The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Kutlubaev M.A.

Bashkir State Medical University

Mendelevich V.D.

Kazan State Medical University

Dyukova G.M.

Loginov Moscow Clinical Research Practical Center

Belousova E.D.

Research Clinical Institute of Pediatric of Pirogov Russian National Research Medical University

The problem of comorbidity of epilepsy and psychogenic paroxysms

Authors:

Kutlubaev M.A., Mendelevich V.D., Dyukova G.M., Belousova E.D.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(5): 138‑145

DOI: 10.17116/jnevro2020120051138

Views: 2966

Downloaded: 70

Download PDF (RU)
Contact the author
Table of contents

THE PROBLEM OF COMORBIDITY OF EPILEPSY AND PSYCHOGENIC PAROXYSMS
THE PROBLEM OF COMORBIDITY OF EPILEPSY AND PSYCHOGENIC PAROXYSMS

To cite this article:

Kutlubaev MA, Mendelevich VD, Dyukova GM, Belousova ED. The problem of comorbidity of epilepsy and psychogenic paroxysms. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(5):138‑145. (In Russ.)
https://doi.org/10.17116/jnevro2020120051138

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
МСФ на ЯМ
Close metadata
Recommended articles:
Long-term follow-up of adult patients with serial and status course of epileptic seizures. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(4):63-68
Features of cognitive impairment in bipo­lar affe­ctive diso­rder. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(6):15-19
Fluvoxamine in the treatment of anxiety-depressive spectrum diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(6):101-109
Epilepsy with PCDH19 muta­tion: poly­pharmacy as a consequence of the complexity and dive­rsity of pathogenesis mechanisms. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(7):51-55
Anxiety diso­rders as como­rbid conditions in neuropsychiatric diseases in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(7):56-64
Study of the practice of prescribing phenosanic acid in epilepsy acco­mpanied by asthenic diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(7):89-97
Personality profile caused by epilepsy acco­rding to the «Big Five» model. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):16-21
Clinical and epidemiological features of atopic type of alopecia areata. Russian Journal of Clinical Dermatology and Vene­reology. 2024;(2):155-160
Continuum of type 2 diabetes mellitus and its como­rbidity with other soma­tic diseases. Russian Journal of Preventive Medi­cine. 2024;(9):123-129
Features of como­rbidity pathology in young people. Russian Journal of Preventive Medi­cine. 2024;(11):63-69

A review of publications over the last two decades is presented. Psychogenic paroxysms develop in approximately 12% of patients with epilepsy. The analysis of social and demographic data, history details, semiological features and results of electrophysiological and neuroimaging studies does not unequivocally support the comorbidity of epilepsy and psychogenic paroxysms. The pathogenetic mechanisms of the development of comorbidity are various and depend on the presence of pharmacoresistance, psychological traumas in the past, intellectual disability etc. Video-EEG-monitoring is the gold standard in the diagnosis of comorbidity of epilepsy and psychogenic paroxysms. Treatment of such cases includes anticonvulsants and cognitive-behavioral therapy.

Keywords:

epilepsy
comorbidity
dissociative convulsions
psychogenic non-epileptic paroxysms
conversion disorder

Authors:

Kutlubaev M.A.

Bashkir State Medical University

Mendelevich V.D.

Kazan State Medical University

Dyukova G.M.

Loginov Moscow Clinical Research Practical Center

Belousova E.D.

Research Clinical Institute of Pediatric of Pirogov Russian National Research Medical University

Received:

28.03.2019

Accepted:

23.01.2020

List of references:

  1. Espay AJ, Aybek S, Carson A, Edwards MJ, Goldstein LH, Hallett M, LaFaver K, LaFrance WC Jr, Lang AE, Nicholson T, Nielsen G, Reuber M, Voon V, Stone J, Morgante F. Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders. JAMA Neurol. 2018 Sep 1;75(9):1132-1141. https://doi.org/10.1001/jamaneurol.2018.1264
  2. Zheleznova EV, Kalinin VV, Kim EV, Zemlyanaya AA, Sokolova LV. Conversion disorders in epilepsy. Rossijskii psikhiatricheskii zhurnal. 2018;3:45-52. 
  3. Kutlubaev MA, Xu Y, Hackett ML, Stone J. Dual diagnosis of epilepsy and psychogenic nonepileptic seizures: Systematic review and meta-analysis of frequency, correlates, and outcomes. Epilepsy Behav. 2018;89:70-78.  https://doi.org/10.1016/j.yebeh.2018.10.010
  4. Lesser RP. Psychogenic seizures. Neurology. 1996;46:1499-1507. https://doi.org/10.1212/wnl.46.6.1499
  5. Brown RJ, Reuber M. Towards an integrative theory of psychogenic non-epileptic seizures (PNES). Clin Psychol Rev. 2016;47:55-70.  https://doi.org/10.1016/j.cpr.2016.06.003
  6. Osman A, Seri S, Cavanna AE. Clinical characteristics of patients with epilepsy in a specialist neuropsychiatry service. Epilepsy Behav. 2016;58:44-47.  https://doi.org/10.1016/j.yebeh.2016.02.033
  7. Whitehead K, O’Sullivan S,Walker M. Impact of psychogenic nonepileptic seizures on epilepsy presurgical investigation and surgical outcomes. Epilepsy Behav. 2015;46:246-248.  https://doi.org/10.1016/j.yebeh.2015.01.017
  8. Vincentiis S, Valente KD, Thomé-Souza S, Kuczinsky E, Fiore LA, Negrão N. Risk factors for psychogenic nonepileptic seizures in children and adolescents with epilepsy. Epilepsy Behav. 2006;8:294-298.  https://doi.org/10.1016/j.yebeh.2005.08.014
  9. Villalobos R, Gonzales E. Non-epileptic seizures in a population of diagnosed pediatric epilepsy patients. Epilepsy Curr. 2015;15:12.274. Abstract.
  10. Sigurdardottir KR, Olafsson E. Incidence of psychogenic seizures in adults: A population-based study in Iceland. Epilepsia. 1998;39:749-752.  https://doi.org/10.1111/j.1528-1157.1998.tb01161.x
  11. Szaflarski JP, Ficker DM, Cahill WT, Privitera MD. Four-year incidence of 397 nonepileptic seizures in Hamilton County, OH. Neurology. 2000;55:1561-1563. https://doi.org/10.1212/wnl.55.10.1561
  12. Elliott JO, Charyton C. Biopsychosocial predictors of psychogenic non-epileptic seizures. Epilepsy Res. 2014;108:1543-1553. https://doi.org/10.1016/j.eplepsyres.2014.09.003
  13. Reuber M, Qurishi A, Bauer J, Helmstaedter C, Fernandez G, Widman G, Elger CE. Are there physical risk factors for psychogenic non-epileptic seizures in patients with epilepsy? Seizure. 2003;12:561-567.  https://doi.org/10.1016/s1059-1311(03)00064-5
  14. Markoula S, De Tisi J, Foong J, Duncan JS. Psychogenic nonepileptic seizures after adult epilepsy surgery. Epilepsy Curr. 2013;13:3.271. Abstract.
  15. Glosser G, Roberts D, Glosser DS. Nonepileptic seizures after resective epilepsy surgery. Epilepsia. 1999;40:1750-1754. https://doi.org/10.1111/j.1528-1157.1999.tb01593.x
  16. Asadi-Pooya AA, Emami M. Demographic and clinical manifestations of psychogenic non-epileptic seizures: The impact of co-existing epilepsy in patients or their family members. Epilepsy Behav. 2013;27:1-3.  https://doi.org/10.1016/j.yebeh.2012.12.010
  17. O’Sullivan SS, Spillane JE, McMahon EM, Sweeney BJ, Galvin RJ, McNamara B, Cassidy EM. Clinical characteristics and outcome of patients diagnosed with psychogenic nonepileptic seizures: A 5-year review. Epilepsy Behav. 2007;11:77-84.  https://doi.org/10.1016/j.yebeh.2007.04.003
  18. Cragar DE, Schmitt FA, Berry DTR, Cibula JE, Dearth CM, Fakhoury TA. A Comparison of MMPI-2 Decision Rules in the Diagnosis of Nonepileptic Seizures. J Clin Exp Neuropsychol. 2003;25:793-804.  https://doi.org/10.1076/jcen.25.6.793.16471
  19. Sadan O, Neufeld MY, Parmet Y, Rozenberg A, Kipervasser S. Psychogenic seizures: Long-term outcome in patients with and without epilepsy. Acta Neurol Scand. 2016;133:145-151.  https://doi.org/10.1111/ane.12458
  20. Turner K, Piazzini A, Chiesa V, Barbieri V, Vignoli A, Gardella E, Tisi G, Scarone S, Canevini MP, Gambini O. Patients with epilepsy and patients with psychogenic non-epileptic seizures: Video-EEG, clinical and neuropsychological evaluation. Seizure. 2011;20:706-710.  https://doi.org/10.1016/j.seizure.2011.07.001
  21. Kuyk J, Swinkels WAM, Spinhoven P. Psychopathologies in patients with nonepileptic seizures with and without comorbid epilepsy: How different are they? Epilepsy Behav. 2003;4:13-18.  https://doi.org/10.1016/s1525-5050(02)00683-2
  22. Wissel BD, Dwivedi AK, Gaston TE, Rodriguez-Porcel FJ, Aljaafari D, Hopp JL, Krumholz A, van der Salm SMA, Andrade DM, Borlot F, Moseley BD, Cavitt JL, Williams S, Stone J, LaFrance WC Jr, Szaflarski JP, Espay AJ. Which patients with epilepsy are at risk for psychogenic nonepileptic seizures (PNES)? A multicenter case–control study. Epilepsy Behav. 2016;61:180-184.  https://doi.org/10.1016/j.yebeh.2016.05.032
  23. Baheti NN, Radhakrishnan A, Radhakrishnan K. A critical appraisal on the utility of long-term video-EEG monitoring in older adults. Epilepsy Res. 2011;97:12-19.  https://doi.org/10.1016/j.eplepsyres.2011.06.014
  24. Bayly J, Carino J, Petrovski S, Smit M, Fernando DA, Vinton A, Yan B, Gubbi JR, Palaniswami MS, O’Brien TJ. Time-frequency mapping of the rhythmic limb movements distinguishes convulsive epileptic from psychogenic nonepileptic seizures. Epilepsia. 2013;54:1402-1408. https://doi.org/10.1111/epi.12207
  25. Cohen RJ, Suter C. Hysterical seizures: Suggestion as a provocative EEG test. Ann Neurol. 1982;11:391-395.  https://doi.org/10.1002/ana.410110413
  26. Dhiman V, Sinha S, Rawat VS, Vijaysagar KJ, Thippeswamy H, Srinath S, Chaturvedi SK, Satishchandra P. Children with psychogenic non-epileptic seizures (PNES): A detailed semiologic analysis and modified new classification. Brain Dev. 2014;36:287-283.  https://doi.org/10.1016/j.braindev.2013.05.002
  27. Caller TA, Chen JJ, Harrington JJ, Bujarski KA, Jobst BC. Predictors for readmissions after video-EEG monitoring. Neurology. 2014;83:450-455.  https://doi.org/10.1212/wnl.0000000000000647
  28. Dhiman V, Sinha S, Rawat VS, Harish T, Chaturvedi SK, Satishchandra P. Semiological characteristics of adults with psychogenic nonepileptic seizures (PNESs): An attempt towards a new classification. Epilepsy Behav. 2013;27:422-427.  https://doi.org/10.1016/j.yebeh.2013.03.005
  29. Devinsky O, Sanchez-Villaseñor F, Vazquez B, Kothari M, Alper K, Luciano D. Clinical profile of patients with epileptic and nonepileptic seizures. Neurology. 1996;46:1530-1533. https://doi.org/10.1212/wnl.46.6.1530
  30. Baroni G, Martins WA, Piccinini V, da Rosa MP, de Paola L, Paglioli E, Margis R, Palmini A. Neuropsychiatric features of the coexistence of epilepsy and psychogenic nonepileptic seizures. J Psychosom Res. 2018 Aug;111:83-88.  https://doi.org/10.1016/j.jpsychores.2018.05.014
  31. Ristic AJ, Petrovic I, Vojvodic N, Janković S, Sokić D. Phenomenology and psychiatric origins of psychogenic non-epileptic seizures. Srp Arh Celok Lek. 2004;132:22-27.  https://doi.org/10.2298/sarh0402022r
  32. Pillai JA, Haut SR. Patients with epilepsy and psychogenic non-epileptic seizures: An inpatient video-EEG monitoring study. Seizure. 2012;21:24-27.  https://doi.org/10.1016/j.seizure.2011.09.002
  33. Lancman ME, Brotherton TA, Asconapé JJ, Penry JK. Psychogenic seizures in adults: a longitudinal analysis. Seizure. 1993;2:281-286.  https://doi.org/10.1016/s1059-1311(05)80141-4
  34. Massot-Tarrús A, McLachlan RS. Marijuana use in adults admitted to a Canadian epilepsy monitoring unit. Epilepsy Behav. 2016;63:73-78. 
  35. Martin R, Burneo JG, Prasad A, Powell T, Faught E, Knowlton R, Mendez M, Kuzniecky R. Frequency of epilepsy in patients with psychogenic seizures monitored by video-EEG. Neurology. 2003;61:1791-1792. https://doi.org/10.1212/01.wnl.0000098890.13946.f5
  36. Rabe F. Die Kombination Hysterischer und epileptische Anfalle. Schriftenreihe Neurologie, Neurology Series. Band 5, Springer-Verlag 1970. https://doi.org/10.1007/978-3-642-86292-2
  37. Niedermayer E, Blumer D, Holscher E, Walker BA. Classical hysterical seizures facilitated by anticonvulsant toxicity. Psychiatr Clin (Basel). 1970;3:71-84.  https://doi.org/10.1159/000278594
  38. Blumer B, Adamolekun B. Treatment of patients with coexisting epileptic and nonepileptic seizures. Epilepsy Behav. 2006;9:498-502.  https://doi.org/10.1016/j.yebeh.2006.07.001
  39. Devinsky O, Gordon E. Epileptic seizures progressing into nonepileptic conversion seizures. Neurology. 1998;51:1293-1296. https://doi.org/10.1212/wnl.51.5.1293
  40. Widdess-Walsh P, Nadkarni S, Devinsky O. Comorbidity of Epileptic and Psychogenic Nonepileptic Seizures Diagnostic Considerations in Book. In: JR Gates, AJ Rowan (Eds.), Non-Epileptic Seizures. Third Edition ed. SC Shachter and WC LeFrance. 2010;5:58-70.  https://doi.org/10.1017/9781316275450.006
  41. D’Alessio L, Giagante B, Oddo S, Silva W W, Solís P, Consalvo D, Kochen S. Psychiatric disorders in patients with psychogenic non-epileptic seizures, with and without comorbid epilepsy. Seizure. 2006;15:333-339.  https://doi.org/10.1016/j.seizure.2006.04.003
  42. Galimberti C, Ratti M, Murelli R, Sartori I, Zanotta N, Manni R, Tartara A. Non-epileptic psychogenic seizures: Clinical and psychological findings. Bol. Lega It. Epil. 1998;327-328. 
  43. Galimberti CA, Teresa Ratti M, Murelli R, Marchioni E, Manni R, Tartara A. Patients with psychogenic nonepileptic seizures, alone or epilepsy-associated, share a psychological profile distinct from that of epilepsy patients. J Neurol. 2003;250:338-346.  https://doi.org/10.1007/s00415-003-1009-0
  44. Asadi-Pooya AA, Emami Y, Emami M, Sperling MR. Prolonged psychogenic nonepileptic seizures or pseudostatus. Epilepsy Behav. 2014;31:304-306.  https://doi.org/10.1016/j.yebeh.2013.10.019
  45. Karatas H, Irsel Tezer F, Dericioglu N, Saygi S. Pitfalls of Psychogenic Non-epileptic Status Epilepticus. Brain Impairment. 2013;13:333-338.  https://doi.org/10.1017/brimp.2012.30
  46. Ziemba KS, Drazkowski JF. Driving safety in people with non-epileptic events. Epilepsy Curr. 2015;15:247. 
  47. Lelliott PT, Fenwick P. Cerebral pathology in pseudoseizures. Acta Neurol Scand. 1991;83:129-132.  https://doi.org/10.1111/j.1600-0404.1991.tb04661.x
  48. Lempert T, Schmidt D. Natural history and outcome of psychogenic seizures: a clinical study in 50 patients. J Neurol. 1990;237:35-38.  https://doi.org/10.1007/bf00319665
  49. Mcsweeney M, Reuber M, Levita L. Neuroimaging studies in patients with psychogenic non-epileptic seizures: A systematic meta-review. Neuroimage Clin. 2017 Jul 27;16:210-221.  https://doi.org/10.1016/j.nicl.2017.07.025
  50. Reuber M, Fernandez G, Bauer J, Singh DD, Elger CE. Interictal EEG abnormalities in patients with psychogenic nonepileptic seizures. Epilepsia. 2002;43:1013-1020. https://doi.org/10.1046/j.1528-1157.2002.52301.x
  51. Konikkara JJ, Pacheco J, Van Ness P, Agostini M, Hays R, Howe-Martin L, Culver CB, Munoz J, Ding K, Modur P, Gupta P. Unique characteristics of patients with comorbid epileptic and psychogenic nonepileptic seizures. Epilepsy Curr. 2015;15:426-427. 
  52. Yadav A, Agarwal R, Park J. Outcome of psychogenic nonepileptic seizures (PNES) in children: A 2-year follow-up study. Epilepsy Behav. 2015;53:168-173.  https://doi.org/10.1016/j.yebeh.2015.10.017
  53. Holmes GL, Sackellares JC, McKiernan J, Ragland M, Dreifuss FE. Evaluation of childhood pseudoseizures using EEG telemetry and video tape monitoring. J Pediatr. 1980;97:554-558.  https://doi.org/10.1016/s0022-3476(80)80008-4
  54. Szabõ L, Siegler Z, Zubek L, Liptai Z, Körhegyi I, Bánsági B, Fogarasi A. A detailed semiologic analysis of childhood psychogenic nonepileptic seizures. Epilepsia. 2012;53:565-570.  https://doi.org/10.1111/j.1528-1167.2012.03404.x
  55. Rawat VS, Dhiman V, Sinha S Vijay Sagar KJ, Thippeswamy H, Chaturvedi SK, Srinath S, Satishchandra P. Comorbidities and outcome of childhood psychogenic non-epileptic seizures — An observational study. Seizure. 2015;25:95-98.  https://doi.org/10.1016/j.seizure.2014.09.011
  56. van Ool JS, Haenen AI, Snoeijen-Schouwenaars FM, Aldenkamp AP, Hendriksen JGM, Schelhaas HJ, Tan IY, Lazeron RHC, Bodde NMG. Psychogenic nonepileptic seizures in adults with epilepsy and intellectual disability: A neglected area. Seizure. 2018;59:67-71.  https://doi.org/10.1016/j.seizure.2018.05.002
  57. Neill JC, Alvarez N. Differential diagnosis of epileptic versus pseudoepileptic seizures in developmentally disabled persons. Appl Res Ment Retard. 1986;7:285-298.  https://doi.org/10.1016/s0270-3092(86)80002-9
  58. Kretschmer E. Hysteria. New York: Nervous and Mental Disease Publ. Co.; 1926. https://doi.org/10.1097/00005053-192607000-00084
  59. Baslet G. Psychogenic non-epileptic seizures: A model of their pathogenic mechanism. Seizure. 2011;20(1):1–13.  https://doi.org/10.1016/j.seizure.2010.10.032
  60. Galtrey CM, Mula M, Cock HR. Stress and epilepsy: Fact or fiction, and what can we do about it? Pract Neurol. 2016;16:270-278.  https://doi.org/10.1136/practneurol-2015-001337
  61. Berg AT, Altalib HH, Devinsky O. Psychiatric and behavioral comorbidities in epilepsy: A critical reappraisal. Epilepsia. 2017;58:1123-1130. https://doi.org/10.1111/epi.13766
  62. Frontera AT Jr. Classification of seizures and epilepsy syndromes. In: Husain AM, Tran TT, editors. Department of Veteran Affairs epilepsy manual. San Francisco: Epilepsy Centers of Excellence, Department of Veterans Affairs; 2014.
  63. Chen DK, Graber KD, Anderson CT, Fisher RS. Sensitivity and specificty of video alone versus electroencephalography alone for the diagnosis of partial seizures. Epilepsy Behav. 2008;13:115-118.  https://doi.org/10.1016/j.yebeh.2008.02.018
  64. LaFrance WC Jr, Reuber M, Goldstein LH. Management of psychogenic nonepileptic seizures. Epilepsia. 2013;54(Suppl 1):53-67. 
  65. Chen DK, Sharma E, LaFrance WC Jr. Psychogenic Non-Epileptic Seizures. Curr Neurol Neurosci Rep. 2017;17(9):71.  https://doi.org/10.1007/s11910-017-0781-7

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.