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Gerasimchuk M.Yu.

Sechenov First Moscow State Medical University, Moscow, Russia

The prognostic significance of biological rhythms assessment in depression

Authors:

Gerasimchuk M.Yu.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(9): 17‑21

DOI: 10.17116/jnevro201811809117

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Table of contents

THE PROGNOSTIC SIGNIFICANCE OF BIOLOGICAL RHYTHMS ASSESSMENT IN DEPRESSION
THE PROGNOSTIC SIGNIFICANCE OF BIOLOGICAL RHYTHMS ASSESSMENT IN DEPRESSION

To cite this article:

Gerasimchuk MYu. The prognostic significance of biological rhythms assessment in depression. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(9):17‑21. (In Russ.)
https://doi.org/10.17116/jnevro201811809117

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Abstract:

Objective. To assess the prognostic significance of biological rhythms in depression on the example of the individual chronotype. Material and methods. One hundred patients (women 68%), aged 18—77 years, mean age 48±16, were examined before and after 8 weeks of treatment. The Morningness-Eveningness Questionnaire (MEQ) was used. Treatment response (a decrease of 50% in total MADRS scores to the 8th week of treatment) and dynamics of depression severity (dMADRS; R) were assessed. Results and conclusion. Evening chronotype was found to be associated with poor prognosis. TCAs and SSRIs were more effective in eveningness, other antidepressants — in morningness. MEQ changes during and after treatment may reflect the resynchronizing activity of antidepressants.

Keywords:

depression
antidepressant
circadian
chronotype (morningness-eveningness)
biology

Authors:

Gerasimchuk M.Yu.

Sechenov First Moscow State Medical University, Moscow, Russia

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