Controversial and unresolved aspects of the problem of epilepsy

Karlov V.A.

Evdokimov Moscow State University of Medicine and Dentistry

Authors:

Karlov V.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(12): 101‑104

DOI: 10.17116/jnevro2022122121101

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To cite this article:

Karlov VA. Controversial and unresolved aspects of the problem of epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(12):101‑104. (In Russ.)
https://doi.org/10.17116/jnevro2022122121101

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OBJECTIVE

Based on the analysis of a comprehensive examination of patients (clinical, neuropsychological, genetic, neuroimaging) to identify the signs that distinguish/preserve the features of cryptogenic epilepsy (CE) relative to symptomatic and generalized idiopathic epilepsy (SE and IE).

MATERIAL AND METHODS

375 patients with various forms of epilepsy were examined: 231 — with SE, 66 — with IE, and 78 — with CE. All patients underwent a generally accepted clinical examination; patients were divided into two clusters: 1 cluster (to identify the distinctive features of the psychoemotional status of patients, to assess the quality of life and compare them with the severity of seizures and other indicators), 2 cluster (to determine the presence of genetic disorders in CI patients and to conduct fMRI in this group).

RESULTS

The features of psychoemotional disorders, indicators of quality of life, genetic characteristics that distinguish CE from IE and SE are established.

CONCLUSION

CE is a consequence of a combination of two main risk factors for epilepsy — 1) hereditary and 2) exogenous brain damage, but less pronounced compared to IE and CE.

Keywords:

definitions of epilepsy

genetic factor

exogenous factor

cryptogenic epilepsy

epilepsy and woman

comorbidity

Authors:

Karlov V.A.

Evdokimov Moscow State University of Medicine and Dentistry

Received:

25.01.2022

Accepted:

08.03.2022

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