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Iakupov É.Z.

Kafedra nevrologii, neĭrokhirurgii i meditsinskoĭ genetiki Kazanskogo gosudarstvennogo meditsinskogo universiteta

Artemieva D.V.

Kazan State Medical University, Kazan, Russia

Troshina Iu.V.

GBOU VPO "Kazanskiĭ gosudarstvennyĭ meditsinskiĭ universitet", Kazan'

Multimodality of clinical effects of orexin

Authors:

Iakupov É.Z., Artemieva D.V., Troshina Iu.V.

More about the authors

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To cite this article:

Iakupov ÉZ, Artemieva DV, Troshina IuV. Multimodality of clinical effects of orexin. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(12):114‑119. (In Russ.)
https://doi.org/10.17116/jnevro2018118121114

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References:

  1. de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FS 2nd, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM, Sutcliffe JG. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA. 1998;95(1):322-327. https://doi.org/10.1073/pnas.95.1.322
  2. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998;92(4):573-585. https://doi.org/10.1016/S0092-8674(00)80949-6
  3. Lin L, Faraco J, Li R, Kadotani H, Rogers W, Lin X, Qiu X, de Jong PJ, Nishino S, Mignot E. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell. 1999;98(3):365-376. https://doi.org/10.1016.S0092-8674(00)81965-0
  4. Challet E, Pevet P, Malan A. Effect of prolonged fasting and subsequent refeeding on free-running rhythms of temperature and locomotor activity in rats. Behav Brain Res. 1997;84:275-284. https://doi.org/10.1016/S0166-4328(97)83335-9
  5. Nishino S, Ripley B, Overeem S, Lammers GJ, Mignot E. Hypocretin (orexin) deficiency in human narcolepsy. Lancet. 2000;355(9197):39-40. https://doi.org/10.1016/S0140-6736(99)05582-8
  6. Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y, Nevsimalova S, Aldrich M, Reynolds D, Albin R, Li R, Hungs M, Pedrazzoli M, Padigaru M, Kucherlapati M, Fan J, Maki R, Lammers GJ, Bouras C, Kucherlapati R, Nishino S, Mignot E. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med. 2000;6(9):991-997. https://doi.org/10.1038/79690
  7. Thannickal TC, Moore RY, Nienhuis R, Ramanathan L, Gulyani S, Aldrich M, Cornford M, Siegel JM. Reduced number of hypocretin neurons in human narcolepsy. Neuron. 2000;27(3):469-474. https://doi.org/10.1016/S0896-6273(00)00058-1
  8. Willie JT, Chemelli RM, Sinton CM, Tokita S, Williams SC, Kisanuki YY, Marcus JN, Lee C, Elmquist JK, Kohlmeier KA, Leonard CS, Richardson JA, Hammer RE, Yanagisawa M. Distinct narcolepsy syndromes in orexin receptor-2 and orexin null mice: molecular genetic dissection of non-REM and REM sleep regulatory processes. Neuron. 2003;38(5):715-730. https://doi.org/10.1016/S0896-6273(03)00330-1
  9. Yamanaka A, Beuckmann CT, Willie JT, Hara J, Tsujino N, Mieda M, Tominaga M, Yagami Ki, Sugiyama F, Goto K, Yanagisawa M, Sakurai T. Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron. 2003;38(5):701-713. https://doi.org/10.1016/S0896-6273(03)00331-3
  10. Mieda M, Willie JT, Hara J, Sinton CM, Sakurai T, Yanagisawa M. Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice. Proc Natl Acad Sci USA. 2004;101(13):4649-4654. https://doi.org/10.1073/pnas.0400590101
  11. Brisbare-Roch C, Dingemanse J, Koberstein R, Hoever P, Aissaoui H, Flores S, Mueller C, Nayler O, van Gerven J, de Haas SL, Hess P, Qiu C, Buchmann S, Scherz M, Weller T, Fischli W, Clozel M, Jenck F. Promotion of sleep by targeting the orexin system in rats, dogs and humans. Nat Med. 2007;13(2):150-155. https://doi.org/10.1038/nm1544
  12. Wang Z, Liu S, Kakizaki M, Hirose Y, Ishikawa Y, Funato H, Yanagisawa M, Yu Y, Liu Q. Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway. J Biol Chem. 2014;289(46):31950-31959. https://doi.org/10.1074/jbc.M114.600015
  13. Muroya S, Funahashi H, Yamanaka A, Kohno D, Uramura K, Nambu T, Shibahara M, Kuramochi M, Takigawa M, Yanagisawa M, Sakurai T, Shioda S, Yada T. Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus. Eur J Neurosci. 2004;19(6):1524-1534. https://doi.org/10.1111/j.1460-9568.2004.03255.x
  14. Poluektov MG. Sleep disorders in neurological practice. Neurology, neurosurgery, psychiatry. 2012;4(4):12-24. (In Russ.) https://doi.org/10.14412/2074-2711-2012-416
  15. Arnulf I, Zeitzer M, File J, Farber N. Kleine—Levin Syndrome Foundation. Brain. 2005;28(12):2763-2776. https://doi.org/10.1093/brain/awh620
  16. Afshar K, Engelfried K, Sharma OP. Sarcoidosis: a rare cause of Kleyne—Levin syndrome. Vasc Diffuse Lung Dis. 2008;25(1):60-63.
  17. Kovalzon VM, Zavalko IM. Neurochemistry of sleep/wake cycle in Parkinson’s disease. Neurochemistry. 2013;30(3):193-206. (In Russ.)
  18. Gusev EI, Gecht AB, Popov GR, Volkova NA, Pastukhova YuF, Pronina TS, Chesnokova AYu, Ekimova IV. Neurodegenerativa diseases. Fundamental aspects and applications. M.: Nauka; 2010. (In Russ.)
  19. Zoccolella S, Savarese M, Lamberti P, Manni R, Pacchetti C, Logroscino G. Sleep disorders and the natural history of Parkinson’s disease: the contribution of epidemiological studies. Sleep Med Rev. 2011;15(1):41-50. https://doi.org/10.1016/j.smrv.2010.02.004
  20. Silkis IG. Search for approaches to the correction of daytime sleepiness caused by dopaminergic drugs in the treatment of Parkinson’s disease: neurochemical aspects. Neurochemistry. 2009;26(3):253-264. (In Russ.)
  21. Arnulf I, Bonnet A-M, Damier P, Bejjani B-P, Seilhean D, Derenne J-P, Agid Y. Hallucinations, REM sleep, and Parkinson’s disease: a medical hypothesis. Neurology. 2000;55(2):281-288. https://doi.org/10.1212/WNL.57.7.1350-a
  22. Fronczek R, Overeem S, Lee SYY, Hegeman IM, van Pelt J, van Duinen SG, Lammers GJ, Swaab DF. Hypocretin (orexin) loss in Parkinson’s disease. Brain. 2007;130(6):1577-1585. https://doi.org/10.1093/brain/awm090
  23. Fronczek R, Overeem S, Lee SYY, Hegeman IM, van Pelt J, van Duinen SG, Lammers GJ, Swaab DF. The brain hypocretins and their receptors: mediators of allostatic arousal. Brain. 2008;9(1):39-45. https://doi.org/10.1016/j.coph.2008.12.018
  24. Thannickal TC, Lai Y-Y, Siegel JM. Hypocretin (orexin) cell loss in Parkinson’s disease. Brain. 2007;130(6):1586-1595. https://doi.org/10.1093/brain/awm097
  25. Thannickal TC, Lai Y-Y, Siegel JM. Hypocretin (orexin) and melanin concentrating hormone loss and the symptoms of Parkinson’s disease. Brain. 2008;131(1):e87. https://doi.org/10.1093/brain/awm221
  26. Lagos P, Torterolo P, Jantos H, Monti JM. Immunoneutralization of melanin-concentrating hormone (MCH) in the dorsal raphe nucleus: effects on sleep and wakefulness. Brain Res. 2011;1369:112-118. https://doi.org/10.1016/j.brainres.2010.11.027
  27. Nakamura T, Uramura K, Nambu T, Yada T, Goto K, Yanagisawa M, Sakurai T. Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system. Brain Res. 2000;873:181-187. https://doi.org/10.1016/S0006-8993(00)02555-5
  28. Baumann CR, Scammell TE, Bassetti CL. Parkinson’s disease, sleepiness and hypocretin/orexin. Brain. 2008;131:e91. https://doi.org/10.1093/brain/awm220
  29. Bassetti CL, Baumann CR, Scammell TE. Narcolepsy: Pathophysiology, Diagnosis, and Treatment. Springer. 2011. https://doi.org/10.1007/978-1-4419-8390-9
  30. Wienecke M, Werth E, Poryazova R, Baumann-Vogel H, Bassetti CL, Weller M, Waldvogel D, Storch A, Baumann CR. Progressive dopamine and hypocretin deficiencies in Parkinson’s disease: is there an impact on sleep and wakefulness? J Sleep Res. 2012;21(6):710-717. https://doi.org/10.1111/j.1365-2869.2012.01027.x
  31. Shumilov EG. Participation of orexin structures of the extended amygdala in the reinforcing action of drug genes: Dis. … kand. med. nauk. SPb. 2016. (In Russ.)
  32. Petrov AM, Giniatullin AR. Nejrobiologiya sna: sovremennyj vzglyad. Uchebnoe posobie. Kazan’: Izdatel’stvo Kazanskogo gosudarstvennogo medicinskogo universiteta; 2012. (In Russ.)
  33. Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, Kilduff TS. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci. 1998;18:9996-10015. https://doi.org/10.1007/978-1-4419-8390-9
  34. Citrome L. Suvorexant for insomnia: a systematic review of the efficacy and safety profile for the newly approved hypnotic — what is the number needed to treat, number needed to harm, and likelihood to be helped or harmed? Int J Clin Pract. 2014;68:1429-1441. https://doi.org/10.1111/ijcp.12568
  35. Cox CD, Breslin MJ, Whitman DB, Schreier JD, McGaughey GB, Bogusky MJ, Roecker AJ, Mercer SP, Bednar RA, Lemaire W, Bruno JG, Reiss DR, Harrell CM, Murphy KL, Garson SL, Doran SM, Prueksaritanont T, Anderson WB, Tang C, Roller S, Cabalu TD, Cui D, Hartman GD, Young SD, Koblan KS, Winrow CJ, Renger JJ, Coleman PJ. Discovery of the dual orexin receptor antagonist methanone (MK-4305) for the treatment of insomnia. J Med Chem. 2010;53:5320-5332. https://doi.org/10.1021/jm100541c
  36. Winrow CJ, Gotter AL, Cox CD, Doran SM, Tannenbaum PL, Breslin MJ, Garson SL, Fox SV, Harrell CM, Stevens J, Reiss DR, Cui D, Coleman PJ, Renger JJ. Promotion of sleep by MK-4305 — a novel dual orexin receptor antagonist. J Neurogenet. 2011;25:52-61. https://doi.org/10.3109/01677063.2011.566953
  37. Herring JW, Snyder E, Budd K, Hutzelmann J, Snavely D, Liu K, Lines C, Roth T, Michelson D. Orexin receptor antagonism for treatment of insomnia: a randomized clinical trial of suvorexant. Neurology. 2012;79:2265-2274. https://doi.org/10.1212/WNL.0b013e31827688ee.
  38. Herring WJ, Connor KM, Snyder E, Snavely DB, Zhang Y, Hutzelmann J, Matzura-Wolfe D, Benca RM, Krystal AD, Walsh JK, Lines C, Roth T, Michelson D. Suvorexant in Patients with Insomnia: Pooled Analyses of Three-Month Data from Phase-3 Randomized Controlled Clinical Trials. Journal of Clinical Sleep Medicine. 2016;12(9):1215-1225. https://doi.org/10.5664/jcsm.6116
  39. Michelson D, Snyder E, Pardis E, Chengan-Liu M, Snavely DB, Hutzelmann J, Walsh JK, Krystal AD, Benca RM, Cohn M, Lines C, Roth T, Herring WJ. Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double blind, placebo-controlled trial. Lancet Neurol. 2014;13:461-471. https://doi.org/10.1016/S1474-4422(14)70053-5
  40. Michelson D. Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2016. https://doi.org/10.1016/S1474-4422(14)70053-5

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