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Csiba L.

Department of Neurology, University of Debrecen, Debrecen, Hungary

Zhussupova A.S.

JSC «Astana Medical University», Astana, Kazakhstan

Likhachev S.A.

Respublikanskiĭ nauchno-prakticheskiĭ tsentr nevrologii i neĭrokhirurgii Ministerstva zdravookhraneniia Respubliki Belarus', Minsk

Parfenov V.A.

Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova, Moskva

Churyukanov M.V.

Sechenov First Moscow State Medical University, Moscow;
Petrovsky Russian Research Center of Surgery, Moscow, Russia

Guekht A.B.

Solov’ev Research and Clinical Center for Neuropsychiatry

A systematic review of using myorelaxants in treatment of low back pain

Authors:

Csiba L., Zhussupova A.S., Likhachev S.A., Parfenov V.A., Churyukanov M.V., Guekht A.B.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(12): 100‑113

DOI: 10.17116/jnevro2018118121100

Read: 14558 times

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Table of contents

A SYSTEMATIC REVIEW OF USING MYORELAXANTS IN TREATMENT OF LOW BACK PAIN
A SYSTEMATIC REVIEW OF USING MYORELAXANTS IN TREATMENT OF LOW BACK PAIN

To cite this article:

Csiba L, Zhussupova AS, Likhachev SA, Parfenov VA, Churyukanov MV, Guekht AB. A systematic review of using myorelaxants in treatment of low back pain. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(12):100‑113. (In Russ.)
https://doi.org/10.17116/jnevro2018118121100

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Использование инфографики авторами научных работ
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Abstract:

A systematic review summarizes the results of studies on the efficacy of myorelaxants (tolperisone, tizanidine, thiocolchicoside or baclofen) in the treatment of acute nonspecific low back pain published up to Dec. 2017. The authors conclude that there are enough data to confirm the efficacy of myorelaxants in treatment of nonspecific low back pain, myorelaxants are recommended as monotherapy or in combination with analgesics or NSAID, the nonsedative drugs tolperisone or thiocolchicoside should be preferred.

Keywords:

dorsopathy
low back pain
tolperisone
tizanidine
thiocolchicoside or baclofen

Authors:

Csiba L.

Department of Neurology, University of Debrecen, Debrecen, Hungary

Zhussupova A.S.

JSC «Astana Medical University», Astana, Kazakhstan

Likhachev S.A.

Respublikanskiĭ nauchno-prakticheskiĭ tsentr nevrologii i neĭrokhirurgii Ministerstva zdravookhraneniia Respubliki Belarus', Minsk

Parfenov V.A.

Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova, Moskva

Churyukanov M.V.

Sechenov First Moscow State Medical University, Moscow;
Petrovsky Russian Research Center of Surgery, Moscow, Russia

Guekht A.B.

Solov’ev Research and Clinical Center for Neuropsychiatry

Close metadata

References:

  1. Woolf A, Pfleger B. Burden of major musculoskeletal conditions. Bulletin of the World Health Organization. 2003;81:646-656.
  2. Balagué F, Mannion AF, Pellisé F, Cedraschi C. Non-specific low back pain. Lancet. 2012;379:482-491.
  3. Parfenov VA. Diagnosis and Treatment of Acute Low Back Pain. Atmosfera. Nervnye Bolezni. 2009;1:25. (In Russ.)
  4. Stanton TR, Latimer J, Maher CG, Hancock MJ. How do we define the condition «recurrent low back pain»? A systematic review. Eur Spine J. 2010;19:533-539.
  5. Henschke N, Maher CG, Refshauge KM, Herbert RD, Cumming RG, Bleasel J, York J, Das A, McAuley JH. Prognosis in patients with recent onset low back pain in Australian primary care: inception cohort study. BMJ. 2008;337:a171.
  6. Verhagen AP, Downie A, Popal N, Maher C, Koes BW. Red flags presented in current low back pain guidelines: a review. Eur Spine J. 2016;25:2788-2802.
  7. Williams JS, NG N, Peltzer K, Yawson A, Biritwum R, Maximova T, Wu F, Arokiasamy P, Kowal P, Chatterji S. Risk Factors and Disability Associated with Low Back Pain in Older Adults in Low- and Middle-Income Countries. Results from the WHO Study on Global AGEing and Adult Health (SAGE). PLoS One. 2015;10(6):e0127880.
  8. Hoy D, Bain C, Williams G, March L, Brooks P, Blyth F, Woolf A, Vos T, Buchbinder R. A systematic review of the global prevalence of low back pain. Arthritis Rheum. 2012;64(6):2028-2037.
  9. Dagenais SDC, Caro J, Haldeman S: A systematic review of low back pain cost of illness studies in the United States and internationally. Spine Journal. 2008;8;8-20.
  10. Katz JN. Lumbar Disc Disorders and Low-Back Pain: Socioeconomic Factors and Consequences. Journal of Bone & Joint. 2006;8(suppl 2):21-24.
  11. Brisby H. Pain Origin and Mechanisms in Low Back Pain. In: van de Kelft E. (eds.). Surgery of the Spine and Spinal Cord. Cham: Springer; 2016.
  12. Roland M. A critical review of the evidence for a pain—spasm—pain cycle in spinal disorders. Clin Biomech. 1986;1:102-109.
  13. Hodges PW, Tucker K. Moving differently in pain: A new theory to explain the adaptation to pain. Pain. 2011;152:90-98.
  14. van Toulder MW, Touray T, Furlan AD, Solway S, Bouter LM. Muscle relaxants for non-specific low-back pain (Review). Cochrane Database of Systematic Reviews. 2003;4:CD004252.
  15. Chou R, Peterson K, Helfand M. Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review. J Pain Symptom Manage. 2004;28(2):140-175.
  16. Shaheed AC, Maher CG, Williams KA, McLachlan AJ. Efficacy and tolerability of muscle relaxants for low back pain: Systematic review and meta-analysis. Eur J Pain. 2017;21(2):228-237.
  17. Pratzel HG, Alken RG, Ramm S. Efficacy and tolerance of repeated oral doses of tolperisone hydrochloride in the treatment of painful reflex muscle spasm: results of a prospective placebo-controlled double-blind trial. Pain. 1996;67(2-3):417-425.
  18. Rao R, Panghate A, Chandanwale A. Clinical comparative study: efficacy and tolerability of tolperisone and thiocolchicoside in acute low back pain and spinal muscle spasticity. Asian Spine J. 2012;6(2):115-122.
  19. Kukushkin ML, Brylev LV, Laskov VB, Makarov NS, Pizova NV, Sokov EL, Chefranova ZY, Sholomov II, Guekht AB. Results of a randomized double blind parallel study on the efficacy and safety of tolpersione in patients with acute nonspecific low back pain. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2017;117(11):69-78. (In Russ.)
  20. Verbitskaya SV, Parfenov VA, Borisov KN. Tolperisone (Mydocalm) as Part of the Multimodal Treatment of Acute Low Back Pain. Clinical Pharmacology and Therapeutics. 2008;17:(2). (In Russ.)
  21. Bhattacharjya B, Naser SM, Biswas A. Effectiveness of Tolperisone Hydrochloride with Aceclofenac as Combined Therapy in Acute Low Back Pain. Indian Journal of Physical Medicine and Rehabilitation. 2012;23(2):74-78.
  22. Abbruzzese G. The medical management of spasticity. Eur J Neurol. 2002;9(suppl 1):30-34; discussion 53-61.
  23. Berry H, Hutchinson DR. A multicentre placebo-controlled study in general practice to evaluate the efficacy and safety of tizanidine in acute low-back pain. J Int Med Res. 1988;16:75-82.
  24. Pareek A, Chandurkar N, Chandanwale AS, Ambade R, Gupta A, Bartakke G. Aceclofenac-tizanidine in the treatment of acute low back pain: A double-blind, double-dummy, randomized, multicentric, comparative study against aceclofenac alone. Eur Spine J. 2009;18:1836-1842.
  25. Sirdalud Ternelin Asia-Pacific Study Group. Efficacy and gastroprotective effects of tizanidine plus diclofenac versus placebo plus diclofenac in patients with painful muscle spasms. Current therapeutic Research. 1998;59:1.
  26. Berry H, Hutchinson DR. Tizanidine and ibuprofen in acute low-back pain: Results of a double-blind multicentre study in general practice. J Int Med Res. 1988;16:83-91.
  27. Ketenci A, Ozcan E, Karamursel S. Assessment of efficacy and psychomotor performances of thiocolchicoside and tizanidine in patients with acute low back pain. Int J Clin Pract. 2005;59:764-770.
  28. Tüzün F, Unalan H, Oner N, Ozgüzel H, Kirazli Y, Içağasioğlu A, Kuran B, Tüzün S, Başar G. Multicenter, randomized, double-blinded, placebo-controlled trial of thiocolchicoside in acute low back pain. Joint Bone Spine. 2003;70:356-361.
  29. Marcel C, Rezvani Y, Revel M. Evaluation of thiocolchicoside as monotherapy in low back pain. Results of a randomized study versus placebo. La Presse Medicale. 1990;24(19):1133-1136.
  30. Aksoy C, Esen G, Karan A, Dıraçoǧlu D. Low back pain. Results of an open clinical trial comparing the standard treatment alone to the combination of standard treatment associated with thiocolchicoside. Osteoporosis Int. 2002;13:54-55.
  31. Akhter N, Siddiq MZ. Comparative Efficacy of Diclofenac Sodium Alone and in Combination with Thiocolchicoside in Patients with Low Back Pain. Med Forum. 2017;28(11):93-96.
  32. Dapas F. Baclofen for the treatment of acute low-back syndrome. Spine. 1985;10(4):345-349.
  33. Karneev AN, Soloviova EY, Fedin AI. The use of baklosan in the complex treatment of back pain. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2008;108(9):48-51. (In Russ.)
  34. Soonawalla DF, Joshi N. Efficacy of thiocolchicoside in Indian patients suffering from low back pain associated with muscle spasm. J Indian Med Assoc. 2008;106(5):331-335.
  35. Miettinen TJ, Kanto JH, Salonen MA. The sedative and sympatholytic effects of oral tizanidine in healthy volunteers. Anesth Analg. 1996;82(4):817-820.
  36. Montané E, Vallano A, Laporte JR. Oral antispastic drugs in nonprogressive neurologic diseases: a systematic review. Neurology. 2004;63(8):1357-1363.
  37. Dulin J, Kovács L, Ramm S. Evaluation of sedative effects of single and repeated doses of 50 mg and 150 mg tolperisone hydrochloride. Results of a prospective, randomized, double-blind, placebo-controlled trial. Pharmacopsychiatry. 1998;31(4):137-142.
  38. Patat A, Klein MJ, Surjus A, Renault M, Rezvani Y, Granier J. Effects of acute and repeated doses of two muscle relaxants chlormezanone and thiocolchicoside on vigilance and psychomotor performance of healthy volunteers. Human Psychopharmacology. 1991;6:285-292.
  39. Koes BW, van Tulder M, Lin CC, Macedo LG, McAuley J, Maher C. An updated overview of clinical guidelines for the management of non-specific low back pain in primary care. Eur Spine J. 2010;19:2075-2094.
  40. Qaseem A, Wilt TJ, McLean RM, Forciea MA; Clinical Guidelines Committee of the American College of Physicians. Noninvasive Treatments for Acute, Subacute, and Chronic Low Back Pain: A Clinical Practice Guideline From the American College of Physicians. Ann Intern Med. 2017;166:514-530.
  41. Agence Nationale d’Accreditation et d’Evaluation en Sante Guidelines department, diagnosis and management of acute low back pain (3 months) with or without sciatica & diagnosis, management and follow-up of patients with chronic low back pain. Paris; 2000. www.anaes.fr or www.sante.fr
  42. Clinic on Low back Pain in Interdisciplinary Practice. Canada. 2007.
  43. The Dutch Institute for Healthcare Improvement (CBO) (2003). Clinical guideline for non-specific low back pain. 2003.
  44. Drug Committee of the German Medical Society Recommendations for treatment of low back pain. Köln, Germany. 2007.
  45. Malmivaara A, Erkintalo M, Jousimaa J: Aikuisten alaselka¨sairaudet. (Low back pain among adults. An update within the Finnish Current Care guidelines). Working group by the Finnish Medical Society Duodecim and the Societas Medicinae Physicalis et Rehabilitationis, Fenniae. Duodecim. 2008;124:2237-2239.
  46. Van Tulder MW, Becker A, Bekkering T, Breen A, del Real MT, Hutchinson A, Koes B, Laerum E, Malmivaara A; COST B13 Working Group on Guidelines for the Management of Acute Low Back Pain in Primary Care. European guidelines for the management of acute low back pain in primary care. Eur Spine J. 2006;15(suppl 2):169-191.
  47. Friedrich M, Likar R. Evidenz- und konsensusbasierte österreichische Leitlinien für das Management akuter und chronischer unspezifischer Kreuzschmerzen. Wien Klin Wochenschr. 2007;119(5-6):189-197.
  48. Verster JC, Pandi-Perumal SR, Streiner DL. Sleep and Quality of Life in Clinical Medicine. Humana Press; 2008.
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