Rare genetic markers of cognitive impairment in diabetes mellitus

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The study of potential mechanisms of cognitive impairments associated with gene expression in patients with diabetes mellitus (DM) is becoming increasingly important due to the increase in the prevalence of dementia in this category of patients. DM is associated with the alteration of neurogenesis, and the variability of glycemia causes the changes in plasma and mitochondria, promotes the formation of free radicals, oxidative stress, activation of apoptosis of neurons, circulation of proinflammatory agents and other pathological factors. The association between diabetes and cognitive impairment is largely mediated by both neurodegeneration markers and cerebrovascular diseases. However, the literature presents conflicting results on the risk and frequency of cognitive impairment in patients with type 1 and 2 diabetes. This is probably explained by limitations and variations of the studies, but also by the contribution of genetic polymorphisms to the development of cognitive impairment in patients with diabetes. This review describes rare genetic markers of cognitive disorders in type 1 and type 2 diabetes as well as their relationship with various parameters of carbohydrate metabolism and clinical manifestations of cognitive disorders.

Keywords:

diabetes mellitus

cognitive impairment

genetic markers

Authors:

Matveeva M.V.

Siberian State Medical University, Tomsk, Russia

Samoĭlova Iu.G.

GBOU VPO "Sibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet" Minzdrava RF, Tomsk

Zhukova N.G.

Siberian State Medical University, Tomsk, Russia

Kudlay D.A.

Institute for Advanced Studies of the Federal Medical and Biological Agency, Moscow, Russia

Rotkank M.A.

Siberian State Medical University, Tomsk, Russia

Leyman O.P.

Siberian State Medical University

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