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Portnova A.A.

Serbsky National Medical Research Center for Psychiatry and Narcology

Sivolap Yu.P.

Sechenov First Moscow State Medical University (Sechenov University)

Challenges of the use of antipsychotics in children and adolescents

Authors:

Portnova A.A., Sivolap Yu.P.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(11): 123‑127

DOI: 10.17116/jnevro2019119111123

Read: 10250 times

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Table of contents

CHALLENGES OF THE USE OF ANTIPSYCHOTICS IN CHILDREN AND ADOLESCENTS
CHALLENGES OF THE USE OF ANTIPSYCHOTICS IN CHILDREN AND ADOLESCENTS

To cite this article:

Portnova AA, Sivolap YuP. Challenges of the use of antipsychotics in children and adolescents. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(11):123‑127. (In Russ.)
https://doi.org/10.17116/jnevro2019119111123

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The more frequent prescription of antipsychotics with high proportion of off label use, in particular for children and adolescents, is seen in many countries, including European Union, United States and Russian Federation. In accordance to current clinical guidelines, second-generation antipsychotics are preferred in clinical practice due to the higher tolerability compared to the first-generation antipsychotics. However, second-generation antipsychotics in children and adolescents, especially in continuous use, are associated with cardiac abnormalities and metabolic disorders, including hyperglycemia, and the risk of type 2 diabetes, weight gain and obesity, an increase in prolactin synthesis and hyperlipidemia. The adverse effects of antipsychotics in children and adolescents determine the need for more balanced approaches to their use, careful monitoring of the safety of treatment and the development of measures to prevent and correct side-effects of these drugs.

Keywords:

second generation antipsychotics
children and adolescents
cardiac abnormalities
type 2 diabetes
weight gain
hyperprolactinemia
hyperlipidemia

Authors:

Portnova A.A.

Serbsky National Medical Research Center for Psychiatry and Narcology

Sivolap Yu.P.

Sechenov First Moscow State Medical University (Sechenov University)

Received:

13.07.2019

Accepted:

07.08.2019

Close metadata

References:

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