuzin KA, Samoilov AS. Antioxidant therapy: current state, possibilities and prospects. Bioradicals and Antioxidants. 2018;5(1):5-23. (In Russ.).
  44. Akhtam’ianov RR, Levakov SA, Gabitova NA. Imbalance between lipid peroxidation and antioxidant defense systems in pregnant women with preeclampsia. Russian Bulletin of Obstetrician-Gynecologist. 2015;15(2):43-48. (In Russ.). https://doi.org/10.17116/rosakush201515243-48
  45. Kosman VM, Karlina MV, Tyutina KV, et al. Preclinical study of the pharmacokinetic processes of phenosanoic acid ADME in in vitro and in vivo systems. Reviews of Clinical Pharmacology and Drug Therapy. 2022;(20)3:297-308. (In Russ.). https://doi.org/10.17816/RCF203297-308
  46. Burd SG, Lebedeva AV, Pantina NV, et al. Clinical results and prospects for the use of phenosanic acid in patients with focal epilepsy. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2021;121(10):52-59. (In Russ.). https://doi.org/10.17116/jnevro202112110152
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