Potential biomarkers of early diagnosis of Alzheimer’s disease

Bogolepova A.N.; Makhnovich E.V.; Kovalenko E.A.; Osinovskaya N.A.

doi:https://doi.org/10.17116/jnevro20221220917

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Abstract:

Alzheimer’s disease (AD) is a progressive neurodegenerative disease of the brain, in which there are cognitive and behavioral disorders, but also visual impairment can occur. Deposits of beta-amyloid (Aβ) were also found in the retina of AD patients. At the same time, primary open-angle glaucoma (POAG) occupies the first place among geronto-ophthalmic pathologies in patients with AD. POAG, like AD, is a neurodegenerative disease. AD and POAG have common symptoms, and therefore several common principles for their early diagnosis can be developed. Therefore, a promising direction is the search for biomarkers for the early detection of AD and POAG. Currently, the diagnosis of early AD biomarkers in cerebrospinal fluid and biomarkers in the brain (imaging of amyloid plaques and tau positron emission tomography) are well studied, while data in literature on using these biomarkers in patients with POAG is scarce. However, the above diagnostic methods are not considered in routine clinical practice due to their invasiveness and high cost. There is a growing need for conventional, affordable biomarkers for AD and POAG, as it is necessary to start treatment of prodromal conditions from symptoms to onset of symptoms. In this connection, biomarkers such as Aβ and tau protein in blood serum and plasma are actively evaluated in patients with AD. In patients with POAG, there is no published data on studies of these biomarkers, which requires scientific research. Many authors discover the role of sirtuins (SIRT) in aging and age-related diseases, such as AD, glaucoma, age-related macular degeneration, and others. Possibly, SIRT could become potential biomarkers of neurodegenerative diseases.

Keywords:

Alzheimer’s disease

primary open-angle glaucoma

neurodegenerative process

MR-morphometry

optical coherence tomography

amyloid-β

total tau protein

hyperphosphorylated tau protein

sirtuins

Authors:

Bogolepova A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

SPIN RSCI: 6775-0279
Scopus AuthorID: 6602240836
ORCID: 0000-0002-6327-3546

Makhnovich E.V.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies

ORCID: 0000-0002-8606-5715

Kovalenko E.A.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies

ORCID: 0000-0003-0828-9868

Osinovskaya N.A.

Federal Center of Brain Research and Neurotechnologies

ORCID: 0000-0003-2313-571X

Received:

18.02.2022

Accepted:

06.04.2022

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References:

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