Prospects for Nagutskaya no. 26 mineral water in correction of carbohydrate and lipid metabolism in patients with insulin resistance

Israfilov R.Ya.; Frolkov V.K.; Edelev D.A.

doi:https://doi.org/10.17116/rbpdpm2025204120

Israfilov R.Ya.

RUSMEDDOK LLC

ORCID: 0009-0001-0944-4869

Frolkov V.K.

Petrovsky National Research Centre of Surgery

SPIN RSCI: 3183-0883
ORCID: 0000-0002-1277-5183

Edelev D.A.

RUSMEDDOK LLC

ORCID: 0000-0002-5863-2284

Prospects for Nagutskaya no. 26 mineral water in correction of carbohydrate and lipid metabolism in patients with insulin resistance

Authors:

Israfilov R.Ya., Frolkov V.K., Edelev D.A.

More about the authors

Journal: Regenerative Biotechnologies, Preventive, Digital and Predictive Medicine. 2025;2(4): 20‑28

DOI: 10.17116/rbpdpm2025204120

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To cite this article:

Israfilov RYa, Frolkov VK, Edelev DA. Prospects for Nagutskaya no. 26 mineral water in correction of carbohydrate and lipid metabolism in patients with insulin resistance. Regenerative Biotechnologies, Preventive, Digital and Predictive Medicine. 2025;2(4):20‑28. (In Russ.)
https://doi.org/10.17116/rbpdpm2025204120

Подписка 2026 Восстановительные биотехнологии, профилактическая, цифровая и предиктивная медицина (Regenerative Biotechnologies, Preventive, Digital and Predictive Medicine)

Использование инфографики авторами научных работ

Abstract:

OBJECTIVE

To analyze biological potential of mineral water “Nagutskaya No. 26” for correction of carbohydrate and lipid metabolism disorders in patients with metabolic syndrome and type 2 diabetes mellitus

MATERIAL AND METHODS

The study included patients with metabolic syndrome (n=40), type 2 diabetes (n=40) and healthy volunteers (n=60). At the first stage, the authors assessed the effect of mineral waters “Nagutskaya No. 26”, “Slavyanovskaya”, and “Essentuki No. 16” on glycemia and insulinemia in oral glucose tolerance test in healthy volunteers (glucose was dissolved in mineral waters, in the control group — in drinking water). Then, the effect of a single dose of mineral water “Nagutskaya No. 26” on hormonal regulation of carbohydrate and lipid metabolism, as well as lipid peroxidation system was analyzed in all groups. Results were evaluated considering blood glucose, total cholesterol, high-density lipoprotein, triglyceride, insulin, cortisol, malondialdehyde, catalase, and superoxide dismutase.

RESULTS

Mineral waters stimulate early phase of insulin secretion and reduce alimentary hyperglycemia in delayed phase. In this regard, the most effective water was Essentuki No. 17 (increased insulinemia by 58.9% with glycemia decrease by 42.3%), less effective — Nagutskaya No. 26 (increased insulinemia by 46.4% with glycemia decrease by 27.8%). Minimal effect was observed for Slavyanovskaya (increased insulinemia by 11.8% with glycemia decrease by 4.1%). When patients with metabolic syndrome took Nagutskaya No. 26 water once, their glycemia decreased by 10.5% while insulin secretion increased by 22.6%, cortisol release decreased by 10.8%, and antioxidant enzymes were activated by 10.3-20.2%. Lipid metabolism parameters did not change significantly. In patients with type 2 diabetes, the effect of mineral water “Nagutskaya No. 26” was less pronounced: insulin production increased by 5.2%, while catalase activity increased by 7.6%.

CONCLUSION

Mineral water “Nagutskaya No. 26” is similar to mineral water “Essentuki No. 17” regarding effect on regulating insulin-mediated carbohydrate metabolism. This water may be included in rehabilitation programs for the treatment of metabolic syndrome and type 2 diabetes. However, its minimal impact on lipid profile requires additional inclusion of factors with anti-atherogenic effects.

Keywords:

mineral water

metabolic syndrome

type 2 diabetes

carbohydrate and lipid metabolism

Authors:

Israfilov R.Ya.

RUSMEDDOK LLC

ORCID: 0009-0001-0944-4869

Frolkov V.K.

Petrovsky National Research Centre of Surgery

SPIN RSCI: 3183-0883
ORCID: 0000-0002-1277-5183

Edelev D.A.

RUSMEDDOK LLC

ORCID: 0000-0002-5863-2284

Received:

15.07.2025

Accepted:

17.08.2025

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