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Vostrikov V.M.

FGBU "Nauchnyĭ tsentr psikhicheskogo zdorov'ia" RAMN, Moskva

Uranova N.A.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Deficit of oligodendrocytes in the frontal cortex in schizophrenia

Authors:

Vostrikov V.M., Uranova N.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(5): 100‑103

DOI: 10.17116/jnevro201811851100

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Table of contents

DEFICIT OF OLIGODENDROCYTES IN THE FRONTAL CORTEX IN SCHIZOPHRENIA
DEFICIT OF OLIGODENDROCYTES IN THE FRONTAL CORTEX IN SCHIZOPHRENIA

To cite this article:

Vostrikov VM, Uranova NA. Deficit of oligodendrocytes in the frontal cortex in schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(5):100‑103. (In Russ.)
https://doi.org/10.17116/jnevro201811851100

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Objective. Oligodendrocyte abnormalities are thought to be one of the key cellular pathologies involved in disturbances of neuronal connectivity in schizophrenia. Material and methods. The density of oligodendrocytes in layer III of the prefrontal cortex, BA10, in schizophrenia (n=20) was compared to controls (n=20) using optical dissector method. MANCOVA was applied for group comparisons. Results and conclusion. The density of oligodendrocytes was significantly lower in each sublayers of layer III (≤20% p≤0.05) in the schizophrenia group as compared to the control group. The deficit of oligodendrocytes in the prefrontal cortex in schizophrenia may be of developmental origin or the result of alterations in the neural tissue of the brain during disease course.

Keywords:

schizophrenia
prefrontal cortex
oligodendrocytes
morphometry

Authors:

Vostrikov V.M.

FGBU "Nauchnyĭ tsentr psikhicheskogo zdorov'ia" RAMN, Moskva

Uranova N.A.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Close metadata

References:

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