The role of functional brain activity in the impairment of inhibitory control in alcohol dependence

Galkin S.A.; Bokhan N.A.

doi:https://doi.org/10.17116/jnevro202112111167

Galkin S.A.

Mental Health Research Institute of the Tomsk National Research Medical Center of the Russian Academy of Science

ORCID: 0000-0002-7709-3917

Bokhan N.A.

Mental Health Research Institute of the Tomsk National Research Medical Center of the Russian Academy of Science

ORCID: 0000-0002-1052-855X

The role of functional brain activity in the impairment of inhibitory control in alcohol dependence

Authors:

Galkin S.A., Bokhan N.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(11): 67‑72

DOI: 10.17116/jnevro202112111167

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To cite this article:

Galkin SA, Bokhan NA. The role of functional brain activity in the impairment of inhibitory control in alcohol dependence. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(11):67‑72. (In Russ.)
https://doi.org/10.17116/jnevro202112111167

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

Использование инфографики авторами научных работ

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Abstract:

OBJECTIVE

Determination of differences in brain function in alcohol—dependent patients with varying degrees of inhibitory control impairment.

MATERIAL AND METHODS

Seventy-five patients with alcohol dependence were examined. The level of inhibitory control was assessed using the Go/No-go test. The background electric activity of the brain was recorded, and the values of spectral power and coherence of theta, alpha, and beta rhythms were analyzed. Two groups of patients — 24 with- and 51 without inhibitory control impairment — were determined.

RESULTS

According to the spectral analysis, high values of alpha rhythm in the frontal-central-parietal-occipital and beta rhythm in the central and left occipital cortex, low values of theta rhythm in the posterior-temporal regions were common for patients with inhibitory control impairment. Visual analysis of the EEG in patients with inhibitory control impairment shows a smoothing of zonal differences in the alpha rhythm, which is not found in patients without the disturbance of inhibitory control. Patients with inhibitory control impairment were characterized by an increase in interhemispheric connections in the alpha and beta frequency ranges and a weakening of intrahemispheric connections on the right in the theta rhythm range.

CONCLUSION

There are significant differences in the functioning of the brain in patients with alcoholism, depending on the presence / absence of inhibitory control impairment.

Keywords:

alcohol dependence

inhibitory control

electroencephalography

power

coherence

Authors:

Galkin S.A.

Mental Health Research Institute of the Tomsk National Research Medical Center of the Russian Academy of Science

ORCID: 0000-0002-7709-3917

Bokhan N.A.

Mental Health Research Institute of the Tomsk National Research Medical Center of the Russian Academy of Science

ORCID: 0000-0002-1052-855X

Received:

01.05.2021

Accepted:

03.06.2021

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References:

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