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Filchenko I.A.

Sechenov Institute of Evolutionary Physiology and Biochemistry of RAS

Korostovtseva L.S.

Almazov National Medical Research Centre

Bochkarev M.V.

Almazov National Medical Research Centre

Sviryaev Yu.V.

Almazov National Medical Research Centre

Brain damage in sleep-disordered breathing: the role of glia

Authors:

Filchenko I.A., Korostovtseva L.S., Bochkarev M.V., Sviryaev Yu.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(1): 15‑22

DOI: 10.17116/jnevro202212201115

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Table of contents

BRAIN DAMAGE IN SLEEP-DISORDERED BREATHING: THE ROLE OF GLIA
BRAIN DAMAGE IN SLEEP-DISORDERED BREATHING: THE ROLE OF GLIA

To cite this article:

Filchenko IA, Korostovtseva LS, Bochkarev MV, Sviryaev YuV. Brain damage in sleep-disordered breathing: the role of glia. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(1):15‑22. (In Russ.)
https://doi.org/10.17116/jnevro202212201115

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

Sleep-disordered breathing (SDB) is one of the most prevalent sleep-wake disorders and is associated with brain damage. In this review, we describe the role of astroglia, microglia and oligodendroglia as the main cellular mediators of brain damage in SDB based on the results of experimental studies. Specifically, we describe the role of the molecules that are expressed by glia and mediate oxidative stress (NADPH-oxidase), inflammation (hypoxia-inducible factor-1, inducible nitric oxide synthase, pro- and anti-inflammatory cytokines) and sympathetic hyperactivation (ATP, lactate).

Keywords:

sleep-disordered breathing
sleep apnea
glia
astroglia
microglia
neuroplasticity
brain damage
cognitive functions

Authors:

Filchenko I.A.

Sechenov Institute of Evolutionary Physiology and Biochemistry of RAS

Korostovtseva L.S.

Almazov National Medical Research Centre

Bochkarev M.V.

Almazov National Medical Research Centre

Sviryaev Yu.V.

Almazov National Medical Research Centre

Received:

21.02.2021

Accepted:

27.08.2021

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