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Miliukhina I.V.

FGBU "Nauchno-issledovatel'skiĭ institut ksperimental'noĭ meditsiny" Severo-Zapadnogo otdeleniia RAMN, Sankt-Peterburg

Gracheva E.V.

St. Petersburg State Pediatric Medical University, St. Petersburg

Modern views on gait impairment in Parkinson`s disease and its correction

Authors:

Miliukhina I.V., Gracheva E.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(6): 96‑101

DOI: 10.17116/jnevro20181186196

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Table of contents

MODERN VIEWS ON GAIT IMPAIRMENT IN PARKINSON`S DISEASE AND ITS CORRECTION
MODERN VIEWS ON GAIT IMPAIRMENT IN PARKINSON`S DISEASE AND ITS CORRECTION

To cite this article:

Miliukhina IV, Gracheva EV. Modern views on gait impairment in Parkinson`s disease and its correction. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(6):96‑101. (In Russ.)
https://doi.org/10.17116/jnevro20181186196

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Abstract:

The article reviews the causes of gait impairment in patients with Parkinson’s disease (PD). The emphasis is made on modern ideas, according to which gait impairment in PD is caused by a multisystem lesion and non-dopaminergic dependent mechanisms play the leading role. It is highlighted that gait impairment in PD is associated with the disruption of frontal/subcortical neural pathways which requires a special approach to pharmacological and non-pharmacological therapy. Based on pathogenetic mechanisms, much attention is paid to anti-dementia medications. Attention is drawn to the fact that the use of memantine hydrochloride (akatinol memantine) is a promising direction for gait impairment correction in the advanced and late stages of PD due to the improvement of glutamatergic transfer from the striatum to the specific areas of the cerebral cortex involved in gait control. The results of the latest clinical trials are analyzed.

Keywords:

gait impairment
Parkinson’s disease
cortical gait control
cognitive gait control
memantine hydrochloride
akatinol memantine

Authors:

Miliukhina I.V.

FGBU "Nauchno-issledovatel'skiĭ institut ksperimental'noĭ meditsiny" Severo-Zapadnogo otdeleniia RAMN, Sankt-Peterburg

Gracheva E.V.

St. Petersburg State Pediatric Medical University, St. Petersburg

Close metadata

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