Correlations between parameters of central hemodynamics and cytokine profile in chronic kidney disease in combination with cerebrovascular diseases

Murkamilov I.T.

Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan;
Kyrgyz Russian Slavic University named after the First President of Russia B.N. Yeltsin, Bishkek, Kyrgyzstan

Sabirov I.S.

Kyrgyz- Russian Slavic University named after the First President of Russia B.N. Yeltsin, Bishkek, Kyrgyzstan

Fomin V.V.

I.M. Sechenov First State Moscow Medical University

Murkamilova J.A.

Family Medicine Center №7, Bishkek, Kyrgyzstan

Sabirova A.I.

First President of Russia B.N. Yeltsin Kyrgyz Russian Slavic University, Bishkek Kyrgyzstan

Tsoi L.G.

First President of Russia B.N. Yeltsin Kyrgyz Russian Slavic University, Bishkek Kyrgyzstan

Aitbaev K.A.

Scientific and Research Institute of Molecular biology and medicine, Bishkek, Kyrgyzstan

Redjapova N.A.

Osh State University, Osh, Kyrgyzstan

Yusupov F.A.

Osh State University, Osh, Kyrgyzstan

Correlations between parameters of central hemodynamics and cytokine profile in chronic kidney disease in combination with cerebrovascular diseases

Authors:

Murkamilov I.T., Sabirov I.S., Fomin V.V., Murkamilova J.A., Sabirova A.I., Tsoi L.G., Aitbaev K.A., Redjapova N.A., Yusupov F.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(6): 65‑71

DOI: 10.17116/jnevro201911906165

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To cite this article:

Murkamilov IT, Sabirov IS, Fomin VV, et al. . Correlations between parameters of central hemodynamics and cytokine profile in chronic kidney disease in combination with cerebrovascular diseases. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(6):65‑71. (In Russ.)
https://doi.org/10.17116/jnevro201911906165

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)

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Objective. To study the relationship between central hemodynamics and arterial stiffness indicators with cystatin C, tumor necrosis factor-alpha (TNF-alpha) and interleukin-(IL)-10 in patients with chronic kidney disease (CKD) in combination with cerebrovascular diseases (CEV). Material and methods. One hundred and twenty patients, aged from 19 to 81 years, with signs of chronic renal dysfunction, including 73 with CKD (1st group) and 47 with CKD in combination with CEH (group 2), were examined. «AngioScan» (Russia) was used to study indices of arterial rigidity. Blood plasma concentrations of TNF-alpha, IL-10 and cystatin C were determined by the enzyme immunoassay. Results. There is a significant increase (p<0.05) in the systolic, diastolic, central levels of arterial pressure, augmentation index, the index of increase at a pulse rate of 75 per min, the age index, the age of the vascular system and cystatin C content in the patients with CKD in combination with CEV compared to the patients with CKD without accompanying CEH. In the group of patients with CKD in combination with CEV, a correlation was found between the level of TNF-alpha and arterial stiffness index on one side (r=0.318; p<0.05) and the augmentation index on the other (r=0.299; p<0.05). Conclusion. The results confirm the fact that there is a significant increase in the level of plasma cystatin C and a decrease in GFR in patients with CKD in combination with CEV. Correlations were found between the level of TNF-alpha, augmentation index and deterioration of parameters of central hemodynamics and arterial stiffness in CKD in combination with CEH.

Keywords:

chronic kidney disease

cerebrovascular diseases

cytokines

cystatin C

glomerular filtration rate

augmentation index

Authors:

Murkamilov I.T.

Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan;
Kyrgyz Russian Slavic University named after the First President of Russia B.N. Yeltsin, Bishkek, Kyrgyzstan

Sabirov I.S.

Kyrgyz- Russian Slavic University named after the First President of Russia B.N. Yeltsin, Bishkek, Kyrgyzstan

Fomin V.V.

I.M. Sechenov First State Moscow Medical University

Murkamilova J.A.

Family Medicine Center №7, Bishkek, Kyrgyzstan

Sabirova A.I.

First President of Russia B.N. Yeltsin Kyrgyz Russian Slavic University, Bishkek Kyrgyzstan

Tsoi L.G.

First President of Russia B.N. Yeltsin Kyrgyz Russian Slavic University, Bishkek Kyrgyzstan

Aitbaev K.A.

Scientific and Research Institute of Molecular biology and medicine, Bishkek, Kyrgyzstan

Redjapova N.A.

Osh State University, Osh, Kyrgyzstan

Yusupov F.A.

Osh State University, Osh, Kyrgyzstan

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