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Zhidkova I.A.

Kafedra nervnykh bolezneĭ Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta

Karlov V.A.

Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet

Vlasov P.N.

GBUZ MO "Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii", Moskva

New possibilities of pharmacotherapy of epilepsy: eslicarbazepine acetate in treatment of focal epilepsy

Authors:

Zhidkova I.A., Karlov V.A., Vlasov P.N.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(4): 140‑145

DOI: 10.17116/jnevro201811841140-145

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To cite this article:

Zhidkova IA, Karlov VA, Vlasov PN. New possibilities of pharmacotherapy of epilepsy: eslicarbazepine acetate in treatment of focal epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(4):140‑145. (In Russ.)
https://doi.org/10.17116/jnevro201811841140-145

 
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The article provides an analysis of the latest antiepileptic drug eslicarbazepine acetate (ESL) for the treatment of focal epilepsy in adults as monotherapy and adjunctive therapy. Pharmacokinetics, pharmacodynamics, drug-drug interactions, indications and dosage regimen are described. The authors present the latest data on the efficacy, tolerability and safety of ESL including an exploratory pooled analysis of data from 14 European clinical practice studies (Euro-Esli) as well as their own observations of 34 patients receiving ESL in monotherapy or combination therapy.

Keywords:

focal epilepsy
pharmacotherapy
eslicarbazepine acetate
efficacy
tolerability

Authors:

Zhidkova I.A.

Kafedra nervnykh bolezneĭ Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta

Karlov V.A.

Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet

Vlasov P.N.

GBUZ MO "Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii", Moskva

List of references:

  1. Karlov VA, Gekht AB, Guzeva VI, Lipatova LV, Bazilevich SN, Mkrtchan VR, Vlasov PN, Zhidkova IA, Mukhin KYu, Petrukhin AS, Lebedeva AV. Algorithms of mono- and polytherapy in clinical epileptology. Part 1. General principles of drug choice. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2016;116(6):109-114. (In Russ.) https://doi.org/10.17116/jnevro201611661109-114
  2. Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel J Jr, Forsgren L, French JA, Glunn M, Hesdorffer DC, Lee BI, Mathern GW, Moshé SL, Perucca E, Scheffer IE, Tomson T, Watanabe M, Wiebe S. ILAE Official Report: A practical clinical definition of epilepsy. Epilepsia. 2014;55(4):475-482. https://doi.org/10.1111/epi.12550
  3. Karlov VA. From phenobarbital to eslicarbazepine. Epilepsiya i paroksizmal’nye sostoyaniya (spets. vypusk). 2015;1. (In Russ.)
  4. Ferreira J, Mestre T. Eslicarbazepine acetate: a new option for the treatment of focal epilepsy. Expert Opin Investig Drugs. 2008;18(2):221-229. https://doi.org/10.1517/13543780802635107
  5. Vlasov PN. Eslicarbazepine. Mechanism of action. Epilepsiya i paroksizmal’nye sostoyaniya (spets. vypusk). 2015;2-4. (In Russ.)
  6. Shirley M, Dhillon S. Eslicarbazepine Acetate Monotherapy: A Review in Partial-Onset Seizures. Drugs. 2016;76(6). Published online: 07 April 2016. https://doi.org/10.1007/s40265-016-0570-7
  7. Bialer M, Soares-da-Silva P. Pharmacokinetics and drug interactions of eslicarbazepine acetate. Epilepsia. 2012;53(6):935-946. https://doi.org/10.1111/j.1528-1167.2012.03519.x
  8. Falcão A, Vaz-da-Silva M, Gama H, Nunes T, Almeida L, Soares-da-Silva P. Effect of eslicarbazepine acetate on the pharmacokinetics of a combined ethinylestradiol/levonorgestrel oral contraceptive in healthy women. Epilepsy Res. 2013;105(3):368-376. https://doi.org/10.1016/j.eplepsyres.2013.02.020
  9. Rudakova IG. Drug interactions Eslicarbazepine. Epilepsiya i paroksizmal’nye sostoyaniya (spets. vypusk). 2015;5-7. (In Russ.)
  10. Ermolenko NA, Buchneva IA. Exalief as a newer antiepileptic drug for adjunctive therapy of refractory partial-onset seizures. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2014;114(11):129-134. (In Russ.)
  11. Trinka E, Ben-Menachem E, Kowacs PA, Elger C, Keller B, Löffler K, Rocha JF, Soares-da-Silva P. Efficacy and safety of eslicarbazepine acetate versus controlled-release carbamazepine monotherapy in newly diagnosed epilepsy: A phase III double-blind, randomized, parallel-group, multicenter study. Epilepsia. 2018;59(2):479-491. https://doi.org/10.1111/epi.13993
  12. Villanueva V, Holtkamp M, Delanty N, Rodriguez-Uranga J, McMurray R, Santagueda P. Euro-Esli: a European audit of real-world use of eslicarbazepine acetate as a treatment for partial-onset seizures. J Neurol. 2017;264(11):2232-2248. https://doi.org/10.1007/s00415-017-8618-5
  13. Baulac M. Rational conversion from antiepileptic polytherapy to monotherapy. Epileptic Disord. 2003;5:125-132.
  14. Brodie M, Sills G. Combining antiepileptic drugs — Rational polytherapy? Seizure. 2011;20(5):369-375. https://doi.org/10.1016/j.seizure.2011.01.004
  15. Shorvon S, Trinka E, Steinhoff B, Holtkamp M, Villanueva V, Peltola J, Ben-Menachem E. Eslicarbazepine acetate: its effectiveness as adjunctive therapy in clinical trials and open studies. J Neurol. 2017;264:421-431. https://doi.org/10.1007/s00415-016-8338-2
  16. Ley M, Principe A, Jiménez-Conde J, Rocamora R. Assessing long-term effects of eslicarbazepine acetate on lipid metabolism profile, sodium values and liver function tests. Epilepsy Res. 2015;115:147-152. https://doi.org/10.1016/j.eplepsyres.2015.06.013
  17. Holtkamp M, McMurray R, Bagul M, Sousa R, Kockelmann E. Real-world data on eslicarbazepine acetate as add-on to antiepileptic monotherapy. Acta Neurol Scand. 2016;134(1):76-82. https://doi.org/10.1111/ane.12574
  18. Halasz P, Cramer JA, Hodoba D, Czlonkowska A, Guekht A, Maia J, Elger C, Almeida L, Soares-da-Silva P, on behalf of the BIA-2093-301 Study Group. Long-term efficacy and safety of eslicarbazepine acetate: results of a 1-year open-label extension study in partial-onset seizures in adults with epilepsy. Epilepsia. 2010;51(10):1963-1969. https://doi.org/10.1111/j.1528-1167.2010.02660.x
  19. Avakyan GN. Exalief as new perspectives for the treatment of epilepsy. Epilepsiya i paroksizmal’nye sostoyaniya (spets. vypusk). 2015;18-19. (In Russ.)
  20. Peltola J, Holtkamp M, Rocamora R, Ryvlin P, Sieradzan K, Villanueva V. Practical guidance and considerations for transitioning patients from oxcarbazepine or carbamazepine to eslicarbazepine acetate — Expert opinion. Epilepsy & Behavior. 2015;50:46-49. https://doi.org/10.1016/j.yebeh.2015.05.036
  21. Holtkamp M, et al. Poster P0912 presented at the 32nd International Epilepsy Congress, Barcelona, Spain; 2—6 September 2017.

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