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Moiseev D.A.

Pirogov Russian National Research Medical University

Zueva A.A.

Pirogov Russian National Research Medical University

Kopetsky I.S.

Pirogov Russian National Research Medical University

Budkina D.A.

Pirogov Russian National Research Medical University

Galchabekova M.A.

Pirogov Russian National Research Medical University

Gus L.A.

Central Research Institute of Stomatology and Maxillofacial Surgery

The fundamental foundations of periodontal aging. Part 1

Authors:

Moiseev D.A., Zueva A.A., Kopetsky I.S., Budkina D.A., Galchabekova M.A., Gus L.A.

More about the authors

Journal: Russian Journal of Operative Surgery and Clinical Anatomy. 2025;9(2): 63‑69

DOI: 10.17116/operhirurg2025902163

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Table of contents

THE FUNDAMENTAL FOUNDATIONS OF PERIODONTAL AGING. PART 1
THE FUNDAMENTAL FOUNDATIONS OF PERIODONTAL AGING. PART 1

To cite this article:

Moiseev DA, Zueva AA, Kopetsky IS, Budkina DA, Galchabekova MA, Gus LA. The fundamental foundations of periodontal aging. Part 1. Russian Journal of Operative Surgery and Clinical Anatomy. 2025;9(2):63‑69. (In Russ.)
https://doi.org/10.17116/operhirurg2025902163

Подписка 2025-2 (Russian Journal of Operative Surgery and Clinical Anatomy)
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Due to progress in the social sphere, the development of medicine, as well as the widespread availability of medicines and innovative technologies, the average life expectancy in the world has increased significantly. With age, there are changes in the entire body that are reflected in the oral cavity: decreased tissue elasticity, decreased muscle tone, and degenerative changes in hard and soft structures. Periodontitis is considered as the main age-associated disease of the oral cavity and the main cause of tooth loss in the adult population of the planet. The study of the fundamental mechanisms of periodontal aging is an extremely urgent task of modern gerontostomatology.

OBJECTIVE

To summarize the available scientific data on the aging of periodontal tissues.

MATERIAL AND METHODS

A systematic review of the literature data was conducted, and 5897 publications were found in international electronic databases: PubMed, Cochrane, Google Search, Ebsco, Embase, Web of Science, ScienceDirect, SciELO, and eLibrary from 2000 to 2025. The methodology of this study meets the requirements for PRISMA systematic reviews and meta-analyses.

RESULTS

Based on the selection criteria, 94 publications were selected, which included the results of studies of human aging, aging of organs and tissues of the oral cavity, aging of periodontal tissues, mechanisms of periodontal aging, the molecular basis of aging of tissues and organs, changes in individual tissues and organs during aging, the effects of drugs on aging, the influence of external factors on aging.

CONCLUSION

In the context of global demographic aging, the problem of maintaining oral health among the elderly is becoming particularly important. The presented detailed systematic analysis showed that periodontal aging is a complex biological process reflecting changes in the body, including both general and tissue-specific factors. Behavioral factors such as smoking and stress affect the rate of periodontal aging.

Keywords:

aging
oral aging
periodontal aging
age-related changes
immune aging
inflammatory aging

Authors:

Moiseev D.A.

Pirogov Russian National Research Medical University

Zueva A.A.

Pirogov Russian National Research Medical University

Kopetsky I.S.

Pirogov Russian National Research Medical University

Budkina D.A.

Pirogov Russian National Research Medical University

Galchabekova M.A.

Pirogov Russian National Research Medical University

Gus L.A.

Central Research Institute of Stomatology and Maxillofacial Surgery

Received:

25.04.2025

Accepted:

30.04.2025

List of references:

  1. Gil-Montoya JA, de Mello AL, Barrios R, Gonzalez-Moles MA, Bravo M. Oral health in the elderly patient and its impact on general well-being: a nonsystematic review. Clin Interv Aging. 2015;10:461-467.  https://doi.org/10.2147/CIA.S54630
  2. Ahmad A, Banerjee S, Wang Z, Kong D, Majumdar AP, Sarkar FH. Aging and inflammation: Etiological culprits of cancer. Cur Aging Sci. 2009;2:174-186.  https://doi.org/10.2174/1874609810902030174
  3. Liberale L, Montecucco F, Schwarz L, Lüscher TF, Camici GG. Inflammation and cardiovascular diseases: Lessons from seminal clinical trials. Cardiovasc Res. 2021;117:411-422.  https://doi.org/10.1093/cvr/cvaa211
  4. Chung HY, Kim DH, Lee EK, Chung KW, Chung S, Lee B, Seo AY, Chung JH, Jung YS, Im E. Redefining chronic inflammation in aging and age-related diseases: Proposal of the senoinflammation concept. Aging Dis. 2019;10:367. 
  5. Franceschi C, Garagnani P, Vitale G, Capri M, Salvioli S. Inflammaging and ‘Garb-aging’. Trends Endocrinol Metab. 2017;28(3):199-212.  https://doi.org/10.1016/j.tem.2016.09.005PMID:27789101.
  6. Ferrucci L, Fabbri E. Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Nat Rev Cardiol. 2018;15(9):505-522.  https://doi.org/10.1038/s41569-018-0064-2
  7. Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol Ser A Biomed Sci Med Sci. 2014;69:4-9.  https://doi.org/10.1093/gerona/glu057
  8. Ferrucci L, Semba RD, Guralnik JM, Ershler WB, Bandinelli S, Patel KV, Sun K, Woodman RC, Andrews NC, Cotter RJ, Ganz T, Nemeth E, Longo DL. Proinflammatory state, hepcidin, and anemia in older persons. Blood. 2010;6;115(18):3810-3816. https://doi.org/10.1182/blood-2009-02-201087
  9. Marcos-Pérez D, Sánchez-Flores M, Proietti S, Bonassi S, Costa S, Teixeira JP, Fernández-Tajes J, Pásaro E, Laffon B, Valdiglesias V. Association of inflammatory mediators with frailty status in older adults: results from a systematic review and meta-analysis. Geroscience. 2020; 42(6):1451-1473. https://doi.org/10.1007/s11357-020-00247-4
  10. Newman AB, Sanders JL, Kizer JR, Boudreau RM, Odden MC, Adina Zeki Al Hazzouri, Arnold AM. Trajectories of function and biomarkers with age: the CHS All Stars Study. Int J Epidemiol. 2016;45(4):1135-1145. https://doi.org/10.1093/ije/dyw092
  11. Gerli R, Monti D, Bistoni O, Mazzone AM, Peri G, Cossarizza A, Di Gioacchino M, Cesarotti ME, Doni A, Mantovani A, Franceschi C, Paganelli R. Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians. Mech Ageing Dev. 2000;121:37-46.  https://doi.org/10.1016/s0047-6374(00)00195-0
  12. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153:1194-1217. https://doi.org/10.1016/j.cell.2013.05.039
  13. Kennedy BK, Berger SL, Brunet A et al. Geroscience: linking aging to chronic disease. Cell. 2014;159;709-713.  https://doi.org/10.1016/j.cell.2014.10.039
  14. Campisi J, D’Adda Di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol. 2007;8:729-740.  https://doi.org/10.1038/nrm2233
  15. Sharpless NE, Sherr CJ Forging a signature of in vivo senescence. Nat Rev Cancer. 2015;15:397-408.  https://doi.org/10.1038/nrc3960
  16. Bernardes de Jesus B, Blasco MA. Assessing cell and organ senescence biomarkers. Circ Res. 2012;111:97-109.  https://doi.org/10.1161/CIRCRESAHA.111.247866
  17. Roh JS, Sohn DH. Damage-Associated Molecular Patterns in Inflammatory Diseases. Immune Netw. 2018;18(4):e27.  https://doi.org/10.4110/in.2018.18.e27
  18. Hernandez-Segura A, Tristan V de Jong, Simon Melov, et al. Unmasking transcriptional heterogeneity in senescent cells. Curr Biol. 2017; 27:2652-2660.e4  https://doi.org/10.1016/j.cub.2017.07.033
  19. Borodkina AV, Deryabin PI, Giukova AA & Nikolsky NN ‘Social life’ of senescent sells: what is SASP and why study it? Acta Naturae. 2018; 10:4-14. 
  20. Medina CB, Ravichandran KS. Do not let death do us part: ‘find-me’ signals in communication between dying cells and the phagocytes. Cell Death Differ. 2016;23:979-989.  https://doi.org/10.1038/cdd.2016.13
  21. Youm YH, Grant RW, McCabe LR et al. Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metab. 2013;18:519-532.  https://doi.org/10.1016/j.cmet.2013.09.010
  22. Goldberg EL, Dixit VD. Drivers of age-related inflammation and strategies for healthspan extension. Immunol Rev. 2015;265:63-74.  https://doi.org/10.1111/imr.12295
  23. Medzhitov R, Janeway CA Jr. Decoding the patterns of self and nonself by the innate immune system. Science. 2002;296(5566):298-300.  https://doi.org/10.1126/science.1068883
  24. Müller L, di Benedetto S, Pawelec G. The immune system and its dysregulation with Aging. Subcell Biochem. 2019;91:21-43.  https://doi.org/10.1007/978-981-13-3681-2_2
  25. Akha AAS. Aging and the immune system: An overview. J Immunol Methods. 2018;463:21-26.  https://doi.org/10.1016/j.jim.2018.08.005
  26. Shaw AC, Joshi S, Greenwood H, Panda A, Lord J. M Aging of the innate immune system. Curr Opin Immunol. 2010;22(4):507-513.  https://doi.org/10.1016/j.coi.2010.05.003
  27. Yuzhaninova SV, Saidakova EV. The phenomenon of immune exhaustion. Uspekhi sovremennoj biologii. Advances in Modern Biology. 2017; 137(1):70-83. (In Russ.).
  28. Farzi A, Fröhlich EE, Holzer P. Gut microbiota and the neuroendocrine system. Neurotherapeutics. 2018;15(1):5-22.  https://doi.org/10.1007/s13311-017-0600-5
  29. Nikolich-Žugich J. The twilight of immunity: emerging concepts in aging of the immune system. Nat Immunol. 2018;19(1):10-19.  https://doi.org/10.1038/s41590-017-0006-x
  30. GBD 2017 Oral Disorders Collaborators; Bernabe E, Marcenes W, Hernandez C, Bailey J, Abreu L, Alipour V, Amini S, Arabloo J, Arefi Z. Global, regional, and national levels and trends in burden of oral conditions from 1990 to 2017: A systematic analysis for the global burden of disease 2017 study. J Dent Res. 2020;99:362-373.  https://doi.org/10.1177/0022034520908533
  31. Bertl K, Tangl S, Rybaczek T, Berger B, Traindl-Prohazka M, Schuller-Götzburg P, Grossschmidt K. Prevalence and severity of periodontal disease in a historical Austrian population. J Periodontal Res. 2020;55:931-945.  https://doi.org/10.1111/jre.12785
  32. Eke PI, Dye B, Wei L, Thornton-Evans G, Genco R. Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Den Res. 2012;91:914-920.  https://doi.org/10.1177/0022034512457373
  33. Ebersole JL, Graves CL, Gonzalez OA, Dawson D III, Morford LA, Huja PE, Hartsfield JK, Jr, Huja SS, Pandruvada S, Wallet SM. Aging, inflammation, immunity and periodontal disease. Periodontology 2000. 2016;72:54-75.  https://doi.org/10.1111/prd.12135
  34. Tonetti MS, Jepsen S, Jin L, Otomo-Corgel J. Impact of the global burden of periodontal diseases on health, nutrition and wellbeing of mankind: A call for global action. J Clin Periodontol. 2017;44:456-462.  https://doi.org/10.1111/jcpe.12732

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