Anxiety-depressive disorders and stress factors in patients with systemic lupus erythematosus and antiphospholipid syndrome

Borisova A.B.

Moscow Research Institute of Psychiatry — Branch «Serbsky National Medical Research Center of Psychiatry and Narcology»;
Nasonova Research Institute of Rheumatology

Veltishchev D.Yu.

Moscow Research Institute of Psychiatry — Branch «Serbsky National Medical Research Center of Psychiatry and Narcology»;
Pirogov Russian National Research Medical University

Lisitsyna T.A.

Nasonova Research Institute of Rheumatology

Reshetnyak T.M.

Nasonova Research Institute of Rheumatology;
Russian Medical Academy of Continuing Professional Education

Seravina O.F.

Moscow Research Institute of Psychiatry — Branch «Serbsky National Medical Research Center of Psychiatry and Narcology»

Kovalevskaya O.B.

Moscow Research Institute of Psychiatry — Branch «Serbsky National Medical Research Center of Psychiatry and Narcology»

Cheldieva F.A.

Nasonova Research Institute of Rheumatology;
Russian Medical Academy of Continuing Professional Education

Abramkin A.A.

Nasonova Research Institute of Rheumatology

Anxiety-depressive disorders and stress factors in patients with systemic lupus erythematosus and antiphospholipid syndrome

Authors:

Borisova A.B., Veltishchev D.Yu., Lisitsyna T.A., Reshetnyak T.M., Seravina O.F., Kovalevskaya O.B., Cheldieva F.A., Abramkin A.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(3): 65‑71

DOI: 10.17116/jnevro202212203165

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To cite this article:

Borisova AB, Veltishchev DYu, Lisitsyna TA, et al. . Anxiety-depressive disorders and stress factors in patients with systemic lupus erythematosus and antiphospholipid syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(3):65‑71. (In Russ.)
https://doi.org/10.17116/jnevro202212203165

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

The aim of this work was to analyze the frequency and, spectrum of mental disorders (MD), and stressful factors, as well as the characteristics of anxiety and depressive spectrum disorders (ADSD) in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS).

MATERIAL AND METHODS

The study included 155 patients (37 (23.9%) men and 118 (76.1%) women) aged 18 to 69 years ((M±SD) 37.7±12.3 years), including. 61 (39.3%) patients — with a reliable diagnosis of SLE according to the 2019 EULAR/ACR criteria, 48 (30.9%) patients with — SLE with secondary APS and 46 (29.7%) — with primary APS (PAPS), established according to the international criteria of 2006.

RESULTS

The majority of the examined patients were found to hadve MD (current MD in 145 (93.5%) patients). ADSD prevailed in all groups: in 58 (95.1%) patients with SLE, in 42 (87.5%) — with SLE with APS and in, 39 (84.8%) — with APS. Patients with SLE were exposed to stressful events in childhood (predominantly parental deprivation) more often than patients with SLE with APS and PAPS were exposed to stressful events in childhood (93.4% versus 81.2% and 69.6%, respectively; predominantly parental deprivation). ADSD in these patients developed mainly in pre-adolescence, with a tendency towards chronic variants without remission, which leads to a greater vulnerability of the patients in this group to stressful events compared with patients with APS (p=0.05).

CONCLUSION

When diagnosing and treating MD in patients with SLE and APS, special attention should be paid to the analysis of the history of stressful eventsstress history of patients, which affects the formation of common predisposing and provoking factors, both MD and RD, aggravating their course and prognosis.

Keywords:

system lupus erythematosus

antiphospholipid syndrome

depression

anxiety

stress

Authors:

Borisova A.B.

Moscow Research Institute of Psychiatry — Branch «Serbsky National Medical Research Center of Psychiatry and Narcology»;
Nasonova Research Institute of Rheumatology

Veltishchev D.Yu.

Moscow Research Institute of Psychiatry — Branch «Serbsky National Medical Research Center of Psychiatry and Narcology»;
Pirogov Russian National Research Medical University

Lisitsyna T.A.

Nasonova Research Institute of Rheumatology

Reshetnyak T.M.

Nasonova Research Institute of Rheumatology;
Russian Medical Academy of Continuing Professional Education

Seravina O.F.

Moscow Research Institute of Psychiatry — Branch «Serbsky National Medical Research Center of Psychiatry and Narcology»

Kovalevskaya O.B.

Moscow Research Institute of Psychiatry — Branch «Serbsky National Medical Research Center of Psychiatry and Narcology»

Cheldieva F.A.

Nasonova Research Institute of Rheumatology;
Russian Medical Academy of Continuing Professional Education

Abramkin A.A.

Nasonova Research Institute of Rheumatology

Received:

23.11.2021

Accepted:

30.11.2021

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