The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Kovrov G.V.

GBOU VPO Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova

Medvedeva A.V.

Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia

Aronson A.V.

Sechenov First Moscow State Medical Univesity, Moscow, Russia

Berleva Yu.V.

Sechenov First Moscow State Medical Univesity, Moscow, Russia

Esyunina I.S.

Sechenov First Moscow State Medical Univesity, Moscow, Russia

Kulikova V.S.

Sechenov First Moscow State Medical Univesity, Moscow, Russia

Marshanskaya M.A.

Sechenov First Moscow State Medical Univesity, Moscow, Russia

Daytime sleepiness and cognitive disorders in elderly patients

Authors:

Kovrov G.V., Medvedeva A.V., Aronson A.V., Berleva Yu.V., Esyunina I.S., Kulikova V.S., Marshanskaya M.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(1): 96‑102

DOI: 10.17116/jnevro202012001196

Read: 11716 times

Download PDF (RU)
Contact the author
Table of contents

DAYTIME SLEEPINESS AND COGNITIVE DISORDERS IN ELDERLY PATIENTS
DAYTIME SLEEPINESS AND COGNITIVE DISORDERS IN ELDERLY PATIENTS

To cite this article:

Kovrov GV, Medvedeva AV, Aronson AV, Berleva YuV, Esyunina IS, Kulikova VS, Marshanskaya MA. Daytime sleepiness and cognitive disorders in elderly patients. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(1):96‑102. (In Russ.)
https://doi.org/10.17116/jnevro202012001196

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Cognitive impairment in patients with Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):81-90
Como­rbidity of depression and deme­ntia: epidemiological, biological and therapeutic aspe­cts. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):113-121
Acti­vation of endo­genous mechanisms of sano­genesis in cognitive impairment in cere­bral small vessel disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):7-13
Cognitive impairment in bili­nguals with neurological diseases. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):26-29
Modern aspe­cts of chro­nic cere­bral ischemia pathogenetic therapy. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):106-113
The rela­tionship between neuropsychological indi­cators and neuroimaging changes acco­rding to MRI morphometry in patients with Alzheimer’s disease and glaucoma. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):142-152
Non-invasive biomarkers for early diagnosis of Alzheimer’s disease in bodily fluids. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(1):8-16
Nutritional care for patients with neurodegenerative diseases in the outpatient practice of a neurologist. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(1):76-83
Inflammatory aging. Part 1. The principal biochemical mechanisms. Russian Journal of Preventive Medi­cine. 2024;(12):145-150
Inflammatory aging. Part 2. Are there diagnostic biomarkers available. Russian Journal of Preventive Medi­cine. 2025;(1):89-95
Abstract:

Data on the contribution of daytime sleepiness to cognitive impairment in elderly patients are presented. Currently, diagnostic methods of daytime sleepiness, which include diaries, neurological, clinical and instrumental tools, are used. It has been shown that daytime sleepiness correlates with different types of dementia that suggests the involvement of common neurochemical mechanisms. Multiple studies report that daytime sleepiness increases the risk of dementia in elderly people. Future research of daytime sleepiness could be focused on its clinical and paraclinical presentations to facilitate the prognosis of dementia.

Keywords:

aging
daytime sleepiness
cognitive impairment
dementia

Authors:

Kovrov G.V.

GBOU VPO Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova

Medvedeva A.V.

Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia

Aronson A.V.

Sechenov First Moscow State Medical Univesity, Moscow, Russia

Berleva Yu.V.

Sechenov First Moscow State Medical Univesity, Moscow, Russia

Esyunina I.S.

Sechenov First Moscow State Medical Univesity, Moscow, Russia

Kulikova V.S.

Sechenov First Moscow State Medical Univesity, Moscow, Russia

Marshanskaya M.A.

Sechenov First Moscow State Medical Univesity, Moscow, Russia

Close metadata

References:

  1. Pahwa P, Karunanayake CP, Hagel L, Gjevre JA, Rennie D, Lawson J, Dosman JA. Prevalence of high Epworth Sleepiness Scale scores in a rural population. Canadian Respiratory Journal. 2012;19(2):10-14. https://doi.org/10.1155/2012/287309
  2. Kovrov GV. Brief Guidelines of clinical somnology. M.: MEDpress-inform; 2018. (In Russ.)
  3. Kalinkin AL Incidence of excessive daytime sleepness in Russian Federation. Nervno-Mishechnie Bolesni. 2018;8(4):43-48. (In Russ.) https://doi.org/10.17650/2222-8721-2018-8-4-43-48
  4. Omori Y, Kanbayashi T, Imanishi A, Tsutsui K, Sagawa Y, Kikuchi YS, Takeshima M, Yoshizawa K, Uemura S, Shimizu T. Orexin/hypocretin levels in the cerebrospinal fluid and characteristics of patients with myotonic dystrophy type 1 with excessive daytime sleepiness. Neuropsychiatr Dis Treat. 2018;14:451-457. https://doi.org/10.2147/NDT.S158651
  5. Hays RD, Stewart AL, Ware JE. Measuring functioning and well-being: The Medical Outcomes Study approach. Durham, NC: Duke University Press; 1992. https://doi.org/10.7249/CB361
  6. Viala-Danten M, Martin S, Guillemin I, Hays RD. Evaluation of the reliability and validity of the Medical Outcomes Study sleep scale in patients with painful diabetic peripheral neuropathy during an international clinical trial. Health Qual Life Outcomes. 2008;6:113. https://doi.org/10.1186/1477-7525-6-113
  7. Kovalson VM. The role of orexin system in regulation of cyclewakefulnessand sleep. Effectivnaya farmakoterapia. Nevrologia. (Spec vipusk «Son i ego rasstroistva». 2016;4. (In Russ.)
  8. XieL, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, O’Donnell J, Christensen DJ, Nicholson C, Iliff1 JJ, Takano T, Deane R, Nedergaard M. Sleep drives metabolite clearance from the adult brain. Science. 2013;342:373-377. https://doi.org/10.1126/science.1241224
  9. Liguori C, Nuccetelli M, Izzia F, Sancesario G, Romigi A, Martorana A, Amoroso C, Bernardini S, Marciani MG, Mercuri NB, Placidi F. Rapid eye movement sleep disruption and sleep fragmentation are associated with increased orexin-A cerebrospinal-fluid levels in mild cognitive impairment due to Alzheimer’s disease. Neurobiology of Aging. 2016;40:120-126. https://doi.org/10.1016/j.neurobiolaging.2016.01.007
  10. Koval'zon VM, Dolgih VV, Regulation of sleep—wakefulness cycle. Nevrologicheskij zhurnal. 2016;21(6):316-322. (In Russ.) https://doi.org/10.18821/1560-9545-2016-21-6-316-322
  11. Nieto-Alamilla G, Márquez-Gómez R, García-Gálvez A-N, Morales-Figueroa G-E, Arias-Montaño J-A. The Histamine H3 Receptor: Structure, Pharmacology, and Function. Molecular Pharmacology. 2016;90(5):649-673. https://doi.org/10.1124/mol.116.104752
  12. Keage HA, Banks S, Yang KL, Morgan K, Brayne C, Matthews FE. What sleep characteristics predict cognitive decline in the elderly? Sleep Med. 2012;13:886-892. https://doi.org/10.1016/j.sleep.2012.02.003
  13. Kasanuki K, Ferman TJ, Murray ME, Heckman MG, Pedraza O, Al-Shaikha FSH, Mishima T, Diehl NN, van Gerpen JA, Uitti RJ, Wszolek ZK, Graff-Radford NR, Dickson DW. Daytime sleepiness in dementia with Lewy bodies is associated with neuronal depletion of the nucleus basalis of Meynert. Parkinsonism Relat Disord. 2018;50:99-103. https://doi.org/10.1016/j.parkreldis.2018.02.003
  14. Claustrata B, Leston J. Melatonin: Physiological effects in humans. Neurochirurgie. 2015;61(2-3):77-84. https://doi.org/10.1016/j.neuchi.2015.03.002
  15. Shukla M, Govitrapong P, Boontem P, Reiter RJ, Satayavivad J. mechanisms of melatonin in alleviating Alzheimer’s Disease. Curr Neuropharmacol. 2017;15(7):1010-1031. https://doi.org/10.2174/1570159X15666170313123454
  16. Peng CX, Hu J, Liu D, Hong XP, Wu YY, Zhu LQ, Wang JZ. Disease-modified glycogen synthase kinase-3β intervention by melatonin arrests the pathology and memory deficits in an Alzheimer’s animal model. Neurobiology of Aging. 2013;34(6):1555-1563. https://doi.org/10.1016/j.neurobiolaging.2012.12.010
  17. Carvalho DZ, St Louis EK, Knopman DS, Boeve BF. Lowe Association of excessive daytime sleepiness with longitudinal β-amyloid accumulation in elderly persons without dementia. JAMA Neurology. 2018;75(6):672-680. https://doi.org/10.1001/jamaneurol.2018.0049
  18. Bendlin BB, Racine AM, Okonkwo OC, Christian BT, Koscik RL, Sager MA, Asthana S, Johnson SC, Benca RM, Sprecher KE. Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults. Neurobiology of Aging. 2015;36:2568-2576. https://doi.org/10.1016/j.neurobiolaging.2015.05.004
  19. Bendlin BB, Racine AM, Okonkwo OC, Christian BT, Koscik RL, Sager MA, Asthana S, Johnson SC, Benca RM, Sprecher KE. Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults. Neurobiology of Aging. 2015;36:2568-2576. https://doi.org/10.1016/j.neurobiolaging.2015.05.004
  20. Nodel MR, Yahno NN, Ukrainceva Yu.V Hypersomnia in Parkinson disease. Nevrologicheskiy Journal. 2014;19(6):9-16. (In Russ.) https://doi.org/10.18821/1560-9545-2014-19-6-9-16
  21. Louveau A, Smirnov I, Keyes TJ. Structural and functional features of central nervous system lymphatics. Nature. 2015;523(7560):337-341. https://doi.org/10.1038/nature14432
  22. Ramanan VK, Risacher SL, Nho K, Kim S, Shen L, McDonald BC, Yoder KK, Hutchins GD, West JD, Tallman EF, Gao S, Foroud TM, Farlow MR, De Jager PL, Bennett DA, Aisen PS, Petersen RC, Jack CRJr, Toga AW, Green RC, Jagust WJ, Weiner Michael W, Saykin AJ. GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer’s disease implicates microglial activation gene IL1RAP. Brain. 2015;138(Pt 10):3076-3088. https://doi.org/10.1093/brain/awv231
  23. Nikolenko VN, Oganesyan MV, Yahno NN, Orlov EA, Porubaeva EE, Popova EYu. Glimphatic system of the brain: functional anatomy and clinical perspectives. Nevrologia, Neuropsychiatria, Psychosomatica. 2018;10(4):94-100. (In Russ.) https://doi.org/10.14412/2074-2711-2018-4-94-100
  24. Ferrie JE, Shipley MJ, Akbaraly TN, Marmot MG, Kivimäki M, Singh-Manoux A. Change in sleep duration and cognitive function: Findings from the Whitehall II Study. Sleep. 2011;34:565-573. https://doi.org/10.1093/sleep/34.5.565
  25. Virta JJ, Heikkila K, Perola M, Koskenvuo M, Räihä I, Rinne JO, Kaprio J. Midlife sleep characteristics associated with late life cognitive function. Sleep. 2013;36:1533-1541. https://doi.org/10.5665/sleep.3052
  26. van Oostrom SH, Nooyens ACJ, van Boxtel MPJ. Verschuren Long sleep duration is associated with lower cognitive function among middle-age adults — the Doetinchem Cohort Study. Sleep Med. 2018;41:78-85. https://doi.org/10.1016/j.sleep.2017.07.029
  27. Ohara T, Honda T, Hata J. Association between daily sleep duration and risk of dementia and mortality in a Japanese community. Journal of the American Geriatrics Society. 2018;66(10):1911-1918. https://doi.org/10.1111/jgs.15446
  28. Benito-Leon J, Bermejo-Pareja F, Vega S, Louis ED. Total daily sleep duration and the risk of dementia: A prospective population-based study. Eur J Neurol. 2009;16:990-997. https://doi.org/10.1111/j.1468-1331.2009.02618.x
  29. Hahn EA, Wang HX, Andel R, Fratiglioni L. A change in sleep pattern may predict Alzheimer disease. Am J Geriatr Psychiatry. 2014;22:1262-1271. https://doi.org/10.1016/j.jagp.2013.04.015
  30. Foley D, Monjan A, Masaki K, Ross W, Havlik R, White L, Launer L. Daytime sleepiness is associated with 3-year incident dementia and cognitive decline in older Japanese-American men. J Am Geriatr Soc. 2001;49:1628-1632. https://doi.org/10.1046/j.1532-5415.2001.t01-1-49271.x
  31. Cagnin A, Fragiacomo F, Camporese G, Turco M, Bussè C, Ermani M, Montagnese S. Sleep-wake profile in dementia with Lewy bodies, Alzheimer’s disease, and normal aging. Journal of Alzheimer’s Disease. 2017;55:1529-1536. https://doi.org/10.3233/JAD-160385
  32. Merlino G, Piani A. Sleep Med. Daytime sleepiness is associated with dementia and cognitive decline in older Italian adults: a population-based study. Sleep Medicine. 2010;11(4):372-377. https://doi.org/10.1016/j.sleep.2009.07.018
  33. Haba-Rubio J, Marti-Soler H, Tobback N, Andries D, Marques-Vidal P, Waeber G, Vollenweider P, von Gunten A, Preisig M, Castelao E, Tafti M, Heinzer R, Popp J. Sleep characteristics and cognitive impairment in the general population. The Hypno Laus study. 2017;88(5):463-469. https://doi.org/10.1212/WNL.0000000000003557
  34. Keage HA, Banks S, Yang KL, Morgan K, Brayne C, Matthews EF. What sleep characteristics predict cognitive decline in the elderly? Sleep Med. 2012;13:886-892. https://doi.org/10.1016/j.sleep.2012.02.003
  35. Ohayon MM, Vecchierini MF. Daytime sleepiness and cognitive impairment in the elderly population. Archives of Internal Medicine. 2002;162(2):201-208. https://doi.org/10.1001/archinte.162.2.201
  36. Ramos AR, Gardener H, Rundek T, Elkind MSV, Boden-Albala B, Dong C, Cheung YK, Stern Y, Sacco RL, Wrightet CB. Sleep disturbances and cognitive decline in the Northern Manhattan Study. Neurology. 2016;87:1511-1516. https://doi.org/10.1212/WNL.0000000000003168
  37. Gronewold J, Haensel R, Kleinschnitz C, Frohnhofen H, Hermann DM. Sleep-disordered breathing in hospitalized geriatric patients with mild dementia and Its association with cognition, emotion and mobility. Int J Environ Res Public Health. 2019;16(5):863. https://doi.org/10.3390/ijerph16050863
  38. Yaffe K, Laffan AM, Harrison SL, Redline S, Spira AP, Ensrud KE, Ancoli-Israel S, Stone KL. Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA. 2011;306(6):613-619. https://doi.org/10.1001/jama.2011.1115
  39. Zhou J, Camacho M, Tang X, Kushida CA. A review of neurocognitive function and obstructive sleep apnea with or without daytime sleepiness. Sleep Med. 2016;23:99-108. https://doi.org/10.1016/j.sleep.2016.02.008
  40. Gagnon K, Gosselin N. Detection of mild cognitive impairment in middle-aged and older adults with obstructive sleep apnoea: does excessive daytime sleepiness play a role? European Respiratory Journal. 2019;53:1802113. https://doi.org/10.1183/13993003.02113-2018
  41. Rozzini L, Conti M, Riva M, Ceraso A, Caratozzolo S, Zanetti M, Padovani A. Non-amnestic mild cognitive impairment and sleep complaints: a bidirectional relationship? Aging Clinical and Experimental Research. 2018;30(6):661-668. https://doi.org/10.1007/s40520-017-0814-8
  42. Ferman TJ, Smith GE, Dickson DW, Graff Radford NR, Chi Lin S, Wszolek ZK, Van Gerpen JA, Uitti R, Knopman DS, Petersen RC, Parisi JE, Silber MH, Boeve BF. Abnormal daytime sleepiness in dementia with Lewy bodies compared to Alzheimer’s disease using the Multiple Sleep Latency Test. Alzheimer’s Research and Therapy. 2014;6(9):76. https://doi.org/10.1186/s13195-014-0076-z
  43. Simuni T, Caspell-Garcia C, Coffey C, Chahine LM, Lasch S, Oertel WH, Mayer G, Högl B, Postuma R, Videnovic A, Amara AW, Marek K. Correlates of excessive daytime sleepiness in de novo Parkinson’s disease: A case control study. Movement Disorders. 2015;30(10):1371-1381. https://doi.org/10.1002/mds.26248
  44. Elwood PC, Bayer AJ, Fish M, Pickering J, Mitchell C, Gallacher JEJ. Sleep disturbance and daytime sleepiness predict vascular dementia. Journal of Epidemiology & Community Health. 2011;65:820-824. https://doi.org/10.1136/jech.2009.100503
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.