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Stulin I.D.

Moscow State University of Medicine and Dentistry n.a. A.I. Evdokimov

Tardov M.V.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

Damulin I.V.

Medical Institute of Russian Peoples’ Friendship University;
Sechenov First Moscow State Medical University (Sechenov University)

Tinnitus: clinical and pathogenetic aspects

Authors:

Stulin I.D., Tardov M.V., Damulin I.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(6): 100‑105

DOI: 10.17116/jnevro2021121061100

Read: 5848 times

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Table of contents

TINNITUS: CLINICAL AND PATHOGENETIC ASPECTS
TINNITUS: CLINICAL AND PATHOGENETIC ASPECTS

To cite this article:

Stulin ID, Tardov MV, Damulin IV. Tinnitus: clinical and pathogenetic aspects. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(6):100‑105. (In Russ.)
https://doi.org/10.17116/jnevro2021121061100

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The article discusses the pathogenetic and clinical features of tinnitus. It is emphasized that various causes contribute to the appearance of tinnitus, including somatic diseases, excess body weight, iatrogenies, otological diseases with an outcome in hearing loss. The anatomical and physiological features of the structure of the central part of the auditory system are considered. It is suggested that the occurrence of tinnitus is associated with the processes of maladaptive neuroplasticity caused by pathological changes in the neuronal activity of cortical structures of the CNS, and not with changes in the peripheral part of the auditory analyzer — the structures of the cochlea. The results of recent studies, including those using functional neuroimaging methods, indicate the significance of cortical connection disorders (human connectome) in patients with tinnitus. In patients with tinnitus, there are changes in regional neuronal activity and connections not only in the auditory cortex, but also in areas not directly related to the analysis of auditory afferentation. Thus, tinnitus can be considered as one of the variants of dysfunction of the human connectome, triggered primarily from the «auditory input».

Keywords:

review
tinnitus
maladaptive neuroplasticity
human connectome

Authors:

Stulin I.D.

Moscow State University of Medicine and Dentistry n.a. A.I. Evdokimov

Tardov M.V.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

Damulin I.V.

Medical Institute of Russian Peoples’ Friendship University;
Sechenov First Moscow State Medical University (Sechenov University)

Received:

29.06.2020

Accepted:

05.07.2020

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References:

  1. Baguley DM, Andersson G. Factor analysis of the tinnitus handicap inventory. American Journal of Audiology. 2003;12(1):31-34.  https://doi.org/10.1044/1059-0889(2003/007)
  2. Jastreboff PJ. Phantom auditory perception (tinnitus): mechanisms of generation and perception. Neuroscience Research. 1990;8(4):221-254.  https://doi.org/10.1016/0168-0102(90)90031-9
  3. Chari DA, Limb CJ. Tinnitus. Medical Clinics of North America. 2018;102(6):1081-1093. https://doi.org/10.1016/j.mcna.2018.06.014
  4. Kappel V, de Paula Moreno AC, Buss CH. Plasticity of the auditory system: Theoretical considerations. Brazilian Journal of Otorhinolaryngology. 2011;77(5):670-674.  https://doi.org/10.1590/s1808-86942011000500022
  5. Swanson LW. Basic Principles of Mammalian CNS Systems: Nervous System Organization: Connectomics and the Connectome. In: Neuroscience in the 21st Century: From Basic to Clinical. Ed. by D.W. Pfaff. Ch.44. New York etc.: Springer; 2013;1385-1420.
  6. Mesulam M-M. From sensation to cognition. Brain. 1998;121(6):1013-1052. https://doi.org/10.1093/brain/121.6.1013
  7. Roder B. Sensory deprivation and the development of multisensory integration. In: Multisensory Development. Ed. by Bremner A.J., Lewkowicz D.J., Spence C. Ch.13. Oxford: Oxford University Press; 2012.
  8. Wallace MT, Ghose D, Nidiffer AR, Fister MC, Fister JK. Development of multisensory integration in subcortical and cortical brain networks. In: Multisensory Development. Ed. by Bremner A.J., Lewkowicz D.J., Spence C. Ch.14. Oxford: Oxford University Press; 2012.
  9. Bremner AJ, Holmes NP, Spence C. The development of multisensory representations of the body and of the space around the body. In: Multisensory Development. Ed. by Bremner A.J., Lewkowicz D.J., Spence C. Ch.5. Oxford: Oxford University Press; 2012.
  10. Moller AR, Rollins PR. The non-classical auditory pathways are involved in hearing in children but not in adults. Neuroscience Letters. 2002;319(1):41-44.  https://doi.org/10.1016/s0304-3940(01)02516-2
  11. Sharma N, Classen J, Cohen LG. Neural plasticity and its contribution to functional recovery. In: Handbook of Clinical Neurology, Vol. 110 (3rd series). Neurological Rehabilitation. Barnes M.P. and Good D.C. (editors). Ch.1. msterdam etc.: Elsevier; 2013;3-12.  https://doi.org/10.1016/b978-0-444-52901-5.00001-0
  12. Takeuchi N, Izumi S-I. Maladaptive plasticity for motor recovery after stroke: mechanisms and approaches. Neural Plasticity. 2012;2012:1-9.  https://doi.org/10.1155/2012/359728
  13. Eggermont JJ, Tass PA. Maladaptive neural synchrony in tinnitus: origin and restoration. Frontiers in Neurology. 2015;6:29.  https://doi.org/10.3389/fneur.2015.00029
  14. Han Q, Zhang Y, Liu D, Wang Y, Feng Y, Yin X, Wang J. Disrupted local neural activity and functional connectivity in subjective tinnitus patients: evidence from resting-state fMRI study. Neuroradiology. 2018;60(11):1193-1201. https://doi.org/10.1007/s00234-018-2087-0
  15. Okamoto H. Manipulation of auditory inputs as rehabilitation therapy for maladaptive auditory cortical reorganization. Neural Plasticity. 2018;2018:1-9.  https://doi.org/10.1155/2018/2546250
  16. Wu C, Stefanescu RA, Martel DT, Shore SE. Tinnitus: maladaptive auditory — somatosensory plasticity. Hearing Research. 2016;334:20-29.  https://doi.org/10.1016/j.heares.2015.06.005
  17. Lamichhane B, Dhamala M. The salience network and its functional architecture in a perceptual decision: an effective connectivity study. Brain Connectivity. 2015;5(6):362-370.  https://doi.org/10.1089/brain.2014.0282
  18. Sanchez TG, da Silva Lima A, Brandao AL, Lorenzi MC, Bento RF. Somatic modulation of tinnitus: test reliability and results after repetitive muscle contraction training. Annals of Otology, Rhinology & Laryngology. 2007;116(1):30-35.  https://doi.org/10.1177/000348940711600106
  19. Baguley DM, Phillips J, Humphriss RL, Jones S, Axon PR, Moffat DA. The prevalence and onset of gaze modulation of tinnitus and increased sensitivity to noise after translabyrinthine vestibular schwannoma excision. Otology & Neurotology. 2006;27(2):220-224.  https://doi.org/10.1097/01.mao.0000172412.87778.28
  20. Rocha CA, Sanchez TG. Myofascial trigger points: another way of modulating tinnitus. Progress Brain Research. 2007;166:209-914. 
  21. Cacace AT, Cousins JP, Parnes SM, Semenoff D, Holmes T, McFarland DJ, Davenport C, Stegbauer K, Lovely TJ. Cutaneous-evoked tinnitus. Audiology and Neuro-Otology. 1999;4(5):247-257.  https://doi.org/10.1159/000013848
  22. Cullington H. Tinnitus evoked by finger movement: Brain plasticity after peripheral deafferentation. Neurology. 2001;56(7):978-979.  https://doi.org/10.1212/wnl.56.7.978
  23. Pinchoff RJ, Burkard RF, Salvi RJ, Coad ML, Lockwood AH. Modulation of tinnitus by voluntary jaw movements. American Journal of Otology. 1998;19:785-789. 
  24. Shore SE. Plasticity of somatosensory inputs to the cochlear nucleus — Implications for tinnitus. Hearing Research. 2011;281(1-2):38-46.  https://doi.org/10.1016/j.heares.2011.05.001
  25. Boyen K, de Kleine E, van Dijk P, Langers DRM. Tinnitus-related dissociation between cortical and subcortical neural activity in humans with mild to moderate sensorineural hearing loss. Hearing Research. 2014;312:48-59.  https://doi.org/10.1016/j.heares.2014.03.001
  26. Han L, Yawen L, Hao W, Chunli L, Pengfei Z, Zhengyu Z, Zhaodi W, Zhenghan Y, Shusheng G, Zhenchang W. Effects of sound therapy on resting-state functional brain networks in patients with tinnitus: A graph-theoretical-based study. Journal of Magnetic Resonance Imaging. 2019;50(6):1731-1741. https://doi.org/10.1002/jmri.26796
  27. Han L, Na Z, Chunli L, Yuchen C, Pengfei Z, Hao W, Xu C, Peng Z, Zheng W, Zhenghan Y, Shusheng G, Zhenchang W. Baseline functional connectivity features of neural network nodes can predict improvement after sound therapy through adjusted narrow band noise in tinnitus patients. Frontiers in Neuroscience. 2019;13:614.  https://doi.org/10.3389/fnins.2019.00614
  28. Johnsrude IS, Giraud AL, Frackowiak RSJ. Functional imaging of the auditory system: the use of positron emission tomography. Audiology and Neuro-Otology. 2002;7(5):251-276.  https://doi.org/10.1159/000064446
  29. Laureano MR, Onishi ET, Bressan RA, Neto PB, Castiglioni MLV, Batista IR, Reis MA, Garcia MV, de Andrade AN, Sanchez ML, Moreira HC, de Almeida RR, Garrido GJ, Jackowski AP. The effectiveness of acupuncture as a treatment for tinnitus: a randomized controlled trial using 99mTc-ECD SPECT. European Radiology. 2016;26(9):3234-3242. https://doi.org/10.1007/s00330-015-4164-7
  30. Smits M, Kovacs S, de Ridder D, Peeters RR, van Hecke P, Sunaert S. Lateralization of functional magnetic resonance imaging (fMRI) activation in the auditory pathway of patients with lateralized tinnitus. Neuroradiology. 2007;49(8):669-679.  https://doi.org/10.1007/s00234-007-0231-3
  31. Eggermont JJ. Neural substrates of tinnitus in animal and human cortex. Cortical correlates of tinnitus. HNO. 2015;63(4):298-301.  https://doi.org/10.1007/s00106-014-2980-8
  32. Maudoux A, Lefebvre P, Cabay J-E, Demertzi A, Vanhaudenhuyse A, Laureys S, Soddu A. Auditory resting-state network connectivity in tinnitus: a functional MRI study. PLoS ONE. 2012;7(5):e36222. https://doi.org/10.1371/journal.pone.0036222
  33. Norena AJ, Farley BJ. Tinnitus-related neural activity: Theories of generation, propagation, and centralization. Hearing Research. 2013;295:161-171.  https://doi.org/10.1016/j.heares.2012.09.010
  34. Minami SB, Oishi N, Watabe T, Uno K, Kaga K, Ogawa K. Auditory resting-state functional connectivity in tinnitus and modulation with transcranial direct current stimulation. Acta Oto-Laryngologica. 2015;135(12):1286-1292. https://doi.org/10.3109/00016489.2015.1068952
  35. Cai W-W, Li Z-C, Yang Q-T, Zhang T. Abnormal spontaneous neural activity of the central auditory system changes the functional connectivity in the tinnitus brain: a resting-state functional MRI study. Frontiers in Neuroscience. 2019;13:1314. https://doi.org/10.3389/fnins.2019.01314
  36. Han L, Pengfei Z, Zhaohui L, Rui L, Ling Z, Peng W, Fei Y, Liheng L, Guopeng W, Rong Z, Ting L, Cheng D, Shusheng G, Zhenchang W. Abnormal regional activity and functional connectivity in resting-state brain networks associated with etiology confirmed unilateral pulsatile tinnitus in the early stage of disease. Hearing Research. 2017;346:55-61.  https://doi.org/10.1016/j.heares.2017.02.004
  37. Song J-J, Vanneste S, Schlee W, Van de Heyning P, De Ridder D. Onset-related differences in neural substrates of tinnitus-related distress: the anterior cingulate cortex in late-onset tinnitus, and the frontal cortex in early-onset tinnitus. Brain Structure and Function. 2013;220(1):571-584.  https://doi.org/10.1007/s00429-013-0648-x
  38. Minami SB, Oishi N, Watabe T, Uno K, Ogawa K. Auditory related resting state fMRI functional connectivity in tinnitus patients. Otology & Neurotology. 2017;1(2): 34-38  https://doi.org/10.1097/mao.0000000000001626
  39. Zheng W, Peng Z, Pengfei Z, Jing L, Heyu D, Hongxia Y, Yawen L, Zhengyu Z, Shusheng G, Zhenghan Y, Han L, Zhenchang W. Long-term reactions to pulsatile tinnitus are marked by weakened short-range functional connectivity within a brain network in the right temporal lobe. Journal of Magnetic Resonance Imaging. 2019;49(6):1629-1637. https://doi.org/10.1002/jmri.26545
  40. Tai Y, Husain FT. Right-ear advantage for speech-in-noise recognition in patients with nonlateralized tinnitus and normal hearing sensitivity. Journal of the Association for Research in Otolaryngology. 2018;19(2):211-221.  https://doi.org/10.1007/s10162-017-0647-3
  41. Han L, Zhaohui L, Fei Y, Ting L, Pengfei Z, Wang D, Cheng D, Pengde G, Xiaoyi H, Xiao W, Rui L, Zhenchang W. Abnormal baseline brain activity in patients with pulsatile tinnitus: a resting-state fMRI study. Neural Plasticity. 2014;2014:1-10.  https://doi.org/10.1155/2014/549162
  42. Carpenter-Thompson JR, Schmidt SA, Husain FT. Neural plasticity of mild tinnitus: an fMRI investigation comparing those recently diagnosed with tinnitus to those that had tinnitus for a long period of time. Neural Plasticity. 2015;2015:1-11.  https://doi.org/10.1155/2015/161478
  43. Labar D, Labar AS, Edwards D. Long-term distributed repetitive transcranial magnetic stimulation for tinnitus: a feasibility study. Neuromodulation. 2016;19:249-253.  https://doi.org/10.1111/ner.12390
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