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Ershov A.V.

Chazov National Medical Research Center of Cardiology

Elfimova E.M.

Chazov National Medical Research Centre of Cardiology

Mikhailova O.O.

Chazov National Medical Research Centre of Cardiology

Yarovoy S.Yu.

Chazov National Medical Research Center of Cardiology

Danilov N.M.

Chazov National Medical Research Center of Cardiology

Martynyuk t.V.

Chazov National Medical Research Center of Cardiology

Litvin A.Yu.

Chazov National Medical Research Center of Cardiology;
Pirogov Russian National Research Medical University

Chazova I.E.

Chazov National Medical Research Center of Cardiology

Efficacy and safety of short-term PAP therapy (in automatic mode) in patients with sleep disordered breathing and chronic thromboembolic pulmonary hypertension

Authors:

Ershov A.V., Elfimova E.M., Mikhailova O.O., Yarovoy S.Yu., Danilov N.M., Martynyuk t.V., Litvin A.Yu., Chazova I.E.

More about the authors

Journal: Russian Cardiology Bulletin. 2025;20(4): 64‑70

DOI: 10.17116/Cardiobulletin20252004164

Read: 684 times

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Table of contents

EFFICACY AND SAFETY OF SHORT-TERM PAP THERAPY (IN AUTOMATIC MODE) IN PATIENTS WITH SLEEP DISORDERED BREATHING AND CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION
EFFICACY AND SAFETY OF SHORT-TERM PAP THERAPY (IN AUTOMATIC MODE) IN PATIENTS WITH SLEEP DISORDERED BREATHING AND CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION

To cite this article:

Ershov AV, Elfimova EM, Mikhailova OO, et al. Efficacy and safety of short-term PAP therapy (in automatic mode) in patients with sleep disordered breathing and chronic thromboembolic pulmonary hypertension. Russian Cardiology Bulletin. 2025;20(4):64‑70. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20252004164

Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To evaluate short-term APAP therapy safety and efficacy in patients with moderate-to-severe OSA and CTEPH.

MATERIAL AND METHODS

The study included 67 patients with CTEPH between December 2023 and February 2025. Clinical status, echocardiography and right heart catheterization data were assessed. All patients competed international questionnaires (STOP-Bang, Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index) and multifunctional sleep study was performed. In case of moderate-to-severe OSA, we initiated APAP therapy.

RESULTS. IN

39 patients, we diagnosed moderate-to-severe OSA and offered initiation of in-hospital APAP. Among 30 patients agreed to continue study, 5 ones refused further titration of respiratory support due to inability to sleep, and 25 patients achieved efficacy criteria (residual apnea/hypopnea index <5.0, mean night saturation> 90%) within 1.8±1.2 nights. Supplemental oxygen therapy was required in 5 patients. Safety of APAP therapy was confirmed by daily monitoring.

CONCLUSION

APAP therapy demonstrated a favorable safety and efficacy profile in patients with OSA and CTEPH. Our findings support consideration of APAP therapy as initial treatment option that can improve the quality of medical care.

Keywords:

chronic thromboembolic pulmonary hypertension
sleep-disordered breathing
obstructive sleep apnea
nocturnal hypoxemia
PAP therapy

Authors:

Ershov A.V.

Chazov National Medical Research Center of Cardiology

Elfimova E.M.

Chazov National Medical Research Centre of Cardiology

Mikhailova O.O.

Chazov National Medical Research Centre of Cardiology

Yarovoy S.Yu.

Chazov National Medical Research Center of Cardiology

Danilov N.M.

Chazov National Medical Research Center of Cardiology

Martynyuk t.V.

Chazov National Medical Research Center of Cardiology

Litvin A.Yu.

Chazov National Medical Research Center of Cardiology;
Pirogov Russian National Research Medical University

Chazova I.E.

Chazov National Medical Research Center of Cardiology

Received:

02.07.2025

Accepted:

15.07.2025

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References:

  1. Bixler EO, Vgontzas AN, Ten Have T et al. Effects of age on sleep apnea in men: I. Prevalence and severity. Am J Respir Crit Care Med. 1998;157(1):144-148.  https://doi.org/10.1164/ajrccm.157.1.9706079
  2. Olson L, King M, Hensley MJ et al. A community study of snoring and sleep-disordered breathing. Prevalence. Am J Respir Crit Care Med. 1995; 152(2):711-716. 
  3. Minic M; Granton JT; Ryan CM. Sleep disordered breathing in group 1 pulmonary arterial hypertension. J Clin Sleep Med. 2014;10(3):277-283.  https://doi.org/10.5664/jcsm.3528
  4. Orr JE, Auger WR, DeYoung PN, Kim NH, Malhotra A, Owens RL. Usefulness of Low Cardiac Index to Predict Sleep-Disordered Breathing in Chronic Thromboembolic Pulmonary Hypertension. Am J Cardiol. 2016 Mar 15;117(6):1001-5.  https://doi.org/10.1016/j.amjcard.2015.12.035
  5. Francesco Fanfulla, Eugenia Taurina, Gian Doenico Pinna et al. Sleep Disordered Breathing (SDB) and Chronic Thromboembolic Pulmonary Hypertension: the Effects of Pulmonary. Endoarterectomy European Respiratory Journal. 2017 50: PA4722. https://doi.org/10.1183/1393003.congress-2017.PA4722
  6. La Rovere MT, Fanfulla F, Taurino AE, Bruschi C, Maestri R, Robbi E, Maestroni R, Pronzato C, Pin M, D’Armini AM, Pinna GD. Chronic thromboembolic pulmonary hypertension: Reversal of pulmonary hypertension but not sleep disordered breathing following pulmonary endarterectomy. Int J Cardiol. 2018 Aug 1;264:147-152.  https://doi.org/10.1016/j.ijcard.2018.02.112
  7. Yu X, Huang Z, Zhang Y, Liu Z, Luo Q, Zhao Z, Zhao Q, Gao L, Jin Q, Yan L. Obstructive sleep apnea in patients with chronic thromboembolic pulmonary hypertension. J Thorac Dis. 2018 Oct;10(10):5804-5812. https://doi.org/10.21037/jtd.2018.09.118
  8. Nagaoka M, Goda A, Takeuchi K, Kikuchi H, Finger M, Inami T, Soejima K, Satoh T. Nocturnal Hypoxemia, But Not Sleep Apnea, Is Associated With a Poor Prognosis in Patients With Pulmonary Arterial Hypertension. Circ J. 2018 Nov 24;82(12):3076-3081. https://doi.org/10.1253/circj.CJ-18-0636
  9. Dyachenko MA, Simakova MA, Korostovtseva LS, Bochkarev MV, Goncharova NS, Sviryaev YuV, Moiseeva OM. Sleep-related breathing disorders in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Arterial’naya Gipertenziya (Arterial Hypertension). 2020;26(1):85-93. (In Russ.). https://doi.org/10.18705/1607-419X-2020-26-1-85-93
  10. Murta MS, Duarte RLM, Waetge D, Gozal D, Cardoso AP, Mello FCQ. Sleep-Disordered Breathing in Adults with Precapillary Pulmonary Hypertension: Prevalence and Predictors of Nocturnal Hypoxemia. Lung. 2022 Aug;200(4):523-530.  https://doi.org/10.1007/s00408-022-00547-w
  11. Osa in patients with chronic thromboembolic pulmonary hypertension Seckin, Zeynep Idil et al. CHEST, Volume 162, Issue 4, A2447. https://doi.org/10.1016/j.chest.2022.08.2005
  12. Çınar C, Yıldızeli ŞO, Balcan B, Yıldızeli B, Mutlu B, Peker Y. Determinants of Severe Nocturnal Hypoxemia in Adults with Chronic Thromboembolic Pulmonary Hypertension and Sleep-Related Breathing Disorders. J Clin Med. 2023 Jul 12;12(14):4639. https://doi.org/10.3390/jcm12144639
  13. Li H-T, Yuan P, Jiang R, Zhao Q-H, Sun Y-Y, Zhang J, Gong S-G, Li J-L, Qiu H-L, Wu W-H, Luo C-J, Xu J, Wang L and Liu J-M. (2024), Sleep-disordered breathing and nocturnal hypoxemia in chronic thromboembolic pulmonary disease. Intern Med J. 54: 1292-1301. https://doi.org/10.1111/imj.16359
  14. Ershov AV, Elfimova EM, Mikhailova OO, Litvin AYu, Danilov NM, Valieva ZS, Chazova IE. Sleep-related breathing disorders in patients with chronic thromboembolic pulmonary hypertension. Systemic Hypertension. 2025;22(1):27-34. (In Russ.). https://doi.org/10.38109/2075-082X-2025-1-27-34
  15. Bugaev TD, Elfimova EM, Ageeva NV, et al. Coagulation markers in patients with obstructive sleep apnea syndrome and effects of continuous positive airway pressure. Systemic Hypertension. 2016;13(4):41-46 (in Russ.)
  16. Avdeev SN, Barbarash OL, Valieva ZS, Volkov AV, Veselova TN, Galyavich AS, Goncharova NS, Gorbachevsky SV, Gramovich VV, Danilov NM, Klimenko AA, Martynyuk TV, Moiseeva OM, Ryzhkova DV, Simakova MA, Sinitsyn VE, Stukalova OV, Chazova IE, Chernogrivov IE, Shmalts AA, Tsareva NA. 2024 Clinical practice guidelines for Pulmonary hypertension, including chronic thromboembolic pulmonary hypertension. Russian Journal of Cardiology. 2024;29(11):6161. (In Russ.). https://doi.org/10.15829/1560-4071-2024-6161
  17. Litvin AYu, Chazova IE, Elfimova EM, Pevzner AV, Poluektov MG, Danilov NM, Mikhailova OO, Aksenova AV. Eurasian Association of Cardiology (EAC)/Russian society of somnologists (RSS) guidelines for the diagnosis and treatment of obstructive sleep apnea in patients with cardiovascular diseases (2024). Eurasian heart journal. 2024;(3):6-27. (In Russ.). https://doi.org/10.38109/2225-1685-2024-3-6-27
  18. Patil SP, Ayappa IA, Caples SM, Kimoff RJ, Patel SR, Harrod CG. Treatment of adult obstructive sleep apnea with positive airway pressure: an American Academy of Sleep Medicine clinical practice guideline. J Clin Sleep Med. 2019;15(2):335—343.  https://doi.org/10.5664/jcsm.7640
  19. Chung F, Yegneswaran B, Liao P et al. STOP questionnaire: a tool to screen patients for obstructive sleep apnea. Anesthesiology. 2008 May;108(5):812-21.  https://doi.org/10.1097/ALN.0b013e31816d83e4
  20. Farney RJ, Walker BS, Farney RM, Snow GL, Walker JM The STOP-Bang equivalent model and prediction of severity of obstructive sleep apnea: relation to polysomnographic measurements of the apnea/hypopnea index. J Clin Sleep Med. 2011 Oct 15;7(5):459-65B.  https://doi.org/10.5664/JCSM.1306
  21. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991 Dec;14(6):540-5.  https://doi.org/10.1093/sleep/14.6.540
  22. Rosenthal LD, Dolan DC. The Epworth sleepiness scale in the identification of obstructive sleep apnea. J Nerv Ment Dis. 2008 May;196(5):429-31.  https://doi.org/10.1097/NMD.0b013e31816ff3bf
  23. Tiede H, Rorzyczka J, Dumitrascu R, Belly M, Reichenberger F, Ghofrani HA, Seeger W, Heitmann J, Schulz R. Poor sleep quality is associated with exercise limitation in precapillary pulmonary hypertension. BMC Pulm Med. 2015 Feb 13;15:11.  https://doi.org/10.1186/s12890-015-0005-3
  24. Patel S, Jose A, Mohiuddin SS. Physiology, Oxygen Transport And Carbon Dioxide Dissociation Curve. [Updated 2023 Mar 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
  25. Gottlieb DJ, Punjabi NM, Mehra R, Patel SR, Quan SF, Babineau DC, Tracy RP, Rueschman M, Blumenthal RS, Lewis EF, Bhatt DL, Redline S. CPAP versus oxygen in obstructive sleep apnea. N Engl J Med. 2014 Jun 12;370(24):2276-85.  https://doi.org/10.1056/NEJMoa1306766
  26. Imran TF, Ghazipura M, Liu S, Hossain T, Ashtyani H, Kim B, Michael Gaziano J, Djoussé L. Effect of continuous positive airway pressure treatment on pulmonary artery pressure in patients with isolated obstructive sleep apnea: a meta-analysis. Heart Fail Rev. 2016 Sep;21(5):591-8.  https://doi.org/10.1007/s10741-016-9548-5
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