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Sergeeva S.P.

Sechenov First Moscow State Medical University (Sechenov University)

Savin A.A.

Yevdokimov Moscow State University of Medicine and Dentistry

Litvitsky P.F.

Sechenov First Moscow State Medical University (Sechenov University)

Lyundup A.V.

Sechenov First Moscow State Medical University (Sechenov University)

Breslavich I.D.

Sechenov First Moscow State Medical University (Sechenov University)

Manasova Z.Sh.

Sechenov First Moscow State Medical University (Sechenov University)

Neurohumoral response and Fas-ligand-induced apoptosis in peripheral blood of patients with acute ischemic stroke

Authors:

Sergeeva S.P., Savin A.A., Litvitsky P.F., Lyundup A.V., Breslavich I.D., Manasova Z.Sh.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(6): 57‑63

DOI: 10.17116/jnevro202012006157

Read: 2063 times

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Table of contents

NEUROHUMORAL RESPONSE AND FAS-LIGAND-INDUCED APOPTOSIS IN PERIPHERAL BLOOD OF PATIENTS WITH ACUTE ISCHEMIC STROKE
NEUROHUMORAL RESPONSE AND FAS-LIGAND-INDUCED APOPTOSIS IN PERIPHERAL BLOOD OF PATIENTS WITH ACUTE ISCHEMIC STROKE

To cite this article:

Sergeeva SP, Savin AA, Litvitsky PF, Lyundup AV, Breslavich ID, Manasova ZSh. Neurohumoral response and Fas-ligand-induced apoptosis in peripheral blood of patients with acute ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(6):57‑63. (In Russ.)
https://doi.org/10.17116/jnevro202012006157

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To identify an effect of the neurohumoral response on the severity and orientation of Fas-ligand-initiated processes in the acute period of IS.

MATERIAL AND METHODS

The study included 155 patients with IS in the territory of the left and right middle cerebral arteries, the control group consisted of 28 people. The National Institutes of Health Stroke Scale (NIHSS), the Hospital Anxiety and Depression Scale (HADS), and the Daily Life Stress scale were used. Concentrations of sFas, sFasL, cortisol (K), adrenaline (A), norepinephrine (NE), adrenocorticotropic hormone (ACTH) in the blood plasma of patients with IS were measured by enzyme-linked immunosorbent assay on days 1, 7 and 21 and once in the control group. CD3CD95+ lymphocytes phenotyping was performed using flow cytometry.

RESULTS AND CONCLUSION

The hypothalamic-pituitary-adrenal axis dominance is associated with the activation of the apoptosis-inducing properties of peripheral blood in the first week after the IS onset and their decrease towards the end of the acute period, which is clinically represented by the increased levels of anxiety and depression, an unfavorable outcome of the acute period of IS.

Keywords:

ischemic stroke
stress response
neurohumoral regulation
Fas-ligand
apoptosis
rehabilitation

Authors:

Sergeeva S.P.

Sechenov First Moscow State Medical University (Sechenov University)

Savin A.A.

Yevdokimov Moscow State University of Medicine and Dentistry

Litvitsky P.F.

Sechenov First Moscow State Medical University (Sechenov University)

Lyundup A.V.

Sechenov First Moscow State Medical University (Sechenov University)

Breslavich I.D.

Sechenov First Moscow State Medical University (Sechenov University)

Manasova Z.Sh.

Sechenov First Moscow State Medical University (Sechenov University)

Received:

19.01.2020

Accepted:

19.02.2020

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