The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Chebanenko N.V.

Russian Medical Academy of Continuous Professional Education

Zykov V.P.

Russian Medical Academy Continuing Professional Education

Komarova I.B.

Russian Medical Academy Continuing Professional Education

Vergizova A.A.

Russian Medical Academy of Continuous Professional Education

Egozheva A.A.

Russian Medical Academy of Continuous Professional Education

Alternating hemiplegia with epilepsy

Authors:

Chebanenko N.V., Zykov V.P., Komarova I.B., Vergizova A.A., Egozheva A.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(3): 121‑126

DOI: 10.17116/jnevro2021121031121

Views: 2092

Downloaded: 90

Download PDF (RU)
Contact the author
Table of contents

ALTERNATING HEMIPLEGIA WITH EPILEPSY
ALTERNATING HEMIPLEGIA WITH EPILEPSY

To cite this article:

Chebanenko NV, Zykov VP, Komarova IB, Vergizova AA, Egozheva AA. Alternating hemiplegia with epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(3):121‑126. (In Russ.)
https://doi.org/10.17116/jnevro2021121031121

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
МСФ на ЯМ
Close metadata
Recommended articles:
Epilepsy with PCDH19 muta­tion: poly­pharmacy as a consequence of the complexity and dive­rsity of pathogenesis mechanisms. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(7):51-55
Study of the practice of prescribing phenosanic acid in epilepsy acco­mpanied by asthenic diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(7):89-97
Personality profile caused by epilepsy acco­rding to the «Big Five» model. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):16-21
Brain microstructural abno­rmalities asse­ssed by diffusion kurtosis MRI in patients with focal temporal lobe epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):171-177
Ototoxicity caused by anti-epileptic drugs. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):14-19
Abse­nce status epilepticus in adults. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):47-56
Como­rbid anxiety diso­rders in patients with neurological pathology: current state of the problem and the role of etifoxine in treatment stra­tegy. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):126-136
Auto­nomic cardiovascular diso­rders in patients with epileptic and psychogenic non-epileptic seizures: a pilot study. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(2):13-20
A personalized approach to the diagnosis of epilepsy in obese children. Labo­ratory Service. 2025;(1):5-12

A clinical case of a genetically confirmed diagnosis of alternating hemiplegia associated with epilepsy is presented. The combination of two types of seizures in a child made it difficult to make a diagnosis. The result of video-EEG monitoring made it possible to understand that a child showed both epileptic seizures and non-epileptic seizures simultaneously with different periodicities. The mutation in the ATP1A3 gene was verified with genome-wide sequencing and targeted therapy was prescribed in a timely manner. As a result, both types of seizures stopped after treatment.

Keywords:

alternating hemiplegia
epilepsy
ATP1A3 gene
non-epileptic seizure
nystagmus

Authors:

Chebanenko N.V.

Russian Medical Academy of Continuous Professional Education

Zykov V.P.

Russian Medical Academy Continuing Professional Education

Komarova I.B.

Russian Medical Academy Continuing Professional Education

Vergizova A.A.

Russian Medical Academy of Continuous Professional Education

Egozheva A.A.

Russian Medical Academy of Continuous Professional Education

Received:

09.04.2020

Accepted:

20.04.2020

List of references:

  1. Heinzen EL, Swoboda KJ, Hitomi Y, et al. De novo mutations in ATP1A3 cause alternating hemiplegia of childhood. Nat Genet. 2012;44(9):1030-1034. https://doi.org/10.1038/ng.2358
  2. Sweney MT, Silver K, Gerard-Blanluet M, et al. Alternating hemiplegia of childhood: early characteristics and evolution of a neurodevelopmental syndrome. Pediatrics. 2009;123(3):e534-541.  https://doi.org/10.1542/peds.2008-2027
  3. Rosewich H, Thiele H, Ohlenbusch A, et al. Heterozygous de-novo mutations in ATP1A3 in patients with alternating hemiplegia of childhood: a whole-exome sequencing gene-identification study. Lancet Neurol. 2012;11(9):764-773.  https://doi.org/10.1016/S1474-4422(12)70182-5
  4. Panagiotakaki E, Gobbi G, Neville B, et al. Evidence of a non-progressive course of alternating hemiplegia of childhood: study of a large cohort of children and adults. Brain. 2010;133(12):3598-3610. https://doi.org/10.1093/brain/awq295
  5. Li M, Jazayeri D, Corry B, et al. A functional correlate of severity in alternating hemiplegia of childhood. Neurobiol Dis. 2015;77:88-93.  https://doi.org/10.1016/j.nbd.2015.02.002
  6. Duan BC, Wong LC, Lee WT. Alternating hemiplegia and paroxysmal torticollis caused by SCN4A mutation. A new phenotype? Neurology. 2019;93:673-674.  https://doi.org/10.1212/WNL.0000000000008212
  7. Lingrel JB, Williams MT, Vorhees CV, Moseley AE. Na, K-ATPase and the role of alpha isoforms in behaviour. J Bioenerg Biomembr. 2007;39(5-6):385-389.  https://doi.org/10.1007/s10863-007-9107-9
  8. Uchitel J, Helseth A, Prange L, et al. The epileptology of alternating hemiplegia of childhood. Neurology. 2019;93(13):1248-1259. https://doi.org/10.1212/WNL.0000000000008159
  9. Gergont A, Kaciński M. Alternating hemiplegia of childhood: New diagnostic options. Neurol Neurochir Pol. 2014;48(2):130-135.  https://doi.org/10.1016/j.pjnns.2013.05.003
  10. Luo R. Diagnosis of alternating hemiplegia of childhood. Zhongguo Dang Dai Er Ke Za Zhi. 2017;19(9):959-961.  https://doi.org/10.7499/j.issn.1008-8830.2017.09.004
  11. Samanta D. Management of Alternating Hemiplegia of Childhood: A review. Pediatric Neurology. 2020;103:12-20.  https://doi.org/10.1016/j.pediatrneurol.2019.10.003
  12. Sasaki M, Matsufuji H, Inui T, Arima K. Absence of small-vessel abnormalities in alternating hemiplegia of childhood. Brain Dev. 2011;33:390-393.  https://doi.org/10.1016/j.braindev.2010.08.011
  13. Kanavakis E, Xaidara A, Papathanasiou-Klontza D, et al. Alternating hemiplegia of childhood: a syndrome inherited with an autosomal dominant trait. Dev Med Child Neurol. 2003;45:833-836.  https://doi.org/10.1017/s0012162203001543
  14. Pisciotta L, Gherzi M, Stagnaro M, et al. Alternating Hemiplegia of Childhood: Pharmacological treatment of 30 Italian patients. Brain Dev. 2017;39(6):521-528.  https://doi.org/10.1016/j.braindev.2017.02.001
  15. Di Rosa G, Spanó M, Pustorino G, et al. Alternating hemiplegia of childhood successfully treated with topiramate: 18 months of follow up. Neurology. 2006;66(1):146.  https://doi.org/10.1212/01.wnl.0000191401.37260.f5

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.