Correlations between parameters of central hemodynamics and cytokine profile in chronic kidney disease in combination with cerebrovascular diseases

Murkamilov I.T.; Sabirov I.S.; Fomin V.V.; Murkamilova J.A.; Sabirova A.I.; Tsoi L.G.; Aitbaev K.A.; Redjapova N.A.; Yusupov F.A.

doi:https://doi.org/10.17116/jnevro201911906165

Murkamilov I.T.

Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan;
Kyrgyz Russian Slavic University named after the First President of Russia B.N. Yeltsin, Bishkek, Kyrgyzstan

Sabirov I.S.

Kyrgyz- Russian Slavic University named after the First President of Russia B.N. Yeltsin, Bishkek, Kyrgyzstan

Fomin V.V.

I.M. Sechenov First State Moscow Medical University

Murkamilova J.A.

Family Medicine Center №7, Bishkek, Kyrgyzstan

Sabirova A.I.

First President of Russia B.N. Yeltsin Kyrgyz Russian Slavic University, Bishkek Kyrgyzstan

Tsoi L.G.

First President of Russia B.N. Yeltsin Kyrgyz Russian Slavic University, Bishkek Kyrgyzstan

Aitbaev K.A.

Scientific and Research Institute of Molecular biology and medicine, Bishkek, Kyrgyzstan

Redjapova N.A.

Osh State University, Osh, Kyrgyzstan

Yusupov F.A.

Osh State University, Osh, Kyrgyzstan

Correlations between parameters of central hemodynamics and cytokine profile in chronic kidney disease in combination with cerebrovascular diseases

Authors:

Murkamilov I.T., Sabirov I.S., Fomin V.V., Murkamilova J.A., Sabirova A.I., Tsoi L.G., Aitbaev K.A., Redjapova N.A., Yusupov F.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(6): 65‑71

DOI: 10.17116/jnevro201911906165

Read: 1047 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Murkamilov IT, Sabirov IS, Fomin VV, et al. . Correlations between parameters of central hemodynamics and cytokine profile in chronic kidney disease in combination with cerebrovascular diseases. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(6):65‑71. (In Russ.)
https://doi.org/10.17116/jnevro201911906165

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

The relationship between inflammatory markers, fatigue, and effort-based decision-making in patients at clinical high risk for psychosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):85-91

The role of immuno-inflammatory factors in the development of negative symptoms in schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):42-48

Modern aspects of chronic cerebral ischemia pathogenetic therapy. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):106-113

Local cytokine profile of the endometrium in patients with repeated implantation failures and its pharmacological correction by the secretome of peripheral blood mononuclear cells. Russian Journal of Human Reproduction. 2024;(5):46-54

Assessment of risk of developing fractures and sarcopenia and quality of life of patients with chronic kidney disease at the outpatient stage. Russian Journal of Preventive Medicine. 2024;(12):88-91

Inflammatory aging. Part 1. The principal biochemical mechanisms. Russian Journal of Preventive Medicine. 2024;(12):145-150

Recommendations for the rehabilitation of patients with chronic kidney disease requiring hemodialysis (literature review). Problems of Balneology, Physiotherapy and Exercise Therapy. 2024;(6):62-73

Immunomodulatory therapy in the postoperative period in chronic purulent otitis media. Russian Bulletin of Otorhinolaryngology. 2024;(6):10-17

Functional cytokine redundancy in pregnancy. Russian Journal of Human Reproduction. 2024;(6):73-80

Results of clinical and immunomorphological analysis in chronic post-traumatic uveitis. Russian Annals of Ophthalmology. 2024;(6):39-44

Abstract:

Objective. To study the relationship between central hemodynamics and arterial stiffness indicators with cystatin C, tumor necrosis factor-alpha (TNF-alpha) and interleukin-(IL)-10 in patients with chronic kidney disease (CKD) in combination with cerebrovascular diseases (CEV). Material and methods. One hundred and twenty patients, aged from 19 to 81 years, with signs of chronic renal dysfunction, including 73 with CKD (1st group) and 47 with CKD in combination with CEH (group 2), were examined. «AngioScan» (Russia) was used to study indices of arterial rigidity. Blood plasma concentrations of TNF-alpha, IL-10 and cystatin C were determined by the enzyme immunoassay. Results. There is a significant increase (p<0.05) in the systolic, diastolic, central levels of arterial pressure, augmentation index, the index of increase at a pulse rate of 75 per min, the age index, the age of the vascular system and cystatin C content in the patients with CKD in combination with CEV compared to the patients with CKD without accompanying CEH. In the group of patients with CKD in combination with CEV, a correlation was found between the level of TNF-alpha and arterial stiffness index on one side (r=0.318; p<0.05) and the augmentation index on the other (r=0.299; p<0.05). Conclusion. The results confirm the fact that there is a significant increase in the level of plasma cystatin C and a decrease in GFR in patients with CKD in combination with CEV. Correlations were found between the level of TNF-alpha, augmentation index and deterioration of parameters of central hemodynamics and arterial stiffness in CKD in combination with CEH.

Keywords:

chronic kidney disease

cerebrovascular diseases

cytokines

cystatin C

glomerular filtration rate

augmentation index

Authors:

Murkamilov I.T.

Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan;
Kyrgyz Russian Slavic University named after the First President of Russia B.N. Yeltsin, Bishkek, Kyrgyzstan

Sabirov I.S.

Kyrgyz- Russian Slavic University named after the First President of Russia B.N. Yeltsin, Bishkek, Kyrgyzstan

Fomin V.V.

I.M. Sechenov First State Moscow Medical University

Murkamilova J.A.

Family Medicine Center №7, Bishkek, Kyrgyzstan

Sabirova A.I.

First President of Russia B.N. Yeltsin Kyrgyz Russian Slavic University, Bishkek Kyrgyzstan

Tsoi L.G.

First President of Russia B.N. Yeltsin Kyrgyz Russian Slavic University, Bishkek Kyrgyzstan

Aitbaev K.A.

Scientific and Research Institute of Molecular biology and medicine, Bishkek, Kyrgyzstan

Redjapova N.A.

Osh State University, Osh, Kyrgyzstan

Yusupov F.A.

Osh State University, Osh, Kyrgyzstan

Close metadata

References:

Mukhin NA. Nephrology. National leadership. Brief edition. M. 2016. (In Russ.)
Locatelli F, Pozzoni P, Tentori F, & Del Vecchio L. Epidemiology of cardiovascular risk in patients with chronic kidney disease. Nephrology Dialysis Transplantation. 2003;18:7:2-9. https://doi.org/10.1093/ndt/gfg1072
Rogova IV, Fomin VV, Damulin IV, Minakova EG, Selivanova OYu, Petleva YuA. Vascular cognitive impairments in chronic kidney disease. Neurology, Neuropsychiatry, Psychosomatics. 2015;1:11-18. (In Russ.) https://doi.org/10.14412/2074-2711-2015-1-11-18
Bazyluk A, Malyszko J, Zbroch E. Cardiovascular risk in chronic kidney disease-what is new in the pathogenesis and treatment? Postgraduate Medicine. 2018.
Murkamilov IT, Sabirov IS, Fomin VV, Murkamilova ZhA, Aytbaev KA, Rayimzhanov ZR. Evaluation of nephrocerebral risk using cystatin C in patients with chronic kidney disease. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2018;118(9):10-16. (In Russ.) https://doi.org/10.17116/jnevro201811809110
Rudenko TE, Kutyrina IM, Shvetsov MYu. Myocardial remodeling risk factors at stage ii-iv chronic kidney disease. Therapeutic Archive. 2012;6:21-26. (In Russ.)
Chillon JM, Massy ZA, Stengel B. Neurological complications in chronic kidney disease patients. Nephrology Dialysis Transplantation. 2015;31:10:1606-1614. https://doi.org/10.1093/ndt/gfv315
Spoto B, Leonardis D, Parlongo RM, Pizzini P, Pisano A, Cutrupi S & Mallamaci F. Plasma cytokines, glomerular filtration rate and adipose tissue cytokines gene expression in chronic kidney disease (CKD) patients. Nutrition, Metabolism and Cardiovascular Diseases. 2012;22:11:981-988. https://doi.org/10.1016/j.numecd.2011.01.005
Agharazii M, St-Louis R, Gautier-Bastien A, Ung RV, Mokas S, Larivière R, Richard DE. Inflammatory cytokines and reactive oxygen species as mediators of chronic kidney disease-related vascular calcification. American Journal of Hypertension. 2014;28:6:746-755. https://doi.org/10.1093/ajh/hpu225
Levey AS, Coresh J, Bolton K, Culleton B, Harvey KS, Ikizler TA, Levin A. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. American Journal of Kidney Diseases. 2002;39:2(suppl 1).
Parfenov AS. Early diagnosis of cardiovascular diseases using hardware-software complex «Angioscan -01». Poliklinika. 2012;2:1:70-74. (In Russ.)
Hoek FJ, Kemperman FA, Krediet RT. A comparison between cystatin C, plasma cre atinine and the Cockcroft and Gault formula for the estimation of glomerular filtration rate. Nephrol Dial Transplant. 2003;18:10:2024-2031. https://doi.org/10.1093/ndt/gfg349
Grinhalh T. The basics of evidence-based medicine. M.: Geotar-Med; 2004. (In Russ.)
Doll DN, Barr TL, Simpkins JW. Cytokines: Their Role in Stroke and Potential Use as Biomarkers and Therapeutic Targets. Aging and Disease. 2014;5(5):294-306. https://doi.org/10.14336/AD.2014.0500294
Liu T, Clark RK, McDonnell PC, Young PR, White RF, Barone FC, & Feuerstein G. Z. Tumor necrosis factor-alpha expression in ischemic neurons. Stroke; a Journal of Cerebral Circulation. 1994;25:7:1481-1488. https://doi.org/10.1161/01.STR.25.7.1481
Murkamilov IT, Fomin VV, Aitbaev KA, Rayimzhanov ZR, Redzhapova NA, Yusupov FA, Aydarov ZA. Cytokine model of the development of cardiovascular complications in chronic kidney disease. Clinical Nephrology. 2017;2:71-75. (In Russ.)
Nanes MS. Tumor necrosis factor-α: molecular and cellular mechanisms in skeletal pathology. Gene. 2003;321:1-15. https://doi.org/10.1016/S0378-1119(03)00841-2
Larrick JW, Wright SC. Cytotoxic mechanism of tumor necrosis factor-alpha. The FASEB Journal. 1990;4:14:3215-3223. https://doi.org/10.1096/fasebj.4.14.2172061
Stenvinkel P, Ketteler M, Johnson RJ, Lindholm B, Pecoits-Filho R, Riella M, Girndt M. IL-10, IL-6, and TNF-α: central factors in the altered cytokine network of uremia-the good, the bad, and the ugly. Kidney Int. 2005;67:4:1216-1233. https://doi.org/10.1111/j.1523-1755.2005.00200.x
Wanidvoranun C, Strober W. Predominant role of tumor necrosis factor-α in human monocyte IL-10 synthesis. J Immunol. 1993;151:12:6853-6861.
Asseman C, Mauze S, Leach MW, Coffman RL, Powrie F. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. Journal of Experimental Medicine. 1999;190:7:995-1004. https://doi.org/10.1084/jem.190.7.995
Coelho SN, Saleem S, Konieczny BT, Parekh KR, Baddoura FK, & Lakkis FG. Immunologic determinants of susceptibility to experimental glomerulonephritis: role of cellular immunity. Kidney Int. 1997;51:3:646-652. https://doi.org/10.1038/ki.1997.94
Scholz J, Lukacs-Kornek V, Engel DR, Specht S, Kiss E, Eitner F, Kurts C. Renal dendritic cells stimulate IL-10 production and attenuate nephrotoxic nephritis. Journal of the American Society of Nephrology. 2008;19:3:527-537. https://doi.org/10.1681/ASN.2007060684
Myśliwska J, Zorena K, Semetkowska-Jurkiewicz E, Rachoń D, Suchanek H, Myśliwski A. High levels of circulating interleukin-10 in diabetic nephropathy patients. European Cytokine Network. 2005;16:2:117-122.
Klahr S, Morrissey JJ. The role of vasoactive compounds, growth factors and cytokines in the progression of renal disease. Kidney Int. 2000;57:7-14. https://doi.org/10.1046/j.1523-1755.2000.07509.x
Pirotzki E, Dellatre RM, Hellegouarch A, Lonchampt M. O, Aarden L, Braquet P, Galanaud P. Interleukin-6 production by tumor necrosis factor and lipopolysaccharide-stimulated rat renal cells. Clin Immunol Immunopathol. 1990;56:271-279. https://doi.org/10.1016/0090-1229(90)90148-J
Tipping PG, Kitching AR, Huang XR, Mutch DA, Holdsworth SR. Immune modulation with interleukin-4 and interleukin-10 prevent crescent formation and glomerular injury in experimental glomerulonephritis. Eur J Immunol. 1997;27:530-537. https://doi.org/10.1002/eji.1830270226
Pestka S, Krause CD, Sarkar D, Walter MR, Shi Y, Fisher PB. Interleukin-10 and related cytokines and receptors. Annu Rev Immunol. 2004;22:929-979. https://doi.org/10.1146/annurev.immunol.22.012703.104622
Clarkson AN, Sutherland BA, Appleton I. The biology and pathologyof hypoxia-ischemia: an update. Arch Immunol Ther Exp (Warsz). 2005;53:3:213-225. http://www.aite-online/pdf/vol_53/no_3/7445.pdf
Pascoe MC, Crewther SG, Carey LM, Crewther DP. Inflammation and depression: why poststroke depression may be the norm and not the exception. Int J Stroke. 2011;6:2:128-135. https://doi.org/10.1111/j.1747-4949.2010.00565.x
Gusev EI, Chukanova AS. Modern pathogenetic aspects of development of cerebral chronic ischemia. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2015;115:3:4-8. (In Russ.) https://doi.org/10.17116/jnevro2015115314-8
Kutlubaev MA, Akhmadeeva LR. Neuroimmune mechanisms in the development of post-stroke depression. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2013;113(2):76-79. (In Russ.)
Tuomisto K, Jousilahti P, Sundvall J, Pajunen P, Salomaa V. C-reactive protein, interleukin-6 and tumor necrosis factor alpha as predictors of incident coronary and cardiovascular events and total mortality. Thrombosis and Haemostasis. 2006;96:03:511-518. https://doi.org/10.1160/TH05-08-0571
Guo G, Morrissey J, McCracken R, Tolley T, Liapis H, Klahr S. Contributions of angiotensin II and tumor necrosis factor-α to the development of renal fibrosis. American Journal of Physiology-Renal Physiology. 2001;280:5:777-785. https://doi.org/10.1152/ajprenal.2001.280.5.F777
Kulesh A, Drobakha V, Kuklina E, Nekrasova I, Shestakov V. Cytokine Response, Tract-Specific Fractional Anisotropy, and Brain Morphometry in Post-Stroke Cognitive Impairment. Journal of Stroke and Cerebrovascular Diseases. 2018;27:7:1752-1759. https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.02.004
Konenkov VI, Klimontov VV, Myakina NE, Tyan NV, Fazullina ON, Romanov VV. Increased serum concentrations of inflammatory cytokines in type 2 diabetic patients with chronic kidney disease. Therapeutic Archive. 2015;6:45-49. (In Russ.) https://doi.org/10.17116/terarkh201587645-49
Simonov AN, Klyushnik TP, Androsova LV, Mikhaylova NM. Quantification of the relationship between inflammatory markers and Alzheimer’s disease. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2018;118(5):58-63. (In Russ.) https://doi.org/10.17116/jnevro20181185158
Al-Khazraji BK, Appleton CT, Beier F, Birmingham TB, Shoemaker JK. Osteoarthritis, cerebrovascular dysfunction and the common denominator of inflammation: a narrative review. Osteoarthritis Cartilage. 2018;26(4):462-470. https://doi.org/10.1016/j.joca.2018.01.011
Murkamilov IT, Fomin VV, Aitbaev KA, Murkamilova ZhA, Sabirov IS. Blood plasma cystatin c level and its relationship with the augmentation index and central arterial pressure in therapeutic patients. Clinical Nephrology. 2018;3:31-40. (In Russ.) https://doi.org/10.18565/nephrology.20183.31-40
Murkamilov IT, Fomin VV, Aitbaev KA, Rayimzhanov ZR, Redzhapova NA, Yusupov FA, Aydarov ZA. Chronic kidney disease and cerebrovascular disorders: the role of cystatin C. Clinical Nephrology. 2017;3:60-67. (In Russ.)