Проблема коморбидности эпилепсии и психогенных пароксизмов

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Представлен обзор научной литературы преимущественно последних двух десятилетий. Установлено, что психогенные пароксизмы наблюдаются примерно у 12% пациентов с эпилепсией. При анализе социально-демографических показателей, данных анамнеза, семиологических характеристик, результатов электрофизиологических и нейровизуализационных исследований однозначных коррелятов развития коморбидности выявлено не было. Тем не менее отмечено значение для ее возникновения фармакорезистентности эпилепсии, психотравмирующих событий в анамнезе и умственной отсталости. «Золотым стандартом» диагностики коморбидности эпилепсии и психогенных пароксизмов является видео-электроэнцефалографический мониторинг. Лечение случаев сочетания эпилепсии и психогенных пароксизмов проводится минимально эффективными дозами противоэпилептических препаратов в сочетании с когнитивно-поведенческой психотерапией.

Ключевые слова:

эпилепсия

коморбидность

диссоциативные судороги

психогенные неэпилептические пароксизмы

конверсионное расстройство

Авторы:

Кутлубаев М.А.

ГБУЗ «Республиканская клиническая больница им. Г.Г. Куватова»; ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России

Менделевич В.Д.

ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава России

Дюкова Г.М.

ГБУЗ «Московский клинический научно-практический центр им. А.С. Логинова» Департамента здравоохранения Москвы

Белоусова Е.Д.

Научно-исследовательский клинический институт педиатрии ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России

Даты поступления:

28.03.2019

Даты принятия в печать:

23.01.2020

Список литературы:

Espay AJ, Aybek S, Carson A, Edwards MJ, Goldstein LH, Hallett M, LaFaver K, LaFrance WC Jr, Lang AE, Nicholson T, Nielsen G, Reuber M, Voon V, Stone J, Morgante F. Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders. JAMA Neurol. 2018 Sep 1;75(9):1132-1141. https://doi.org/10.1001/jamaneurol.2018.1264
Железнова Е.В., Калинин В.В., Ким Е.В., Земляная А.А., Соколова Л.В. Конверсионные расстройства при эпилепсии. Российский психиатрический журнал. 2018;3:45-52.
Kutlubaev MA, Xu Y, Hackett ML, Stone J. Dual diagnosis of epilepsy and psychogenic nonepileptic seizures: Systematic review and meta-analysis of frequency, correlates, and outcomes. Epilepsy Behav. 2018;89:70-78. https://doi.org/10.1016/j.yebeh.2018.10.010
Lesser RP. Psychogenic seizures. Neurology. 1996;46:1499-1507. https://doi.org/10.1212/wnl.46.6.1499
Brown RJ, Reuber M. Towards an integrative theory of psychogenic non-epileptic seizures (PNES). Clin Psychol Rev. 2016;47:55-70. https://doi.org/10.1016/j.cpr.2016.06.003
Osman A, Seri S, Cavanna AE. Clinical characteristics of patients with epilepsy in a specialist neuropsychiatry service. Epilepsy Behav. 2016;58:44-47. https://doi.org/10.1016/j.yebeh.2016.02.033
Whitehead K, O’Sullivan S,Walker M. Impact of psychogenic nonepileptic seizures on epilepsy presurgical investigation and surgical outcomes. Epilepsy Behav. 2015;46:246-248. https://doi.org/10.1016/j.yebeh.2015.01.017
Vincentiis S, Valente KD, Thomé-Souza S, Kuczinsky E, Fiore LA, Negrão N. Risk factors for psychogenic nonepileptic seizures in children and adolescents with epilepsy. Epilepsy Behav. 2006;8:294-298. https://doi.org/10.1016/j.yebeh.2005.08.014
Villalobos R, Gonzales E. Non-epileptic seizures in a population of diagnosed pediatric epilepsy patients. Epilepsy Curr. 2015;15:12.274. Abstract.
Sigurdardottir KR, Olafsson E. Incidence of psychogenic seizures in adults: A population-based study in Iceland. Epilepsia. 1998;39:749-752. https://doi.org/10.1111/j.1528-1157.1998.tb01161.x
Szaflarski JP, Ficker DM, Cahill WT, Privitera MD. Four-year incidence of 397 nonepileptic seizures in Hamilton County, OH. Neurology. 2000;55:1561-1563. https://doi.org/10.1212/wnl.55.10.1561
Elliott JO, Charyton C. Biopsychosocial predictors of psychogenic non-epileptic seizures. Epilepsy Res. 2014;108:1543-1553. https://doi.org/10.1016/j.eplepsyres.2014.09.003
Reuber M, Qurishi A, Bauer J, Helmstaedter C, Fernandez G, Widman G, Elger CE. Are there physical risk factors for psychogenic non-epileptic seizures in patients with epilepsy? Seizure. 2003;12:561-567. https://doi.org/10.1016/s1059-1311(03)00064-5
Markoula S, De Tisi J, Foong J, Duncan JS. Psychogenic nonepileptic seizures after adult epilepsy surgery. Epilepsy Curr. 2013;13:3.271. Abstract.
Glosser G, Roberts D, Glosser DS. Nonepileptic seizures after resective epilepsy surgery. Epilepsia. 1999;40:1750-1754. https://doi.org/10.1111/j.1528-1157.1999.tb01593.x
Asadi-Pooya AA, Emami M. Demographic and clinical manifestations of psychogenic non-epileptic seizures: The impact of co-existing epilepsy in patients or their family members. Epilepsy Behav. 2013;27:1-3. https://doi.org/10.1016/j.yebeh.2012.12.010
O’Sullivan SS, Spillane JE, McMahon EM, Sweeney BJ, Galvin RJ, McNamara B, Cassidy EM. Clinical characteristics and outcome of patients diagnosed with psychogenic nonepileptic seizures: A 5-year review. Epilepsy Behav. 2007;11:77-84. https://doi.org/10.1016/j.yebeh.2007.04.003
Cragar DE, Schmitt FA, Berry DTR, Cibula JE, Dearth CM, Fakhoury TA. A Comparison of MMPI-2 Decision Rules in the Diagnosis of Nonepileptic Seizures. J Clin Exp Neuropsychol. 2003;25:793-804. https://doi.org/10.1076/jcen.25.6.793.16471
Sadan O, Neufeld MY, Parmet Y, Rozenberg A, Kipervasser S. Psychogenic seizures: Long-term outcome in patients with and without epilepsy. Acta Neurol Scand. 2016;133:145-151. https://doi.org/10.1111/ane.12458
Turner K, Piazzini A, Chiesa V, Barbieri V, Vignoli A, Gardella E, Tisi G, Scarone S, Canevini MP, Gambini O. Patients with epilepsy and patients with psychogenic non-epileptic seizures: Video-EEG, clinical and neuropsychological evaluation. Seizure. 2011;20:706-710. https://doi.org/10.1016/j.seizure.2011.07.001
Kuyk J, Swinkels WAM, Spinhoven P. Psychopathologies in patients with nonepileptic seizures with and without comorbid epilepsy: How different are they? Epilepsy Behav. 2003;4:13-18. https://doi.org/10.1016/s1525-5050(02)00683-2
Wissel BD, Dwivedi AK, Gaston TE, Rodriguez-Porcel FJ, Aljaafari D, Hopp JL, Krumholz A, van der Salm SMA, Andrade DM, Borlot F, Moseley BD, Cavitt JL, Williams S, Stone J, LaFrance WC Jr, Szaflarski JP, Espay AJ. Which patients with epilepsy are at risk for psychogenic nonepileptic seizures (PNES)? A multicenter case–control study. Epilepsy Behav. 2016;61:180-184. https://doi.org/10.1016/j.yebeh.2016.05.032
Baheti NN, Radhakrishnan A, Radhakrishnan K. A critical appraisal on the utility of long-term video-EEG monitoring in older adults. Epilepsy Res. 2011;97:12-19. https://doi.org/10.1016/j.eplepsyres.2011.06.014
Bayly J, Carino J, Petrovski S, Smit M, Fernando DA, Vinton A, Yan B, Gubbi JR, Palaniswami MS, O’Brien TJ. Time-frequency mapping of the rhythmic limb movements distinguishes convulsive epileptic from psychogenic nonepileptic seizures. Epilepsia. 2013;54:1402-1408. https://doi.org/10.1111/epi.12207
Cohen RJ, Suter C. Hysterical seizures: Suggestion as a provocative EEG test. Ann Neurol. 1982;11:391-395. https://doi.org/10.1002/ana.410110413
Dhiman V, Sinha S, Rawat VS, Vijaysagar KJ, Thippeswamy H, Srinath S, Chaturvedi SK, Satishchandra P. Children with psychogenic non-epileptic seizures (PNES): A detailed semiologic analysis and modified new classification. Brain Dev. 2014;36:287-283. https://doi.org/10.1016/j.braindev.2013.05.002
Caller TA, Chen JJ, Harrington JJ, Bujarski KA, Jobst BC. Predictors for readmissions after video-EEG monitoring. Neurology. 2014;83:450-455. https://doi.org/10.1212/wnl.0000000000000647
Dhiman V, Sinha S, Rawat VS, Harish T, Chaturvedi SK, Satishchandra P. Semiological characteristics of adults with psychogenic nonepileptic seizures (PNESs): An attempt towards a new classification. Epilepsy Behav. 2013;27:422-427. https://doi.org/10.1016/j.yebeh.2013.03.005
Devinsky O, Sanchez-Villaseñor F, Vazquez B, Kothari M, Alper K, Luciano D. Clinical profile of patients with epileptic and nonepileptic seizures. Neurology. 1996;46:1530-1533. https://doi.org/10.1212/wnl.46.6.1530
Baroni G, Martins WA, Piccinini V, da Rosa MP, de Paola L, Paglioli E, Margis R, Palmini A. Neuropsychiatric features of the coexistence of epilepsy and psychogenic nonepileptic seizures. J Psychosom Res. 2018 Aug;111:83-88. https://doi.org/10.1016/j.jpsychores.2018.05.014
Ristic AJ, Petrovic I, Vojvodic N, Janković S, Sokić D. Phenomenology and psychiatric origins of psychogenic non-epileptic seizures. Srp Arh Celok Lek. 2004;132:22-27. https://doi.org/10.2298/sarh0402022r
Pillai JA, Haut SR. Patients with epilepsy and psychogenic non-epileptic seizures: An inpatient video-EEG monitoring study. Seizure. 2012;21:24-27. https://doi.org/10.1016/j.seizure.2011.09.002
Lancman ME, Brotherton TA, Asconapé JJ, Penry JK. Psychogenic seizures in adults: a longitudinal analysis. Seizure. 1993;2:281-286. https://doi.org/10.1016/s1059-1311(05)80141-4
Massot-Tarrús A, McLachlan RS. Marijuana use in adults admitted to a Canadian epilepsy monitoring unit. Epilepsy Behav. 2016;63:73-78.
Martin R, Burneo JG, Prasad A, Powell T, Faught E, Knowlton R, Mendez M, Kuzniecky R. Frequency of epilepsy in patients with psychogenic seizures monitored by video-EEG. Neurology. 2003;61:1791-1792. https://doi.org/10.1212/01.wnl.0000098890.13946.f5
Rabe F. Die Kombination Hysterischer und epileptische Anfalle. Schriftenreihe Neurologie, Neurology Series. Band 5, Springer-Verlag 1970. https://doi.org/10.1007/978-3-642-86292-2
Niedermayer E, Blumer D, Holscher E, Walker BA. Classical hysterical seizures facilitated by anticonvulsant toxicity. Psychiatr Clin (Basel). 1970;3:71-84. https://doi.org/10.1159/000278594
Blumer B, Adamolekun B. Treatment of patients with coexisting epileptic and nonepileptic seizures. Epilepsy Behav. 2006;9:498-502. https://doi.org/10.1016/j.yebeh.2006.07.001
Devinsky O, Gordon E. Epileptic seizures progressing into nonepileptic conversion seizures. Neurology. 1998;51:1293-1296. https://doi.org/10.1212/wnl.51.5.1293
Widdess-Walsh P, Nadkarni S, Devinsky O. Comorbidity of Epileptic and Psychogenic Nonepileptic Seizures Diagnostic Considerations in Book. In: JR Gates, AJ Rowan (Eds.), Non-Epileptic Seizures. Third Edition ed. SC Shachter and WC LeFrance. 2010;5:58-70. https://doi.org/10.1017/9781316275450.006
D’Alessio L, Giagante B, Oddo S, Silva W W, Solís P, Consalvo D, Kochen S. Psychiatric disorders in patients with psychogenic non-epileptic seizures, with and without comorbid epilepsy. Seizure. 2006;15:333-339. https://doi.org/10.1016/j.seizure.2006.04.003
Galimberti C, Ratti M, Murelli R, Sartori I, Zanotta N, Manni R, Tartara A. Non-epileptic psychogenic seizures: Clinical and psychological findings. Bol. Lega It. Epil. 1998;327-328.
Galimberti CA, Teresa Ratti M, Murelli R, Marchioni E, Manni R, Tartara A. Patients with psychogenic nonepileptic seizures, alone or epilepsy-associated, share a psychological profile distinct from that of epilepsy patients. J Neurol. 2003;250:338-346. https://doi.org/10.1007/s00415-003-1009-0
Asadi-Pooya AA, Emami Y, Emami M, Sperling MR. Prolonged psychogenic nonepileptic seizures or pseudostatus. Epilepsy Behav. 2014;31:304-306. https://doi.org/10.1016/j.yebeh.2013.10.019
Karatas H, Irsel Tezer F, Dericioglu N, Saygi S. Pitfalls of Psychogenic Non-epileptic Status Epilepticus. Brain Impairment. 2013;13:333-338. https://doi.org/10.1017/brimp.2012.30
Ziemba KS, Drazkowski JF. Driving safety in people with non-epileptic events. Epilepsy Curr. 2015;15:247.
Lelliott PT, Fenwick P. Cerebral pathology in pseudoseizures. Acta Neurol Scand. 1991;83:129-132. https://doi.org/10.1111/j.1600-0404.1991.tb04661.x
Lempert T, Schmidt D. Natural history and outcome of psychogenic seizures: a clinical study in 50 patients. J Neurol. 1990;237:35-38. https://doi.org/10.1007/bf00319665
Mcsweeney M, Reuber M, Levita L. Neuroimaging studies in patients with psychogenic non-epileptic seizures: A systematic meta-review. Neuroimage Clin. 2017 Jul 27;16:210-221. https://doi.org/10.1016/j.nicl.2017.07.025
Reuber M, Fernandez G, Bauer J, Singh DD, Elger CE. Interictal EEG abnormalities in patients with psychogenic nonepileptic seizures. Epilepsia. 2002;43:1013-1020. https://doi.org/10.1046/j.1528-1157.2002.52301.x
Konikkara JJ, Pacheco J, Van Ness P, Agostini M, Hays R, Howe-Martin L, Culver CB, Munoz J, Ding K, Modur P, Gupta P. Unique characteristics of patients with comorbid epileptic and psychogenic nonepileptic seizures. Epilepsy Curr. 2015;15:426-427.
Yadav A, Agarwal R, Park J. Outcome of psychogenic nonepileptic seizures (PNES) in children: A 2-year follow-up study. Epilepsy Behav. 2015;53:168-173. https://doi.org/10.1016/j.yebeh.2015.10.017
Holmes GL, Sackellares JC, McKiernan J, Ragland M, Dreifuss FE. Evaluation of childhood pseudoseizures using EEG telemetry and video tape monitoring. J Pediatr. 1980;97:554-558. https://doi.org/10.1016/s0022-3476(80)80008-4
Szabõ L, Siegler Z, Zubek L, Liptai Z, Körhegyi I, Bánsági B, Fogarasi A. A detailed semiologic analysis of childhood psychogenic nonepileptic seizures. Epilepsia. 2012;53:565-570. https://doi.org/10.1111/j.1528-1167.2012.03404.x
Rawat VS, Dhiman V, Sinha S Vijay Sagar KJ, Thippeswamy H, Chaturvedi SK, Srinath S, Satishchandra P. Comorbidities and outcome of childhood psychogenic non-epileptic seizures — An observational study. Seizure. 2015;25:95-98. https://doi.org/10.1016/j.seizure.2014.09.011
van Ool JS, Haenen AI, Snoeijen-Schouwenaars FM, Aldenkamp AP, Hendriksen JGM, Schelhaas HJ, Tan IY, Lazeron RHC, Bodde NMG. Psychogenic nonepileptic seizures in adults with epilepsy and intellectual disability: A neglected area. Seizure. 2018;59:67-71. https://doi.org/10.1016/j.seizure.2018.05.002
Neill JC, Alvarez N. Differential diagnosis of epileptic versus pseudoepileptic seizures in developmentally disabled persons. Appl Res Ment Retard. 1986;7:285-298. https://doi.org/10.1016/s0270-3092(86)80002-9
Kretschmer E. Hysteria. New York: Nervous and Mental Disease Publ. Co.; 1926. https://doi.org/10.1097/00005053-192607000-00084
Baslet G. Psychogenic non-epileptic seizures: A model of their pathogenic mechanism. Seizure. 2011;20(1):1–13. https://doi.org/10.1016/j.seizure.2010.10.032
Galtrey CM, Mula M, Cock HR. Stress and epilepsy: Fact or fiction, and what can we do about it? Pract Neurol. 2016;16:270-278. https://doi.org/10.1136/practneurol-2015-001337
Berg AT, Altalib HH, Devinsky O. Psychiatric and behavioral comorbidities in epilepsy: A critical reappraisal. Epilepsia. 2017;58:1123-1130. https://doi.org/10.1111/epi.13766
Frontera AT Jr. Classification of seizures and epilepsy syndromes. In: Husain AM, Tran TT, editors. Department of Veteran Affairs epilepsy manual. San Francisco: Epilepsy Centers of Excellence, Department of Veterans Affairs; 2014.
Chen DK, Graber KD, Anderson CT, Fisher RS. Sensitivity and specificty of video alone versus electroencephalography alone for the diagnosis of partial seizures. Epilepsy Behav. 2008;13:115-118. https://doi.org/10.1016/j.yebeh.2008.02.018
LaFrance WC Jr, Reuber M, Goldstein LH. Management of psychogenic nonepileptic seizures. Epilepsia. 2013;54(Suppl 1):53-67.
Chen DK, Sharma E, LaFrance WC Jr. Psychogenic Non-Epileptic Seizures. Curr Neurol Neurosci Rep. 2017;17(9):71. https://doi.org/10.1007/s11910-017-0781-7

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