Oxidative stress in epilepsy

Fedin A.I.; Starykh E.V.; Torshin D.V.

doi:https://doi.org/10.17116/jnevro201911901197

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Abstract:

This article contains an analysis of clinical and experimental studies in which oxidative stress is considered as a possible mechanism in the pathogenesis of epilepsy. Oxidative stress occurs as a result of brain damage after epileptic seizures and may later cause epileptogenesis. Patients with epilepsy showed a high level of lipid peroxidation markers, while the activity of antioxidant defense system was low. The level of oxidative stress was shown to be significantly higher in epileptics with associated mental disorders and in patients with refractory epilepsy. Further study of oxidative stress in epilepsy may play the key role in the treatment of this disease.

Keywords:

oxidative stress

epilepsy

antioxidant defense

Authors:

Fedin A.I.

Kafedra nevrologii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta

SPIN RSCI: 8834-0085
Scopus AuthorID: 7007163263
ORCID: 0000-0002-6996-2828

Starykh E.V.

Kafedra nevrologii fakul'teta usovershenstvovaniia vracheĭ GBOU VPO "Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova", Moskva;
Tsentral'naia klinicheskaia bol'nitsa Sviatitelia Aleksiia, Moskva

Torshin D.V.

City Clinical Hospital №13, Moscow, Russia

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